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1. 发明申请

WO1995002816A1 ANALYSIS SYSTEM AND COMPONENTS 审中-公开
标题翻译：分析系统和组件
公开(公告)号：WO1995002816A1
公开(公告)日：1995-01-26
申请号：PCT/US1994007509
申请日：1994-07-06
申请人： BAXTER DIAGNOSTICS INC.
发明人： BAXTER DIAGNOSTICS INC. , CORMIER, Alan, D. , WEINBERG, Melvin, S. , JONES, Ronald, L. , VITIELLO, Janet, D.
IPC分类号： G01N27/28
CPC分类号： G01N33/492 , G01N33/4915
摘要： The present invention provides sensing electrodes and electrode assemblies for use in measuring the activity of ions in a fluid sample; measuring blocks which include a sensing module housing such sensing electrodes and a reference electrode; and a fluid analysis system which includes such measuring blocks.
摘要翻译：本发明提供了用于测量流体样品中离子的活性的感测电极和电极组件; 测量块，其包括容纳这种感测电极和参考电极的感测模块; 以及包括这种测量块的流体分析系统。

2. 发明申请

WO1995002190A1 FLUID DISPENSING APPARATUS AND METHOD 审中-公开
标题翻译：流体分配装置
公开(公告)号：WO1995002190A1
公开(公告)日：1995-01-19
申请号：PCT/US1994007506
申请日：1994-07-06
申请人： BAXTER DIAGNOSTICS INC.
发明人： BAXTER DIAGNOSTICS INC. , JONES, Donald
IPC分类号： G01N35/00
CPC分类号： G01N35/0099 , G01N35/1002 , Y10T436/11 , Y10T436/113332
摘要： A chemical analyser (10) includes a fluid dispensing system (46) with a carrier member (18) and fluid dispensing head (72). The carrier member (18) includes a docking fixture (52) and the fluid dispensing head includes a docking receptacle (54). By engagment of the docking fixture and receptacle the carrier member carries the fluid dispensing head to a position above a recess (34) into which fluid is precisely dispensed. The carrier member also returns the fluid dispensing head to a storage location (64) substantially separating the fluids to be dispensed from the environment of the analyzer. When the fluid dispensing head is in its storage location the carrier member may disengage to perform other functions in the analyzer.
摘要翻译：化学分析器（10）包括具有载体构件（18）和流体分配头（72）的流体分配系统（46）。承载构件（18）包括对接固定件（52），并且流体分配头包括对接插座（54）。通过接合对接固定件和容器，承载构件将流体分配头运送到凹槽（34）上方的位置，精确地分配流体。载体构件还将流体分配头返回到基本上将待分配的流体与分析器的环境分离的存储位置（64）。当流体分配头处于其存储位置时，承载构件可以脱离以在分析器中执行其它功能。

3. 发明申请

WO1995000854A1 AUTOMATED CHEMICAL ANALYZER WITH APPARATUS AND METHOD FOR CONVEYING AND TEMPORARY STORAGE OF SAMPLE TUBES 审中-公开
标题翻译：自动化学分析仪，用于输送和临时存储样品管的方法
公开(公告)号：WO1995000854A1
公开(公告)日：1995-01-05
申请号：PCT/US1994007255
申请日：1994-06-28
申请人： BAXTER DIAGNOSTICS INC.
发明人： BAXTER DIAGNOSTICS INC. , MAZZA, John, C. , STARK, William, A , SCRIBNER, Richard, A. , FRYE, Stephen, L. , HARDIMAN, Kempton, H.
IPC分类号： G01N35/04
CPC分类号： B01L3/50855 , B01L9/06 , G01N35/04 , G01N2035/00752 , G01N2035/0406
摘要： An automated chemical analyzer (8) includes an automated conveyor apparatus (10) for receiving a variety of sizes of test tubes, cuvettes, and sample tubes in a standard carrier member (16) receivable into the analyzer. The standard carrier members may be interlocked in ranks and placed side by side in file to replicate the size and handling convenience of conventional test tube racks. However, the conveyor apparatus also provides for receipt of the carriers either as individuals for stat handling (14), or in interlocked ranks, or as rank and file groups for routine handling (20). The interlocked ranks of carriers are automatically unlocked from one another and fed along with the carriers having stat samples therein to a recirculating endless loop conveyor device (34) which conveys the samples to at least one chemical analysis module (40), as well as providing a storage capacity both for samples in testing, and those samples awaiting verification of test results. Carriers with samples on which testing is completed and verified are discharged from the endless loop conveyor device into an off-loading facility (52-58) which again interlocks the carriers and presents them in rank and file groups for subsequent handling like conventional test tube racks.
摘要翻译：一种自动化学分析仪（8）包括用于在可接收到分析器中的标准载体构件（16）中接收各种尺寸的试管，比色皿和样品管的自动输送装置（10）。标准载体构件可以排列成并排放置，以复制常规试管架的尺寸和操作方便性。然而，传送装置还提供作为用于统计处理的个人（14）或联锁队列的个人或作为例行处理（20）的排名和文件组的接收者。互锁的载体排自动地彼此解锁并与其中具有状态样本的载体一起供给到循环无端环输送装置（34），该输送装置将样品输送到至少一个化学分析模块（40），以及提供测试样品的存储容量，以及等待验证测试结果的样品。测试完成和验证的样品的载体从无端循环输送装置排出到卸载设备（52-58）中，该卸载设备（52-58）再次使载体互锁，并将它们以级别和文件组提供，以便随后处理，如常规试管架。

4. 发明申请

WO1994002644A1 IN SITU DETECTION OF NUCLEIC ACIDS USING 3SR AMPLIFICATION 审中-公开
标题翻译：使用3SR放大技术检测核酸
公开(公告)号：WO1994002644A1
公开(公告)日：1994-02-03
申请号：PCT/US1993006716
申请日：1993-07-16
申请人： APROGENEX, INC. , BAXTER DIAGNOSTICS INC. , BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM
发明人： APROGENEX, INC. , BAXTER DIAGNOSTICS INC. , BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM , READING, Christopher, Lewis , CUBBAGE, Michael, Lee , HAYDOCK, Paul, Vincent , BRESSER, Joel , PRASHAD, Nagindra , BLICK, Mark , WEBER, William, Dugald , JU, Shyh, Chen , ASGARI, Morteza , COLVIN, David , JURTSHUK, Rebecca
IPC分类号： C12Q01/68
CPC分类号： G01N33/58 , C12Q1/6841 , G01N33/5005 , G01N33/5306 , G01N33/56966 , G01N33/56983 , C12Q2531/143
摘要： The process of detecting RNA molecules in situ using the 3SR amplification process, for example where the molecules are translocation-junction-spanning molecules in cells that have undergone chromosomal translocation. Also process modifications that enhance its effectiveness.
摘要翻译：使用3SR扩增方法原位检测RNA分子的过程，例如其中分子是已经经历染色体易位的细胞中的易位结跨跨分子。还可以处理增强其有效性的修改。

5. 发明申请

WO1993024840A1 MEASUREMENT OF PLATELET ACTIVITIES 审中-公开
标题翻译：测量板材活动
公开(公告)号：WO1993024840A1
公开(公告)日：1993-12-09
申请号：PCT/US1993005436
申请日：1993-06-03
申请人： BAXTER DIAGNOSTICS INC.
发明人： BAXTER DIAGNOSTICS INC. , HEMKER, Hendrik, C. , WAGENVOORD, Robert, J.
IPC分类号： G01N33/86
CPC分类号： G01N33/86 , C12Q1/56 , C12Q2337/12 , G01N2333/96444 , G01N2333/974 , G01N2405/04
摘要： Methods are provided for measuring the procoagulant activity of platelets in blood by means of a chromogenic assay which is specific for procoagulant phospholipids. These methods include the determination of the resting activity and/or excitability of platelets, which determines the threshold at which activating clotting factors (circulating in blood) are dangerous. Also methods are provided for screening drugs for their potential inhibitory effect on the activation of platelets.

6. 发明申请

WO1993015111A1 A DNA SEQUENCE AND ENCODED POLYPEPTIDE USEFUL IN THE DIAGNOSIS OF HEPATITIS DISEASE 审中-公开
标题翻译： DNA序列和编码的多肽在肝炎病毒诊断中的应用
公开(公告)号：WO1993015111A1
公开(公告)日：1993-08-05
申请号：PCT/US1993000927
申请日：1993-02-03
申请人： BAXTER DIAGNOSTICS INC.
发明人： BAXTER DIAGNOSTICS INC. , RYAN, Terence, E. , SAEED, Badr , KIESELBURG, Mark, K. , BYRNE, Robert, E. , STEVENS, Priscilla, Wilkins , ARIMA, Terukatsu , TODD, John, A.
IPC分类号： C07K07/10
CPC分类号： G01N33/5767 , A61K39/00 , C07K14/005 , C12N2770/24222 , C12Q1/707 , Y10S436/82
摘要： A novel cDNA clone, 20E, has been isolated and characterized as encoding a previously unknown polypeptide antigen recognized by antibodies in the serum of certain patients with non-A, non-B hepatitis (NANBH). The nucleic acid sequence is not represented in the genome of the Hepatitis C Virus (HCV). Neither is the nucleic acid sequence represented in the human genome. The data suggest that the RNA sequence corresponding to clone 20E is contained within the genome of an external infective agent other than HCV, and therefore may represent an additional etiologic agent or contributing factor to the development of NANBH in human patients. The 20E nucleic acid and corresponding polypeptide and respective variants thereof will be useful in a variety of procedures directed at prevention and diagnosis of NANBH.
摘要翻译：已经分离了一种新的cDNA克隆20E，并将其表征为编码在某些非A非乙型肝炎（NANBH）患者的血清中被抗体识别的先前未知的多肽抗原。核酸序列不在丙型肝炎病毒（HCV）的基因组中表示。核酸序列也不在人类基因组中表示。数据表明，对应于克隆20E的RNA序列被包含在HCV以外的外部感染因子的基因组中，因此可能代表另外的病原体或人类患者中NANBH发展的促成因子。 20E核酸和相应的多肽及其相应变体可用于针对NANBH的预防和诊断的多种方法。

7. 发明申请

WO1993012432A1 PROBE WASH FOR LIQUID ANALYSIS APPARATUS 审中-公开
标题翻译：用于液体分析装置的探针洗涤
公开(公告)号：WO1993012432A1
公开(公告)日：1993-06-24
申请号：PCT/US1992010661
申请日：1992-12-10
申请人： BAXTER DIAGNOSTICS, INC.
发明人： BAXTER DIAGNOSTICS, INC. , MAHAFFEY, Richard, C. , MAZZA, John, C.
IPC分类号： G01N35/06
CPC分类号： G01N35/1004 , Y10T436/114998 , Y10T436/117497 , Y10T436/118339 , Y10T436/119163 , Y10T436/2575
摘要： The invention relates to an improved system for cleaning of a probe (10) used in analytic equipment, for example, that used in analysis of body fluids, between samples in order to reduce carry-over of materials from one sample to the next. A probe wash is provided in which the simultaneous introduction of pressurized air and water creates a turbulent flow including the use of a pressurized gas stream of short duration to blow the residue of the previous sample out of the probe prior to washing with additional diluent liquid. Also, a waste receptacle (35) is provided which uses a filtered air vent (38) and a liquid saturated material (42) around the probe receiving opening to prevent the escape of aerosols from the receptacle.
摘要翻译：本发明涉及用于清洁在分析设备中使用的探针（10）的改进系统，例如用于分析体液的样品之间的探针（10），以便减少材料从一个样品到下一个样品的携带。提供了一种探针洗涤液，其中同时引入加压空气和水产生湍流，包括使用短时间的加压气流，在用另外的稀释液洗涤之前将先前样品的残余物从探针中吹出。而且，提供废物容器（35），其使用过滤的排气孔（38）和围绕探头接收口的液体饱和材料（42）来防止气溶胶从容器逸出。

8. 发明申请

WO1992017612A1 ASSAY FOR NON-A NON-B HEPATITIS 审中-公开
标题翻译：非B型非特异性抗体测定
公开(公告)号：WO1992017612A1
公开(公告)日：1992-10-15
申请号：PCT/US1992002527
申请日：1992-03-26
申请人： BAXTER DIAGNOSTICS INC.
发明人： BAXTER DIAGNOSTICS INC. , LEAHY, David, C. , TODD, John, A. , JOLLEY, Michael, E. , SHAH, Dinesh, O. , BETHELL, Delia, R. , ARIMA, Terukatsu
IPC分类号： C12Q01/70
CPC分类号： C07K14/005 , C12N2770/24222 , G01N33/5767
摘要： New assays for diagnosing NANBH utilizing novel peptide fragments derived from polypeptide antigens reactive to antibodies present in the sera of infected patients are disclosed. In producing these peptides, the portion of polypeptide contributing to high backgrounds is deleted thereby resulting in assays with an exceptionally high signal to background ratio.
摘要翻译：公开了利用衍生自对感染患者血清中存在的抗体具有反应性的多肽抗原的新肽片段来诊断NANBH的新的测定法。在生产这些肽时，有助于高背景的多肽的部分被缺失，从而导致具有非常高的信号与背景比的测定。

9. 发明申请

WO1992012257A1 METHOD AND COMPOSITION FOR DETERMINING ANTIMICROBIAL SUSCEPTIBILITY OF THE MAJORITY OF CLINICALLY SIGNIFICANT GRAM POSITIVE ORGANISMS 审中-公开
标题翻译：确定临床重要标志物阳性有机体重要性的抗微生物可检测性的方法和组合物
公开(公告)号：WO1992012257A1
公开(公告)日：1992-07-23
申请号：PCT/US1991009720
申请日：1991-12-23
申请人： BAXTER DIAGNOSTICS INC.
发明人： BAXTER DIAGNOSTICS INC. , BADAL, Robert , KELLEY, Roger , SAND, Theodore, T. , BASCOMB, Shoshana
IPC分类号： C12Q01/02
CPC分类号： C12Q1/04 , C12Q1/18 , C12Q2337/22 , Y10S435/968 , Y10S436/80
摘要： This invention relates to a method to determine susceptibility to antimicrobial agents of a majority of clinically significant Gram positive organisms. This invention also relates to a mixture of fluorogenic substrates used to detect the growth of Gram positive Bacteria.
摘要翻译：本发明涉及一种确定大多数临床有意义的革兰氏阳性生物体对抗微生物剂的敏感性的方法。本发明还涉及用于检测革兰氏阳性细菌生长的荧光底物的混合物。

10. 发明申请

WO1992008123A1 MEASUREMENT OF COLOR REACTIONS BY MONITORING A CHANGE OF FLUORESCENCE 审中-公开
标题翻译：通过监测荧光变化来测量颜色反应
公开(公告)号：WO1992008123A1
公开(公告)日：1992-05-14
申请号：PCT/US1991008118
申请日：1991-10-30
申请人： BAXTER DIAGNOSTICS INC.
发明人： BAXTER DIAGNOSTICS INC. , MORRIS, Roger, James , BASCOMB, Shoshana , OLSON, Carolyn, Shelchuk
IPC分类号： G01N21/78
CPC分类号： G01N21/17 , G01N21/534 , G01N21/78 , G01N2201/122 , Y10S436/80
摘要： The present invention relates to a process to determine the concentration of any substance in a colorimetric, turbidimetric or nephelometric reaction using a fluorometric detector to measure fluorescence intensity. In particular, a change in color can be monitored by observing the measurement of fluorescence intensity of a fluorophore in an inert matrix. The absorption spectrum of the chromophore may overlap the excitation and/or emission spectrum of the fluorophore, thereby allowing the change in fluoroscence to be related to the intensity of color in the reaction and thus related to the quantity of the substance of interest.
摘要翻译：本发明涉及使用荧光检测器测定荧光强度的比色法，比浊法或比浊法反应中任何物质的浓度的方法。特别地，可以通过观察惰性基质中荧光团的荧光强度的测量来监测颜色变化。发色团的吸收光谱可能与荧光团的激发和/或发射光谱重叠，从而允许荧光的变化与反应中的颜色强度相关，并且因此与感兴趣的物质的量有关。

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