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1. 发明申请

WO2005028030A1 HEART STIMULATION DEVICE 审中-公开
标题翻译：心脏刺激装置
公开(公告)号：WO2005028030A1
公开(公告)日：2005-03-31
申请号：PCT/SE2003/001494
申请日：2003-09-25
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , BJÖRLING, Anders , HOLMSTRÖM, Nils , LAGERCRANTZ, Per
发明人： HEDBERG, Sven-Erik , BJÖRLING, Anders , HOLMSTRÖM, Nils , LAGERCRANTZ, Per
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/368 , A61N1/3684
摘要： A biventricular stimulation device comprises a pulse generator for delivering stimulation pulses at least to the ventricles of a patient's heart. An evoked response detector has first and second, independent ventricular sensing channels for ventricular evoked response detection in the ventricles. The pulse generator is controlled to deliver stimulation pulses (106) to the second ventricle (RV) with a VV time delay after stimulation pulse delivery (104) to the first stimulated ventricle (LV) which is shorter than an evoked response detection time window (106) following the delivery of the stimulation pulse (104) to the first ventricle. The evoked response detector is arranged to close the evoked response detection time window (106) or discard detections therein in response to the emission of a stimulation pulse (107) to the second ventricle (RV) during the evoked response detection time window (106) of the first stimulated ventricle (LV).
摘要翻译：双心室刺激装置包括用于至少向患者心脏的心室输送刺激脉冲的脉冲发生器。诱发反应检测器具有第一和第二独立心室感知通道，用于心室中的心室诱发反应检测。脉冲发生器被控制以在刺激脉冲传送（104）之后的VV时间延迟到第一激励心室（LV）处将刺激脉冲（106）传递到第二心室（RV），所述第一受激心室（LV）比诱发的响应检测时间窗 106）在将刺激脉冲（104）递送到第一脑室之后。诱发响应检测器被安排为在诱发响应检测时间窗口（106）期间响应于向第二心室（RV）发射刺激脉冲（107）而关闭诱发响应检测时间窗口（106）或丢弃其中的检测，的第一个刺激心室（LV）。

2. 发明申请

WO2007086782A1 ANODAL CAPTURE 审中-公开
标题翻译：阳极捕获
公开(公告)号：WO2007086782A1
公开(公告)日：2007-08-02
申请号：PCT/SE2006/000119
申请日：2006-01-26
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , BJÖRLING, Anders
发明人： HOLMSTRÖM, Nils , BJÖRLING, Anders
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3684
摘要： Implantable heart stimulating device comprising a left ventricular (LV) coronary sinus (CS) electrode lead at least provided with a tip electrode, a right ventricular (RV) electrode lead at least provided with a ring electrode, a pulse generating means connected to said leads and adapted to apply a stimulation pulse between said tip electrode and ring electrode, wherein the tip electrode being the cathode. The device comprises a monitoring means adapted to monitor for and detect anodal capture at said right ventricular ring electrode subsequent to a stimulation. If anodal capture at said right ventricular ring electrode is detected one of the following is performed. Either a threshold search is performed by varying the pulse width and/or pulse amplitude in order to identify stimulation pulse characteristics that avoid anodal capture at the ring electrode, or at least one further electrode is arranged to function as indifferent electrode together with the ring electrode, also in order to avoid anodal capture at the ring electrode.
摘要翻译：可植入心脏刺激装置，其包括至少设置有尖端电极的左心室（LV）冠状窦（CS）电极引线，至少设置有环形电极的右心室（RV））电极引线，连接到所述引线的脉冲发生装置并且适于在所述尖端电极和环形电极之间施加刺激脉冲，其中所述尖端电极为阴极。该装置包括适于在刺激之后监测并检测所述右心室环电极处的阳极捕获的监测装置。如果检测到所述右心室环电极处的阳极捕获，则执行以下之一。通过改变脉冲宽度和/或脉冲幅度来执行阈值搜索，以便识别避免在环形电极处的阳极捕获的刺激脉冲特性，或者至少一个另外的电极被布置成与环电极一起用作无关电极，也是为了避免在环形电极处的阳极捕获。

3. 发明申请

WO2007053064A1 AN IMPLANTABLE HEART STIMULATING DEVICE, SYSTEM AND METHOD 审中-公开
标题翻译：可植入心脏刺激装置，系统和方法
公开(公告)号：WO2007053064A1
公开(公告)日：2007-05-10
申请号：PCT/SE2005/001629
申请日：2005-10-31
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , HOLMSTRÖM, Nils , JÄRVERUD, Karin
发明人： BJÖRLING, Anders , HOLMSTRÖM, Nils , JÄRVERUD, Karin
IPC分类号： A61N1/37 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3712
摘要： The invention concerns an implantable bi- ventricular heart stimulating device (10) including a control circuit (14) comprising a first atrial sensing and/or pacing circuit (25, 27) and ventricular sensing (35, 45) and pacing (37, 47) circuits for a first (IV) and a second (2V) ventricle. The device (10) is arranged to normally operate with a time VV between a pacing pulse delivered, or inhibited, by a first ventricular pacing circuit (37) and a pacing pulse delivered, or inhibited, by a second ventricular pacing circuit (47). The device (10) is arranged to determine a particular time VV cts that is to be used instead of VV during a capture threshold search. The invention also concerns a system including such a device (10) and a method of, in a human or animal being, performing a capture threshold search.
摘要翻译：本发明涉及一种可植入的双心室心脏刺激装置（10），其包括包括第一心房感测和/或起搏电路（25,27）和心室感测（35,45）和起搏（37,47）的控制电路（14））电路用于第一（IV）和第二（2V）心室。设备（10）被布置成通过由第一心室起搏电路（37）递送或抑制的起搏脉冲与由第二心室起搏电路（47）输送或抑制的起搏脉冲之间的时间VV进行正常操作，。设备（10）被布置成在捕获阈值搜索期间确定要用于代替VV的特定时间V V C c C s。本发明还涉及一种包括这样的装置（10）的系统以及在人或动物中执行捕获阈值搜索的方法。

4. 发明申请

WO2006093442A1 BIVENTRICULAR HEART STIMULATOR AND METHOD OF CONTROLLING A BIVENTRICULAR HEART STIMULATOR 审中-公开
标题翻译：双向心脏刺激器和控制双向心脏刺激器的方法
公开(公告)号：WO2006093442A1
公开(公告)日：2006-09-08
申请号：PCT/SE2005/000313
申请日：2005-03-03
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , HOLMSTRÖM, Nils
发明人： BJÖRLING, Anders , HOLMSTRÖM, Nils
IPC分类号： A61N1/37 , A61N1/368
CPC分类号： A61N1/3712 , A61N1/368 , A61N1/3684
摘要： A biventricular heart stimulator and a method for controlling such a biventricular heart stimulator. Successive stimulation pulses are delivered to the ventricles of a human heart such that stimulation pulses in a single heart beat cycle is first delivered to the first ventricle and then to the second ventricle. Capture or loss of capture in response to stimulation pulses delivered to one ventricle is detected. As a result of a detected loss of capture, preventive measures are taken for prevention of loss of capture in the other ventricle.
摘要翻译：双心室心脏刺激器和控制这种双心室心脏刺激器的方法。连续的刺激脉冲被输送到人心脏的心室，使得单个心搏周期中的刺激脉冲首先被递送到第一心室，然后传送到第二脑室。检测到响应于输送到一个脑室的刺激脉冲的捕获或丢失。由于检测到的捕获损失，采取预防措施来防止在另一个心室中的捕获损失。

5. 发明申请

WO2006065184A1 IMPLANTABLE HEART STIMULATOR AND METHOD AT AN IMPLANTABLE HEART STIMULATOR 审中-公开
标题翻译：可植入心脏刺激器和可植入心脏刺激器的方法
公开(公告)号：WO2006065184A1
公开(公告)日：2006-06-22
申请号：PCT/SE2004/001924
申请日：2004-12-17
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , HOLMSTRÖM, Nils
发明人： BJÖRLING, Anders , HOLMSTRÖM, Nils
IPC分类号： A61N1/37 , A61N1/18
CPC分类号： A61N1/3712
摘要： An implantable heart stimulator for delivering stimulation pulses of varying amplitudes. Threshold searches are performed at selectable time intervals, which threshold searches determine a threshold value required for effectuating capture. The amplitudes of the stimulation pulses are set to a value exceeding the determined threshold value by a safety margin, which safety margin is selected as a function of said selected time intervals.
摘要翻译：一种植入式心脏刺激器，用于传递不同幅度的刺激脉冲。阈值搜索以可选择的时间间隔执行，阈值搜索确定实现捕获所需的阈值。刺激脉冲的幅度被设置为超过所确定的阈值的值，该安全裕度选择作为所选择的时间间隔的函数的安全裕度。

6. 发明申请

WO2009082286A1 IMPLANTABLE ANALYTE RF SPECTROSCOPY MEASURING SYSTEM 审中-公开
标题翻译：可伸缩分析仪射频光谱测量系统
公开(公告)号：WO2009082286A1
公开(公告)日：2009-07-02
申请号：PCT/SE2007/001157
申请日：2007-12-21
申请人： ST. JUDE MEDICAL AB , ABRAHAMSON, Hans , BJÖRLING, Anders , SNITTING, Tomas , HOLMSTRÖM, Nils , ERIKSSON, Tom
发明人： ABRAHAMSON, Hans , BJÖRLING, Anders , SNITTING, Tomas , HOLMSTRÖM, Nils , ERIKSSON, Tom
IPC分类号： G01N33/483 , A61B5/145 , A61N1/372 , G01N22/00
CPC分类号： A61B5/05 , A61B5/14546 , A61B5/7253 , A61N1/36557 , A61N1/3702 , A61N1/37252
摘要： An analyte measuring system (1) comprises and implantable medical device (100; 400) having a RF signal source (120; 420) arranged for generating a RF signal and a transmitting antenna (300) for transmitting the RF signal into a surrounding tissue (10) in a subject body (5). The system (1) has a receiving RF antenna (310) for receiving the RF signal from the tissue (10) and a signal processor (130; 530) arranged for generating an estimate of a concentration of an analyte in the tissue (10) based on a spectrum analysis of the received RF signal.
摘要翻译：分析物测量系统（1）包括具有设置用于产生RF信号的RF信号源（120; 420）和用于将RF信号传输到周围组织的发射天线（300）的可植入医疗设备（100; 400） 10）在主体（5）中。系统（1）具有用于接收来自组织（10）的RF信号的接收RF天线（310）和布置成用于产生组织（10）中分析物浓度的估计的信号处理器（130; 530）基于所接收的RF信号的频谱分析。

7. 发明申请

WO2009082285A1 IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：WO2009082285A1
公开(公告)日：2009-07-02
申请号：PCT/SE2007/001156
申请日：2007-12-21
申请人： ST. JUDE MEDICAL AB , ABRAHAMSON, Hans , BJÖRLING, Anders , SNITTING, Tomas , HOLMSTRÖM, Nils
发明人： ABRAHAMSON, Hans , BJÖRLING, Anders , SNITTING, Tomas , HOLMSTRÖM, Nils
IPC分类号： A61B5/053 , A61N1/365
CPC分类号： A61B5/053 , A61B5/14546 , A61N1/36557
摘要： An analyte measuring system (1) comprises and implantable medical device (100) having a signal source (120) arranged for generating a current signal and electrodes (202, 204; 212, 214) for applying the current signal to a surrounding tissue (10) in a subject body (5). The device (100) measures a resulting voltage signal with the electrodes (202, 204; 212, 214) and calculates an impedance signal therefrom. The system (1) comprises a signal processor (150; 550) arranged for generating an estimate of a concentration of an analyte in the tissue (10) based on a spectrum analysis of the determined impedance signal.
摘要翻译：分析物测量系统（1）包括可植入医疗设备（100），其具有布置成产生电流信号的信号源（120）和用于将电流信号施加到周围组织（10,20）的电极（202,204; 212,214））在主体（5）中。装置（100）利用电极（202,204; 212,214）测量得到的电压信号，并从其计算阻抗信号。系统（1）包括信号处理器（150; 550），信号处理器被设置用于基于所确定的阻抗信号的频谱分析来生成组织（10）中的分析物的浓度的估计。

8. 发明申请

WO2011040840A1 IMPLANTABLE MEDICAL DEVICE AND METHOD FOR MULTISITE MEASUREMENT OF INTRACARDIAC IMPEDANCE 审中-公开
标题翻译：可植入医疗装置和方法用于多药耐药的测量
公开(公告)号：WO2011040840A1
公开(公告)日：2011-04-07
申请号：PCT/SE2009/000428
申请日：2009-09-29
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , BJÖRLING, Anders
发明人： HOLMSTRÖM, Nils , BJÖRLING, Anders
IPC分类号： A61B5/053 , A61N1/368
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/686 , A61N1/3627 , A61N1/3702 , A61N1/3956
摘要： The present invention generally relates to an implantable medical device and method for detecting and monitoring cardiac status of a patient using simultaneous multisite measurements of the intracardiac impedance and in particular to ischemia detection using the simultaneous multisite measurements. The device comprises an impedance measuring unit being connectable to a plurality of electrode configurations including a current generating device adapted to generate a current and apply the current between two electrodes of a current injecting electrode configuration of the electrode configurations and a voltage sensing device including a plurality of voltage sensing circuits arranged in parallel. Each voltage sensing circuit being connectable to a specific voltage sensing electrode configuration of the electrode configurations and being arranged to sense a voltage over the voltage sensing electrode configuration resulting from the applied current, wherein the voltage sensing circuits are capable of sensing the resulting voltages simultaneously. The device further comprises an impedance calculating module adapted to calculate a plurality of impedance values, each impedance value being based on the applied current and a resulting voltage.
摘要翻译：本发明总体上涉及一种可植入医疗装置和方法，用于使用同时进行心脏内阻抗的多站点测量来检测和监测患者的心脏状态，特别是使用同时多站点测量的缺血检测。该装置包括阻抗测量单元，其可连接到多个电极配置，包括适于产生电流的电流产生装置，并施加电极配置的电流注入电极配置的两个电极之间的电流;以及电压感测装置，包括多个的电压感测电路并联布置。每个电压感测电路可连接到电极配置的特定电压感测电极配置，并且布置成感测由所施加的电流产生的电压感测电极配置上的电压，其中电压感测电路能够同时感测所得到的电压。该装置还包括适于计算多个阻抗值的阻抗计算模块，每个阻抗值基于所施加的电流和所得到的电压。

9. 发明申请

WO2011134499A1 ARRHYTHMIA CLASSIFICATION 审中-公开
标题翻译： ARRHYTHMIA分类
公开(公告)号：WO2011134499A1
公开(公告)日：2011-11-03
申请号：PCT/EP2010/055639
申请日：2010-04-27
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , HOLLMARK, Malin , SVENSSON, Tomas , HJELM, Stefan , NORÉN, Kjell , JÄRVERUD, Karin
发明人： BJÖRLING, Anders , HOLLMARK, Malin , SVENSSON, Tomas , HJELM, Stefan , NORÉN, Kjell , JÄRVERUD, Karin
IPC分类号： A61B5/0452 , A61B5/053 , A61N1/365
CPC分类号： A61B5/0452 , A61B5/053 , A61B5/0538 , A61B5/7257 , A61B5/7264 , A61N1/3622 , A61N1/36521 , A61N1/36564 , A61N1/36585 , A61N1/3962
摘要： An implantable medical device (100) is configured for generating a cardiogenic impedance signal representative of the cardiogenic impedance of at least a portion of a heart (10) of a subject (20) during multiple cardiac cycles. A transform processor (132) generates a spectrum signal by applying a time- to-frequency transform to the cardiogenic impedance signal. The spectrum signal is processed by a distribution processor (133) configured to calculate a distribution parameter indicative of a distribution in at least a portion of the spectrum signal. The calculated distribution parameter is of high diagnostic value and is employed by an arrhythmia classifier (134) in order to classify a detected arrhythmia of the heart (10), such as discriminate between hemodynamically stable or unstable arrhythmias and/or supraventricular or ventricular tachycardia.
摘要翻译：可植入医疗装置（100）被配置为在多个心动周期期间产生代表受试者（20）的心脏（10）的至少一部分的心源阻抗的心源阻抗信号。变换处理器（132）通过对心源性阻抗信号进行时间 - 频率变换来产生频谱信号。频谱信号由分配处理器（133）处理，分配处理器（133）被配置为计算指示频谱信号的至少一部分中的分布的分布参数。计算出的分布参数具有很高的诊断价值，并被心律失常分类器（134）采用，以便将检测到的心脏心律不齐（10）进行分类，例如区分血流动力学稳定或不稳定的心律失常和/或室上或室性心动过速。

10. 发明申请

WO2007133130A1 AN IMPLANTABLE HEART STIMULATING DEVICE AND METHOD 审中-公开
标题翻译：可植入心脏刺激装置及方法
公开(公告)号：WO2007133130A1
公开(公告)日：2007-11-22
申请号：PCT/SE2006/000568
申请日：2006-05-16
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders
发明人： BJÖRLING, Anders
IPC分类号： A61N1/37 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3682 , A61N1/3684 , A61N1/3712
摘要： The invention concerns an implantable heart stimulating device (10). The device has a control circuit (14). The control circuit (14) is arranged to be able to detect an evoked responses to delivered pacing pulses and to carry out an automatic capture routine. The control circuit (14) is arranged to automatically temporarily disable the automatic capture routine on the basis of at least one of the following criteria: a1) if more than a predetermined number of threshold searches have been performed during a certain time, b1) if the evoked response signals vary more than a predetermined amount, c1) if a variable time delay with which the device (10) operates is changed such that a pacing pulse may be delivered by the device (10) during the evoked response time window. The invention also concerns a method of operating an implantable heart stimulating device.
摘要翻译：本发明涉及可植入心脏刺激装置（10）。该装置具有控制电路（14）。控制电路（14）被布置成能够检测对发送的起搏脉冲的诱发响应并执行自动捕获程序。控制电路（14）被布置成基于以下标准中的至少一个自动临时禁用自动捕获例程：a1）如果在特定时间内已经执行了多于一个预定数量的阈值搜索，则b1）if 诱发响应信号变化大于预定量，c1）如果设备（10）操作的可变时间延迟改变，使得在诱发响应时间窗口期间可由设备（10）传送起搏脉冲。本发明还涉及一种操作可植入心脏刺激装置的方法。

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