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1. 发明申请

WO2005028030A1 HEART STIMULATION DEVICE 审中-公开
标题翻译：心脏刺激装置
公开(公告)号：WO2005028030A1
公开(公告)日：2005-03-31
申请号：PCT/SE2003/001494
申请日：2003-09-25
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , BJÖRLING, Anders , HOLMSTRÖM, Nils , LAGERCRANTZ, Per
发明人： HEDBERG, Sven-Erik , BJÖRLING, Anders , HOLMSTRÖM, Nils , LAGERCRANTZ, Per
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/368 , A61N1/3684
摘要： A biventricular stimulation device comprises a pulse generator for delivering stimulation pulses at least to the ventricles of a patient's heart. An evoked response detector has first and second, independent ventricular sensing channels for ventricular evoked response detection in the ventricles. The pulse generator is controlled to deliver stimulation pulses (106) to the second ventricle (RV) with a VV time delay after stimulation pulse delivery (104) to the first stimulated ventricle (LV) which is shorter than an evoked response detection time window (106) following the delivery of the stimulation pulse (104) to the first ventricle. The evoked response detector is arranged to close the evoked response detection time window (106) or discard detections therein in response to the emission of a stimulation pulse (107) to the second ventricle (RV) during the evoked response detection time window (106) of the first stimulated ventricle (LV).
摘要翻译：双心室刺激装置包括用于至少向患者心脏的心室输送刺激脉冲的脉冲发生器。诱发反应检测器具有第一和第二独立心室感知通道，用于心室中的心室诱发反应检测。脉冲发生器被控制以在刺激脉冲传送（104）之后的VV时间延迟到第一激励心室（LV）处将刺激脉冲（106）传递到第二心室（RV），所述第一受激心室（LV）比诱发的响应检测时间窗 106）在将刺激脉冲（104）递送到第一脑室之后。诱发响应检测器被安排为在诱发响应检测时间窗口（106）期间响应于向第二心室（RV）发射刺激脉冲（107）而关闭诱发响应检测时间窗口（106）或丢弃其中的检测，的第一个刺激心室（LV）。

2. 发明申请

WO2012084044A1 METHOD AND SYSTEM FOR OPTIMIZING CARDIAC PACING SETTINGS 审中-公开
标题翻译：优化心脏瓣膜设置的方法和系统
公开(公告)号：WO2012084044A1
公开(公告)日：2012-06-28
申请号：PCT/EP2010/070640
申请日：2010-12-23
申请人： ST. JUDE MEDICAL AB , GUSTAFSSON, John , KARLSSON, Andreas , BLOMQVIST, Andreas , HEDBERG, Sven-Erik , HOLMSTRÖM, Nils
发明人： GUSTAFSSON, John , KARLSSON, Andreas , BLOMQVIST, Andreas , HEDBERG, Sven-Erik , HOLMSTRÖM, Nils
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368 , A61B5/0205 , A61B5/0215 , A61B8/04
CPC分类号： A61N1/36571 , A61B5/02028 , A61B5/0215 , A61B5/028 , A61B5/029 , A61B5/0472 , A61B5/0538 , A61B5/1116 , A61B5/686 , A61B8/06 , A61B2562/0219 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3682
摘要： The present invention relates generally to methods and systems for optimizing stimulation of a heart of a patient. More specifically, hemodynamical index signals reflecting a mechanical functioning of a heart of a patient are recorded at different hemodynamical states. Further, corresponding hemodynamical reference signals at corresponding hemodynamical states are recorded. Further, at least one hemodynamical index parameter is extracted from the recorded hemodynamical index signals, the at least one hemodynamical index parameter being a measure of the mechanical functioning of the heart and a hemodynamical index model is created, wherein the hemodynamical index model is based on the at least one hemodynamical index parameter and a comparison between output results from the hemodynamical index model and corresponding hemodynamical reference signals. From this hemodynamical index model, a hemodynamical index can be derived, which then can be used in determining patient customized cardiac pacing settings of the cardiac stimulator.
摘要翻译：本发明一般涉及优化患者心脏的刺激的方法和系统。更具体地，反映患者心脏的机械功能的血液动力学指标信号记录在不同的血液动力学状态。此外，记录相应的血流动力学状态下的相应血液动力学参考信号。此外，从记录的血液动力学指标信号中提取至少一个血液动力学指标参数，所述至少一个血液动力学指数参数是心脏的机械功能的量度，并且产生血液动力学指标模型，其中血液动力学指数模型基于所述至少一个血液动力学指标参数以及来自血液动力学指标模型的输出结果与相应的血液动力学参考信号之间的比较。从该血液动力学指标模型可以得出血流动力学指标，然后可以用于确定心脏刺激器患者定制的心脏起搏设置。

3. 发明申请

WO2009078758A1 AN IMPLANTABLE HEART MONITORING DEVICE, SYSTEM AND METHOD 审中-公开
标题翻译：可植入心脏监测装置，系统和方法
公开(公告)号：WO2009078758A1
公开(公告)日：2009-06-25
申请号：PCT/SE2007/001134
申请日：2007-12-19
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas , HOLMSTRÖM, Nils , HEDBERG, Sven-Erik , ÖHLANDER, Malin
发明人： BLOMQVIST, Andreas , HOLMSTRÖM, Nils , HEDBERG, Sven-Erik , ÖHLANDER, Malin
IPC分类号： A61N1/365 , A61B5/053
CPC分类号： A61N1/36521 , A61B5/0456 , A61B5/053 , A61B5/0538 , A61N1/3622 , A61N1/3684
摘要： The invention concerns an implantable heart monitoring device (10) comprising, inter alia, a control circuit (14) configured to be able to measure an impedance across at least part of an atrium, such that the variation of the impedance is related to the volume change of the atrium. The control circuit (14) is configured to carry out certain steps, and to store values at different occasions that indicate the rate of change of the meas¬ ured impedance. The stored values have been determined such that, when the device (10) is used in a living being, the variation of the stored values will be related to the variation of the speed with which the atrium is filled with blood during the atrial dias¬ tole. The invention also concerns a corresponding system and method.
摘要翻译：本发明涉及可植入心脏监测装置（10），其特别地包括控制电路（14），其被配置为能够测量穿过至少部分心房的阻抗，使得阻抗的变化与体积改变中庭。控制电路（14）被配置为执行某些步骤，并且在指示所测量的阻抗的变化率的不同场合存储值。存储的值已经被确定为使得当在生物体中使用装置（10）时，所存储的值的变化将与心房中的心脏充满血液的速度的变化有关托勒。本发明还涉及相应的系统和方法。

4. 发明申请

WO2007081246A1 IMPLANTABLE SENSOR LEAD 审中-公开
标题翻译：可植入传感器引线
公开(公告)号：WO2007081246A1
公开(公告)日：2007-07-19
申请号：PCT/SE2006/000046
申请日：2006-01-12
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , LAGERCRANTZ, Per
发明人： HEDBERG, Sven-Erik , LAGERCRANTZ, Per
IPC分类号： A61N1/05 , A61N1/365
CPC分类号： A61N1/056 , A61B5/0422 , A61B5/053 , A61N1/3627 , A61N1/365 , A61N2001/0585
摘要： An implantable sensor lead (2) for sensing mechanical cardiac activity of a person is provided with a plurality of sensing elements (6) arranged along an implantable lead body for sensing mechanical cardiac activity and delivering corresponding electric signals. An electronic device comprises electric sensor signal processing electronics to which the lead (2) is connectable. An implantable cardiac stimulator comprises such an electronic device. In a method of sensing mechanical cardiac activity of a person the cardiac activity is sensed in a part of the person's heart (4) by a plurality of sensing elements (6) spread out in said part of the person's heart.
摘要翻译：用于感测人的机械心脏活动的可植入传感器引线（2）设置有沿着可植入引线主体布置的多个感测元件（6），用于感测机械心脏活动并输送相应的电信号。电子设备包括电导体信号处理电子器件，引线（2）可连接到电子传感器信号处理电子器件。可植入心脏刺激器包括这种电子装置。在感测人的机械心脏活动的方法中，通过在人的心脏的所述部分中分散的多个感测元件（6）在人的心脏（4）的一部分中感测心脏活动。

5. 发明申请

WO2008118047A1 IMPLANTABLE MEDICAL DEVICE COMPRISING AN OXYGEN SENSOR 审中-公开
标题翻译：包含氧传感器的可植入医疗装置
公开(公告)号：WO2008118047A1
公开(公告)日：2008-10-02
申请号：PCT/SE2007/001044
申请日：2007-11-27
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LINDKVIST, Leif , LÖNN, Urban , HOLMSTRÖM, Nils
发明人： HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LINDKVIST, Leif , LÖNN, Urban , HOLMSTRÖM, Nils
IPC分类号： A61N1/37 , A61B5/02 , A61B5/08 , A61N1/02
CPC分类号： A61N1/3702 , A61B5/14542 , A61B5/1459 , A61N1/056 , A61N1/36557
摘要： Implantable medical device comprising an oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison, and that the indication signal is indicative of the lung functionality of the patient.
摘要翻译：可植入医疗装置，其包括适于测量氧合血液中的氧气水平的氧传感器，以及根据氧水平产生氧测量信号。氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。将获得的氧测量信号与预定阈值电平进行比较，并且根据比较生成指示信号，并且指示信号指示患者的肺功能。

6. 发明申请

WO2008105690A1 AN IMPLANTABLE HEART ANALYSING DEVICE SYSTEM AND METHOD 审中-公开
标题翻译：可植入心脏分析装置系统及方法
公开(公告)号：WO2008105690A1
公开(公告)日：2008-09-04
申请号：PCT/SE2007/000193
申请日：2007-02-28
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , BLOMQVIST, Andreas , LARSSON, Berit , JÄRVERUD, Karin , HEDBERG, Sven-Erik
发明人： HOLMSTRÖM, Nils , BLOMQVIST, Andreas , LARSSON, Berit , JÄRVERUD, Karin , HEDBERG, Sven-Erik
IPC分类号： A61N1/365 , A61B5/0215
CPC分类号： A61B5/1107 , A61B5/0051 , A61B5/4519 , A61B5/6869 , A61N1/36578
摘要： The invention concerns an implantable heart analysing device (10) comprising a housing (12) and a control circuit (14) located within said housing (12). The control circuit (14) is adapted to generate an output signal adapted to actuate an activator (43), which is able to make a wall of the heart deflect or vibrate. The control circuit (14) is also adapted to communicate with a sensor (44), which can be identical with said activator (43), with the help of which the movement of said heart wall can be sensed. The control circuit (14) is arranged to be able to carry out a procedure that involves the generation of an output signal and sensing a corresponding sensor signal, and to be able to derive information concerning the tension of said heart wall. The invention also concerns a system including such a device (10) and also a method of analysing the tension of a wall of a heart.
摘要翻译：本发明涉及可植入心脏分析装置（10），其包括位于所述壳体（12）内的壳体（12）和控制电路（14）。控制电路（14）适于产生适于致动激活器（43）的输出信号，其能够使心脏的壁发生偏转或振动。控制电路（14）还适于与可与所述激活器（43）相同的传感器（44）通信，借助于此可以感测到所述心脏壁的移动。控制电路（14）被布置为能够执行涉及生成输出信号并感测相应的传感器信号的过程，并且能够导出关于所述心脏壁的张力的信息。本发明还涉及包括这种装置（10）的系统以及分析心脏壁的张力的方法。

7. 发明申请

WO2012163414A1 DYNAMIC CARDIAC RESYNCHRONIZATION THERAPY BY TRACKING INTER -ATRIAL CONDUCTION DELAYS 审中-公开
标题翻译：通过跟踪直接导联延迟进行动态心脏再生治疗
公开(公告)号：WO2012163414A1
公开(公告)日：2012-12-06
申请号：PCT/EP2011/058982
申请日：2011-05-31
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , HOLMSTRÖM, Nils , JÄRVERUD, Karin
发明人： HEDBERG, Sven-Erik , HOLMSTRÖM, Nils , JÄRVERUD, Karin
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3682 , A61N1/3684
摘要： The present invention relates generally to implantable medical devices and more particularly to systems and methods for stimulating a heart of a patient. A first ventricle is activated by delivering stimulation to at least one stimulation site, a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the first ventricle is estimated and a first activation time interval substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site in the first ventricle to the AV node using the estimated point of time for arrival of the depolarization wave and a point of time for delivery of stimulation is computed. Thereafter, the other ventricle is stimulated by delivering stimulation to at least one stimulation site. A point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the other ventricle is then estimated and a second activation time interval substantially corresponding to the time required for at least one depolarization wave to travel from the stimulation site in the other ventricle to the AV node using the estimated arrival of the depolarization wave and the point of time for delivery of stimulation is computed. Based on these activation time intervals and a difference between the intervals, a pacing therapy can be determined, wherein the first ventricle is paced prior to activation of the other ventricle if the activation time difference indicates that the first activation time interval is longer than the second activation time interval and the other ventricle is paced prior to activation of the first ventricle if the activation time difference indicates that the second activation time interval is longer than the first activation time interval.
摘要翻译：本发明一般涉及可植入医疗装置，更具体地涉及用于刺激患者心脏的系统和方法。通过向至少一个刺激部位递送刺激来激活第一脑室，估计到达在第一脑室刺激产生的至少一个去极化波的AV节点的时间点，并且基本对应于计算使用去极化波的到达的估计时间点和用于递送刺激的时间点的至少一个去极化波从第一脑室的刺激部位行进到AV节点所需的时间间隔。此后，通过将刺激递送至至少一个刺激部位刺激另一个心室。然后估计到达AV节点对于在另一个心室中的刺激产生的至少一个去极化波的时间点，并且基本对应于至少一个去极化波从刺激行进所需的时间的第二激活时间间隔计算使用去极化波的估计到达和输送刺激的时间点在AV节点的另一脑室中的位置。基于这些激活时间间隔和间隔之间的差异，可以确定起搏治疗，其中如果激活时间差指示第一激活时间间隔长于第二心室第二激活时间间隔，则第一心室在另一心室激活之前起搏如果所述激活时间差指示所述第二激活时间间隔长于所述第一激活时间间隔，则所述激活时间间隔和所述另一个心室在所述第一心室激活之前起步。

8. 发明申请

WO2009082284A1 METHOD AND DEVICE FOR MONITORING ACUTE DECOMPENSATED HEART FAILURE. 审中-公开
标题翻译：用于监测急性脱发性心脏衰竭的方法和装置。
公开(公告)号：WO2009082284A1
公开(公告)日：2009-07-02
申请号：PCT/SE2007/001155
申请日：2007-12-21
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas , HOLMSTRÖM, Nils , HEDBERG, Sven-Erik , ÖHLANDER, Malin
发明人： BLOMQVIST, Andreas , HOLMSTRÖM, Nils , HEDBERG, Sven-Erik , ÖHLANDER, Malin
IPC分类号： A61B5/053 , A61B5/0245 , A61N1/365
CPC分类号： A61B5/053 , A61B5/0245 , A61B5/0452
摘要： An implantable medical device (100) comprises an impedance determiner (120) for determining a cardiogenic impedance signal (20, 30) based on electric signals sensed by connected electrodes. A parameter calculator (130) processes the impedance signal (20, 30) to calculate an impedance parameter representative of the cardiogenic impedance in connection with the diastolic phase of a heart cycle. This parameter is then employed by the device (100) for monitoring acute decompensated heart failure status of a subject (1).
摘要翻译：可植入医疗装置（100）包括阻抗确定器（120），用于基于由连接的电极感测的电信号来确定心源阻抗信号（20,30）。参数计算器（130）处理阻抗信号（20,30）以计算与心脏循环的舒张期相关的代表心源阻抗的阻抗参数。该装置（100）然后使用该参数来监测对象（1）的急性失代偿性心力衰竭状态。

9. 发明申请

WO2008153450A1 AN IMPLANTABLE MEDICAL DEVICE AND A METHOD COMPRISING MEANS FOR DETECTING AND CLASSIFYING VENTRICULAR TACHYARRHYTMIAS 审中-公开
标题翻译：一种可植入医疗装置和一种包含检测和分类静脉曲张虫的手段的方法
公开(公告)号：WO2008153450A1
公开(公告)日：2008-12-18
申请号：PCT/SE2007/000581
申请日：2007-06-13
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , BLOMQVIST, Andreas , HEDBERG, Sven-Erik , ÖHLANDER, Malin
发明人： HOLMSTRÖM, Nils , BLOMQVIST, Andreas , HEDBERG, Sven-Erik , ÖHLANDER, Malin
IPC分类号： A61N1/362 , A61N1/365 , A61N1/37 , A61N1/372 , A61N1/38
CPC分类号： A61N1/3702 , A61B5/0464 , A61B5/053 , A61B5/7264
摘要： The invention relates to ventricular tachyarrhythmia detection and classification. Upon detection of a ventricular tachyarrhythmia based on an electrocardiogram signal, cardiogenic impedance data representative of ventricular volume dynamics are collected and used for classifying the detected tachyarrhythmia as stable or unstable. In the latter case but typically not in the former case, defibrillation shocks or other forms of therapy are applied to combat the unstable ventricular tachyarrhythmia.
摘要翻译：本发明涉及室性快速性心律失常检测和分类。在基于心电图信号检测到心室快速性心律失常时，收集代表心室体积动力学的心源阻抗数据，并用于将检测到的快速性心律失常分类为稳定或不稳定。在后一种情况下，但通常不是在前一种情况下，应用除颤电击或其他形式的治疗来对抗不稳定性室性快速性心律失常。

10. 发明申请

WO2008130291A1 IMPLANTABLE MEDICAL SYSTEM FOR DETECTING INCIPIENT EDEMA 审中-公开
标题翻译：用于检测机动车辆的可植入医疗系统
公开(公告)号：WO2008130291A1
公开(公告)日：2008-10-30
申请号：PCT/SE2007/000396
申请日：2007-04-24
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LINDKVIST, Leif , LÖNN, Urban
发明人： HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LINDKVIST, Leif , LÖNN, Urban
IPC分类号： A61N1/05 , A61N1/365
CPC分类号： A61N1/05 , A61B5/0084 , A61B5/0086 , A61B5/08 , A61B5/1116 , A61B5/1118 , A61B5/4878 , A61B5/7207 , A61N1/025 , A61N1/056 , A61N1/362
摘要： The present invention generally relates implantable medical systems and, in particular, to systems, devices and methods for detecting incipient edema. The medical system comprises an implantable medical lead including an optical sensor comprising a light source and a light detector. The medical system further comprises an edema detection circuit being adapted to: activate the light source to emit light, wherein said light is directed into lung tissue of a patient; obtain a light intensity value corresponding to an intensity of light received by the light detector; and evaluate the light intensity value to detect a consistency with incipient edema.
摘要翻译：本发明通常涉及可植入医疗系统，特别是涉及用于检测初期水肿的系统，装置和方法。医疗系统包括可植入医疗引线，其包括包括光源和光检测器的光学传感器。医疗系统还包括水肿检测电路，其适于：激活光源以发光，其中所述光被引导到患者的肺组织中; 获得与由光检测器接收的光的强度对应的光强度值; 并评估光强值以检测与初期水肿的一致性。

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