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1. 发明申请

WO2008008008A1 INFORMATION MANAGEMENT IN DEVICES WORN BY A USE 审中-公开
标题翻译：使用信息管理信息
公开(公告)号：WO2008008008A1
公开(公告)日：2008-01-17
申请号：PCT/SE2006/000883
申请日：2006-07-13
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , MALMBERG, Patrik , LYCHOU, Leif , KERSTNA, Jürgen , TJÄLLDIN, Ellen
发明人： HEDBERG, Sven-Erik , MALMBERG, Patrik , LYCHOU, Leif , KERSTNA, Jürgen , TJÄLLDIN, Ellen
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： A61N1/37211 , A61B5/0402 , A61B5/6843 , A61N1/37282 , G06F19/00 , G16H40/63
摘要： The invention involves a device (100), e.g. an implantable medical device, adapted for physical connection to a body (10) of a user. The device (100) comprises an information manager (120) for managing sensitive information associated with the user or device (100), such as being arranged for retrieving the sensitive information from a memory (122) in the device (100). A sensor (130, 170) is arranged in or connected to the device (100) for sensing whether the device (100) is physically connected to the body (10) and worn by the user and for generating a signal representative of whether the device (100) is actually physically connected to the body (10). The information manager (120) is connected to the sensor (130) and is responsive to the generated signal and performs its information managing function based on the signal. The invention prevents, among others, fraudulent retrieval of sensitive data from the device (100) if the device (100) is not connected to or implanted in the intended user body (10).
摘要翻译：本发明涉及一种装置（100），例如可植入医疗装置，适于物理连接到使用者的身体（10）。设备（100）包括用于管理与用户或设备（100）相关联的敏感信息的信息管理器（120），诸如被安排用于从设备（100）中的存储器（122）检索敏感信息。传感器（130,170）布置在设备（100）中或连接到设备（100），用于感测设备（100）物理地连接到主体（10）并且被用户佩戴，并且用于生成表示设备（100）实际上物理地连接到主体（10）。信息管理器（120）连接到传感器（130）并且响应于所产生的信号并且基于该信号执行其信息管理功能。如果设备（100）未连接到或植入预期用户体（10）中，则本发明防止了来自设备（100）的敏感数据的欺骗性检索。

2. 发明申请

WO2007139456A1 A METHOD IN AN IMD SYSTEM 审中-公开
标题翻译： IMD系统中的一种方法
公开(公告)号：WO2007139456A1
公开(公告)日：2007-12-06
申请号：PCT/SE2006/000646
申请日：2006-05-31
申请人： ST. JUDE MEDICAL AB , KERSTNA, Jürgen , MALMBERG, Patrik , HEDBERG, Sven-Erik , LYCHOU, Leif
发明人： KERSTNA, Jürgen , MALMBERG, Patrik , HEDBERG, Sven-Erik , LYCHOU, Leif
IPC分类号： A61N1/372 , G06F19/00
CPC分类号： A61N1/37282 , G06F19/00 , G06F19/3418 , G06Q50/24
摘要： A method for adapting functions of a clinician's workstation in an Implantable Medical Device, IMD, system, said clinician's workstation communicating with at least one IMD implanted to a patient. According to the invention the method comprises the steps of: - collecting patient and/or IMD data in the clinician's workstation; and - dynamically adapting the functions of the clinician's workstation in dependence of the patient and/or IMD data.
摘要翻译：一种在植入式医疗装置IMD系统中适应临床医生工作站的功能的方法，所述临床医生的工作站与植入患者的至少一个IMD通信。根据本发明，该方法包括以下步骤： - 收集临床医师工作站中的患者和/或IMD数据; 以及 - 根据患者和/或IMD数据动态调整临床医师工作站的功能。

3. 发明申请

WO2009064222A1 TACHYCARDIA CLASSIFICATION 审中-公开
标题翻译： TACHYCARDIA分类
公开(公告)号：WO2009064222A1
公开(公告)日：2009-05-22
申请号：PCT/SE2007/001006
申请日：2007-11-14
申请人： ST JUDE MEDICAL AB , HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , HOLMSTRÖM, Nils , LARSON, Berit
发明人： HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , HOLMSTRÖM, Nils , LARSON, Berit
IPC分类号： A61N1/362 , A61B5/0464 , A61N1/05
CPC分类号： A61B5/0422 , A61B5/04525 , A61B5/0464 , A61B5/7264 , A61N1/0587 , A61N1/3621 , A61N1/3702 , A61N1/385 , A61N1/3925 , A61N1/3962
摘要： An implantable medical device (100) is connectable to an epicardial multi-electrode lead (200) employed for registering a depolarization wave propagation pattern across a ventricle (12) of a heart (10). A signal processor (130) generates, based on the electrical activity sensed by the lead (200), a representation of the depolarization wave propagation pattern. A tachycardia classifier (140) of the medical device (100) classifies a tachycardia event of the heart (10) based on a comparison of the generated representation and a template representation of a template depolarization wave propagation pattern across the ventricle (12).
摘要翻译：可植入医疗装置（100）可连接到心外膜多电极引线（200），用于记录穿过心脏（10）的心室（12）的去极化波传播模式。信号处理器（130）基于由引线（200）感测的电活动，生成去极化波传播模式的表示。医疗装置（100）的心动过速分类器（140）基于生成的表示与穿过心室（12）的模板去极化波传播模式的模板表示的比较，对心脏（10）的心动过速事件进行分类。

4. 发明申请

WO2008118047A1 IMPLANTABLE MEDICAL DEVICE COMPRISING AN OXYGEN SENSOR 审中-公开
标题翻译：包含氧传感器的可植入医疗装置
公开(公告)号：WO2008118047A1
公开(公告)日：2008-10-02
申请号：PCT/SE2007/001044
申请日：2007-11-27
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LINDKVIST, Leif , LÖNN, Urban , HOLMSTRÖM, Nils
发明人： HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LINDKVIST, Leif , LÖNN, Urban , HOLMSTRÖM, Nils
IPC分类号： A61N1/37 , A61B5/02 , A61B5/08 , A61N1/02
CPC分类号： A61N1/3702 , A61B5/14542 , A61B5/1459 , A61N1/056 , A61N1/36557
摘要： Implantable medical device comprising an oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison, and that the indication signal is indicative of the lung functionality of the patient.
摘要翻译：可植入医疗装置，其包括适于测量氧合血液中的氧气水平的氧传感器，以及根据氧水平产生氧测量信号。氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。将获得的氧测量信号与预定阈值电平进行比较，并且根据比较生成指示信号，并且指示信号指示患者的肺功能。

5. 发明申请

WO2008105690A1 AN IMPLANTABLE HEART ANALYSING DEVICE SYSTEM AND METHOD 审中-公开
标题翻译：可植入心脏分析装置系统及方法
公开(公告)号：WO2008105690A1
公开(公告)日：2008-09-04
申请号：PCT/SE2007/000193
申请日：2007-02-28
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , BLOMQVIST, Andreas , LARSSON, Berit , JÄRVERUD, Karin , HEDBERG, Sven-Erik
发明人： HOLMSTRÖM, Nils , BLOMQVIST, Andreas , LARSSON, Berit , JÄRVERUD, Karin , HEDBERG, Sven-Erik
IPC分类号： A61N1/365 , A61B5/0215
CPC分类号： A61B5/1107 , A61B5/0051 , A61B5/4519 , A61B5/6869 , A61N1/36578
摘要： The invention concerns an implantable heart analysing device (10) comprising a housing (12) and a control circuit (14) located within said housing (12). The control circuit (14) is adapted to generate an output signal adapted to actuate an activator (43), which is able to make a wall of the heart deflect or vibrate. The control circuit (14) is also adapted to communicate with a sensor (44), which can be identical with said activator (43), with the help of which the movement of said heart wall can be sensed. The control circuit (14) is arranged to be able to carry out a procedure that involves the generation of an output signal and sensing a corresponding sensor signal, and to be able to derive information concerning the tension of said heart wall. The invention also concerns a system including such a device (10) and also a method of analysing the tension of a wall of a heart.
摘要翻译：本发明涉及可植入心脏分析装置（10），其包括位于所述壳体（12）内的壳体（12）和控制电路（14）。控制电路（14）适于产生适于致动激活器（43）的输出信号，其能够使心脏的壁发生偏转或振动。控制电路（14）还适于与可与所述激活器（43）相同的传感器（44）通信，借助于此可以感测到所述心脏壁的移动。控制电路（14）被布置为能够执行涉及生成输出信号并感测相应的传感器信号的过程，并且能够导出关于所述心脏壁的张力的信息。本发明还涉及包括这种装置（10）的系统以及分析心脏壁的张力的方法。

6. 发明申请

WO2008039110A1 A MEDICAL SYSTEM AND A METHOD FOR DETERMINING SETTINGS OF AN IMPLANTABLE DEVICE 审中-公开
标题翻译：一种用于确定可植入装置的设置的医疗系统和方法
公开(公告)号：WO2008039110A1
公开(公告)日：2008-04-03
申请号：PCT/SE2006/001081
申请日：2006-09-25
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , MALMBERG, Patrik , LYCHOU, Leif , KERSTNA, Jürgen
发明人： HEDBERG, Sven-Erik , MALMBERG, Patrik , LYCHOU, Leif , KERSTNA, Jürgen
IPC分类号： A61N1/372 , A61N1/365
CPC分类号： A61N1/36585 , A61N1/025 , A61N1/3682 , A61N1/37247 , A61N1/37252 , G06F19/00 , G16H40/40
摘要： The present invention relates to medical systems and methods for such systems, which systems include an implantable medical device of a patient, a programmer device, and an extracorporeal stress equipment adapted to exert a physiological stress on the patient, for automatically determining settings of a sensor for sensing a physiological parameter of the patient or for automatically determining a pacing setting of the device over a broad range of workloads of the equipment. The ingoing units and/or devices of the medical system, i.e. the implantable medical device of a patient, the programmer device, and the extracorporeal stress equipment, communicate bi-directionally with each other and form a closed loop.
摘要翻译：本发明涉及用于这种系统的医疗系统和方法，该系统包括患者的可植入医疗装置，编程器装置和适于对患者施加生理压力的体外应力设备，用于自动确定传感器的设定用于感测患者的生理参数或用于在设备的广泛工作负载下自动确定设备的起搏设置。医疗系统的进入单元和/或装置，即患者的可植入医疗装置，程序设备和体外应力设备，彼此双向地通信并形成闭环。

7. 发明申请

WO2007123444A1 A PIEZOELECTRIC SENSOR, A METHOD FOR MANUFACTURING A PIEZOELECTRIC SENSOR AND A MEDICAL IMPLANTABLE LEAD COMPRISING SUCH A PIEZOELECTRIC SENSOR 审中-公开
标题翻译：压电传感器，制造压电传感器的方法和包含这种压电传感器的医用可植入引线
公开(公告)号：WO2007123444A1
公开(公告)日：2007-11-01
申请号：PCT/SE2006/000479
申请日：2006-04-25
申请人： ST. JUDE MEDICAL AB , ERIKSSON, Tom , NILSSON, Kenth , HEDBERG, Sven-Erik
发明人： ERIKSSON, Tom , NILSSON, Kenth , HEDBERG, Sven-Erik
IPC分类号： A61B5/0215 , A61N1/05 , H01L41/087
CPC分类号： A61N1/056 , A61B5/0215 , A61N1/0565 , A61N1/36542 , A61N1/36564 , G01L9/0026 , G01L9/08 , H01L41/087 , H01L41/1132
摘要： The invention relates to a piezoelectric sensor comprising a layer of a piezoelectric material (3) , having aligned, polarized dipoles, which is applied to a tubular supporting substrate (2) , and having at least one electrode (2) connected to its outer surface as well as at least one electrode (5) connected to its inner surface. The piezoelectric material (3) is applied on the inner circumference of the tubular supporting substrate (2) . The invention also relates to a method for manufacturing a piezoelectric sensor and a medical implantable lead comprising such a piezoelectric sensor.
摘要翻译：本发明涉及一种压电传感器，其包括压电材料层（3），其具有对准的偏振偶极子，其被施加到管状支撑衬底（2）上，并且具有连接到其外表面的至少一个电极（2）以及连接到其内表面的至少一个电极（5）。压电材料（3）被施加在管状支撑衬底（2）的内圆周上。本发明还涉及一种用于制造压电传感器的方法和包括这种压电传感器的医用可植入引线。

8. 发明申请

WO2007111542A1 MEDICAL SYSTEM FOR MONITORING AND LOCALISATION OF ELECTRODE LEADS IN THE HEART 审中-公开
标题翻译：用于监测和定位心脏中电极引线的医疗系统
公开(公告)号：WO2007111542A1
公开(公告)日：2007-10-04
申请号：PCT/SE2006/000384
申请日：2006-03-27
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , NILSSON, Kenth
发明人： HEDBERG, Sven-Erik , NILSSON, Kenth
IPC分类号： A61B5/06 , A61N1/37
CPC分类号： A61N1/37 , A61B2034/2053 , A61N1/368 , A61N1/3682 , A61N1/3684 , A61N1/3704
摘要： Medical system to be used in connection with an implantable heart stimulator provided with sensing and stimulating heart electrodes. The system comprises a predetermined number of electrode pairs (4), e.g. three patch electrodes, to be arranged at or within a human being or animal such that an electric field through the heart is generated between the electrodes of respective electrode pair. The electric field(s) is/are adapted to be generated by an excitation means (6), including electric field excitation voltage generators, connected to the electrodes, by applying alternating voltages at a preset frequency to the electrodes of the electrode pair(s). The system includes a signal receiving means (8) adapted to receive a signal representing the voltage potential difference between the voltage potential at one of the heart electrodes used as detecting electrode and a reference electrode, wherein the voltage potential is related to the generated electric field. The signal receiving means then to generates a potential difference signal that is applied to a signal controlling and processing means (10) adapted to process the detected potential difference signal in order to determine parameters representing heart activity.
摘要翻译：医疗系统与可植入式心脏刺激器结合使用，可提供感应和刺激心脏电极。该系统包括预定数量的电极对（4），例如，三个贴片电极被布置在人或动物中或内部，使得在各个电极对的电极之间产生通过心脏的电场。电场通过施加连接到电极的电场激励电压发生器的激励装置（6）产生，通过以预定频率向电极对的电极施加交流电压（s））。该系统包括适于接收表示用作检测电极的一个心电极上的电压电位与参考电极之间的电压电位差的信号的信号接收装置（8），其中电压电位与产生的电场相关。然后，信号接收装置产生施加到适于处理检测到的电位差信号的信号控制和处理装置（10）的电位差信号，以便确定表示心脏活动的参数。

9. 发明申请

WO2005110535A1 DETECTION OF DIASTOLIC HEART FAILURE 审中-公开
标题翻译：检测白内障心脏失败
公开(公告)号：WO2005110535A1
公开(公告)日：2005-11-24
申请号：PCT/SE2004/000741
申请日：2004-05-13
申请人： ST JUDE MEDICAL AB , HEDBERG, Sven-Erik , BJÖRLING, Anders , TORPO, Maria , LJUNGSTRÖM, Karin
发明人： HEDBERG, Sven-Erik , BJÖRLING, Anders , TORPO, Maria , LJUNGSTRÖM, Karin
IPC分类号： A61N1/37
CPC分类号： A61B5/0215 , A61B5/053 , A61B5/0538 , A61N1/3627 , A61N1/36514
摘要： An implantable medical apparatus for detecting diastolic heart failure, DHF, comprises a DHF determining device for determining at least one blood pressure parameter for detecting a DHF state of the heart (4) of a patient. The DHF determining device comprises a pressure measuring means (2,26) for measuring the absolute value of left atrial pressure during the diastasis phase just before atrial contraction, or the absolute value of the pressure in the pulmonary vein when the pulmonary valve is closed, for a predetermined workload situation and a rest situation of the patient. A comparison means (18) compares the difference between left atrial pressure or pulmonary vein pressure, in said workload and rest situations, with a predetermined pressure difference reference value. A pacemaker comprises such an apparatus and control means (14) for optimising pacing therapy depending on the result of the comparisons with the reference values. A corresponding method of detecting diastolic heart failure, DHF, comprises the step of determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient. The absolute value of left atrial pressure is measured during the diastasis phase just before atrial contraction, or the absolute value of the pressure in the pulmonary vein when the pulmonary valve is closed, for a predetermined workload situation and a rest situation of the patient. The difference between left atrial pressure or pulmonary vein pressure in said workload and rest situations is compared with a predetermined pressure difference reference value.
摘要翻译：用于检测舒张性心力衰竭的可植入医疗装置DHF包括DHF确定装置，用于确定用于检测患者心脏（4）的DHF状态的至少一个血压参数。 DHF判定装置包括压力测定装置（2,26），用于在心房收缩前的舒张阶段测量左心房的绝对值，或者肺动脉瓣关闭时肺静脉压的绝对值，用于预定工作情况和患者的休息状态。比较装置（18）将所述工作负荷和静止状况下的左心房压力或肺静脉压力之间的差与预定的压力差参考值进行比较。起搏器包括用于根据与参考值的比较的结果来优化起搏治疗的这种装置和控制装置（14）。检测舒张性心力衰竭DHF的相应方法包括确定用于检测患者心脏的DHF状态的至少一个血压参数的步骤。左心房压力的绝对值是在心房收缩前的舒张期或肺动脉瓣关闭时肺静脉压力的绝对值，在预定的工作情况和患者的休息状态下测量的。将所述工作负荷和静止情况下的左心房压力或肺静脉压力之间的差异与预定的压力差参考值进行比较。

10. 发明申请

WO2012163414A1 DYNAMIC CARDIAC RESYNCHRONIZATION THERAPY BY TRACKING INTER -ATRIAL CONDUCTION DELAYS 审中-公开
标题翻译：通过跟踪直接导联延迟进行动态心脏再生治疗
公开(公告)号：WO2012163414A1
公开(公告)日：2012-12-06
申请号：PCT/EP2011/058982
申请日：2011-05-31
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , HOLMSTRÖM, Nils , JÄRVERUD, Karin
发明人： HEDBERG, Sven-Erik , HOLMSTRÖM, Nils , JÄRVERUD, Karin
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3682 , A61N1/3684
摘要： The present invention relates generally to implantable medical devices and more particularly to systems and methods for stimulating a heart of a patient. A first ventricle is activated by delivering stimulation to at least one stimulation site, a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the first ventricle is estimated and a first activation time interval substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site in the first ventricle to the AV node using the estimated point of time for arrival of the depolarization wave and a point of time for delivery of stimulation is computed. Thereafter, the other ventricle is stimulated by delivering stimulation to at least one stimulation site. A point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the other ventricle is then estimated and a second activation time interval substantially corresponding to the time required for at least one depolarization wave to travel from the stimulation site in the other ventricle to the AV node using the estimated arrival of the depolarization wave and the point of time for delivery of stimulation is computed. Based on these activation time intervals and a difference between the intervals, a pacing therapy can be determined, wherein the first ventricle is paced prior to activation of the other ventricle if the activation time difference indicates that the first activation time interval is longer than the second activation time interval and the other ventricle is paced prior to activation of the first ventricle if the activation time difference indicates that the second activation time interval is longer than the first activation time interval.
摘要翻译：本发明一般涉及可植入医疗装置，更具体地涉及用于刺激患者心脏的系统和方法。通过向至少一个刺激部位递送刺激来激活第一脑室，估计到达在第一脑室刺激产生的至少一个去极化波的AV节点的时间点，并且基本对应于计算使用去极化波的到达的估计时间点和用于递送刺激的时间点的至少一个去极化波从第一脑室的刺激部位行进到AV节点所需的时间间隔。此后，通过将刺激递送至至少一个刺激部位刺激另一个心室。然后估计到达AV节点对于在另一个心室中的刺激产生的至少一个去极化波的时间点，并且基本对应于至少一个去极化波从刺激行进所需的时间的第二激活时间间隔计算使用去极化波的估计到达和输送刺激的时间点在AV节点的另一脑室中的位置。基于这些激活时间间隔和间隔之间的差异，可以确定起搏治疗，其中如果激活时间差指示第一激活时间间隔长于第二心室第二激活时间间隔，则第一心室在另一心室激活之前起搏如果所述激活时间差指示所述第二激活时间间隔长于所述第一激活时间间隔，则所述激活时间间隔和所述另一个心室在所述第一心室激活之前起步。

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