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    • 1. 发明申请
    • IMPROVEMENT OF SIMULTANEOUS MEASURE OF THE TEMPERATURE AND THE DISPLACEMENT MEASURED WITH MAGNETIC RESONANCE ACOUSTIC RADIATION FORCE IMAGING
    • 磁共振声辐射力成像测量温度的同时测量和位移的改进
    • WO2018065245A1
    • 2018-04-12
    • PCT/EP2017/074153
    • 2017-09-25
    • KONINKLIJKE PHILIPS N.V.
    • MOUGENOT, Charles
    • G01R33/48A61N7/02
    • G01R33/4804A61N7/02A61N2007/0078A61N2007/0095G01R33/4814G01R33/56358
    • In Magnetic Resonance Acoustic Radiation Force Imaging (MR-ARFI), an MR imaging device (10) performs gradient echo imaging including successive MR dynamics with opposite encoding of displacement to generate MR-ARFI data of a subject comprising successive image frames with opposite displacement encoding. An ultrasound device (12) applies sonication to the subject during the gradient echo imaging. An electronic processor (22) performs MR-ARFI data processing applied to image elements at image frames of the MR-ARFI data. A displacement is computed (30) for the image element at the image frame as proportional to a phase difference between the image element in the image frame and the image element in a succeeding or preceding image frame with opposite displacement encoding. The computed displacement is corrected (32) for a temperature change between the image frame and the succeeding or preceding image frame. The temperature change is determined using the MR-ARFI data.
    • 在磁共振声辐射力成像(MR-ARFI)中,MR成像设备(10)执行梯度回波成像,包括具有相反位移编码的连续MR动态变化以生成受试者的MR-ARFI数据 包括具有相反位移编码的连续图像帧。 超声装置(12)在梯度回波成像期间对受试者应用超声处理。 电子处理器(22)执行应用于MR-ARFI数据的图像帧处的图像元素的MR-ARFI数据处理。 计算(30)图像帧处的图像元素的位移,其与图像帧中的图像元素与具有相反位移编码的后续或前一图像帧中的图像元素之间的相位差成比例。 计算出的位移对图像帧与后续或前面的图像帧之间的温度变化进行校正(32)。 温度变化是使用MR-ARFI数据确定的。
    • 2. 发明申请
    • HIGH-INTENSITY FOCUSED ULTRASOUND IRRADIATION
    • 高强度聚焦超声波辐射
    • WO2014128592A1
    • 2014-08-28
    • PCT/IB2014/058890
    • 2014-02-11
    • KONINKLIJKE PHILIPS N.V.
    • MOUGENOT, Charles
    • A61N7/02A61B5/01A61B19/00
    • A61N7/02A61B5/015A61B5/055A61B8/13A61B34/10A61B2017/00084A61N2007/0078A61N2007/0082A61N2007/0091A61N2007/0095
    • The present invention provides n ultrasonic treatment device (10) for heating a portion of a subject of interest, comprising a ultrasonic irradiation unit (12) for generating high-intensity focused ultrasonic irradiation, whereby a beam path of the ultrasonic irradiation is movable along a trajectory for depositing ultrasonic energy within a target zone (22) of the subject of interest, and a control unit (20) for controlling the ultrasonic irradiation unit (12) to move the beam path of the ultrasonic irradiation along the trajectory and to apply an ultrasonic dose to the target zone (22), wherein the control unit (20) is adapted to receive temperature information of the target zone (22) and to control the ultrasonic irradiation unit (12) based on the received temperature information, and the control unit (20) is adapted to control the ultrasonic irradiation unit (12) based on the temperature of a current (26) and at least one previous direction (28) of the beam path of the ultrasonic irradiation along the trajectory. The invention further provides a corresponding method for ultrasonic treatment and an ultrasonic treatment system, comprising the above ultrasonic treatment device (10) and a diagnostic imaging device for providing temperature information of a target zone (22) of the subject of interest, wherein the control unit (20) of the ultrasonic treatment device (10) is adapted to receive the temperature information from the diagnostic imaging device. By looking at the temperature or a thermal dose distribution along a previous direction of the beam path of the ultrasonic irradiation along the trajectory where the heating has been completed, an improved control of the treatment is achieved. Even if this previous sonication was different to the one currently applied, it represents a good indicator of the tissue and ultrasound system behavior.
    • 本发明提供一种用于加热感兴趣对象的一部分的超声波处理装置(10),其包括用于产生高强度聚焦超声波照射的超声波照射单元(12),由此超声波照射的光束路径可沿着 用于在感兴趣的对象的目标区域(22)内沉积超声能量的轨迹,以及控制单元(20),用于控制超声波照射单元(12)沿着轨迹移动超声波照射的光束路径并施加 超声波剂量到目标区域(22),其中控制单元(20)适于接收目标区域(22)的温度信息并且基于接收的温度信息控制超声波照射单元(12),并且控制 单元(20)适于基于电流(26)的温度和超声波i的光束路径的至少一个先前方向(28)来控制超声波照射单元(12) 沿着轨迹的辐射。 本发明还提供了一种用于超声波处理和超声波处理系统的相应方法,包括上述超声波处理装置(10)和用于提供感兴趣对象的目标区域(22)的温度信息的诊断成像装置,其中控制 超声处理装置(10)的单元(20)适于从诊断成像装置接收温度信息。 通过沿着沿着加热完成的轨迹的超声波照射的光束路径的先前方向观察温度或热剂量分布,实现了治疗的改进的控制。 即使这种以前的超声处理与目前应用的不同,它代表了组织和超声系统行为的良好指标。
    • 3. 发明申请
    • ACOUSTIC RADIATION FORCE IMAGING
    • 声辐射力成像
    • WO2016139113A1
    • 2016-09-09
    • PCT/EP2016/053930
    • 2016-02-25
    • KONINKLIJKE PHILIPS N.V.
    • MOUGENOT, Charles
    • A61N7/02G01R33/54
    • G01R33/4814A61B2090/374A61N7/02G01R33/56308
    • The invention provides for a medical apparatus (100) comprising a high intensity focused ultrasound system (122) and a magnetic resonance imaging system (102). A memory (152) stores machine executable instructions(280, 282, 284, 286) and pulse sequence commands (260) for an acoustic radiation force imaging protocol. The memory further stores first sonication commands(262) and second sonication commands (264) for controlling the high intensity focused ultrasound system to sonicate the sonication region according to the acoustic radiation force imaging protocol. The pulse sequence commands specifies the acquisition of the magnetic resonance data for multiple pulse sequence repetitions. The pulse sequence commands specifies for each of the multiple sequence repetitions a first group of motion encoding gradients (406) and a second group (408) of motion encoding gradients. The execution of the machine executable instructions causes a processor controlling the medical apparatus to: acquire (300) first magnetic resonance data (266) by controlling the magnetic resonance imaging system with the pulse sequence commands and by controlling the high intensity focused ultrasound system with the first sonication commands; acquire (302) second magnetic resonance data (268) by controlling the magnetic resonance imaging system with the pulse sequence commands and by controlling the high intensity focused ultrasound system with the second sonication commands; reconstruct (304) a first motion encoded image (270) from the first magnetic resonance data; reconstruct (306) a second motion encoded image (272) from the second magnetic resonance data; and construct (308) a displacement map (274) from the difference of the first motion encoded image and the second motion encoded image.
    • 本发明提供一种包括高强度聚焦超声系统(122)和磁共振成像系统(102)的医疗装置(100)。 存储器(152)存储用于声辐射力成像协议的机器可执行指令(280,282,284,286)和脉冲序列命令(260)。 存储器还存储用于控制高强度聚焦超声系统的第一超声处理命令(262)和第二超声处理命令(264),以根据声辐射力成像协议超声处理超声处理区域。 脉冲序列命令指定用于多个脉冲序列重复的磁共振数据的获取。 脉冲序列命令为运动编码梯度的第一组运动编码梯度(406)和第二组(408)指定多个序列重复中的​​每一个。 机器可执行指令的执行使得控制医疗装置的处理器通过用脉冲序列命令控制磁共振成像系统并且通过控制具有脉冲序列命令的高强度聚焦超声系统来获取(300)第一磁共振数据(266) 第一次超声处理指令; 通过用脉冲序列命令控制磁共振成像系统并通过用第二超声处理命令控制高强度聚焦超声系统来获取(302)第二磁共振数据(268); 从第一磁共振数据重构(304)第一运动编码图像(270); 从第二磁共振数据重建(306)第二运动编码图像(272); 并根据第一运动编码图像和第二运动编码图像的差异构造(308)位移图(274)。
    • 4. 发明申请
    • MEDICAL APPARATUS FOR RADIOTHERAPY AND ULTRASOUND HEATING
    • 放射治疗和超声波加热的医疗设备
    • WO2015067786A1
    • 2015-05-14
    • PCT/EP2014/074107
    • 2014-11-07
    • KONINKLIJKE PHILIPS N.V.
    • MOUGENOT, Charles
    • G01R33/48A61N7/02A61N5/10
    • A61N7/02A61B5/055A61B34/10A61B2017/00084A61B2034/101A61B2034/105A61B2090/374A61N5/1039A61N5/1064A61N5/1067A61N5/1081A61N2005/1087G01R33/4804G01R33/4814
    • The invention provides for a medical apparatus (100, 300, 400) comprising a processor (104). Execution instructions (120, 122, 124, 370, 372, 374, 376, 378, 380, 382, 384, 386) causes the processor to receive (200) a treatment plan (120) descriptive of an ionizing radiation beam treatment of a target zone (340) within a subject (320) using a radiation beam therapy system (301) with a radiation source (354) and a gantry (350). The radiation source is operable for aiming a radiation beam path (358) at a rotational axis (352) of the gantry. The instructions further cause the processor to receive (202) a planning thermal distribution (122) descriptive of ultrasound heating of the subject with a high intensity focused ultrasound system (304) of a heating zone (338) and an ultrasound beam path (332) within the subject. The target zone is within the heating zone. The instructions further cause the processor to generate (204) radiation control command data (124) using the planning thermal distribution and the treatment plan. The radiation control command data is executable to cause the radiation source to reduce irradiation of the target zone when more than a predetermined volume of the radiation beam path intersects the ultrasound beam path.
    • 本发明提供一种包括处理器(104)的医疗设备(100,300,400)。 执行指令(120,122,124,370,372,374,376,378,380,382,384,386,368,386,378,380,382,338,386)使得处理器接收(200)描述电离辐射束治疗的治疗计划(120) 使用具有辐射源(354)和台架(350)的辐射束治疗系统(301)在受试者(320)内的目标区域(340)。 辐射源可操作以将辐射束路径(358)瞄准台架的旋转轴线(352)。 所述指令还使得所述处理器使用加热区(338)和超声波束路径(332)的高强度聚焦超声系统(304)接收(202)描述所述对象的超声加热的规划热分布(122) 在主题内 目标区域在加热区域内。 该指令还使得处理器使用规划热分布和处理计划来生成(204)辐射控制命令数据(124)。 当超过预定体积的辐射束路径与超声波束路径相交时,辐射控制命令数据可执行以使得辐射源减少目标区域的照射。