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1. 发明申请

WO2010104425A1 ISCHEMIC STATUS MONITORING 审中-公开
标题翻译： ISCHEMIC状态监测
公开(公告)号：WO2010104425A1
公开(公告)日：2010-09-16
申请号：PCT/SE2009/000140
申请日：2009-03-13
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , SVENSSON, Tomas , BROOME, Michael , JÄRVERUD, Karin , HJELM, Stefan
发明人： HEDBERG, Sven-Erik , SVENSSON, Tomas , BROOME, Michael , JÄRVERUD, Karin , HJELM, Stefan
IPC分类号： A61B5/02 , A61B5/00 , A61N1/37 , A61B5/053
CPC分类号： A61B5/0452 , A61B5/026 , A61B5/053 , A61B5/1116 , A61B5/1118 , A61B5/4836 , A61B5/6846 , A61B5/7405 , A61B5/7455 , A61N1/3702
摘要： An ischemia monitoring system (100) comprises detectors (110, 120, 130) for detecting the onset of an ischemic event of a tissue (10) in subject (1), the end of the ischemic event and the end of a following recovery from the ischemic event, respectively. A time processor (130) determines the duration of the ischemic event and the recovery period based on the detected onset and end times. A status processor 150 co-processes the two determined time durations for the purpose of monitoring the ischemic status of the subject and detecting any deterioration in ischemic status for the latest ischemic event as compared to previous ischemic events that have occurred in the subject's tissue (10).
摘要翻译：缺血监测系统（100）包括检测器（110,120,130），用于检测受试者（1）中组织（10）的缺血事件的发作，缺血事件的结束和从缺血事件。时间处理器（130）基于检测到的起始和结束时间来确定缺血事件的持续时间和恢复时段。状态处理器150协调处理两个确定的时间持续时间，用于监测受试者的缺血状态并检测与在受试者组织中发生的先前缺血事件相比最新缺血事件的缺血状态的任何恶化（10 ）。

2. 发明申请

WO2008130291A1 IMPLANTABLE MEDICAL SYSTEM FOR DETECTING INCIPIENT EDEMA 审中-公开
标题翻译：用于检测机动车辆的可植入医疗系统
公开(公告)号：WO2008130291A1
公开(公告)日：2008-10-30
申请号：PCT/SE2007/000396
申请日：2007-04-24
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LINDKVIST, Leif , LÖNN, Urban
发明人： HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LINDKVIST, Leif , LÖNN, Urban
IPC分类号： A61N1/05 , A61N1/365
CPC分类号： A61N1/05 , A61B5/0084 , A61B5/0086 , A61B5/08 , A61B5/1116 , A61B5/1118 , A61B5/4878 , A61B5/7207 , A61N1/025 , A61N1/056 , A61N1/362
摘要： The present invention generally relates implantable medical systems and, in particular, to systems, devices and methods for detecting incipient edema. The medical system comprises an implantable medical lead including an optical sensor comprising a light source and a light detector. The medical system further comprises an edema detection circuit being adapted to: activate the light source to emit light, wherein said light is directed into lung tissue of a patient; obtain a light intensity value corresponding to an intensity of light received by the light detector; and evaluate the light intensity value to detect a consistency with incipient edema.
摘要翻译：本发明通常涉及可植入医疗系统，特别是涉及用于检测初期水肿的系统，装置和方法。医疗系统包括可植入医疗引线，其包括包括光源和光检测器的光学传感器。医疗系统还包括水肿检测电路，其适于：激活光源以发光，其中所述光被引导到患者的肺组织中; 获得与由光检测器接收的光的强度对应的光强度值; 并评估光强值以检测与初期水肿的一致性。

3. 发明申请

WO2012163414A1 DYNAMIC CARDIAC RESYNCHRONIZATION THERAPY BY TRACKING INTER -ATRIAL CONDUCTION DELAYS 审中-公开
标题翻译：通过跟踪直接导联延迟进行动态心脏再生治疗
公开(公告)号：WO2012163414A1
公开(公告)日：2012-12-06
申请号：PCT/EP2011/058982
申请日：2011-05-31
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , HOLMSTRÖM, Nils , JÄRVERUD, Karin
发明人： HEDBERG, Sven-Erik , HOLMSTRÖM, Nils , JÄRVERUD, Karin
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3682 , A61N1/3684
摘要： The present invention relates generally to implantable medical devices and more particularly to systems and methods for stimulating a heart of a patient. A first ventricle is activated by delivering stimulation to at least one stimulation site, a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the first ventricle is estimated and a first activation time interval substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site in the first ventricle to the AV node using the estimated point of time for arrival of the depolarization wave and a point of time for delivery of stimulation is computed. Thereafter, the other ventricle is stimulated by delivering stimulation to at least one stimulation site. A point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the other ventricle is then estimated and a second activation time interval substantially corresponding to the time required for at least one depolarization wave to travel from the stimulation site in the other ventricle to the AV node using the estimated arrival of the depolarization wave and the point of time for delivery of stimulation is computed. Based on these activation time intervals and a difference between the intervals, a pacing therapy can be determined, wherein the first ventricle is paced prior to activation of the other ventricle if the activation time difference indicates that the first activation time interval is longer than the second activation time interval and the other ventricle is paced prior to activation of the first ventricle if the activation time difference indicates that the second activation time interval is longer than the first activation time interval.
摘要翻译：本发明一般涉及可植入医疗装置，更具体地涉及用于刺激患者心脏的系统和方法。通过向至少一个刺激部位递送刺激来激活第一脑室，估计到达在第一脑室刺激产生的至少一个去极化波的AV节点的时间点，并且基本对应于计算使用去极化波的到达的估计时间点和用于递送刺激的时间点的至少一个去极化波从第一脑室的刺激部位行进到AV节点所需的时间间隔。此后，通过将刺激递送至至少一个刺激部位刺激另一个心室。然后估计到达AV节点对于在另一个心室中的刺激产生的至少一个去极化波的时间点，并且基本对应于至少一个去极化波从刺激行进所需的时间的第二激活时间间隔计算使用去极化波的估计到达和输送刺激的时间点在AV节点的另一脑室中的位置。基于这些激活时间间隔和间隔之间的差异，可以确定起搏治疗，其中如果激活时间差指示第一激活时间间隔长于第二心室第二激活时间间隔，则第一心室在另一心室激活之前起搏如果所述激活时间差指示所述第二激活时间间隔长于所述第一激活时间间隔，则所述激活时间间隔和所述另一个心室在所述第一心室激活之前起步。

4. 发明申请

WO2008118042A1 IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：WO2008118042A1
公开(公告)日：2008-10-02
申请号：PCT/SE2007/000289
申请日：2007-03-23
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LÖNN, Urban
发明人： HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LÖNN, Urban
IPC分类号： A61N1/37 , A61B5/02 , A61B5/08 , A61N1/02
CPC分类号： A61N1/3702 , A61B5/14542 , A61B5/1459 , A61N1/056 , A61N1/36557
摘要： Implantable medical device comprising an optical oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison, and that the indication signal is indicative of the lung functionality of the patient.
摘要翻译：可植入医疗装置，其包括适于测量氧合血液中氧气水平的光学氧传感器，并且根据氧气水平产生氧气测量信号。氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。将获得的氧测量信号与预定阈值电平进行比较，并且根据比较生成指示信号，并且指示信号指示患者的肺功能。

5. 发明申请

WO2007064259A1 IMPLANTABLE CARDIAC STIMULATOR, SYSTEM, DEVICE AND METHOD FOR MONITORING CARDIAC SYNCHRONY 审中-公开
标题翻译：可注射的心脏刺激器，系统，设备和监测心脏同步的方法
公开(公告)号：WO2007064259A1
公开(公告)日：2007-06-07
申请号：PCT/SE2005/001806
申请日：2005-11-30
申请人： ST. JUDE MEDICAL AB , JÄRVERUD, Karin , NILSSON, Kenth , HEDBERG, Sven-Erik
发明人： JÄRVERUD, Karin , NILSSON, Kenth , HEDBERG, Sven-Erik
IPC分类号： A61N1/362 , A61B5/00 , A61N1/365
CPC分类号： A61N1/3627 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61N1/36514 , A61N1/36578
摘要： A heart stimulator and a device for monitoring cardiac synchrony in a human heart. At least a first and a second sensor are adapted to be positioned at a first cardiac wall location and a second cardiac wall location subjected to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, respectively. The sensors are arranged for measuring cardiac wall movements at the respective cardiac wall locations. Processing circuitry is arranged for receiving output signals from the sensors, the output signals being indicative of longitudinal valve plane movements at the respective cardiac wall location. The processing circuitry is further arranged for processing the signals and output a synchronization signal indicative of the synchrony in the valve plane movements at the cardiac wall locations .
摘要翻译：心脏刺激器和用于监测人心脏心脏同步的装置。至少第一和第二传感器适于被定位在第一心脏壁位置处，并且第二心脏壁位置分别经受与心脏的纵向轴线的纵向瓣膜平面运动相关的运动。传感器被布置用于测量各个心脏壁位置处的心脏壁移动。处理电路被布置成用于接收来自传感器的输出信号，输出信号表示在相应的心脏壁位置处的纵向阀平面运动。处理电路还被布置用于处理信号并输出指示在心脏壁位置处的阀平面运动中的同步的同步信号。

6. 发明申请

WO2008118047A1 IMPLANTABLE MEDICAL DEVICE COMPRISING AN OXYGEN SENSOR 审中-公开
标题翻译：包含氧传感器的可植入医疗装置
公开(公告)号：WO2008118047A1
公开(公告)日：2008-10-02
申请号：PCT/SE2007/001044
申请日：2007-11-27
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LINDKVIST, Leif , LÖNN, Urban , HOLMSTRÖM, Nils
发明人： HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LINDKVIST, Leif , LÖNN, Urban , HOLMSTRÖM, Nils
IPC分类号： A61N1/37 , A61B5/02 , A61B5/08 , A61N1/02
CPC分类号： A61N1/3702 , A61B5/14542 , A61B5/1459 , A61N1/056 , A61N1/36557
摘要： Implantable medical device comprising an oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison, and that the indication signal is indicative of the lung functionality of the patient.
摘要翻译：可植入医疗装置，其包括适于测量氧合血液中的氧气水平的氧传感器，以及根据氧水平产生氧测量信号。氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。将获得的氧测量信号与预定阈值电平进行比较，并且根据比较生成指示信号，并且指示信号指示患者的肺功能。

7. 发明申请

WO2008105690A1 AN IMPLANTABLE HEART ANALYSING DEVICE SYSTEM AND METHOD 审中-公开
标题翻译：可植入心脏分析装置系统及方法
公开(公告)号：WO2008105690A1
公开(公告)日：2008-09-04
申请号：PCT/SE2007/000193
申请日：2007-02-28
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , BLOMQVIST, Andreas , LARSSON, Berit , JÄRVERUD, Karin , HEDBERG, Sven-Erik
发明人： HOLMSTRÖM, Nils , BLOMQVIST, Andreas , LARSSON, Berit , JÄRVERUD, Karin , HEDBERG, Sven-Erik
IPC分类号： A61N1/365 , A61B5/0215
CPC分类号： A61B5/1107 , A61B5/0051 , A61B5/4519 , A61B5/6869 , A61N1/36578
摘要： The invention concerns an implantable heart analysing device (10) comprising a housing (12) and a control circuit (14) located within said housing (12). The control circuit (14) is adapted to generate an output signal adapted to actuate an activator (43), which is able to make a wall of the heart deflect or vibrate. The control circuit (14) is also adapted to communicate with a sensor (44), which can be identical with said activator (43), with the help of which the movement of said heart wall can be sensed. The control circuit (14) is arranged to be able to carry out a procedure that involves the generation of an output signal and sensing a corresponding sensor signal, and to be able to derive information concerning the tension of said heart wall. The invention also concerns a system including such a device (10) and also a method of analysing the tension of a wall of a heart.
摘要翻译：本发明涉及可植入心脏分析装置（10），其包括位于所述壳体（12）内的壳体（12）和控制电路（14）。控制电路（14）适于产生适于致动激活器（43）的输出信号，其能够使心脏的壁发生偏转或振动。控制电路（14）还适于与可与所述激活器（43）相同的传感器（44）通信，借助于此可以感测到所述心脏壁的移动。控制电路（14）被布置为能够执行涉及生成输出信号并感测相应的传感器信号的过程，并且能够导出关于所述心脏壁的张力的信息。本发明还涉及包括这种装置（10）的系统以及分析心脏壁的张力的方法。

8. 发明申请

WO2008008008A1 INFORMATION MANAGEMENT IN DEVICES WORN BY A USE 审中-公开
标题翻译：使用信息管理信息
公开(公告)号：WO2008008008A1
公开(公告)日：2008-01-17
申请号：PCT/SE2006/000883
申请日：2006-07-13
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , MALMBERG, Patrik , LYCHOU, Leif , KERSTNA, Jürgen , TJÄLLDIN, Ellen
发明人： HEDBERG, Sven-Erik , MALMBERG, Patrik , LYCHOU, Leif , KERSTNA, Jürgen , TJÄLLDIN, Ellen
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： A61N1/37211 , A61B5/0402 , A61B5/6843 , A61N1/37282 , G06F19/00 , G16H40/63
摘要： The invention involves a device (100), e.g. an implantable medical device, adapted for physical connection to a body (10) of a user. The device (100) comprises an information manager (120) for managing sensitive information associated with the user or device (100), such as being arranged for retrieving the sensitive information from a memory (122) in the device (100). A sensor (130, 170) is arranged in or connected to the device (100) for sensing whether the device (100) is physically connected to the body (10) and worn by the user and for generating a signal representative of whether the device (100) is actually physically connected to the body (10). The information manager (120) is connected to the sensor (130) and is responsive to the generated signal and performs its information managing function based on the signal. The invention prevents, among others, fraudulent retrieval of sensitive data from the device (100) if the device (100) is not connected to or implanted in the intended user body (10).
摘要翻译：本发明涉及一种装置（100），例如可植入医疗装置，适于物理连接到使用者的身体（10）。设备（100）包括用于管理与用户或设备（100）相关联的敏感信息的信息管理器（120），诸如被安排用于从设备（100）中的存储器（122）检索敏感信息。传感器（130,170）布置在设备（100）中或连接到设备（100），用于感测设备（100）物理地连接到主体（10）并且被用户佩戴，并且用于生成表示设备（100）实际上物理地连接到主体（10）。信息管理器（120）连接到传感器（130）并且响应于所产生的信号并且基于该信号执行其信息管理功能。如果设备（100）未连接到或植入预期用户体（10）中，则本发明防止了来自设备（100）的敏感数据的欺骗性检索。

9. 发明申请

WO2007139456A1 A METHOD IN AN IMD SYSTEM 审中-公开
标题翻译： IMD系统中的一种方法
公开(公告)号：WO2007139456A1
公开(公告)日：2007-12-06
申请号：PCT/SE2006/000646
申请日：2006-05-31
申请人： ST. JUDE MEDICAL AB , KERSTNA, Jürgen , MALMBERG, Patrik , HEDBERG, Sven-Erik , LYCHOU, Leif
发明人： KERSTNA, Jürgen , MALMBERG, Patrik , HEDBERG, Sven-Erik , LYCHOU, Leif
IPC分类号： A61N1/372 , G06F19/00
CPC分类号： A61N1/37282 , G06F19/00 , G06F19/3418 , G06Q50/24
摘要： A method for adapting functions of a clinician's workstation in an Implantable Medical Device, IMD, system, said clinician's workstation communicating with at least one IMD implanted to a patient. According to the invention the method comprises the steps of: - collecting patient and/or IMD data in the clinician's workstation; and - dynamically adapting the functions of the clinician's workstation in dependence of the patient and/or IMD data.
摘要翻译：一种在植入式医疗装置IMD系统中适应临床医生工作站的功能的方法，所述临床医生的工作站与植入患者的至少一个IMD通信。根据本发明，该方法包括以下步骤： - 收集临床医师工作站中的患者和/或IMD数据; 以及 - 根据患者和/或IMD数据动态调整临床医师工作站的功能。

10. 发明申请

WO2008039110A1 A MEDICAL SYSTEM AND A METHOD FOR DETERMINING SETTINGS OF AN IMPLANTABLE DEVICE 审中-公开
标题翻译：一种用于确定可植入装置的设置的医疗系统和方法
公开(公告)号：WO2008039110A1
公开(公告)日：2008-04-03
申请号：PCT/SE2006/001081
申请日：2006-09-25
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , MALMBERG, Patrik , LYCHOU, Leif , KERSTNA, Jürgen
发明人： HEDBERG, Sven-Erik , MALMBERG, Patrik , LYCHOU, Leif , KERSTNA, Jürgen
IPC分类号： A61N1/372 , A61N1/365
CPC分类号： A61N1/36585 , A61N1/025 , A61N1/3682 , A61N1/37247 , A61N1/37252 , G06F19/00 , G16H40/40
摘要： The present invention relates to medical systems and methods for such systems, which systems include an implantable medical device of a patient, a programmer device, and an extracorporeal stress equipment adapted to exert a physiological stress on the patient, for automatically determining settings of a sensor for sensing a physiological parameter of the patient or for automatically determining a pacing setting of the device over a broad range of workloads of the equipment. The ingoing units and/or devices of the medical system, i.e. the implantable medical device of a patient, the programmer device, and the extracorporeal stress equipment, communicate bi-directionally with each other and form a closed loop.
摘要翻译：本发明涉及用于这种系统的医疗系统和方法，该系统包括患者的可植入医疗装置，编程器装置和适于对患者施加生理压力的体外应力设备，用于自动确定传感器的设定用于感测患者的生理参数或用于在设备的广泛工作负载下自动确定设备的起搏设置。医疗系统的进入单元和/或装置，即患者的可植入医疗装置，程序设备和体外应力设备，彼此双向地通信并形成闭环。

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