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1. 发明申请

WO2011071427A1 IMPLANTABLE HEART STIMULATOR USING END-DIASTOLIC PRESSURE (EDP) 审中-公开
标题翻译：使用终末压力（EDP）的可植入心脏刺激器
公开(公告)号：WO2011071427A1
公开(公告)日：2011-06-16
申请号：PCT/SE2009/051396
申请日：2009-12-09
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas
发明人： BLOMQVIST, Andreas
IPC分类号： A61N1/365 , A61N1/37 , A61B5/053
CPC分类号： A61B5/053 , A61N1/36521 , A61N1/36564
摘要： Implantable heart stimulator comprising a control unit including a memory, a sensing unit, a pulse stimulation unit adapted to generate stimulation pulses separated by a variable predetermined pacing interval (PI), and also a method in a heart stimulator. The heart stimulator is adapted to be connected to one or many heart electrode leads provided with stimulating and sensing electrodes in order to stimulate heart tissue by said stimulation pulses and sense electrical heart events. The heart stimulator comprises a control parameter measurement unit adapted to derive a control parameter value indicative of end- diastolic pressure (EDP). At specified intervals, the control unit is adapted to vary the predetermined pacing interval (PI) according to a predetermined pacing interval (PI) search session scheme, and that control parameter values are determined, by said control parameter measurement unit at the different pacing intervals tested during said PI search session, and in that determined control parameter values and corresponding pacing intervals are stored in said memory. The maximum control parameter value obtained during one PI search session is determined and the corresponding pacing interval, denoted PI opt , is identified and used when stimulating the heart resulting in a maximal end-diastolic pressure.
摘要翻译：可植入心脏刺激器，其包括控制单元，其包括存储器，感测单元，适于产生由可变预定起搏间隔（PI）分离的刺激脉冲的脉冲刺激单元，以及心脏刺激器中的方法。心脏刺激器适于连接到设置有刺激和感测电极的一个或多个心脏电极引线，以便通过所述刺激脉冲刺激心脏组织并感测电心脏事件。心脏刺激器包括适于导出指示舒张末期压力（EDP）的控制参数值的控制参数测量单元。以规定的间隔，控制单元适于根据预定的起搏间隔（PI）搜索会话方案来改变预定的起搏间隔（PI），并且通过所述控制参数测量单元以不同的起搏间隔确定控制参数值在所述PI搜索会话期间进行测试，并且将所确定的控制参数值和相应的起搏间隔存储在所述存储器中。确定在一个PI搜索会话期间获得的最大控制参数值，并且在刺激心脏导致最大舒张末期压力时识别并使用表示为PIopt的相应起搏间隔。

2. 发明申请

WO2010039063A1 HEART FAILURE DETECTOR 审中-公开
标题翻译：心脏故障检测器
公开(公告)号：WO2010039063A1
公开(公告)日：2010-04-08
申请号：PCT/SE2008/000537
申请日：2008-09-30
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , BROOMÉ, Michael , BLOMQVIST, Andreas
发明人： HOLMSTRÖM, Nils , BROOMÉ, Michael , BLOMQVIST, Andreas
IPC分类号： A61B5/053 , A61B5/0452 , A61N1/37
CPC分类号： A61N1/36521 , A61B5/0452 , A61B5/0472 , A61B5/053 , A61N1/36578
摘要： The present invention relates to an apparatus and method for detecting incipient heart failure of a patient. Impedance signals reflecting volume changes of the right ventricle and/or the right atrium of a heart of the patient are required. The impedance signals are processed to determine a first impedance parameter substantially reflecting a volume of the right ventricle, and a heart failure status is determined based on the first impedance parameter, wherein a decreasing first impedance parameter is determined to be an indication of a deterioration of the heart failure status.
摘要翻译：本发明涉及用于检测患者初期心力衰竭的装置和方法。需要反映患者心脏右心室和/或右心房体积变化的阻抗信号。处理阻抗信号以确定基本上反映右心室体积的第一阻抗参数，并且基于第一阻抗参数确定心力衰竭状态，其中减小的第一阻抗参数被确定为恶化的指示心力衰竭状态。

3. 发明申请

WO2010036151A1 SELECTIVE HEART PACING 审中-公开
标题翻译：选择性心脏病
公开(公告)号：WO2010036151A1
公开(公告)日：2010-04-01
申请号：PCT/SE2008/000523
申请日：2008-09-23
申请人： ST.JUDE MEDICAL AB , BLOMQVIST, Andreas
发明人： BLOMQVIST, Andreas
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/36585 , A61N1/3682 , A61N1/3702
摘要： An implantable medical device (100) measures an AV delay in connection with measurement of N physiological patient parameters. The parameters are used for identifying a sub-space (25) of an N -dimensional parameter space (20). An expected AV delay is assigned to the identified sub- space (25) based on the measured AV delay, where the parameter space (20) with expected AV delays constitute decision support information to be used by the device (100) for performing a selective heart pacing. This selective pacing is performed based on a priori probability determined using the support information and a measured set of N parameters. The a priori probability represents the probability of successful AV conduction at a current patient condition determined based on the measured parameters.
摘要翻译：可植入医疗装置（100）测量与N个生理学患者参数的测量有关的AV延迟。这些参数用于识别N维参数空间（20）的子空间（25）。基于所测量的AV延迟，预期的AV延迟被分配给所识别的子空间（25），其中具有预期的AV延迟的参数空间（20）构成要由设备（100）使用以执行选择性的决策支持信息心脏起搏基于使用支持信息确定的先验概率和N个参数的测量集来执行该选择性起搏。先验概率表示在基于所测量的参数确定的当前患者状况下AV传导成功的概率。

4. 发明申请

WO2009096820A1 MEDICAL DEVICE FOR ATRIAL FIBRILLATION PREDICTION 审中-公开
标题翻译：用于ATRIAL FIBRILLATION预测的医疗设备
公开(公告)号：WO2009096820A1
公开(公告)日：2009-08-06
申请号：PCT/SE2008/000078
申请日：2008-01-28
申请人： ST.JUDE MEDICAL AB , BLOMQVIST, Andreas
发明人： BLOMQVIST, Andreas
IPC分类号： A61N1/365 , A61B5/0205 , A61B5/053
CPC分类号： A61N1/36521 , A61B5/0031 , A61B5/02028 , A61B5/0205 , A61B5/0452 , A61B5/053 , A61B5/0809 , A61B5/4818 , A61B5/7239 , A61N1/3622
摘要： The present invention provides means and a method for providing correlated measures for predicting potential occurrence of atrial fibrillation, wherein an impedance of the patient is measured to obtain impedance information; cardiogenic data is determined from the information; respiratory data is determined from the information; at least one hemodynamic measure is calculated from the cardiogenic data and at least one apnea measure is calculated from the respiratory data; the hemodynamic and apnea measures are correlated such that the correlated measures can be utilized for predicting potential occurrence of atrial fibrillation.
摘要翻译：本发明提供了用于提供用于预测房颤的潜在发生的相关措施的方法和方法，其中测量患者的阻抗以获得阻抗信息; 从信息确定心源生成数据; 从信息中确定呼吸数据; 从心源性数据计算出至少一种血液动力学测量，并根据呼吸数据计算至少一种呼吸暂停测量; 血流动力学和呼吸暂停测量是相关的，使得相关度量可以用于预测房颤的潜在发生。

5. 发明申请

WO2009082284A1 METHOD AND DEVICE FOR MONITORING ACUTE DECOMPENSATED HEART FAILURE. 审中-公开
标题翻译：用于监测急性脱发性心脏衰竭的方法和装置。
公开(公告)号：WO2009082284A1
公开(公告)日：2009-07-02
申请号：PCT/SE2007/001155
申请日：2007-12-21
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas , HOLMSTRÖM, Nils , HEDBERG, Sven-Erik , ÖHLANDER, Malin
发明人： BLOMQVIST, Andreas , HOLMSTRÖM, Nils , HEDBERG, Sven-Erik , ÖHLANDER, Malin
IPC分类号： A61B5/053 , A61B5/0245 , A61N1/365
CPC分类号： A61B5/053 , A61B5/0245 , A61B5/0452
摘要： An implantable medical device (100) comprises an impedance determiner (120) for determining a cardiogenic impedance signal (20, 30) based on electric signals sensed by connected electrodes. A parameter calculator (130) processes the impedance signal (20, 30) to calculate an impedance parameter representative of the cardiogenic impedance in connection with the diastolic phase of a heart cycle. This parameter is then employed by the device (100) for monitoring acute decompensated heart failure status of a subject (1).
摘要翻译：可植入医疗装置（100）包括阻抗确定器（120），用于基于由连接的电极感测的电信号来确定心源阻抗信号（20,30）。参数计算器（130）处理阻抗信号（20,30）以计算与心脏循环的舒张期相关的代表心源阻抗的阻抗参数。该装置（100）然后使用该参数来监测对象（1）的急性失代偿性心力衰竭状态。

6. 发明申请

WO2009041867A1 MEDICAL DEVICE FOR DETECTING PULMONARY ARTERY PRESSURE 审中-公开
标题翻译：用于检测肺动脉压的医疗装置
公开(公告)号：WO2009041867A1
公开(公告)日：2009-04-02
申请号：PCT/SE2007/000989
申请日：2007-11-08
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas
发明人： BLOMQVIST, Andreas
IPC分类号： A61B5/0215 , A61B5/021 , A61N1/365 , A61N1/372
CPC分类号： A61B5/053 , A61B5/02028 , A61B5/0215 , A61B5/0538 , A61N1/36521 , A61N1/36564 , G06F19/00
摘要： A medical device adapted to monitor pulmonary artery pressure (PAP) of a patient, the device comprises a first detecting means arranged to measure and determine a first parameter (SVR) related to the right ventricular stroke volume of the patient's heart, and a second detecting means arranged to measure and determine a second parameter (ERR) related to the right ventricular ejection rate of the patient's heart. A pulmonary pressure index (Ip) is determined by combining the first and second parameters, wherein variations of the pulmonary pressure index indicates variations of PAP. The device is in particular adapted to detect and monitor pulmonary artery hypertension (PAH).
摘要翻译：一种适于监测患者的肺动脉压（PAP）的医疗装置，该装置包括第一检测装置，其布置成测量和确定与患者心脏的右心室搏动量相关的第一参数（SVR），以及第二检测用于测量和确定与患者心脏的右心室射血率相关的第二参数（ERR）的装置。通过组合第一和第二参数来确定肺压力指数（Ip），其中肺压力指数的变化指示PAP的变化。该装置特别适用于检测和监测肺动脉高压（PAH）。

7. 发明申请

WO2009002237A1 A METHOD AND DEVICE FOR DETECTING REM SLEEP 审中-公开
标题翻译：一种用于检测休眠的方法和装置
公开(公告)号：WO2009002237A1
公开(公告)日：2008-12-31
申请号：PCT/SE2007/000631
申请日：2007-06-27
申请人： St. JUDE MEDICAL AB , BLOMQVIST, Andreas , BROOME, Michael
发明人： BLOMQVIST, Andreas , BROOME, Michael
IPC分类号： A61N1/362 , A61B5/053
CPC分类号： A61N1/37282 , A61B5/02405 , A61B5/053 , A61B5/076 , A61B5/4812 , A61N1/36521 , A61N1/36585 , A61N1/3702
摘要： In a method and device an efficient REM sleep detector using an impedance signal as input signal, and which hence can detect REM sleep using only sensor signals present in an implantable medical device and which hence enables REM sleep detection of a patient carrying an implantable medical device such as an implanted pacemaker or a cardioverter/defibrillator.
摘要翻译：在方法和装置中，使用阻抗信号作为输入信号的有效的REM睡眠检测器，并且因此可以仅使用存在于可植入医疗装置中的传感器信号来检测REM睡眠，并且因此能够进行携带植入式医疗装置的患者的REM睡眠检测例如植入式心脏起搏器或心律转复/除颤器。

8. 发明申请

WO2008153450A1 AN IMPLANTABLE MEDICAL DEVICE AND A METHOD COMPRISING MEANS FOR DETECTING AND CLASSIFYING VENTRICULAR TACHYARRHYTMIAS 审中-公开
标题翻译：一种可植入医疗装置和一种包含检测和分类静脉曲张虫的手段的方法
公开(公告)号：WO2008153450A1
公开(公告)日：2008-12-18
申请号：PCT/SE2007/000581
申请日：2007-06-13
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , BLOMQVIST, Andreas , HEDBERG, Sven-Erik , ÖHLANDER, Malin
发明人： HOLMSTRÖM, Nils , BLOMQVIST, Andreas , HEDBERG, Sven-Erik , ÖHLANDER, Malin
IPC分类号： A61N1/362 , A61N1/365 , A61N1/37 , A61N1/372 , A61N1/38
CPC分类号： A61N1/3702 , A61B5/0464 , A61B5/053 , A61B5/7264
摘要： The invention relates to ventricular tachyarrhythmia detection and classification. Upon detection of a ventricular tachyarrhythmia based on an electrocardiogram signal, cardiogenic impedance data representative of ventricular volume dynamics are collected and used for classifying the detected tachyarrhythmia as stable or unstable. In the latter case but typically not in the former case, defibrillation shocks or other forms of therapy are applied to combat the unstable ventricular tachyarrhythmia.
摘要翻译：本发明涉及室性快速性心律失常检测和分类。在基于心电图信号检测到心室快速性心律失常时，收集代表心室体积动力学的心源阻抗数据，并用于将检测到的快速性心律失常分类为稳定或不稳定。在后一种情况下，但通常不是在前一种情况下，应用除颤电击或其他形式的治疗来对抗不稳定性室性快速性心律失常。

9. 发明申请

WO2008147253A1 IMPLANTABLE MEDICAL DEVICE FOR MONITORING LUNG DEFICIENCY 审中-公开
标题翻译：用于监测肺功能不全的可植入医疗装置
公开(公告)号：WO2008147253A1
公开(公告)日：2008-12-04
申请号：PCT/SE2007/000511
申请日：2007-05-28
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas
发明人： BLOMQVIST, Andreas
IPC分类号： A61N1/37 , A61N1/365 , A61B5/0205
CPC分类号： A61N1/36521 , A61B5/0205 , A61B5/076 , A61B5/0809 , A61N1/3601 , A61N1/36557
摘要： The invention concerns an implantable medical device (10) for monitoring a lung deficiency in a patient. The device (10) comprises a housing (12) and a control circuit (14) located within the housing (12). The control circuit (14) is configured to be able to analyse one or more signals which represent the breathing of said patient. The control circuit (14) is also configured to be able to monitor a relationship between an expiratory phase and an inspiratory phase of the breathing cycle, or an analogous relationship, and to monitor a change in said lung deficiency by monitoring a change in said relationship. The invention also concerns an implantable medical system including such an implantable medical device (10) as well as a method of monitoring a lung deficiency in a patient.
摘要翻译：本发明涉及一种用于监测患者的肺缺血的可植入医疗装置（10）。装置（10）包括壳体（12）和位于壳体（12）内的控制电路（14）。控制电路（14）被配置为能够分析代表所述患者的呼吸的一个或多个信号。控制电路（14）还被配置为能够监测呼吸周期的呼气阶段和吸气阶段之间的关系或类似的关系，并且通过监视所述关系的变化来监测所述肺缺乏的变化。本发明还涉及包括这种可植入医疗装置（10）的可植入医疗系统以及监测患者的肺缺血的方法。

10. 发明申请

WO2008118042A1 IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：WO2008118042A1
公开(公告)日：2008-10-02
申请号：PCT/SE2007/000289
申请日：2007-03-23
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LÖNN, Urban
发明人： HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LÖNN, Urban
IPC分类号： A61N1/37 , A61B5/02 , A61B5/08 , A61N1/02
CPC分类号： A61N1/3702 , A61B5/14542 , A61B5/1459 , A61N1/056 , A61N1/36557
摘要： Implantable medical device comprising an optical oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison, and that the indication signal is indicative of the lung functionality of the patient.
摘要翻译：可植入医疗装置，其包括适于测量氧合血液中氧气水平的光学氧传感器，并且根据氧气水平产生氧气测量信号。氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。将获得的氧测量信号与预定阈值电平进行比较，并且根据比较生成指示信号，并且指示信号指示患者的肺功能。

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