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1. 发明申请

WO1993009423A1 MULTIDIMENSIONAL IMAGING USING A SINGLE POINT DETECTOR FOR A PHASE ENCODED MODULATED OPTICAL CARRIER 审中-公开
标题翻译：使用单点检测器进行相位编码调制光载波的多维成像
公开(公告)号：WO1993009423A1
公开(公告)日：1993-05-13
申请号：PCT/US1992009715
申请日：1992-11-06
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ...
发明人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ... , KNÜTTEL, Alexander
IPC分类号： G01N21/47
CPC分类号： G01N21/4795 , G01N2021/1759 , G01N2021/1765 , G01N2021/4173 , G01N2201/067
摘要： Optical imaging of an object utilizes a plurality of amplitude modulated light rays propagating through the object, either sequentially or simultaneously, for detection by a single photodetector. The light rays may propagate geometrically (i.e., directly) or diffusively. Each of the rays is encoded with a different phase to provide sufficient information for decoding the light intensity detected by the photodetector. The rays may be applied simultaneously in an array, in which case different carrier frequencies as well as different phases are applied to the different rays by any of a number of modulators. Alternatively, the rays may be individually applied to the object in a sequence of phase encoded rays. In either case, the single photodetector receives sufficient information to image each of the voxels of interest in the object being imaged. Information may be obtained for different voxels selected for imaging without mechanical scanning.

2. 发明申请

WO1995001554A1 SOLID-PHASE BINDING ASSAY SYSTEM AND METHOD FOR INTERFEROMETRICALLY MEASURING ANALYTES BOUND TO AN ACTIVE RECEPTOR 审中-公开
标题翻译：固相结合测定系统和用于间断测量分析物与活性受体有关的方法
公开(公告)号：WO1995001554A1
公开(公告)日：1995-01-12
申请号：PCT/US1994007184
申请日：1994-06-24
申请人： FIRST MEDICAL, INC. , GUSTAFSON, Eric, K. , ALLEN, Jimmy, D. , COBB, Michael, E.
发明人： FIRST MEDICAL, INC.
IPC分类号： G01J03/45
CPC分类号： G01N21/45 , G01N21/75 , G01N2021/1748 , G01N2021/1759 , G01N2021/752 , Y10S435/97
摘要： Apparatus (10) and method for detecting and measuring analyte in biological and other sample solutions. A substrate (20) is provided with at least one active region which specifically binds analyte and an inactive region that does not, and a change in optical path length through the active region due to binding of analyte is measured. The substrate (20) is inserted into one or both beams of an interferometer (10) and moved relative to the interferometer (10). As the substrate (20) moves, the active and inactive regions pass successively through the beam(s) causing a periodic phase shift in the light. When the beams, one or both of which have undergone phase modulation, are recombined with each other, the phase modulation is converted into an amplitude modulation. Each recombined beam is directed to a photodetector (42, 45), which converts the periodically varying optical power into a periodically varying electrical signal. This signal has an amplitude proportional to the amount of bound analyte on the surface of the substrate (20) and a signal frequency equal to that at which the active regions move past the beam(s) in the interferometer (10). Servo control (60, 62, 65) is used to maintain the interferometer at a desired operating point that maximizes the sensitivity and linearity of the system so that the small phase differences due to analyte binding can be measured more accurately.
摘要翻译：用于检测和测量生物样品和其他样品溶液中分析物的装置（10）和方法。衬底（20）设置有至少一个特异性结合被分析物的活性区域和不受分析物结合的活性区域的光路长度的变化，并且由于分析物结合而导致的光路长度的变化。衬底（20）插入干涉仪（10）的一个或两个光束并相对于干涉仪（10）移动。当衬底（20）移动时，有源和无源区域依次通过光束，导致光中的周期性相移。当其中一个或两个已进行相位调制的波束彼此重新组合时，相位调制被转换成幅度调制。每个重新组合的光束被引导到光电检测器（42,45），其将周期性变化的光功率转换成周期性变化的电信号。该信号具有与衬底（20）表面上结合的分析物的量成比例的幅度和等于有源区移动通过干涉仪（10）中的束的信号频率的信号频率。伺服控制（60,62,65）用于将干涉仪保持在使系统的灵敏度和线性度最大化的期望工作点，从而可以更准确地测量由分析物结合引起的小的相位差。

3. 发明申请

WO1993009596A1 SPECIMEN PROCESSING AND ANALYZING SYSTEMS WITH VARIABLE ZENER-DIODE FLYBACK STEPPER MOTOR CONTROL 审中-公开
标题翻译：具有可变ZENER-DIODE FLYBACK STEPPER MOTOR CONTROL的样品处理和分析系统
公开(公告)号：WO1993009596A1
公开(公告)日：1993-05-13
申请号：PCT/US1992009082
申请日：1992-10-27
申请人： BAXTER DIAGNOSTICS INC.
发明人： BAXTER DIAGNOSTICS INC. , GARAND, Steven, A. , DANIEL, Carl, P.
IPC分类号： H02P08/00
CPC分类号： G01N35/1002 , G01N35/025 , G01N35/028 , G01N2021/1759 , G01N2035/00079 , G01N2035/00455 , G01N2035/042 , G01N2035/0425 , G01N2035/0463 , G01N2035/0475 , G01N2201/0407 , G01N2201/0446 , G01N2201/08 , G01N2201/1283
摘要： An improved control system for a stepper motor coil (190) includes a flyback circuit (192) that dissipates coil energy slowly while the coil is energized and operated in the chopping mode, while dissipating coil energy rapidly when the coil is switched to its de-energized phase.
摘要翻译：用于步进电动机线圈（190）的改进的控制系统包括反激电路（192），其在线圈被通电并且以斩波模式操作时缓慢地消散线圈能量，同时当线圈切换到其去耦时消散线圈能量，通电阶段。

4. 发明申请

WO1993000045A1 IMAGING A PHYSICAL PARAMETER USING DIFFUSE WAVES 审中-公开
标题翻译：使用DIFFUSE波形成像一个物理参数
公开(公告)号：WO1993000045A1
公开(公告)日：1993-01-07
申请号：PCT/US1992005331
申请日：1992-06-25
申请人： THE UNITED STATES OF AMERICA, as represented by ...
发明人： THE UNITED STATES OF AMERICA, as represented by ... , KNUTTEL, Alexander , KNUTSON, Jay
IPC分类号： A61B06/00
CPC分类号： G01J1/04 , G01J1/0422 , G01J3/02 , G01J3/0208 , G01J3/0216 , G01J2009/0203 , G01N21/4795 , G01N21/645 , G01N21/65 , G01N21/76 , G01N21/85 , G01N27/44721 , G01N2021/1738 , G01N2021/1759 , G01N2021/178 , G01N2021/1782 , G01N2021/4173 , G01N2021/451 , G01N2021/4702 , G01N2201/0893
摘要： Imaging of a turbid object utilizes interference among the modulation wavefronts (24) of a plurality of modulated light rays (22) propagating through the object by diffusion and having predetermined phases relative to one another. A computer controlled phase and amplitude selecting device, such as a zone plate (34) is used to modulate light rays at appropriate phases in order to obtain constructive interference only at a predetermined portion of the object, including one or more preselected voxels (26). The rays reflected from (or diffusively transmitted through) the predetermined portion are received simultaneously at a detector (16) thus providing simultaneously all the data necessary to describe or image the portion. A single detector (16) element may be used to detect the scattered reflected or transmitted light from the portion and to generate a signal representing the amplitude and phase characteristics for the modulation wavefront, thereby to provide absorption (and other) characteristics descriptive of the portion.

5. 发明申请

WO9218845A3 METHODS OF AND APPARATUS FOR MEASUREMENT USING ACOUSTO-OPTIC DEVICES 审中-公开
标题翻译：使用光学设备测量的方法和装置
公开(公告)号：WO9218845A3
公开(公告)日：1992-12-23
申请号：PCT/GB9200665
申请日：1992-04-13
申请人： BRITISH TECH GROUP
发明人： GASS PAUL ANTHONY , SAMBLES JOHN ROY
IPC分类号： G01B11/30 , G01J3/433 , G01N21/00 , G01N21/01 , G01N21/17 , G01N21/27 , G01N21/31 , G01N21/41 , G01N21/47 , G01N21/55 , G01N21/84 , G01N30/95 , G01D5/26 , G01N21/43 , G02F1/11 , G02F1/33
CPC分类号： G01N21/1717 , G01N21/41 , G01N21/553 , G01N30/95 , G01N2021/1748 , G01N2021/1759 , G01N2021/8427
摘要： Optical measuring apparatus includes a phase sensitive measuring device (8, 9, 14, 16) including an acousto-optic device adapted to modulate a parameter of a light beam (1), beam splitter means (5) to split said light beam into a reference beam (6) and a probe beam (7), detector means (8, 13) respectively to detect said reference beam and said probe beam after interrogation of an element under test, and measuring means (9, 14, 15) to measure the differential of an optical property of the element measured by said probe beam.

6. 发明申请

WO1992018845A2 METHODS OF AND APPARATUS FOR MEASUREMENT USING ACOUSTO-OPTIC DEVICES 审中-公开
标题翻译：使用光学设备测量的方法和装置
公开(公告)号：WO1992018845A2
公开(公告)日：1992-10-29
申请号：PCT/GB1992000665
申请日：1992-04-13
申请人： BRITISH TECHNOLOGY GROUP LIMITED , GASS, Paul, Anthony , SAMBLES, John, Roy
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： G01N21/17
CPC分类号： G01N21/1717 , G01N21/41 , G01N21/553 , G01N30/95 , G01N2021/1748 , G01N2021/1759 , G01N2021/8427
摘要： Optical measuring apparatus includes a phase sensitive measuring device (8, 9, 14, 16) including an acousto-optic device adapted to modulate a parameter of a light beam (1), beam splitter means (5) to split said light beam into a reference beam (6) and a probe beam (7), detector means (8, 13) respectively to detect said reference beam and said probe beam after interrogation of an element under test, and measuring means (9, 14, 15) to measure the differential of an optical property of the element measured by said probe beam.
摘要翻译：光学测量装置包括相位敏感测量装置（8,9,14,16），其包括适于调制光束（1）的参数的声光装置，分束器装置（5）将所述光束分成参考光束（6）和探测光束（7），检测器装置（8,13），分别用于在询问被测元件之后检测所述参考光束和所述探测光束;以及测量装置（9,14,15）由所述探针光束测量的元件的光学性质的差异。

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