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1. 发明申请

WO2021108861A1 TREATMENT OF NEURODEGENERATIVE DISEASES USING ULTRASOUND AND AMYLOID-BETA ANTIBODIES 审中-公开
公开(公告)号：WO2021108861A1
公开(公告)日：2021-06-10
申请号：PCT/AU2020/051320
申请日：2020-12-03
申请人： THE UNIVERSITY OF QUEENSLAND
发明人： GOETZ, Juergen , LEINENGA, Gerhard
IPC分类号： A61K39/395 , C07K16/18 , A61P25/28 , A61N7/00
摘要： The present invention relates to antigen binding sites, compositions and uses thereof in the treatment of conditions associated with pathogenic proteins. In one example the condition is Alzheimer's disease.

2. 发明申请

WO2020077380A1 METHODS AND COMPOSITIONS FOR TREATING TAUOPATHIES 审中-公开
公开(公告)号：WO2020077380A1
公开(公告)日：2020-04-23
申请号：PCT/AU2018/051129
申请日：2018-10-17
申请人： THE UNIVERSITY OF QUEENSLAND
发明人： GOETZ, Juergen , NISBET, Rebecca , JANOWICZ, Phillip , LEINENGA, Gerhard
IPC分类号： A61K39/395 , A61N7/00 , A61P25/28
摘要： The invention relates to tau, to antibodies and related fragments thereof for binding to tau, to production of said antibodies and fragments and to use of said antibodies and fragments for detection and therapy of various conditions, including tauopathies. The invention also relates to compositions comprising tau antibodies for binding to tau and their use in combination with acoustic energy.

3. 发明申请

WO2015192189A1 NEURODEGENERATIVE DISEASE TREATMENT 审中-公开
标题翻译：神经病变疾病治疗
公开(公告)号：WO2015192189A1
公开(公告)日：2015-12-23
申请号：PCT/AU2015/050345
申请日：2015-06-19
申请人： THE UNIVERSITY OF QUEENSLAND
发明人： GOETZ, Juergen , LEINENGA, Gerhard
IPC分类号： A61N7/00 , A61H1/00 , A61N2/00
CPC分类号： A61N7/00 , A61N2007/0026 , A61N2007/0039 , A61N2007/0078 , A61N2007/0082
摘要： The present invention is directed to methods for treating neurodegenerative diseases and/or improving cognitive function, in particular those associated with protein oligomers, aggregates or deposits, using acoustic energy, such as ultrasound. An 5 example of such a neurodegenerative disease is Alzheimer's disease. The present invention provides a method of improving cognitive function and/or memory in an individual with impaired memory and/or executive function, the method including the steps of identifying a region of the brain of the individual to be treated with acoustic energy, applying a clinically safe level of acoustic energy to the region, thereby 10 saturating or substantially saturating the region with acoustic energy, thereby improving memory in the individual.
摘要翻译：本发明涉及使用声能（例如超声）治疗神经变性疾病和/或改善认知功能的方法，特别是与蛋白质低聚物，聚集体或沉积物相关的那些。这种神经变性疾病的5例是阿尔茨海默氏病。本发明提供一种改善受损记忆和/或执行功能的个体的认知功能和/或记忆的方法，所述方法包括以下步骤：用声能识别要治疗的个体的脑区域，应用临床安全的声能级别到该区域，从而使该区域具有声能饱和或基本饱和，从而改善个体的记忆。

4. 发明申请

WO2020172713A1 ACOUSTIC ENERGY TREATMENT 审中-公开
公开(公告)号：WO2020172713A1
公开(公告)日：2020-09-03
申请号：PCT/AU2020/050173
申请日：2020-02-27
申请人： THE UNIVERSITY OF QUEENSLAND
发明人： GOETZ, Juergen , TURPIN, Fabrice , BLACKMORE, Daniel
IPC分类号： A61N7/00 , A61M37/00
摘要： The present invention relates to methods of restoring cognitive function in aged individuals that do not exhibit a clinically detectable neurodegenerative disease. In one aspect, the present invention provides a method of improving cognitive function in an aged individual that does not have a neurodegenerative disease characterized by aggregation of a pathological protein, the method comprising or consisting of: applying a clinically safe level of acoustic energy to sites within a region of the brain, thereby saturating or substantially saturating the region with acoustic energy, thereby improving cognitive function in the aged individual.

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