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1. 发明申请

WO2013186672A2 OPTICAL DETECTION SYSTEM FOR LIQUID SAMPLES 审中-公开
标题翻译：液体样品光学检测系统
公开(公告)号：WO2013186672A2
公开(公告)日：2013-12-19
申请号：PCT/IB2013/054660
申请日：2013-06-06
申请人： BIO-RAD LABORATORIES INC.
发明人： URI, Yochanan , RAN, Boaz , NOTCOVICH, Ariel G. , NIMRI, Shay
IPC分类号： G01N21/03 , G01N21/55
CPC分类号： G01N21/553 , G01N21/253 , G01N21/658 , G01N33/54373 , G01N2021/0328 , G01N2201/0407 , G01N2201/0484 , G01N2201/062
摘要： A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.
摘要翻译：一种用于光学检测系统的尖端，用于使用从分析物结合到所述尖端内部的检测表面反射的光来分析吸入所述尖端的流体样品中的分析物，所述检测表面包括第一检测表面和位于相同的流动路径，没有可分离它们的可控阀，其中第一和第二检测表面具有不同的表面化学性质。

2. 发明申请

WO2018172114A1 A MONITORING DEVICE, A SYSTEM AND A METHOD FOR MONITORING A STATUS OF FRUITS 审中-公开
公开(公告)号：WO2018172114A1
公开(公告)日：2018-09-27
申请号：PCT/EP2018/056036
申请日：2018-03-12
申请人： INL - INTERNATIONAL IBERIAN NANOTECHNOLOGY LABORATORY
发明人： FREITAS, Paulo , PITEIRA, João
IPC分类号： G01N33/02 , G01N21/31 , G01N21/3563 , G01N21/84 , G01N21/64 , G01N21/65
CPC分类号： G01N21/31 , G01N21/3563 , G01N21/6486 , G01N21/65 , G01N33/025 , G01N2021/8466 , G01N2201/0407 , G01N2201/0627 , G01N2201/0628
摘要： A monitoring device (100) for monitoring a status of fruits, the monitoring device (100) comprising: a flexible strip (102) configured to be introduced into a cluster of fruits allowing the flexible strip (102) being embedded in the cluster, the flexible strip (102) comprising a plurality of spatially separated sensing nodes (106), wherein each of the plurality of sensing nodes (106) comprises a sensing node light source (108) configured to emit light and a sensing node light detector (110) configured to detect light, a read out circuitry (112) configured to read out data pertaining to the detected light detected at each of the plurality of sensing nodes (106), a body (114) comprising a wireless communication module (116) configured to transmit the data pertaining to the detected light, wherein the flexible strip (102) is attached to the body (114). A system comprising a plurality of monitoring devices and a method for monitoring a status of fruits are further provided.

3. 发明申请

WO2007103642A3 SYSTEM AND METHOD FOR MULTIMODE IMAGING 审中-公开
标题翻译：用于多模式成像的系统和方法
公开(公告)号：WO2007103642A3
公开(公告)日：2008-04-10
申请号：PCT/US2007062667
申请日：2007-02-23
申请人： GEN ELECTRIC , FOMITCHOV PAVEL A , BARASH EUGENE , YEKTA AHMAD , MASINO JOSEPH
发明人： FOMITCHOV PAVEL A , BARASH EUGENE , YEKTA AHMAD , MASINO JOSEPH
IPC分类号： G01N23/00
CPC分类号： G01N21/6458 , G01N21/47 , G01N2201/0407 , G01N2201/1042 , G02B21/0048 , G02B21/0076 , G02B21/367
摘要： A system and method for multimode imaging of at least one sample is disclosed. The system includes at least one light source; an optical system selected responsive to a mode of operation of the imaging system; and a detector capable of selective reading of pixels. The at least one sample is moved relative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving. The method includes the steps of (1) selecting a mode of operation for the imaging system; (2) transmitting light from at least one light source through an optical system selected in response to the mode of operation for the imaging system; (3) moving the at least one sample relative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving; and (4) selectively reading pixels with a detector.
摘要翻译：公开了一种用于至少一个样品的多模成像的系统和方法。该系统包括至少一个光源; 响应于成像系统的操作模式选择的光学系统; 以及能够选择性地读取像素的检测器。使用选自步骤样品移动和连续样品移动的样品移动技术，使至少一个样品相对于光学系统移动。该方法包括以下步骤：（1）选择成像系统的操作模式; （2）从至少一个光源透射通过响应于成像系统的操作模式选择的光学系统的光; （3）使用选自步骤样品移动和连续样品移动的样本移动技术来移动所述至少一个样品相对于所述光学系统; 和（4）用检测器选择性地读取像素。

4. 发明申请

WO2007103642A2 SYSTEM AND METHOD FOR MULTIMODE IMAGING 审中-公开
标题翻译：用于多模式成像的系统和方法
公开(公告)号：WO2007103642A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/062667
申请日：2007-02-23
申请人： GENERAL ELECTRIC COMPANY , FOMITCHOV, Pavel A. , BARASH, Eugene , YEKTA, Ahmad , MASINO, Joseph
发明人： FOMITCHOV, Pavel A. , BARASH, Eugene , YEKTA, Ahmad , MASINO, Joseph
IPC分类号： G01N21/25
CPC分类号： G01N21/6458 , G01N21/47 , G01N2201/0407 , G01N2201/1042 , G02B21/0048 , G02B21/0076 , G02B21/367
摘要： A system and method for multimode imaging of at least one sample is disclosed. The system includes at least one light source; an optical system selected responsive to a mode of operation of the imaging system; and a detector capable of selective reading of pixels. The at least one sample is moved relative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving. The method includes the steps of (1) selecting a mode of operation for the imaging system; (2) transmitting light from at least one light source through an optical system selected in response to the mode of operation for the imaging system; (3) moving the at least one sample relative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving; and (4) selectively reading pixels with a detector.
摘要翻译：公开了一种用于至少一个样品的多模成像的系统和方法。该系统包括至少一个光源; 响应于成像系统的操作模式选择的光学系统; 以及能够选择性地读取像素的检测器。使用选自步骤样品移动和连续样品移动的样品移动技术，使至少一个样品相对于光学系统移动。该方法包括以下步骤：（1）选择成像系统的操作模式; （2）从至少一个光源透射通过响应于成像系统的操作模式选择的光学系统的光; （3）使用选自步骤样品移动和连续样品移动的样本移动技术来移动所述至少一个样品相对于所述光学系统; 和（4）用检测器选择性地读取像素。

5. 发明申请

WO2007005076A1 VALVE CONTROL SYSTEM FOR A ROTATING MULTIPLEX FLUORESCENCE DETECTION DEVICE 审中-公开
标题翻译：用于旋转多通道荧光检测装置的阀控制系统
公开(公告)号：WO2007005076A1
公开(公告)日：2007-01-11
申请号：PCT/US2006/010750
申请日：2006-03-24
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： BEDINGHAM, William , LUDOWISE, Peter D., , ROBOLE, Barry W.,
IPC分类号： G01N21/64 , G01N35/00
CPC分类号： F16K99/003 , B01L3/502715 , B01L3/502738 , B01L2200/025 , B01L2300/021 , B01L2300/0806 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/004 , F16K2099/0084 , G01N21/0332 , G01N21/07 , G01N21/359 , G01N21/6428 , G01N21/6452 , G01N35/00069 , G01N35/1097 , G01N2021/0325 , G01N2021/6421 , G01N2021/6441 , G01N2035/00267 , G01N2035/00415 , G01N2035/0474 , G01N2201/0407 , G01N2201/0415 , G01N2201/0612 , G01N2201/062 , G01N2201/0833 , Y10T436/11 , Y10T436/111666
摘要： Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.
摘要翻译：描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。例如，系统包括数据采集装置和耦合到数据采集装置的检测装置。检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。该装置还包括多个可移除的光学模块，其被光学配置为激发物种并捕获由不同波长的物质发射的荧光。耦合到多个可移除光学模块的光纤束将来自光学模块的荧光传送到单个检测器。此外，该装置可以通过利用激光加热阀来定位和选择性地打开阀分离腔来控制盘中的流体流动。

6. 发明申请

WO2014040730A1 MESSGERÄT ZUR LUMINESZENZMESSUNG 审中-公开
标题翻译：压力表适用于测量发光
公开(公告)号：WO2014040730A1
公开(公告)日：2014-03-20
申请号：PCT/EP2013/002732
申请日：2013-09-11
申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
发明人： KOZMA, Peter , EHRENTREICH-FÖRSTER, Eva , SCHUMACHER, Soeren
IPC分类号： G01N21/64
CPC分类号： G01N21/6454 , G01N21/0303 , G01N21/648 , G01N21/7703 , G01N2201/0407 , G01N2201/0642
摘要： Die Erfindung betrifft ein Messgerät zur Lumineszenzmessung mit einem Probenträger (8) zur Aufnahme einer lumineszenten Probe (9), einem ersten Linsen-Array (13) mit zahlreichen rasterförmig angeordneten Linsen (14) zur Fokussierung von Lumineszenzstrahlung, die von der lumineszenten Probe (9) ausgeht, sowie mit einem Lichtsensor (16) zur Erfassung der von der lumineszenten Probe (9) emittierten Lumineszenzstrahlung, wobei der Lichtsensor (16) im Strahlengang der Lumineszenzstrahlung hinter dem ersten Linsen-Array (13) angeordnet ist. Es wird vorgeschlagen, dass das erste Linsen-Array (13) ein erstes Mikrolinsen-Array (13) mit zahlreichen Mikrolinsen (14) ist, wobei im Strahlengang der Lumineszenzstrahlung zwi- sehen dem Probenträger (8) und dem ersten Mikrolinsen-Array (13) eine erste Lochmaske (11) mit zahlreichen Löchern (12) angeordnet ist, wobei die einzelnen Mikrolinsen (14) und die Löcher (12) einander zugeordnet sind und übereinstimmende Achsen aufweisen. Der Probenträger (8) kann einen im Wesentlichen planaren Wellenleiter (8) aufweisen, wobei die Anregungsstrahlung von einer Beleuchtungseinheit (1) in eine Wellenleiterkante (10) des Wellenleiters (8) eingekoppelt wird.
摘要翻译：本发明涉及一种测量设备，用于以接收的发光试料（9），第一透镜阵列（13）配有许多布置在光栅透镜（14），用于聚焦所述发光辐射，其（从发光试料9，测定的发光与样品托架（8））延伸，并且与一个光传感器（16），用于检测（发射的光辐射的发光试料9），其中，在所述发光辐射的光束路径中的光传感器（16）位于所述第一透镜阵列（13）的后面的。它提出，所述第一透镜阵列（13）是具有许多微透镜（14）的第一微透镜阵列（13），见是 - 在发光辐射到样品托架（8）和（第一微透镜列阵13上的光束路径）第一荫罩（11）配有许多孔（12）布置，所述各个微透镜（14）和孔（12）彼此相关联，并且具有重合的轴线。所述样品载体（8）可以具有基本上平面的波导（8），其特征在于，从照明单元（1）在所述波导（8）的波导边缘（10）的激发辐射被耦合。

7. 发明申请

WO2013186672A3 OPTICAL DETECTION SYSTEM FOR LIQUID SAMPLES 审中-公开
标题翻译：液体样品光学检测系统
公开(公告)号：WO2013186672A3
公开(公告)日：2014-03-06
申请号：PCT/IB2013054660
申请日：2013-06-06
申请人： BIO RAD LABORATORIES
发明人： URI YOCHANAN , RAN BOAZ , NOTCOVICH ARIEL G , NIMRI SHAY
IPC分类号： G01N21/03 , G01N21/55
CPC分类号： G01N21/553 , G01N21/253 , G01N21/658 , G01N33/54373 , G01N2021/0328 , G01N2201/0407 , G01N2201/0484 , G01N2201/062
摘要： A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.
摘要翻译：一种用于光学检测系统的尖端，用于使用从分析物结合到所述尖端内部的检测表面反射的光来分析吸入所述尖端的流体样品中的分析物，所述检测表面包括第一检测表面和位于相同的流动路径，没有可分离它们的可控阀，其中第一和第二检测表面具有不同的表面化学性质。

8. 发明申请

WO2004005994A1 MICROSCOPE ARRAY FOR SIMULTANEOUSLY IMAGING MULTIPLE OBJECTS 审中-公开
标题翻译：微阵列同时成像多个对象
公开(公告)号：WO2004005994A1
公开(公告)日：2004-01-15
申请号：PCT/US2003/021268
申请日：2003-07-07
申请人： DMETRIX, INC. , OLSZAK, Artur, G.
发明人： OLSZAK, Artur, G.
IPC分类号： G02B21/00
CPC分类号： G02B21/002 , G01N21/253 , G01N2201/0407
摘要： A microscope array for simultaneously imaging multiple objects. A preferred embodiment of a method according to the invention includes arranging the objects (46) into an array (34), providing a microscope array (32) having a plurality of imaging elements with respective fields of view arranged into a corresponding array (38) such that the imaging elements are optically aligned respectively with the objects, and simultaneously imaging the objects with the microscope array to produce respective images of the objects by means of a detector array (40). The invention also provides for scanning while imaging, and for stepping and repeating the imaging process. The plurality of imaging elements form a lens array.
摘要翻译：用于同时成像多个物体的显微镜阵列。根据本发明的方法的优选实施例包括将物体（46）布置成阵列（34），提供具有多个成像元件的显微镜阵列（32），其具有排列成相应阵列（38）的各个视场，使得成像元件分别与物体进行光学对准，并且同时用显微镜阵列成像物体以通过检测器阵列（40）产生物体的相应图像。本发明还提供了成像时的扫描，以及步进和重复成像过程。多个成像元件形成透镜阵列。

9. 发明申请

WO1990003566A1 READING DEVICE FOR A MICROTEST PLATE 审中-公开
标题翻译：用于微型板的读取装置
公开(公告)号：WO1990003566A1
公开(公告)日：1990-04-05
申请号：PCT/EP1989001112
申请日：1989-09-23
申请人： DYNATECH AG
发明人： DYNATECH AG , NITTEL, Alfred
IPC分类号： G01N21/59
CPC分类号： G01N21/253 , G01N2201/0407 , G01N2201/0446
摘要： A reading device for a microtest plate (1) comprises a transport device which displaces the microtest plate (1) and a light unit (6) which emits light beams (100) that pass through a group of depressions (2a-2h) in the microtest plate (1) and enter a detector unit (7). A pulse generated in a detector (9) of the detector unit (7) is transmitted to a control and evaluation unit (45) and displayed. The reading unit consisting of the light unit (6) and the detector unit (7) is positioned obliquely to the direction of movement (150) of the microtest plate (1).

10. 发明申请

WO2017117011A1 SYSTEMS AND METHODS FOR ANALYZING A SAMPLE AND FOR MONITORING THE PERFORMANCE OF AN OPTICAL SIGNAL DETECTOR 审中-公开
标题翻译：用于分析样品和监测光学信号检测器的性能的系统和方法
公开(公告)号：WO2017117011A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/068384
申请日：2016-12-22
申请人： GEN-PROBE INCORPORATED
发明人： OPALSKY, David , RAGHUWANSHI, Srajan , BUI, James
IPC分类号： G01N21/03 , G01N21/64 , G01N21/75 , G01N21/27
CPC分类号： G01N21/645 , G01N21/0332 , G01N21/276 , G01N21/75 , G01N35/00732 , G01N35/025 , G01N2021/6441 , G01N2035/00356 , G01N2035/0455 , G01N2035/0475 , G01N2035/0484 , G01N2201/0407 , G01N2201/0415 , G01N2201/12723
摘要： A system for measuring optical signal detector performance includes an optical signal detector comprising a first detection channel having a first light source and a first sensor. The first detection channel is configured to emit and focus light generated by the first light source at a first detection zone, and to receive and focus light on the first sensor. The system also includes a controller operatively coupled to the optical signal detector and configured to determine an operational performance status of the optical signal detector based on at least one of (i) a first measured characteristic of light focused on the sensor while a first non-fluorescent surface portion is in the first detection zone and (ii) a second measured characteristic of light focused on the sensor while a void is in the first detection zone. The optical signal detector can be a fluorometer.
摘要翻译：用于测量光学信号检测器性能的系统包括光学信号检测器，其包括具有第一光源和第一传感器的第一检测通道。第一检测通道被配置为发射并聚焦由第一光源在第一检测区处产生的光，并且接收并将光聚焦在第一传感器上。所述系统还包括控制器，所述控制器可操作地耦合到所述光学信号检测器，并且被配置为基于以下各项中的至少一个来确定所述光学信号检测器的操作性能状态：（i）聚焦在所述传感器上的光的第一测量特性，荧光表面部分处于第一检测区中，以及（ii）当空隙处于第一检测区中时聚焦在传感器上的光的第二测量特性。光信号检测器可以是荧光计。

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