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1. 发明申请

WO2019116095A1 CONTROLLING DELIVERY OF THERAPEUTIC AGENT IN MICROBUBBLE-ENHANCED ULTRASOUND PROCEDURES 审中-公开
公开(公告)号：WO2019116095A1
公开(公告)日：2019-06-20
申请号：PCT/IB2018/001537
申请日：2018-12-05
申请人： INSIGHTEC, LTD.
发明人： ZADICARIO, Eyal , LEVY, Yoav
IPC分类号： A61N7/00 , A61M37/00 , A61K49/22 , A61B34/10 , A61K41/00 , A61B8/08
CPC分类号： A61B8/481 , A61B90/37 , A61B2017/00106 , A61B2017/22007 , A61B2090/374 , A61B2090/3762 , A61B2090/378 , A61N7/02 , A61N2007/0039 , A61N2007/0056 , A61N2007/0078 , A61N2007/0086 , A61N2007/0095
摘要： Various approaches for microbubble-enhanced ultrasound treatment of target tissue include receiving a desired characteristic of the microbubbles for treating the target tissue; causing the microbubbles to be dispensed from the administration device; and comparing a characteristic of the dispensed microbubbles to the desired characteristic so as to validate a match therebetween.

2. 发明申请

WO2018126322A1 APPARATUS, METHOD, AND USE FOR ULTRASOUND MEDIATED MICROBUBBLE DELIVERY OF PHARMACEUTICAL COMPOSITIONS 审中-公开
公开(公告)号：WO2018126322A1
公开(公告)日：2018-07-12
申请号：PCT/CA2018/050009
申请日：2018-01-05
申请人： LEE, Warren , LEONG-POI, Howard , KARSHAFIAN, Raffi
发明人： LEE, Warren , LEONG-POI, Howard , KARSHAFIAN, Raffi
IPC分类号： A61K9/00 , A61K31/713 , A61K41/00 , A61M37/00 , A61N7/00 , A61P11/00 , A61P7/10 , C12N15/113
CPC分类号： A61P7/10 , A61K9/0019 , A61K9/08 , A61K31/7036 , A61K31/7115 , A61K41/0028 , A61K45/06 , A61K47/14 , A61K47/18 , A61K47/24 , A61K47/6925 , A61K49/223 , A61M37/0092 , A61N7/00 , A61N2007/0039 , A61N2007/0052 , A61N2007/0078 , A61P11/00 , C12N15/113 , C12N2310/141 , C12N2320/31 , C12N2320/32 , A61K2300/00
摘要： An apparatus, method, and use for ultrasound mediated microbubble delivery of pharmaceutical compositions to pulmonary tissue are provided. The pulmonary ultrasound apparatus includes an ultrasound signal generator for generating ultrasonic signals, an ultrasound transducer assembly having an ultrasound transducer operatively connected to the ultrasound signal generator, the ultrasound transducer configured to transmit the ultrasound signal generated by the ultrasound signal generator to pulmonary tissue, wherein the ultrasonic signal is transmitted at a frequency, a pressure, and a pulse duration for cavitating microbubbles to deliver a pharmaceutically active molecule to the pulmonary tissue.

3. 发明申请

WO2018065245A1 IMPROVEMENT OF SIMULTANEOUS MEASURE OF THE TEMPERATURE AND THE DISPLACEMENT MEASURED WITH MAGNETIC RESONANCE ACOUSTIC RADIATION FORCE IMAGING 审中-公开
标题翻译：磁共振声辐射力成像测量温度的同时测量和位移的改进
公开(公告)号：WO2018065245A1
公开(公告)日：2018-04-12
申请号：PCT/EP2017/074153
申请日：2017-09-25
申请人： KONINKLIJKE PHILIPS N.V.
发明人： MOUGENOT, Charles
IPC分类号： G01R33/48 , A61N7/02
CPC分类号： G01R33/4804 , A61N7/02 , A61N2007/0078 , A61N2007/0095 , G01R33/4814 , G01R33/56358
摘要： In Magnetic Resonance Acoustic Radiation Force Imaging (MR-ARFI), an MR imaging device (10) performs gradient echo imaging including successive MR dynamics with opposite encoding of displacement to generate MR-ARFI data of a subject comprising successive image frames with opposite displacement encoding. An ultrasound device (12) applies sonication to the subject during the gradient echo imaging. An electronic processor (22) performs MR-ARFI data processing applied to image elements at image frames of the MR-ARFI data. A displacement is computed (30) for the image element at the image frame as proportional to a phase difference between the image element in the image frame and the image element in a succeeding or preceding image frame with opposite displacement encoding. The computed displacement is corrected (32) for a temperature change between the image frame and the succeeding or preceding image frame. The temperature change is determined using the MR-ARFI data.
摘要翻译：在磁共振声辐射力成像（MR-ARFI）中，MR成像设备（10）执行梯度回波成像，包括具有相反位移编码的连续MR动态变化以生成受试者的MR-ARFI数据包括具有相反位移编码的连续图像帧。超声装置（12）在梯度回波成像期间对受试者应用超声处理。电子处理器（22）执行应用于MR-ARFI数据的图像帧处的图像元素的MR-ARFI数据处理。计算（30）图像帧处的图像元素的位移，其与图像帧中的图像元素与具有相反位移编码的后续或前一图像帧中的图像元素之间的相位差成比例。计算出的位移对图像帧与后续或前面的图像帧之间的温度变化进行校正（32）。温度变化是使用MR-ARFI数据确定的。

4. 发明申请

WO2017223312A1 ULTRASOUND TRANSDUCERS FOR CONSTRUCTIVE SHEAR WAVE INTERFERENCE AND RELATED METHODS AND SYSTEMS 审中-公开
标题翻译：用于构造剪切波干涉的超声换能器及相关方法和系统
公开(公告)号：WO2017223312A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/038742
申请日：2017-06-22
申请人： DUKE UNIVERSITY
发明人： HOLLENDER, Peter J. , PALMERI, Mark
IPC分类号： H01L41/083 , A61B18/00 , A61B17/00 , A61B17/22 , A61B8/08 , G01S7/52
CPC分类号： G01S7/52022 , A61B8/4494 , A61B8/485 , A61B18/00 , A61N7/02 , A61N2007/006 , A61N2007/0065 , A61N2007/0078 , G01S7/52 , G01S7/52042 , G01S7/52079 , G01S15/8918 , G01S15/8922
摘要： A transducer array includes at least one annular shear wave generation transducer that defines an interior area, the at least one annular shear wave generation transducer being configured to generate a shear wave excitation to a region of interest such that the shear wave excitation excites at least a part of a corresponding cylindrical portion of the region of interest and shear waves propagating from the cylindrical portion of the region of interest constructively interfere in an interior region of the cylindrical portion of the region of interest: and at least one tracking transducer positioned in the interior area of the at least one annular shear wave generation transducer, the at least one tracking transducer being configured to detect a shear wave in the interior region of the region of interest.
摘要翻译：换能器阵列包括限定内部区域的至少一个环形剪切波生成换能器，所述至少一个环形剪切波生成换能器被配置为生成对感兴趣区域的剪切波激励，使得剪切波激发激发感兴趣区域的对应圆柱形部分的至少一部分，并且从感兴趣区域的圆柱形部分传播的剪切波建设性地干涉感兴趣区域的圆柱形部分的内部区域;并且在位于所述至少一个环形剪切波生成换能器的内部区域中的至少一个跟踪换能器，所述至少一个跟踪换能器被配置为检测感兴趣区域的内部区域中的剪切波。

5. 发明申请

WO2017064038A1 ULTRASOUND SYSTEM FOR CEREBRAL BLOOD FLOW IMAGING AND MICROBUBBLE-ENHANCED BLOOD CLOT LYSIS 审中-公开
标题翻译：超声系统用于脑血流成像和微泡增强血栓溶解
公开(公告)号：WO2017064038A1
公开(公告)日：2017-04-20
申请号：PCT/EP2016/074298
申请日：2016-10-11
申请人： KONINKLIJKE PHILIPS N.V.
发明人： POWERS, Jeffry, Earl , BRECHBIEL, Tracy, C. , SHI, William, Tao , SEIP, Ralf
IPC分类号： A61B8/06 , A61B8/08 , A61B8/00 , A61N7/00
CPC分类号： A61B8/0816 , A61B8/06 , A61B8/4209 , A61B8/4254 , A61B8/4488 , A61N7/00 , A61N2007/0026 , A61N2007/0052 , A61N2007/0078
摘要： An ultrasonic diagnostic imaging system is described which can diagnose, treat, or monitor the cranial vasculature for obstructions such as blood clots causing ischemic stroke. The system has a headset which maintains two transducer arrays in contact with acoustic windows through the temporal bones on opposite sides of the head. The clinician is aided in properly positioning the arrays over the best acoustic windows through the bone by a signal produced by one of the arrays in response to transmission through the cranium by the other array, which passes through the temporal bones on both sides of the head. The amplitude of this through- transmission signal is detected and displayed to the clinician, either qualitatively or quantitatively, as the arrays are positioned.
摘要翻译：描述了一种超声诊断成像系统，其可以诊断，治疗或监测颅血管阻塞，例如导致缺血性中风的血凝块。该系统有一个头戴式耳机，它通过头部两侧的颞骨保持两个换能器阵列与声窗接触。通过由阵列之一产生的信号，临床医生协助将阵列正确地定位在穿过骨骼的最佳声窗上，以响应由另一个阵列穿过颅骨的传输，该阵列穿过头部两侧的颞骨。这个透射信号的幅度在阵列定位时被检测并显示给临床医生，无论是定性的还是定量的。

6. 发明申请

WO2017011058A1 ULTRASOUND DELIVERY FOR DIAGNOSIS AND/OR THERAPY 审中-公开
标题翻译：超声波诊断和/或治疗
公开(公告)号：WO2017011058A1
公开(公告)日：2017-01-19
申请号：PCT/US2016/029867
申请日：2016-04-28
申请人： MEDTRONIC, INC.
发明人： ALFORD, Jamu K. , SCOTT, Erik R. , LALONDE, John R. , KIM, Yohan , AGRAN, Jason E.
IPC分类号： A61B8/00 , A61N7/00 , A61B8/08
CPC分类号： A61B8/4236 , A61B5/015 , A61B8/085 , A61B8/48 , A61B8/5223 , A61N7/00 , A61N7/02 , A61N2007/0078 , A61N2007/0095
摘要： In some examples, a system includes one or more ultrasound transducers, one or more temperature sensors, a user interface, and one or more processors. The one or more processors are configured to control the one or more ultrasound transducers to deliver ultrasound to a target point of tissue of a patient to heat the target point of tissue, control the one or more temperature sensors to sense a temperature of other tissue of the patient proximate to the target point of tissue a plurality of times over a period of time after the target point of tissue has been heated, and present, via the user interface, information indicating flow of heat from the target point of tissue to the other tissue over the period of time based on the sensed temperatures to facilitate characterization of at least one of anatomy or function of the tissue.
摘要翻译：在一些示例中，系统包括一个或多个超声换能器，一个或多个温度传感器，用户界面以及一个或多个处理器。所述一个或多个处理器被配置成控制所述一个或多个超声换能器以将超声波传送到患者的组织的目标点，以加热组织的目标点，控制所述一个或多个温度传感器以感测其他组织的温度在组织的目标点被加热之后的一段时间内多次接近组织的目标点的患者，并且经由用户界面存在指示从组织的目标点到另一个的热的流动的信息基于所感测的温度在一段时间内的组织，以促进组织的解剖或功能中的至少一个的表征。

7. 发明申请

WO2016134581A1 双倍频共焦叠加聚焦超声球面分裂阵及分裂焦点控制方法审中-公开
公开(公告)号：WO2016134581A1
公开(公告)日：2016-09-01
申请号：PCT/CN2015/084678
申请日：2015-07-21
申请人：西安交通大学
发明人：陆明珠 , 万明习 , 关宇波 , 董腾驹
IPC分类号： A61B17/00
CPC分类号： A61N7/022 , A61N7/02 , A61N2007/0065 , A61N2007/0073 , A61N2007/0078 , A61N2007/0082
摘要：一种双倍频共焦叠加聚焦超声球面分裂阵及分裂焦点控制方法，包括球面共焦阵元，球面共焦阵元的阵元数为偶数；其中一半阵元工作在低频，另一半阵元工作在高频，所述低频和高频均为MHz高频；每一阵元对应一个频率驱动，每一阵元波束在焦区外不重叠；每一阵元通过一个对应的阻抗匹配（2）与一个通道放大器（3）连接，多通道波形控制器（4）连接通道放大器（3），用于控制每一通道的幅度和相位。双倍频球面扇形分裂阵，在双频下可产生焦平面的分裂多点，从而扩大一次治疗的焦区体积，同时也可控制相邻焦点处的瞬态空化群的强干涉获得好的空化转热效率。

8. 发明申请

WO2015192189A1 NEURODEGENERATIVE DISEASE TREATMENT 审中-公开
标题翻译：神经病变疾病治疗
公开(公告)号：WO2015192189A1
公开(公告)日：2015-12-23
申请号：PCT/AU2015/050345
申请日：2015-06-19
申请人： THE UNIVERSITY OF QUEENSLAND
发明人： GOETZ, Juergen , LEINENGA, Gerhard
IPC分类号： A61N7/00 , A61H1/00 , A61N2/00
CPC分类号： A61N7/00 , A61N2007/0026 , A61N2007/0039 , A61N2007/0078 , A61N2007/0082
摘要： The present invention is directed to methods for treating neurodegenerative diseases and/or improving cognitive function, in particular those associated with protein oligomers, aggregates or deposits, using acoustic energy, such as ultrasound. An 5 example of such a neurodegenerative disease is Alzheimer's disease. The present invention provides a method of improving cognitive function and/or memory in an individual with impaired memory and/or executive function, the method including the steps of identifying a region of the brain of the individual to be treated with acoustic energy, applying a clinically safe level of acoustic energy to the region, thereby 10 saturating or substantially saturating the region with acoustic energy, thereby improving memory in the individual.
摘要翻译：本发明涉及使用声能（例如超声）治疗神经变性疾病和/或改善认知功能的方法，特别是与蛋白质低聚物，聚集体或沉积物相关的那些。这种神经变性疾病的5例是阿尔茨海默氏病。本发明提供一种改善受损记忆和/或执行功能的个体的认知功能和/或记忆的方法，所述方法包括以下步骤：用声能识别要治疗的个体的脑区域，应用临床安全的声能级别到该区域，从而使该区域具有声能饱和或基本饱和，从而改善个体的记忆。

9. 发明申请

WO2015192046A1 SYSTEM FOR FAST ULTRASOUND TREATMENT 审中-公开
标题翻译：快速超声治疗系统
公开(公告)号：WO2015192046A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035615
申请日：2015-06-12
申请人： GUIDED THERAPY SYSTEMS, LLC
发明人： BARTHE, Peter, G. , SLAYTON, Michael, H.
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B18/1815 , A61B18/203 , A61B2017/00075 , A61B2017/00106 , A61B2017/00119 , A61B2017/00128 , A61B2018/00452 , A61B2018/00648 , A61B2018/0066 , A61B2018/00672 , A61B2018/00678 , A61B2018/00708 , A61B2018/00791 , A61B2018/00875 , A61B2018/00994 , A61B2018/1807 , A61B2018/1876 , A61B2090/064 , A61B2090/065 , A61N7/02 , A61N2007/0034 , A61N2007/0065 , A61N2007/0078 , A61N2007/0082
摘要： This disclosure provides systems and methods for fast ultrasound treatment. The systems and methods can involve a treatment device including a housing, a transducer module, and a control module. Energy emitted from an energy source of the treatment device can pass through an acoustic window having a non-zero radius of curvature. The treatment device can be moved along a target surface while retaining contact between the acoustic window and the target surface. Coupling between the energy source and a region of interest can be retained upon a change in an angle of incidence of the energy relative to the target surface.
摘要翻译：本公开提供用于快速超声治疗的系统和方法。该系统和方法可涉及包括壳体，换能器模块和控制模块的处理装置。从治疗装置的能源发射的能量可以通过具有非零曲率半径的声窗口。治疗装置可以沿着目标表面移动，同时保持声窗和目标表面之间的接触。能量源和感兴趣区域之间的耦合可以在能量相对于目标表面的入射角的变化时保持。

10. 发明申请

WO2015176001A1 PULSE AMPLIFIER FOR DRIVING ULTRASOUND TRANSDUCERS 审中-公开
标题翻译：用于驱动超声波传感器的脉冲放大器
公开(公告)号：WO2015176001A1
公开(公告)日：2015-11-19
申请号：PCT/US2015031189
申请日：2015-05-15
申请人： MAXWELL ADAM D , CUNITZ BRYAN , BAILEY MICHAEL R , KHOKHLOVA VERA , HALL TIMOTHY L
发明人： MAXWELL ADAM D , CUNITZ BRYAN , BAILEY MICHAEL R , KHOKHLOVA VERA , HALL TIMOTHY L
IPC分类号： A61B8/13 , B06B1/06 , B06B3/00
CPC分类号： A61N7/00 , A61B17/22004 , A61N7/02 , A61N2007/0073 , A61N2007/0078 , A61N2007/0095 , B06B1/0215 , B06B2201/55 , G01S7/5202
摘要： Embodiments of the invention include improved radioirequency (RF) pulse amplifier systems that incorporate an energy array comprising multiple capacitors connected in parallel. The energy array extends the maximum length of pulses and the maximum achievable peak power output of the amplifier when compared to similar systems. Embodiments also include systems comprising the amplifier configured to drive a load, wherein the load may include one or more ultrasound (e.g., piezoelectric) transducers. Related methods of using the amplifier are also provided.
摘要翻译：本发明的实施例包括改进的无线电频率（RF）脉冲放大器系统，其结合包括并联连接的多个电容器的能量阵列。与类似系统相比，能量阵列扩展了放大器的最大脉冲长度和最大可实现的峰值功率输出。实施例还包括包括被配置为驱动负载的放大器的系统，其中负载可以包括一个或多个超声（例如压电）换能器。还提供了使用放大器的相关方法。

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