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1. 发明申请

WO0044237A2 HYPER-ABSORPTION OF VITAMIN E DISPERSED IN MILKS 审中-公开
标题翻译：维生素E在奶酪中的超吸收
公开(公告)号：WO0044237A2
公开(公告)日：2000-08-03
申请号：PCT/US0001597
申请日：2000-01-21
申请人： UNIV BRANDEIS , PERLMAN DANIEL , HAYES KENNETH C
发明人： PERLMAN DANIEL , HAYES KENNETH C
IPC分类号： A23C9/158 , A23C11/04 , A23C19/09 , A23L33/15 , A23C9/00
CPC分类号： A23C9/158 , A23C11/04 , A23C19/0921 , A23L33/15 , A23V2002/00 , A23V2250/5424 , A23V2250/712
摘要： A milk product including a level of at least 31IU vitamin E per serving of said product which can conveniently provide at least 100 IU of vitamin E per day to an individual ingesting the product. The vitamin E is uniformly microdispersed throughout the product, and ingestion of at least 100 IU of vitamin E per day in the product is sufficient to cause the fasting plasma vitamin E/cholesterol ratio in human subjects to be elevated at least 50 % above the basal fasting level of vitamin E measured in the same subjects consuming no vitamin E dietary supplements. A method for elevating the plasma vitamin E level at least 50 % in human subjects is also described. The method includes ingesting a milk product as described.
摘要翻译：一种含有至少31IU维生素E的奶制品，每份所述产品每天可以方便地提供至少100IU的维生素E至摄取产品的个体。维生素E在整个产品中均匀地微分散，并且每天在产品中摄入至少100IU的维生素E足以使人受试者的空腹血浆维生素E /胆固醇比例升高至基础以上至少50％维生素E的空腹水平在同一受试者中测量不消耗维生素E膳食补充剂。还描述了在人受试者中提高血浆维生素E水平至少50％的方法。该方法包括如上所述摄取牛奶制品。

2. 发明申请

WO2012151387A2 AMPHIPHILIC STEROL/FAT-BASED PARTICLES 审中-公开
标题翻译： AMPHIPHILIC STEROL / FAT-BASED PARTICLES
公开(公告)号：WO2012151387A2
公开(公告)日：2012-11-08
申请号：PCT/US2012036300
申请日：2012-05-03
申请人： UNIV BRANDEIS , PERLMAN DANIEL , HAYES KENNETH C , PRONCZUK ANDRZEJ , CHAABO FADI
发明人： PERLMAN DANIEL , HAYES KENNETH C , PRONCZUK ANDRZEJ , CHAABO FADI
IPC分类号： A23L1/035 , A23C9/152 , A23L1/30 , A23L2/52
CPC分类号： A23D9/013 , A23C9/152 , A23C11/103 , A23C2240/10 , A23D7/0053 , A23D7/011 , A23D9/007 , A23L23/00 , A23L27/60 , A23L29/10 , A23L33/11 , A23V2002/00 , A23V2200/222 , A23V2250/2136
摘要： The present invention relates to amphiphilic sterol- and fat-based particles, which can be dispersed in liquid foods and beverages such as milk. The compositions provided, when consumed, reduce low-density lipoprotein (LDL) and total plasma cholesterol (TC) levels.
摘要翻译：本发明涉及可分散在液体食品和饮料如牛奶中的两亲甾醇和脂肪基颗粒。当消耗时，提供的组合物降低低密度脂蛋白（LDL）和总血浆胆固醇（TC）水平。

3. 发明申请

WO2011106618A8 BALANCED MYRISTATE- AND LAURATE-CONTAINING EDIBLE OIL 审中-公开
标题翻译：平衡含糖和含莴苣的可食用油
公开(公告)号：WO2011106618A8
公开(公告)日：2012-09-13
申请号：PCT/US2011026203
申请日：2011-02-25
申请人： UNIV BRANDEIS , PERLMAN DANIEL , HAYES KENNETH C
发明人： PERLMAN DANIEL , HAYES KENNETH C
IPC分类号： A23D7/00 , A23D9/00 , A23L1/29 , A23L1/30
CPC分类号： A23D7/001 , A23D7/003 , A23D9/00 , A23K20/158 , A23L33/12 , A23V2002/00 , A61K31/20 , A61K31/201 , A61K45/06 , A61K2300/00 , A23V2250/1882 , A23V2200/3262 , A23V2250/186 , A23V2250/1872
摘要： Nutritional fat or oil-based compositions for increasing HDL cholesterol, decreasing total cholesterol (TC), LDL cholesterol and decreasing the LDL/HDL cholesterol ratio in human plasma are described. The compositions can advantageously include at least 10% of myristic acid and/or lauric acid in which at least 3% of said fatty acid composition is myristic acid and at least 3% is lauric acid; in some cases at least 1% by weight myristic acid and/or lauric acid is esterified at the sn-2 position in triglyceride molecules. The compositions also include between 5% and 40% by weight linoleic acid, and typically further include at least 10% by weight monounsaturated fatty acids and between 15% and 55% by weight total saturated fatty acids. The sum of weight percentages for saturated, monounsaturated and polyunsaturated fatty acids equals 100%. In desirable cases, the composition is substantially cholesterol-free. Also described are fat compositions and diets which are adapted to limit increases in blood triglycerides, total cholesterol, LDL, and VLDL, even in the presence of dietary cholesterol.
摘要翻译：描述了用于增加HDL胆固醇，降低总胆固醇（TC），低密度脂蛋白胆固醇和降低人血浆中LDL / HDL胆固醇比例的营养脂肪或油基组合物。组合物可以有利地包括至少10％的肉豆蔻酸和/或月桂酸，其中至少3％的所述脂肪酸组合物是肉豆蔻酸，并且至少3％是月桂酸; 在一些情况下，至少1重量％的肉豆蔻酸和/或月桂酸在甘油三酯分子的sn-2位被酯化。组合物还包括5重量％至40重量％的亚油酸，并且通常还包括至少10重量％的单不饱和脂肪酸和15重量％至55重量％的总饱和脂肪酸。饱和，单不饱和和多不饱和脂肪酸的重量百分比之和等于100％。在期望的情况下，组合物基本上不含胆固醇。还描述了脂肪组合物和饮食，其适于限制血液甘油三酯，总胆固醇，低密度脂蛋白和VLDL的增加，即使在膳食胆固醇的存在下。

4. 发明申请

WO2010027433A3 SN-2 MYRISTATE-CONTAINING EDIBLE OIL 审中-公开
标题翻译： SN-2含有香料的食用油
公开(公告)号：WO2010027433A3
公开(公告)日：2010-05-14
申请号：PCT/US2009004860
申请日：2009-08-25
申请人： UNIV BRANDEIS , PERLMAN DANIEL , HAYES KENNETH C
发明人： PERLMAN DANIEL , HAYES KENNETH C
IPC分类号： A23D7/00
CPC分类号： C11C3/10 , A23D9/02 , A23L33/12
摘要： A nutritional fat or oil-based composition for increasing HDL cholesterol, decreasing LDL cholesterol and decreasing the LDL/HDL cholesterol ratio in human plasma is described. The composition can advantageously include at least 1 % by weight myristic acid esterified at the sn-2 position in triglyceride molecules, includes between 10% and 40% by weight linoleic acid, and further includes between 30% and 65% by weight oleic acid and between 15% and 40% by weight total saturated fatty acids. The ratio of sn-2 myristic acid to sn-2 palmitic acid is typically greater than 1 :1 and the sum of weight percentages for saturated, monounsaturated and polyunsaturated fatty acids equals 100%. In desirable cases, the composition is substantially cholesterol-free.
摘要翻译：描述了用于增加人血浆中HDL胆固醇，降低LDL胆固醇和降低LDL / HDL胆固醇比的营养型油或脂基组合物。所述组合物可以有利地包含在甘油三酯分子中在sn-2位酯化的至少1重量％的肉豆蔻酸，包含10重量％至40重量％的亚油酸，并且还包含30重量％至65重量％的油酸和按重量计15％至40％的总饱和脂肪酸。 sn-2肉豆蔻酸与sn-2棕榈酸的比例通常大于1：1，饱和，单不饱和脂肪酸和多不饱和脂肪酸的重量百分比之和等于100％。在理想的情况下，该组合物基本上不含胆固醇。

5. 发明申请

WO2008055250A3 GELLED VEGETABLE OIL CONDIMENT UTILIZING GLYCEROL AND HYDROPHILIC MICROPARTICULATE SILICON DIOXIDE 审中-公开
标题翻译：利用甘油和亲水性微粒二氧化硅凝胶化植物油调味料
公开(公告)号：WO2008055250A3
公开(公告)日：2008-07-17
申请号：PCT/US2007083263
申请日：2007-10-31
申请人： UNIV BRANDEIS , PERLMAN DANIEL
发明人： PERLMAN DANIEL
IPC分类号： A23L27/00 , B01F3/12
CPC分类号： A23D9/00
摘要： An orally dispersible, substantially water-free edible oil-based gel composition for food use, that typically contains between 74% and 99% by weight triglyceride-based edible oil, up to 2.0% by weight hydrophilic microparticulate silicon dioxide, between 0.1% and 1.0% by weight of at least one edible polyol, less than 1% by weight water and less than 25% by weight of additional suspended solids. The polyol and the silicon dioxide have been fully dispersed in the oil-based composition to cause gelling of the edible oil. The composition commonly includes added flavoring agents and can include flavor enhancers.
摘要翻译：用于食品用途的可口服分散的基本上无水的基于食用油的凝胶组合物通常含有基于甘油三酯的食用油74重量％至99重量％，亲水性微粒二氧化硅至多2.0重量％，以及0.1重量％ 1.0重量％的至少一种可食用多元醇，少于1重量％的水和少于25重量％的另外的悬浮固体。多元醇和二氧化硅已经完全分散在油基组合物中以引起食用油的胶凝。该组合物通常包括添加的调味剂并且可以包括风味增强剂。

6. 发明申请

WO2007030570A2 DIETARY SUPPLEMENTS AND PREPARED FOODS CONTAINING TRIGLYCERIDE-RECRYSTALLIZED NON-ESTERIFIED PHYTOSTEROLS 审中-公开
标题翻译：含有TRIGLYCERIDE-重组非离子植物甾醇的膳食补充剂和准备食品
公开(公告)号：WO2007030570A2
公开(公告)日：2007-03-15
申请号：PCT/US2006034776
申请日：2006-09-06
申请人： UNIV BRANDEIS , PERLMAN DANIEL , HAYES KENNETH , PRONCZUK ANDRZEJ
发明人： PERLMAN DANIEL , HAYES KENNETH , PRONCZUK ANDRZEJ
IPC分类号： A23D9/00
CPC分类号： A23D9/007 , A23L2/52 , A23L13/428 , A23L13/43 , A23L23/00 , A23L27/60 , A23L27/63 , A23L33/11 , A23L33/115 , A23L33/12 , A23V2002/00 , C11B5/0021 , C11B5/0085 , A23V2250/1882 , A23V2250/061 , A23V2250/5118 , A23V2250/5108 , A23V2250/70 , A23V2250/156 , A23V2250/54246
摘要： A nutritional supplement, prepared food product, or direct food additive for ingestion by mammals, and methods for preparing such products, are provided. Products of the invention comprise an oxidation-resistant fat-based composition substantially free of exogenous solubilizing and dispersing agents for phytosterols. The fat-based composition includes greater than 25% and less than 75% by weight of one or more triglyceride-based edible oil or fat, and greater than 25% and less than 75% by weight of one or more non-esterified phytosterols. The fat-based composition, when exposed to air, contains a reduced amount of oxidative by-products compared to a similar fat-based composition lacking non-esterified phytosterols. Also provided are methods for reducing plasma cholesterol in mammals, and methods for protecting plasma lipoproteins and cholesterol from oxidation by ingestion of products of the invention.
摘要翻译：提供营养补充剂，制备的食品或哺乳动物摄入的直接食品添加剂，以及制备这些产品的方法。本发明的产品包含基本上不含用于植物甾醇的外源增溶和分散剂的抗氧化脂肪基组合物。基于脂肪的组合物包含大于25重量％且小于75重量％的一种或多种甘油三酯基食用油或脂肪，以及大于25重量％且小于75重量％的一种或多种非酯化植物甾醇。基于脂肪的组合物当暴露于空气中时，与缺乏非酯化植物甾醇的类似的基于脂肪的组合物相比，含有减少量的氧化副产物。还提供了用于降低哺乳动物血浆胆固醇的方法，以及通过摄入本发明的产品来保护血浆脂蛋白和胆固醇免于氧化的方法。

7. 发明申请

WO2010096597A2 STABILIZATION OF PHENOLIC ANTIOXIDANTS IN FAT-CONTAINING FOODS 审中-公开
标题翻译：含肉类抗氧化剂在含脂肪食品中的稳定性
公开(公告)号：WO2010096597A2
公开(公告)日：2010-08-26
申请号：PCT/US2010024637
申请日：2010-02-18
申请人： PERLMAN DANIEL
发明人： PERLMAN DANIEL
IPC分类号： A23D9/007
CPC分类号： A23D9/007 , A23D9/06
摘要： A fat-containing processed food composition is described that is suitable for human consumption, and that contains exogenously added microparticles of phenolic antioxidants dispersed but not dissolved in an antioxidant-protective edible oil/fat portion of the food composition. The oxidative stability of the phenolic antioxidants in the fat or oil portion of the food composition is substantially greater than when dissolved in an equal portion of water at pH 7.
摘要翻译：描述了适用于人类消费的含脂肪加工食品组合物，其含有分散但未溶解在食品组合物的抗氧化保护性食用油/脂肪部分中的外来添加的酚类抗氧化剂微粒。酚类抗氧化剂在食物组合物的脂肪或油部分中的氧化稳定性基本上大于当溶解在pH7的相等部分水中时的氧化稳定性。

8. 发明申请

WO2009045520A2 WATER-DISPERSIBLE PHYTOSTEROL-SURFACTANT CONGLOMERATE PARTICLES 审中-公开
标题翻译：水分散性植物固醇表面活性剂聚合物颗粒
公开(公告)号：WO2009045520A2
公开(公告)日：2009-04-09
申请号：PCT/US2008011481
申请日：2008-10-03
申请人： PERLMAN DANIEL
发明人： PERLMAN DANIEL
IPC分类号： A23L33/00 , A61K9/14 , A23L2/52 , A23L27/30 , A61K31/56 , A61P3/06
CPC分类号： A61K31/56 , A23L29/10 , A23L33/11 , A23V2002/00 , A23V2200/3262 , A23V2250/2136 , A23V2200/222
摘要： A water-dispersible dry-milled composition including phytosterol-surfactant conglomerate (PSC) particles which include a blend of dry microparticulate non- ester phytosterols and dry surfactant, e.g., dry binary surfactant is described. The composition further optionally includes one or more additional dry ingredients such as anti-caking agents, anti-foam agents, natural and artificial sweeteners, non-dairy creamers and flavoring agents.
摘要翻译：描述了包括植物甾醇 - 表面活性剂聚集体（PSC）颗粒的水分散性干磨组合物，其包括干燥微粒非酯植物甾醇和干燥表面活性剂如干二元表面活性剂的混合物。该组合物进一步任选地包含一种或多种额外的干成分，例如防结块剂，消泡剂，天然和人造甜味剂，非乳制奶精和调味剂。

9. 发明申请

WO2007025261A3 NON-IRRITATING SOLVENT-BORNE POLYMERIC COATINGS FOR APPLICATION TO THE SKIN 审中-公开
标题翻译：非刺激性溶剂型聚合物涂层用于皮肤
公开(公告)号：WO2007025261A3
公开(公告)日：2007-10-04
申请号：PCT/US2006033589
申请日：2006-08-28
申请人： PERLMAN DANIEL
发明人： PERLMAN DANIEL
IPC分类号： A61K31/717 , A61K9/70
CPC分类号： A61K31/717 , A61K9/70 , A61L26/0023 , C08L1/00
摘要： A method and composition for reducing or eliminating stinging that may accompany application of topical solution of a skin-compatible polymeric material to a skin wound, abrasion, burn or other skin injury. The topical solution may contain one or more skin-irritating chemicals, such as diethyl ether, ethanol, ethyl acetate, methyl acetate, acetone, methyl ethyl ketone and combinations thereof. The method includes: (i) providing a composition that contains between 1% and 10% by weight of the skin-compatible polymeric material dissolved in a liquid medium suitable for human topical use in which the liquid medium includes less than 20% combined weight of skin-irritating chemicals, and at least 45% combined weight of at least one volatile solvent and/or volatile co-solvent, in which the molecules constituting this 45% combined weight portion of the liquid medium contain at least 5 carbon atoms, and the liquid medium has an initial boiling point at 1 atmosphere of greater than 35°C and less than 150°C, and causes little or no stinging when applied to a skin injury, and (ii) applying the composition to the skin of a patient at the site of the skin injury.
摘要翻译：用于减少或消除可能伴随皮肤相容性聚合物材料的局部溶液应用于皮肤伤口，磨损，灼伤或其他皮肤损伤的刺痛的方法和组合物。局部溶液可含有一种或多种皮肤刺激性化学物质，如乙醚，乙醇，乙酸乙酯，乙酸甲酯，丙酮，甲乙酮及其组合。该方法包括：（i）提供一种组合物，其含有溶解在适用于人体局部应用的液体介质中的1重量％至10重量％的所述皮肤相容性聚合物材料，其中所述液体介质包含小于20重量％刺激皮肤的化学物质和至少45％的组合重量的至少一种挥发性溶剂和/或挥发性共溶剂，其中构成该液体介质的45重量％组合重量部分的分子含有至少5个碳原子，并且液体培养基在1个大气压下的初始沸点大于35℃且小于150℃，并且当施用于皮肤损伤时引起很少或没有刺痛，和（ii）将所述组合物施用于患者的皮肤上皮肤损伤的部位。

10. 发明申请

WO2015009481A2 PAR-BAKED AND MILLED COFFEE BEANS FOR USE IN FOODS, BEVERAGES AND DIETARY SUPPLEMENTS 审中-公开
标题翻译：用于食品，饮料和膳食补充剂的PAR-烘焙和研磨咖啡豆
公开(公告)号：WO2015009481A2
公开(公告)日：2015-01-22
申请号：PCT/US2014045676
申请日：2014-07-08
申请人： UNIV BRANDEIS
发明人： PERLMAN DANIEL
IPC分类号： A23F5/04
CPC分类号： A23F5/02 , A23F5/04 , A23L2/52 , A23L33/105 , A23V2002/00
摘要： The present invention concerns compositions and methods relating to the addition and use of par-baked and milled coffee beans in food products, beverages, and dietary supplements. Par-baked and milled coffee beans are a novel alternative to more costly chlorogenic acid extracts, and are edible and palatable as a food ingredient. The ingredient is prepared from the entire Coffea robusta or arabica green coffee bean and provides substantially increased amounts of dietary chlorogenic acid antioxidants compared to roasted beans. When the green coffee bean is appropriately par-baked at a temperature significantly lower than coffee roasting temperatures, the bean retains significant moisture, yet becomes embrittled, enabling milling to produce fine and beneficially hydrophilic particles, without any significant loss of bioactive chlorogenic acid and without significant pyrolysis occurring. As described herein, the par-baked coffee bean is superior to both the green coffee bean and the traditionally roasted coffee bean for adding chlorogenic acids to foods, beverages and dietary supplements.
摘要翻译：本发明涉及关于在食品，饮料和膳食补充剂中添加和使用熟化和磨碎的咖啡豆的组合物和方法。平面烘焙和磨碎的咖啡豆是更昂贵的绿原酸提取物的新型替代品，并且作为食物成分是可食用和可口的。该成分由整个咖啡豆或阿拉伯咖啡豆咖啡豆制成，与焙炒豆相比，提供了显着增加的膳食绿原酸抗氧化剂的量。当绿咖啡豆在显着低于咖啡焙烧温度的温度下进行适当的烘烤时，豆保留显着的水分，但变得脆弱，使得能够研磨以产生精细和有益的亲水性颗粒，而没有生物活性绿原酸没有明显损失发生明显的热解。如本文所述，经焙烤的咖啡豆优于绿咖啡豆和传统的焙炒咖啡豆，以将绿原酸添加到食品，饮料和膳食补充剂中。

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