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1. 发明授权

US08637234B2 Molecular scaffolds for HIV-1 epitopes 失效
标题翻译： HIV-1表位的分子支架
公开(公告)号：US08637234B2
公开(公告)日：2014-01-28
申请号：US11578761
申请日：2005-04-08
申请人： George M. Shaw , James E. Robinson , Frederic Bibollet-Ruche , Julie M. Decker , Beatrice H. Hahn , Peter D. Kwong
发明人： George M. Shaw , James E. Robinson , Frederic Bibollet-Ruche , Julie M. Decker , Beatrice H. Hahn , Peter D. Kwong
IPC分类号： C12Q1/70 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/38 , C07K16/00
CPC分类号： G01N33/56988 , C07K16/1063 , C07K16/2812 , C07K2317/32 , C07K2317/34 , C07K2317/76 , G01N2469/20
摘要： Methods and compositions are provided for the use of an envelope polypeptide or a functional variant thereof from a lentivirus that is not HIV-1 as a molecular scaffold for HIV-1 epitopes. The HIV-1 epitopes can be recognized by HIV-1 binding antibodies, HIV-1 neutralizing antibodies and/or CD4-induced antibodies. Thus, methods are provided for detecting HIV-1 binding antibodies in a subject infected with HTV-1. Further provided are methods to determine an epitope for an HIV-1 binding antibody; methods to assay for an HIV-1 binding antibody; methods to identify a soluble CD4 mimic; methods to neutralize an non-HIV-1 virus; diagnostic assays to monitor HIV disease in a subject or to monitor the subject's response to immunization by a HIV vaccine; and methods to alter the neutralization potential of an HIV-1 derived CD4-induced antibody. Chimeric polypeptides, chimeric polynucleotides, kits, cells and viruses are also provided.
摘要翻译：提供了使用来自不是HIV-1作为HIV-1表位的分子支架的慢病毒的包膜多肽或其功能变体的方法和组合物。 HIV-1表位可被HIV-1结合抗体，HIV-1中和抗体和/或CD4诱导的抗体识别。因此，提供了用于检测感染HTV-1的受试者中的HIV-1结合抗体的方法。还提供了确定HIV-1结合抗体的表位的方法; 测定HIV-1结合抗体的方法; 识别可溶性CD4模拟物的方法; 中和非HIV-1病毒的方法; 用于监测受试者中艾滋病病毒的诊断测定或监测受试者对HIV疫苗免疫接种的反应; 以及改变HIV-1衍生的CD4诱导抗体的中和电位的方法。还提供嵌合多肽，嵌合多核苷酸，试剂盒，细胞和病毒。

2. 发明授权

US08647818B2 Molecular scaffolds for HIV-1 immunogens 失效
标题翻译： HIV-1免疫原的分子支架
公开(公告)号：US08647818B2
公开(公告)日：2014-02-11
申请号：US11816624
申请日：2006-02-16
申请人： George M. Shaw , Beatrice H. Hahn , Frederic Bibollet-Ruche , Peter D. Kwong
发明人： George M. Shaw , Beatrice H. Hahn , Frederic Bibollet-Ruche , Peter D. Kwong
IPC分类号： C12Q1/70 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/38 , C07K16/00
CPC分类号： A61K39/21 , A61K39/12 , A61K39/385 , A61K2039/53 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： Methods and compositions are provided which employ chimeric polypeptides having at least one heterologous epitope for a human immunodeficiency virus type 1 (HIV-1) neutralizing antibody. These chimeric polypeptides behave as molecular scaffolds which are capable of presenting the various heterologous HIV-1 epitopes. The invention demonstrates that a heterologous epitope recognized by the HIV-1 neutralizing antibody can be more fully exposed to neutralizing antibodies when presented within the backbone of the chimeric polypeptide than when the epitope is presented within the context of an HIV-1 backbone. Polynucleotides encoding these chimeric polypeptides are also provided. Immunogenic compositions are provided which comprise a chimeric polypeptide having at least one heterologous epitope that interacts with an HIV-1 neutralizing antibody. Immuno genie compositions comprising chimeric polynucleotides encoding the chimeric polypeptides of the invention are also provided. Vaccines comprising such immunogenic compositions are also provided. Further provided are methods which employ the immunogenic compositions of the invention. Such methods include, for example, methods for eliciting an immune response in a subject, methods for generating antibodies specific for the chimeric polypeptide or the chimeric polypeptide, and methods for inhibiting or preventing infection by HIV-1 in a subject.
摘要翻译：提供了使用针对人免疫缺陷病毒1型（HIV-1）中和抗体具有至少一个异源表位的嵌合多肽的方法和组合物。这些嵌合多肽表现为能够呈递各种异源HIV-1表位的分子支架。本发明证明当HIV-1中和抗体在HIV-1主链的上下文中呈现时，HIV-1中和抗体识别的异源表位可以更好地暴露于中和抗体。还提供了编码这些嵌合多肽的多核苷酸。提供免疫原性组合物，其包含具有至少一种与HIV-1中和抗体相互作用的异源表位的嵌合多肽。还提供了包含编码本发明的嵌合多肽的嵌合多核苷酸的免疫精华组合物。还提供了包含这种免疫原性组合物的疫苗。还提供了采用本发明的免疫原性组合物的方法。这样的方法包括例如在受试者中引发免疫应答的方法，用于产生对嵌合多肽或嵌合多肽具有特异性的抗体的方法，以及用于抑制或预防受试者中HIV-1感染的方法。

3. 发明申请

US20090162390A1 Molecular Scaffolds for HIV-1 Immunogens 失效
标题翻译： HIV-1免疫原的分子支架
公开(公告)号：US20090162390A1
公开(公告)日：2009-06-25
申请号：US11816624
申请日：2006-02-16
申请人： George M. Shaw , Beatrice H. Hahn , Frederic Bibollet-Ruche , Peter D. Kwong
发明人： George M. Shaw , Beatrice H. Hahn , Frederic Bibollet-Ruche , Peter D. Kwong
IPC分类号： A61K39/21 , A61K31/711 , C07K14/155 , C12N15/31 , A61P31/18
CPC分类号： A61K39/21 , A61K39/12 , A61K39/385 , A61K2039/53 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： Methods and compositions are provided which employ chimeric polypeptides having at least one heterologous epitope for a human immunodeficiency virus type 1 (HIV-1) neutralizing antibody. These chimeric polypeptides behave as molecular scaffolds which are capable of presenting the various heterologous HIV-1 epitopes. The invention demonstrates that a heterologous epitope recognized by the HIV-1 neutralizing antibody can be more fully exposed to neutralizing antibodies when presented within the backbone of the chimeric polypeptide than when the epitope is presented within the context of an HIV-1 backbone. Polynucleotides encoding these chimeric polypeptides are also provided. Immunogenic compositions are provided which comprise a chimeric polypeptide having at least one heterologous epitope that interacts with an HIV-1 neutralizing antibody. Immuno genie compositions comprising chimeric polynucleotides encoding the chimeric polypeptides of the invention are also provided. Vaccines comprising such immunogenic compositions are also provided. Further provided are methods which employ the immunogenic compositions of the invention. Such methods include, for example, methods for eliciting an immune response in a subject, methods for generating antibodies specific for the chimeric polypeptide or the chimeric polypeptide, and methods for inhibiting or preventing infection by HIV-1 in a subject.
摘要翻译：提供了使用针对人免疫缺陷病毒1型（HIV-1）中和抗体具有至少一个异源表位的嵌合多肽的方法和组合物。这些嵌合多肽表现为能够呈递各种异源HIV-1表位的分子支架。本发明证明当HIV-1中和抗体在HIV-1主链的上下文中呈现时，HIV-1中和抗体识别的异源表位可以更好地暴露于中和抗体。还提供了编码这些嵌合多肽的多核苷酸。提供免疫原性组合物，其包含具有至少一种与HIV-1中和抗体相互作用的异源表位的嵌合多肽。还提供了包含编码本发明的嵌合多肽的嵌合多核苷酸的免疫精华组合物。还提供了包含这种免疫原性组合物的疫苗。还提供了采用本发明的免疫原性组合物的方法。这样的方法包括例如在受试者中引发免疫应答的方法，用于产生对嵌合多肽或嵌合多肽具有特异性的抗体的方法，以及用于抑制或预防受试者中HIV-1感染的方法。

4. 发明申请

US20140023683A1 IDENTIFICATION OF TRANSMITTED HEPATITIS C VIRUS (HCV) GENOMES BY SINGLE GENOME AMPLIFICATION 审中-公开
标题翻译：通过单因素扩增鉴定传播的丙型肝炎病毒（HCV）基因
公开(公告)号：US20140023683A1
公开(公告)日：2014-01-23
申请号：US13821886
申请日：2011-09-08
申请人： George M. Shaw , Hui Li , Beatrice H. Hahn , Barton F. Haynes
发明人： George M. Shaw , Hui Li , Beatrice H. Hahn , Barton F. Haynes
IPC分类号： C12Q1/70 , A61K39/29
CPC分类号： C12Q1/707 , A61K39/29
摘要： This invention provides methods for identifying HCV genomes and more specifically, methods for identifying nucleotide sequence of viral structural proteins at the time of HCV viral transmission. The method of the invention utilizes single genome amplification and sequencing of circulating virus as well as phylogenetic analysis of the resulting nucleotide sequence for identifying transmitted HCV genomes. Also provided are HCV genomes and corresponding nucleotide sequence for transmitted and circulating HCV virus. The invention further provides methods of administering a vaccine comprising one or more identified transmitted HCV sequences.
摘要翻译：本发明提供用于鉴定HCV基因组的方法，更具体地，用于在HCV病毒传播时鉴定病毒结构蛋白的核苷酸序列的方法。本发明的方法利用循环病毒的单基因组扩增和测序以及所得核苷酸序列的系统发育分析来鉴定传播的HCV基因组。还提供了HCV基因组和用于传播和循环HCV病毒的相应核苷酸序列。本发明还提供了施用包含一种或多种所鉴定的传播的HCV序列的疫苗的方法。

5. 发明授权

US09844589B2 Modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins capable of inducing broadly reactive T- and B-cell responses 有权
公开(公告)号：US09844589B2
公开(公告)日：2017-12-19
申请号：US13137517
申请日：2011-08-23
申请人： Barton F. Haynes , Feng Gao , Bette T. Korber , Beatrice H. Hahn , George M. Shaw , Denise Kothe , Ying Ying Li , Julie Decker , Hua-Xin Liao
发明人： Barton F. Haynes , Feng Gao , Bette T. Korber , Beatrice H. Hahn , George M. Shaw , Denise Kothe , Ying Ying Li , Julie Decker , Hua-Xin Liao
IPC分类号： A61K39/21 , C07K14/005 , C07K16/42 , A61K39/12 , A61K39/00
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K16/4225 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16322
摘要： The invention relates to HIV-1 envelope polypeptides comprising the consensus envelope of SEQ ID NO: 35, compositions comprising these envelopes and methods for using same.

6. 发明申请

US20140248301A1 METHOD OF INDUCING THE PRODUCTION OF PROTECTIVE ANTI-HIV-1 ANTIBODIES 审中-公开
标题翻译：诱导产生抗HIV-1抗体的方法
公开(公告)号：US20140248301A1
公开(公告)日：2014-09-04
申请号：US14106461
申请日：2013-12-13
申请人： Barton F. Haynes , Hua-Xin Liao , Li-Hua Ping , Ronald Swanstrom , Beatrice H. Hahn , George M. Shaw
发明人： Barton F. Haynes , Hua-Xin Liao , Li-Hua Ping , Ronald Swanstrom , Beatrice H. Hahn , George M. Shaw
IPC分类号： C07K16/10
CPC分类号： A61K39/21 , A61K39/0005 , A61K39/0258 , A61K2039/53 , A61K2039/58 , C07K16/1063 , C12N2740/16034 , C12N2740/16134
摘要： The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective anti-HIV antibodies by targeting B cell germline and clone intermediates using a combination of HIV envelope and non-HIV immunogens. The invention also relates to compositions suitable for use in such a method.
摘要翻译：本发明一般涉及用于HIV疫苗接种的免疫原，特别涉及通过使用HIV包膜和非HIV的组合靶向B细胞种系和克隆中间体来诱导产生保护性抗HIV抗体的方法免疫原。本发明还涉及适用于这种方法的组合物。

7. 发明申请

US20120087938A1 Consensus/ancestral immunogens 有权
标题翻译：共识/祖传免疫原
公开(公告)号：US20120087938A1
公开(公告)日：2012-04-12
申请号：US13137517
申请日：2011-08-23
申请人： Barton F. Haynes , Feng Gao , Bette T. Korber , Beatrice H. Hahn , George M. Shaw , Denise Kothe , Ying Ying Li , Julie Decker , Hua-Xin Liao
发明人： Barton F. Haynes , Feng Gao , Bette T. Korber , Beatrice H. Hahn , George M. Shaw , Denise Kothe , Ying Ying Li , Julie Decker , Hua-Xin Liao
IPC分类号： A61K39/21 , A61P31/18 , C12N15/63 , C07K14/16 , C12N15/49
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K16/4225 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16322
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
摘要翻译：本发明一般涉及免疫原，特别涉及用于诱导中和大范围的HIV初级分离物和/或诱导T细胞免疫应答的免疫原的抗体的免疫原。本发明还涉及使用这种免疫原诱导抗HIV抗体的方法和/或诱导T细胞免疫应答的方法。本发明还涉及编码本发明免疫原的核酸序列。

8. 发明授权

US06492110B1 Reference clones and sequences for non-subtype B isolates of human immunodeficiency virus type 1 失效
标题翻译：人类免疫缺陷病毒1型非亚型B分离株的参考克隆和序列
公开(公告)号：US06492110B1
公开(公告)日：2002-12-10
申请号：US09184418
申请日：1998-11-02
申请人： Beatrice H. Hahn , George M. Shaw , Feng Gao
发明人： Beatrice H. Hahn , George M. Shaw , Feng Gao
IPC分类号： C12Q168
CPC分类号： C07K14/005 , A01N63/00 , A01N63/04 , A61K8/22 , A61K8/602 , A61K8/66 , A61K2800/524 , A61Q5/00 , A61Q11/00 , A61Q17/005 , A61Q19/00 , C07H21/02 , C09D5/025 , C09D5/14 , C11D3/0078 , C11D3/2034 , C11D3/38654 , C11D3/48 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/703 , A01N2300/00
摘要： The nucleotide sequences of the genomes of eleven molecular clones for non-subtype B isolates of human immunodeficiency virus type 1 are disclosed. The invention relates to the nucleic acids and peptides encoded by and/or derived from these sequences and their use in diagnostic methods and as immunogens.
摘要翻译：公开了人类免疫缺陷病毒1型非亚型B分离株的11个分子克隆的基因组的核苷酸序列。本发明涉及由这些序列编码和/或衍生自这些序列的核酸和肽及其在诊断方法中的用途和作为免疫原。

9. 发明授权

US09309574B1 Molecular cloning of HIV-1 from immortalized cell lines 失效
标题翻译：来自永生化细胞系的HIV-1的分子克隆
公开(公告)号：US09309574B1
公开(公告)日：2016-04-12
申请号：US08385231
申请日：1995-02-08
申请人： Robert C. Gallo , Flossie Wong-Staal , Mikulas Popovic , Beatrice H. Hahn , George M. Shaw , Amanda G. Fisher
发明人： Robert C. Gallo , Flossie Wong-Staal , Mikulas Popovic , Beatrice H. Hahn , George M. Shaw , Amanda G. Fisher
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/703 , C12N15/63 , C12Q1/6834 , C12Q1/6876
摘要： Disclosed is the molecular cloning of HTLV-III, the adult leukemia and acquired immune deficiency syndrome (AIDS) virus. Clone BH10 contains a 9.0 Kb viral insert constituting the entire HTLV-III genome. Clones BH8 and BH5 contain viral inserts of 5.5 Kb and 3.5 Kb, respectively. These clones are suitable for the development of diagnostic and therapeutic measures for AIDS, as well as use as probes for the detection of AIDS. By scientific convention, HTLV-III, referred to herein also as HIV, has been renamed as HIV-1.
摘要翻译：公开了HTLV-III的分子克隆，成人白血病和获得性免疫缺陷综合征（AIDS）病毒。克隆BH10含有构成整个HTLV-III基因组的9.0Kb病毒插入物。克隆BH8和BH5分别含有5.5Kb和3.5Kb的病毒插入物。这些克隆适合于开发艾滋病的诊断和治疗措施，以及用作艾滋病检测的探针。根据科学惯例，HTLV-III在本文中也称为HIV，已被更名为HIV-1。

10. 发明申请

US20130177583A1 MOLECULAR CLONE OF HIV-1 审中-公开
标题翻译：分子克隆HIV-1
公开(公告)号：US20130177583A1
公开(公告)日：2013-07-11
申请号：US13582319
申请日：2011-03-03
申请人： George M. Shaw , Beatrice H. Hahn , Hui Li , Barton F. Haynes , Martin Markowitz
发明人： George M. Shaw , Beatrice H. Hahn , Hui Li , Barton F. Haynes , Martin Markowitz
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K39/12 , C12N7/00 , C12N2740/16021 , C12N2740/16034
摘要： The present invention relates, in general, to HIV-1 and, in particular, to a molecular clone of HIV-1. The invention further relates to methods of inducing an immune response to HIV-1 in a patient and to immunogens suitable for use in such methods. The invention also relates to anti-HIV-1 antibodies and to methods of using same to prevent or treat HIV-infection.
摘要翻译：本发明一般涉及HIV-1，特别是涉及HIV-1的分子克隆。本发明还涉及在患者体内诱导针对HIV-1的免疫应答的方法以及适用于这些方法的免疫原。本发明还涉及抗HIV-1抗体及其用于预防或治疗HIV感染的方法。

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