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    • 3. 发明申请
    • DYNAMIC CARDIAC RESYNCHRONIZATION THERAPY BY TRACKING INTER -ATRIAL CONDUCTION DELAYS
    • 通过跟踪直接导联延迟进行动态心脏再生治疗
    • WO2012163414A1
    • 2012-12-06
    • PCT/EP2011/058982
    • 2011-05-31
    • ST. JUDE MEDICAL ABHEDBERG, Sven-ErikHOLMSTRÖM, NilsJÄRVERUD, Karin
    • HEDBERG, Sven-ErikHOLMSTRÖM, NilsJÄRVERUD, Karin
    • A61N1/362A61N1/368
    • A61N1/368A61N1/3622A61N1/3682A61N1/3684
    • The present invention relates generally to implantable medical devices and more particularly to systems and methods for stimulating a heart of a patient. A first ventricle is activated by delivering stimulation to at least one stimulation site, a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the first ventricle is estimated and a first activation time interval substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site in the first ventricle to the AV node using the estimated point of time for arrival of the depolarization wave and a point of time for delivery of stimulation is computed. Thereafter, the other ventricle is stimulated by delivering stimulation to at least one stimulation site. A point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the other ventricle is then estimated and a second activation time interval substantially corresponding to the time required for at least one depolarization wave to travel from the stimulation site in the other ventricle to the AV node using the estimated arrival of the depolarization wave and the point of time for delivery of stimulation is computed. Based on these activation time intervals and a difference between the intervals, a pacing therapy can be determined, wherein the first ventricle is paced prior to activation of the other ventricle if the activation time difference indicates that the first activation time interval is longer than the second activation time interval and the other ventricle is paced prior to activation of the first ventricle if the activation time difference indicates that the second activation time interval is longer than the first activation time interval.
    • 本发明一般涉及可植入医疗装置,更具体地涉及用于刺激患者心脏的系统和方法。 通过向至少一个刺激部位递送刺激来激活第一脑室,估计到达在第一脑室刺激产生的至少一个去极化波的AV节点的时间点,并且基本对应于 计算使用去极化波的到达的估计时间点和用于递送刺激的时间点的至少一个去极化波从第一脑室的刺激部位行进到AV节点所需的时间间隔。 此后,通过将刺激递送至至少一个刺激部位刺激另一个心室。 然后估计到达AV节点对于在另一个心室中的刺激产生的至少一个去极化波的时间点,并且基本对应于至少一个去极化波从刺激行进所需的时间的第二激活时间间隔 计算使用去极化波的估计到达和输送刺激的时间点在AV节点的另一脑室中的位置。 基于这些激活时间间隔和间隔之间的差异,可以确定起搏治疗,其中如果激活时间差指示第一激活时间间隔长于第二心室第二激活时间间隔,则第一心室在另一心室激活之前起搏 如果所述激活时间差指示所述第二激活时间间隔长于所述第一激活时间间隔,则所述激活时间间隔和所述另一个心室在所述第一心室激活之前起步。
    • 9. 发明申请
    • HEART STIMULATION DEVICE
    • 心脏刺激装置
    • WO2005028030A1
    • 2005-03-31
    • PCT/SE2003/001494
    • 2003-09-25
    • ST. JUDE MEDICAL ABHEDBERG, Sven-ErikBJÖRLING, AndersHOLMSTRÖM, NilsLAGERCRANTZ, Per
    • HEDBERG, Sven-ErikBJÖRLING, AndersHOLMSTRÖM, NilsLAGERCRANTZ, Per
    • A61N1/37
    • A61N1/371A61N1/368A61N1/3684
    • A biventricular stimulation device comprises a pulse generator for delivering stimulation pulses at least to the ventricles of a patient's heart. An evoked response detector has first and second, independent ventricular sensing channels for ventricular evoked response detection in the ventricles. The pulse generator is controlled to deliver stimulation pulses (106) to the second ventricle (RV) with a VV time delay after stimulation pulse delivery (104) to the first stimulated ventricle (LV) which is shorter than an evoked response detection time window (106) following the delivery of the stimulation pulse (104) to the first ventricle. The evoked response detector is arranged to close the evoked response detection time window (106) or discard detections therein in response to the emission of a stimulation pulse (107) to the second ventricle (RV) during the evoked response detection time window (106) of the first stimulated ventricle (LV).
    • 双心室刺激装置包括用于至少向患者心脏的心室输送刺激脉冲的脉冲发生器。 诱发反应检测器具有第一和第二独立心室感知通道,用于心室中的心室诱发反应检测。 脉冲发生器被控制以在刺激脉冲传送(104)之后的VV时间延迟到第一激励心室(LV)处将刺激脉冲(106)传递到第二心室(RV),所述第一受激心室(LV)比诱发的响应检测时间窗 106)在将刺激脉冲(104)递送到第一脑室之后。 诱发响应检测器被安排为在诱发响应检测时间窗口(106)期间响应于向第二心室(RV)发射刺激脉冲(107)而关闭诱发响应检测时间窗口(106)或丢弃其中的检测, 的第一个刺激心室(LV)。
    • 10. 发明申请
    • AN IMPLANTABLE HEART STIMULATING DEVICE, SYSTEM AND METHOD
    • 可植入心脏刺激装置,系统和方法
    • WO2007053064A1
    • 2007-05-10
    • PCT/SE2005/001629
    • 2005-10-31
    • ST. JUDE MEDICAL ABBJÖRLING, AndersHOLMSTRÖM, NilsJÄRVERUD, Karin
    • BJÖRLING, AndersHOLMSTRÖM, NilsJÄRVERUD, Karin
    • A61N1/37A61N1/368
    • A61N1/3627A61N1/368A61N1/3684A61N1/3712
    • The invention concerns an implantable bi- ventricular heart stimulating device (10) including a control circuit (14) comprising a first atrial sensing and/or pacing circuit (25, 27) and ventricular sensing (35, 45) and pacing (37, 47) circuits for a first (IV) and a second (2V) ventricle. The device (10) is arranged to normally operate with a time VV between a pacing pulse delivered, or inhibited, by a first ventricular pacing circuit (37) and a pacing pulse delivered, or inhibited, by a second ventricular pacing circuit (47). The device (10) is arranged to determine a particular time VV cts that is to be used instead of VV during a capture threshold search. The invention also concerns a system including such a device (10) and a method of, in a human or animal being, performing a capture threshold search.
    • 本发明涉及一种可植入的双心室心脏刺激装置(10),其包括包括第一心房感测和/或起搏电路(25,27)和心室感测(35,45)和起搏(37,47)的控制电路(14) )电路用于第一(IV)和第二(2V)心室。 设备(10)被布置成通过由第一心室起搏电路(37)递送或抑制的起搏脉冲与由第二心室起搏电路(47)输送或抑制的起搏脉冲之间的时间VV进行正常操作, 。 设备(10)被布置成在捕获阈值搜索期间确定要用于代替VV的特定时间V V C c C s。 本发明还涉及一种包括这样的装置(10)的系统以及在人或动物中执行捕获阈值搜索的方法。