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1. 发明申请

WO2012158018A3 COMPOSITIONS COMPRISING EXTRACTS OR MATERIALS DERIVED FROM PALM OIL VEGETATION LIGUOR FOR INHIBITION OF VISION LOSS DUE TO ANGIOGENESIS AND METHOD OF PREPARATION THEREOF 审中-公开
标题翻译：包含从棕榈油植物提取物提取的提取物或材料的组合物，用于抑制血液发生的视力损失及其制备方法
公开(公告)号：WO2012158018A3
公开(公告)日：2013-03-28
申请号：PCT/MY2012000102
申请日：2012-05-18
申请人： MALAYSIAN PALM OIL BOARD , MOGHADAM ALI HAFEZI , SAMBANTHAMURTHI RAVIGADEVI , TAN YEW AI , P MANICKAM KALYANA SUNDRAM , HAYES KENNETH C , SOUSKA ZANDI
发明人： MOGHADAM ALI HAFEZI , SAMBANTHAMURTHI RAVIGADEVI , TAN YEW AI , P MANICKAM KALYANA SUNDRAM , HAYES KENNETH C , SOUSKA ZANDI
IPC分类号： A61K36/889 , A61P3/00 , A61P3/10 , A61P17/00
CPC分类号： A61K36/889 , A23L33/105 , A61K31/05
摘要： The present invention relates generally to a composition comprising palm fruit juice for use in a method of preventing and inhibiting vision loss due to angiogenesis related diseases. The composition of the present invention aids to decrease in CNV size using confocal microscopy, in addition to reduction in macrophage infiltration using immune staining; decrease in VEGF- A-induced angiogenesis using established cornea pocket assay, inhibition of IKB-D phosphorylation in laser treated choroidal tissues and reduction in macrophage recruitment to CNV lesions.
摘要翻译：本发明一般涉及包含棕榈果汁的组合物，其用于预防和抑制由血管生成相关疾病引起的视力丧失的方法。本发明的组合物除了通过免疫染色减少巨噬细胞浸润外，还有助于使用共焦显微镜降低CNV大小; 使用已建立的角膜口袋测定法，激光治疗的脉络膜组织中IKB-D磷酸化的抑制以及巨噬细胞募集到CNV病变中的VEGF-A诱导的血管生成降低。

2. 发明申请

WO2009146102A1 METHODS FOR THE TREATMENT OR PREVENTION OF DIABETES MELLITUS AND OTHER METABOLIC IMBALANCES 审中-公开
标题翻译：治疗或预防糖尿病及其他代谢性不平衡的方法
公开(公告)号：WO2009146102A1
公开(公告)日：2009-12-03
申请号：PCT/US2009/039296
申请日：2009-04-02
申请人： BRANDEIS UNIVERSITY , MALAYSIAN PALM OIL BOARD , HAYES, Kenneth, C. , SUNDRAM, Kalyana , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew, Ai
发明人： HAYES, Kenneth, C. , SUNDRAM, Kalyana , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew, Ai
IPC分类号： A61K36/889 , A61P3/10 , A61K36/9068 , A61K31/216
CPC分类号： A61K31/192 , A61K2300/00
摘要： The invention relates to methods for treatment and prevention of a metabolic imbalance, including diabetes mellitus and other related diseases or disorders, using an extract from a fruit of genus Elaeis.
摘要翻译：本发明涉及使用来自水蛭属的果实的提取物治疗和预防代谢失调的方法，包括糖尿病和其它相关疾病或病症。

3. 发明申请

WO2007111582A1 AUDIO SYSTEM WITH PARENTAL MAXIMUM VOLUME CONTROL 审中-公开
标题翻译：具有家庭最大音量控制的音频系统
公开(公告)号：WO2007111582A1
公开(公告)日：2007-10-04
申请号：PCT/US2006/010925
申请日：2006-03-24
申请人： PANASONIC AUTOMOTIVE SYSTEMS COMPANY OF AMERICA DIVISION OF PANASONIC CORPORATION OF NORTH AMERICA , HAYES, Kenneth, Edward,
发明人： HAYES, Kenneth, Edward,
IPC分类号： H03G3/00
CPC分类号： H03G11/00 , H03G3/04
摘要： The disclosed embodiments relate to an audio system (100) and an associate method. An exemplary embodiment of the system (100) comprises a user interface (104) that enables adjustment of a volume level of an audio signal being reproduced on at least a portion of the audio system to a desired maximum volume level. The user interface further enabling the desired maximum volume level to be selected as a set maximum volume level. A processor (102) electrically interconnected with the user interface is adapted to limit the volume at which audio programs are reproduced on at least a portion of the audio system to said set maximum volume level. An exemplary method comprises generating an audio signal, adjusting a volume level of the audio signal to a desired maximum volume level in response to a user input, and establishing the desired maximum volume level as a set maximum volume level for audio programs played on at least a portion of the audio system (100).
摘要翻译：所公开的实施例涉及音频系统（100）和关联方法。系统（100）的示例性实施例包括用户界面（104），其能够将在音频系统的至少一部分上再现的音频信号的音量水平调整到期望的最大音量水平。用户界面进一步使所需的最大音量水平被选择为设定的最大音量。与用户接口电互连的处理器（102）适于将音频系统的至少一部分上的音频节目再现的音量限制到所述设定的最大音量水平。一种示例性方法包括：生成音频信号，响应于用户输入将音频信号的音量调整到期望的最大音量水平，并且建立期望的最大音量水平作为至少在音乐节目上播放的音频节目的设定最大音量水平音频系统（100）的一部分。

4. 发明申请

WO2006122198A3 IMPLANTABLE CARDIOVERTER DEFIBRILLATOR WITH PROGRAMMABLE CAPACITOR CHARGING LEVEL 审中-公开
标题翻译：带可编程电容充电电位器的可移植式减载器
公开(公告)号：WO2006122198A3
公开(公告)日：2007-02-22
申请号：PCT/US2006018115
申请日：2006-05-11
申请人： CARDIAC PACEMAKERS INC , YOUKER NICK A , HAYES KENNETH , LINDER WILLIAM J
发明人： YOUKER NICK A , HAYES KENNETH , LINDER WILLIAM J
IPC分类号： A61N1/39 , A61N1/372
CPC分类号： A61N1/3708 , A61N1/37235 , A61N1/3925 , A61N1/3956 , A61N1/3975 , A61N1/3981
摘要： An implantable cardioverter defibrillator (ICD) has a programmable ICD energy level corresponding to the maximum defibrillation energy deliverable with each defibrillation shock pulse. The ICD energy level is programmable within the maximum energy capacity of the defibrillation capacitor(s) of the ICD. In various embodiments, after a uses enters the ICD energy level, one or more corresponding ICD performance parameters are presented. Restrictions are applied to the energy level programming of the ICD to ensure the predictability of the one or more ICD performance parameters.
摘要翻译：植入式心律转复除颤器（ICD）具有对应于每个除颤冲击脉冲可递送的最大除颤能量的可编程ICD能量水平。 ICD能量级可在ICD的除颤电容器的最大能量容量内编程。在各种实施例中，在使用进入ICD能级之后，呈现一个或多个相应的ICD性能参数。限制适用于ICD的能量级编程，以确保一个或多个ICD性能参数的可预测性。

5. 发明申请

WO1996039857A1 MODIFIED FAT BLENDS 审中-公开
标题翻译：改性脂肪混合物
公开(公告)号：WO1996039857A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008965
申请日：1996-06-07
申请人： PERLMAN, Daniel , HAYES, Kenneth, C. , MASSIE, Cecil
IPC分类号： A23D09/00
CPC分类号： A23D9/00 , A21D2/16 , A23D7/001
摘要： Blended cholesterol-reduced animal fat and vegetable oil which are combined in a proportion such that the weight ratio of linoleic acid (18:2) content divided by myristic acid (14:2) content is between 2 and 9 inclusive. In addition, cholesterol-reduced animal fat can be blended with cholesterol-reduced fish oil to stabilize the fish oil against air-oxidation at room temperature.
摘要翻译：将胆固醇降低的动物脂肪和植物油混合在一起，使得亚油酸（18:2）含量除以肉豆蔻酸（14：2）含量的重量比在2和9之间。此外，胆固醇降低的动物脂肪可以与胆固醇降低的鱼油混合，以稳定鱼油，防止室温下的空气氧化。

6. 发明申请

WO2012075119A1 ADJUSTING CARDIAC PACING RESPONSE SENSING INTERVALS 审中-公开
标题翻译：调整心脏反应感应间隔
公开(公告)号：WO2012075119A1
公开(公告)日：2012-06-07
申请号：PCT/US2011/062598
申请日：2011-11-30
申请人： CARDIAC PACEMAKERS, INC. , DONG, Yanting , SHOME, Shibaji , MCCABE, Aaron , BRISBEN, Amy, J. , FOSTER, Clayton , YOST, David, W. , HAYES, Kenneth, N.
发明人： DONG, Yanting , SHOME, Shibaji , MCCABE, Aaron , BRISBEN, Amy, J. , FOSTER, Clayton , YOST, David, W. , HAYES, Kenneth, N.
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61B5/0422 , A61B5/04525 , A61B5/0456 , A61B5/4836 , A61B5/7217 , A61B5/7267 , A61N1/3712
摘要： Discrimination between different types of possible cardiac pacing responses may depend on the timing of expected features that are sensed within a temporal framework. The temporal framework may include classification intervals, blanking periods and appropriately timed back up paces. The classification intervals and blanking periods of the temporal framework are intervals of time that have time parameters that include start time, end time, and length. The relationships and timing parameters of the elements of the temporal framework, e.g., blanking periods, classification intervals, delay periods, and backup pacing, should support detection of features used to discriminate between different types of pacing responses. As the system learns the morphology of the particular patient by analyzing the waveform of the pacing response signal, the temporal framework for pacing response determination may be adjusted to accommodate the individual patient.
摘要翻译：不同类型的可能心脏起搏反应之间的歧视可能取决于在时间框架内感测到的预期特征的时间。时间框架可以包括分类间隔，消隐期和适当定时的后台步数。时间框架的分类间隔和消隐期是具有包括开始时间，结束时间和长度的时间参数的时间间隔。时间框架的元素的关系和定时参数，例如消隐期，分类间隔，延迟周期和备份起搏应该支持用于区分不同类型的起搏响应的特征的检测。当系统通过分析起搏响应信号的波形来学习特定患者的形态时，可调整起搏响应确定的时间框架以适应个体患者。

7. 发明申请

WO2012019036A1 USER INTERFACE SYSTEM FOR USE WITH MULTIPOLAR PACING LEADS 审中-公开
标题翻译：用户界面系统，用于多用途铅笔
公开(公告)号：WO2012019036A1
公开(公告)日：2012-02-09
申请号：PCT/US2011/046637
申请日：2011-08-04
申请人： CARDIAC PACEMAKERS, INC. , SAHA, Sunipa , HAYES, Kenneth , HERRMANN, Keith L. , KALGREN, James , MCCABE, Aaron , ROCKWEILER, Holly , SHOME, Shibaji , SIEJKO, Krzysztof Z.
发明人： SAHA, Sunipa , HAYES, Kenneth , HERRMANN, Keith L. , KALGREN, James , MCCABE, Aaron , ROCKWEILER, Holly , SHOME, Shibaji , SIEJKO, Krzysztof Z.
IPC分类号： A61N1/372
CPC分类号： A61N1/37247 , A61N1/056 , A61N1/36185 , A61N1/3686 , A61N1/37241
摘要： An interactive representation of electrostimulation electrodes or vectors can be provided, such as for configuring combinations of electrostimulation electrodes. In an example, electrodes or test parameters can be presented graphically or in a table. A user interface can be configured to receive user-input designating electrode combinations or vectors for test or for use in programming an implantable or ambulatory medical device. The interface can be used to indicate suggested electrode combinations or vectors in response to a first selection of an electrode. Tests can be performed on electrode combinations and vectors, and the results of the tests can be presented to a user using the interactive representation. In an example, test results can be analyzed by a processor and optionally used to program an implantable or ambulatory medical device.
摘要翻译：可以提供电刺激电极或载体的交互式表示，例如用于配置电刺激电极的组合。在一个示例中，电极或测试参数可以图形化或在表中呈现。用户界面可以被配置为接收用户输入的指定电极组合或矢量，用于测试或用于编程可植入或动态医疗设备。该界面可用于响应于电极的第一选择来指示建议的电极组合或载体。可以对电极组合和载体进行测试，并且可以使用交互式表示向使用者呈现测试结果。在一个示例中，测试结果可以由处理器分析，并且可选地用于编程可植入或移动的医疗设备。

8. 发明申请

WO2010027433A2 SN-2 MYRISTATE-CONTAINING EDIBLE OIL 审中-公开
标题翻译： SN-2含糖食品
公开(公告)号：WO2010027433A2
公开(公告)日：2010-03-11
申请号：PCT/US2009/004860
申请日：2009-08-25
申请人： BRANDEIS UNIVERSITY , PERLMAN, Daniel , HAYES, Kenneth, C.
发明人： PERLMAN, Daniel , HAYES, Kenneth, C.
IPC分类号： A61K31/231
CPC分类号： C11C3/10 , A23D9/02 , A23L33/12
摘要： A nutritional fat or oil-based composition for increasing HDL cholesterol, decreasing LDL cholesterol and decreasing the LDL/HDL cholesterol ratio in human plasma is described. The composition can advantageously include at least 1 % by weight myristic acid esterified at the sn-2 position in triglyceride molecules, includes between 10% and 40% by weight linoleic acid, and further includes between 30% and 65% by weight oleic acid and between 15% and 40% by weight total saturated fatty acids. The ratio of sn-2 myristic acid to sn-2 palmitic acid is typically greater than 1 :1 and the sum of weight percentages for saturated, monounsaturated and polyunsaturated fatty acids equals 100%. In desirable cases, the composition is substantially cholesterol-free.
摘要翻译：描述了用于增加HDL胆固醇，降低LDL胆固醇和降低人血浆中LDL / HDL胆固醇比例的营养型油脂或组合物。该组合物可以有利地包括在甘油三酯分子中在sn-2位置酯化的至少1重量％的肉豆蔻酸，包括10重量％至40重量％的亚油酸，并且还包含30重量％至65重量％的油酸和 15％至40％（重量）的总饱和脂肪酸。 sn-2肉豆蔻酸与sn-2棕榈酸的比例通常大于1:1，饱和，单不饱和和多不饱和脂肪酸的重量百分比之和等于100％。在期望的情况下，组合物基本上不含胆固醇。

9. 发明申请

WO2012158018A2 COMPOSITIONS COMPRISING EXTRACTS OR MATERIALS DERIVED FROM PALM OIL VEGETATION LIGUOR FOR INHIBITION OF VISION LOSS DUE TO ANGIOGENESIS AND METHOD OF PREPARATION THEREOF 审中-公开
标题翻译：包含从棕榈油植物提取物提取的提取物或材料的组合物，用于抑制血液发生的视力损失及其制备方法
公开(公告)号：WO2012158018A2
公开(公告)日：2012-11-22
申请号：PCT/MY2012/000102
申请日：2012-05-18
申请人： MALAYSIAN PALM OIL BOARD , MOGHADAM, Ali Hafezi , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew Ai , P MANICKAM, Kalyana Sundram , HAYES, Kenneth, C. , SOUSKA, Zandi
发明人： MOGHADAM, Ali Hafezi , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew Ai , P MANICKAM, Kalyana Sundram , HAYES, Kenneth, C. , SOUSKA, Zandi
CPC分类号： A61K36/889 , A23L33/105 , A61K31/05
摘要： The present invention relates generally to a composition comprising palm fruit juice for use in a method of preventing and inhibiting vision loss due to angiogenesis related diseases. The composition of the present invention aids to decrease in CNV size using confocal microscopy, in addition to reduction in macrophage infiltration using immune staining; decrease in VEGF- A-induced angiogenesis using established cornea pocket assay, inhibition of IKB-D phosphorylation in laser treated choroidal tissues and reduction in macrophage recruitment to CNV lesions.
摘要翻译：本发明一般涉及包含棕榈果汁的组合物，其用于预防和抑制由血管生成相关疾病引起的视力丧失的方法。本发明的组合物除了通过免疫染色减少巨噬细胞浸润外，还有助于使用共焦显微镜降低CNV大小; 使用已建立的角膜口袋测定法，激光治疗的脉络膜组织中IKB-D磷酸化的抑制以及巨噬细胞募集到CNV病变中的VEGF-A诱导的血管生成降低。

10. 发明申请

WO2012151387A3 AMPHIPHILIC STEROL/FAT-BASED PARTICLES 审中-公开
公开(公告)号：WO2012151387A3
公开(公告)日：2012-11-08
申请号：PCT/US2012/036300
申请日：2012-05-03
申请人： BRANDEIS UNIVERSITY , PERLMAN, Daniel , HAYES, Kenneth, C. , PRONCZUK, Andrzej , CHAABO, Fadi
发明人： PERLMAN, Daniel , HAYES, Kenneth, C. , PRONCZUK, Andrzej , CHAABO, Fadi
IPC分类号： A23L1/035 , A23L2/52 , A23L1/30 , A23C9/152
摘要： The present invention relates to amphiphilic sterol- and fat-based particles, which can be dispersed in liquid foods and beverages such as milk. The compositions provided, when consumed, reduce low-density lipoprotein (LDL) and total plasma cholesterol (TC) levels.

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