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1. 发明申请

WO2008130291A1 IMPLANTABLE MEDICAL SYSTEM FOR DETECTING INCIPIENT EDEMA 审中-公开
标题翻译：用于检测机动车辆的可植入医疗系统
公开(公告)号：WO2008130291A1
公开(公告)日：2008-10-30
申请号：PCT/SE2007/000396
申请日：2007-04-24
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LINDKVIST, Leif , LÖNN, Urban
发明人： HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LINDKVIST, Leif , LÖNN, Urban
IPC分类号： A61N1/05 , A61N1/365
CPC分类号： A61N1/05 , A61B5/0084 , A61B5/0086 , A61B5/08 , A61B5/1116 , A61B5/1118 , A61B5/4878 , A61B5/7207 , A61N1/025 , A61N1/056 , A61N1/362
摘要： The present invention generally relates implantable medical systems and, in particular, to systems, devices and methods for detecting incipient edema. The medical system comprises an implantable medical lead including an optical sensor comprising a light source and a light detector. The medical system further comprises an edema detection circuit being adapted to: activate the light source to emit light, wherein said light is directed into lung tissue of a patient; obtain a light intensity value corresponding to an intensity of light received by the light detector; and evaluate the light intensity value to detect a consistency with incipient edema.
摘要翻译：本发明通常涉及可植入医疗系统，特别是涉及用于检测初期水肿的系统，装置和方法。医疗系统包括可植入医疗引线，其包括包括光源和光检测器的光学传感器。医疗系统还包括水肿检测电路，其适于：激活光源以发光，其中所述光被引导到患者的肺组织中; 获得与由光检测器接收的光的强度对应的光强度值; 并评估光强值以检测与初期水肿的一致性。

2. 发明申请

WO2008118042A1 IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：WO2008118042A1
公开(公告)日：2008-10-02
申请号：PCT/SE2007/000289
申请日：2007-03-23
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LÖNN, Urban
发明人： HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LÖNN, Urban
IPC分类号： A61N1/37 , A61B5/02 , A61B5/08 , A61N1/02
CPC分类号： A61N1/3702 , A61B5/14542 , A61B5/1459 , A61N1/056 , A61N1/36557
摘要： Implantable medical device comprising an optical oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison, and that the indication signal is indicative of the lung functionality of the patient.
摘要翻译：可植入医疗装置，其包括适于测量氧合血液中氧气水平的光学氧传感器，并且根据氧气水平产生氧气测量信号。氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。将获得的氧测量信号与预定阈值电平进行比较，并且根据比较生成指示信号，并且指示信号指示患者的肺功能。

3. 发明申请

WO2008118047A1 IMPLANTABLE MEDICAL DEVICE COMPRISING AN OXYGEN SENSOR 审中-公开
标题翻译：包含氧传感器的可植入医疗装置
公开(公告)号：WO2008118047A1
公开(公告)日：2008-10-02
申请号：PCT/SE2007/001044
申请日：2007-11-27
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LINDKVIST, Leif , LÖNN, Urban , HOLMSTRÖM, Nils
发明人： HEDBERG, Sven-Erik , BLOMQVIST, Andreas , JÄRVERUD, Karin , LJUNGSTRÖM, Karin , LINDKVIST, Leif , LÖNN, Urban , HOLMSTRÖM, Nils
IPC分类号： A61N1/37 , A61B5/02 , A61B5/08 , A61N1/02
CPC分类号： A61N1/3702 , A61B5/14542 , A61B5/1459 , A61N1/056 , A61N1/36557
摘要： Implantable medical device comprising an oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison, and that the indication signal is indicative of the lung functionality of the patient.
摘要翻译：可植入医疗装置，其包括适于测量氧合血液中的氧气水平的氧传感器，以及根据氧水平产生氧测量信号。氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。将获得的氧测量信号与预定阈值电平进行比较，并且根据比较生成指示信号，并且指示信号指示患者的肺功能。

4. 发明申请

WO2008105690A1 AN IMPLANTABLE HEART ANALYSING DEVICE SYSTEM AND METHOD 审中-公开
标题翻译：可植入心脏分析装置系统及方法
公开(公告)号：WO2008105690A1
公开(公告)日：2008-09-04
申请号：PCT/SE2007/000193
申请日：2007-02-28
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , BLOMQVIST, Andreas , LARSSON, Berit , JÄRVERUD, Karin , HEDBERG, Sven-Erik
发明人： HOLMSTRÖM, Nils , BLOMQVIST, Andreas , LARSSON, Berit , JÄRVERUD, Karin , HEDBERG, Sven-Erik
IPC分类号： A61N1/365 , A61B5/0215
CPC分类号： A61B5/1107 , A61B5/0051 , A61B5/4519 , A61B5/6869 , A61N1/36578
摘要： The invention concerns an implantable heart analysing device (10) comprising a housing (12) and a control circuit (14) located within said housing (12). The control circuit (14) is adapted to generate an output signal adapted to actuate an activator (43), which is able to make a wall of the heart deflect or vibrate. The control circuit (14) is also adapted to communicate with a sensor (44), which can be identical with said activator (43), with the help of which the movement of said heart wall can be sensed. The control circuit (14) is arranged to be able to carry out a procedure that involves the generation of an output signal and sensing a corresponding sensor signal, and to be able to derive information concerning the tension of said heart wall. The invention also concerns a system including such a device (10) and also a method of analysing the tension of a wall of a heart.
摘要翻译：本发明涉及可植入心脏分析装置（10），其包括位于所述壳体（12）内的壳体（12）和控制电路（14）。控制电路（14）适于产生适于致动激活器（43）的输出信号，其能够使心脏的壁发生偏转或振动。控制电路（14）还适于与可与所述激活器（43）相同的传感器（44）通信，借助于此可以感测到所述心脏壁的移动。控制电路（14）被布置为能够执行涉及生成输出信号并感测相应的传感器信号的过程，并且能够导出关于所述心脏壁的张力的信息。本发明还涉及包括这种装置（10）的系统以及分析心脏壁的张力的方法。

5. 发明申请

WO2012163414A1 DYNAMIC CARDIAC RESYNCHRONIZATION THERAPY BY TRACKING INTER -ATRIAL CONDUCTION DELAYS 审中-公开
标题翻译：通过跟踪直接导联延迟进行动态心脏再生治疗
公开(公告)号：WO2012163414A1
公开(公告)日：2012-12-06
申请号：PCT/EP2011/058982
申请日：2011-05-31
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , HOLMSTRÖM, Nils , JÄRVERUD, Karin
发明人： HEDBERG, Sven-Erik , HOLMSTRÖM, Nils , JÄRVERUD, Karin
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3682 , A61N1/3684
摘要： The present invention relates generally to implantable medical devices and more particularly to systems and methods for stimulating a heart of a patient. A first ventricle is activated by delivering stimulation to at least one stimulation site, a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the first ventricle is estimated and a first activation time interval substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site in the first ventricle to the AV node using the estimated point of time for arrival of the depolarization wave and a point of time for delivery of stimulation is computed. Thereafter, the other ventricle is stimulated by delivering stimulation to at least one stimulation site. A point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the other ventricle is then estimated and a second activation time interval substantially corresponding to the time required for at least one depolarization wave to travel from the stimulation site in the other ventricle to the AV node using the estimated arrival of the depolarization wave and the point of time for delivery of stimulation is computed. Based on these activation time intervals and a difference between the intervals, a pacing therapy can be determined, wherein the first ventricle is paced prior to activation of the other ventricle if the activation time difference indicates that the first activation time interval is longer than the second activation time interval and the other ventricle is paced prior to activation of the first ventricle if the activation time difference indicates that the second activation time interval is longer than the first activation time interval.
摘要翻译：本发明一般涉及可植入医疗装置，更具体地涉及用于刺激患者心脏的系统和方法。通过向至少一个刺激部位递送刺激来激活第一脑室，估计到达在第一脑室刺激产生的至少一个去极化波的AV节点的时间点，并且基本对应于计算使用去极化波的到达的估计时间点和用于递送刺激的时间点的至少一个去极化波从第一脑室的刺激部位行进到AV节点所需的时间间隔。此后，通过将刺激递送至至少一个刺激部位刺激另一个心室。然后估计到达AV节点对于在另一个心室中的刺激产生的至少一个去极化波的时间点，并且基本对应于至少一个去极化波从刺激行进所需的时间的第二激活时间间隔计算使用去极化波的估计到达和输送刺激的时间点在AV节点的另一脑室中的位置。基于这些激活时间间隔和间隔之间的差异，可以确定起搏治疗，其中如果激活时间差指示第一激活时间间隔长于第二心室第二激活时间间隔，则第一心室在另一心室激活之前起搏如果所述激活时间差指示所述第二激活时间间隔长于所述第一激活时间间隔，则所述激活时间间隔和所述另一个心室在所述第一心室激活之前起步。

6. 发明申请

WO2010104425A1 ISCHEMIC STATUS MONITORING 审中-公开
标题翻译： ISCHEMIC状态监测
公开(公告)号：WO2010104425A1
公开(公告)日：2010-09-16
申请号：PCT/SE2009/000140
申请日：2009-03-13
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , SVENSSON, Tomas , BROOME, Michael , JÄRVERUD, Karin , HJELM, Stefan
发明人： HEDBERG, Sven-Erik , SVENSSON, Tomas , BROOME, Michael , JÄRVERUD, Karin , HJELM, Stefan
IPC分类号： A61B5/02 , A61B5/00 , A61N1/37 , A61B5/053
CPC分类号： A61B5/0452 , A61B5/026 , A61B5/053 , A61B5/1116 , A61B5/1118 , A61B5/4836 , A61B5/6846 , A61B5/7405 , A61B5/7455 , A61N1/3702
摘要： An ischemia monitoring system (100) comprises detectors (110, 120, 130) for detecting the onset of an ischemic event of a tissue (10) in subject (1), the end of the ischemic event and the end of a following recovery from the ischemic event, respectively. A time processor (130) determines the duration of the ischemic event and the recovery period based on the detected onset and end times. A status processor 150 co-processes the two determined time durations for the purpose of monitoring the ischemic status of the subject and detecting any deterioration in ischemic status for the latest ischemic event as compared to previous ischemic events that have occurred in the subject's tissue (10).
摘要翻译：缺血监测系统（100）包括检测器（110,120,130），用于检测受试者（1）中组织（10）的缺血事件的发作，缺血事件的结束和从缺血事件。时间处理器（130）基于检测到的起始和结束时间来确定缺血事件的持续时间和恢复时段。状态处理器150协调处理两个确定的时间持续时间，用于监测受试者的缺血状态并检测与在受试者组织中发生的先前缺血事件相比最新缺血事件的缺血状态的任何恶化（10 ）。

7. 发明申请

WO2007064259A1 IMPLANTABLE CARDIAC STIMULATOR, SYSTEM, DEVICE AND METHOD FOR MONITORING CARDIAC SYNCHRONY 审中-公开
标题翻译：可注射的心脏刺激器，系统，设备和监测心脏同步的方法
公开(公告)号：WO2007064259A1
公开(公告)日：2007-06-07
申请号：PCT/SE2005/001806
申请日：2005-11-30
申请人： ST. JUDE MEDICAL AB , JÄRVERUD, Karin , NILSSON, Kenth , HEDBERG, Sven-Erik
发明人： JÄRVERUD, Karin , NILSSON, Kenth , HEDBERG, Sven-Erik
IPC分类号： A61N1/362 , A61B5/00 , A61N1/365
CPC分类号： A61N1/3627 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61N1/36514 , A61N1/36578
摘要： A heart stimulator and a device for monitoring cardiac synchrony in a human heart. At least a first and a second sensor are adapted to be positioned at a first cardiac wall location and a second cardiac wall location subjected to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, respectively. The sensors are arranged for measuring cardiac wall movements at the respective cardiac wall locations. Processing circuitry is arranged for receiving output signals from the sensors, the output signals being indicative of longitudinal valve plane movements at the respective cardiac wall location. The processing circuitry is further arranged for processing the signals and output a synchronization signal indicative of the synchrony in the valve plane movements at the cardiac wall locations .
摘要翻译：心脏刺激器和用于监测人心脏心脏同步的装置。至少第一和第二传感器适于被定位在第一心脏壁位置处，并且第二心脏壁位置分别经受与心脏的纵向轴线的纵向瓣膜平面运动相关的运动。传感器被布置用于测量各个心脏壁位置处的心脏壁移动。处理电路被布置成用于接收来自传感器的输出信号，输出信号表示在相应的心脏壁位置处的纵向阀平面运动。处理电路还被布置用于处理信号并输出指示在心脏壁位置处的阀平面运动中的同步的同步信号。

8. 发明申请

WO2009082284A1 METHOD AND DEVICE FOR MONITORING ACUTE DECOMPENSATED HEART FAILURE. 审中-公开
标题翻译：用于监测急性脱发性心脏衰竭的方法和装置。
公开(公告)号：WO2009082284A1
公开(公告)日：2009-07-02
申请号：PCT/SE2007/001155
申请日：2007-12-21
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas , HOLMSTRÖM, Nils , HEDBERG, Sven-Erik , ÖHLANDER, Malin
发明人： BLOMQVIST, Andreas , HOLMSTRÖM, Nils , HEDBERG, Sven-Erik , ÖHLANDER, Malin
IPC分类号： A61B5/053 , A61B5/0245 , A61N1/365
CPC分类号： A61B5/053 , A61B5/0245 , A61B5/0452
摘要： An implantable medical device (100) comprises an impedance determiner (120) for determining a cardiogenic impedance signal (20, 30) based on electric signals sensed by connected electrodes. A parameter calculator (130) processes the impedance signal (20, 30) to calculate an impedance parameter representative of the cardiogenic impedance in connection with the diastolic phase of a heart cycle. This parameter is then employed by the device (100) for monitoring acute decompensated heart failure status of a subject (1).
摘要翻译：可植入医疗装置（100）包括阻抗确定器（120），用于基于由连接的电极感测的电信号来确定心源阻抗信号（20,30）。参数计算器（130）处理阻抗信号（20,30）以计算与心脏循环的舒张期相关的代表心源阻抗的阻抗参数。该装置（100）然后使用该参数来监测对象（1）的急性失代偿性心力衰竭状态。

9. 发明申请

WO2008153450A1 AN IMPLANTABLE MEDICAL DEVICE AND A METHOD COMPRISING MEANS FOR DETECTING AND CLASSIFYING VENTRICULAR TACHYARRHYTMIAS 审中-公开
标题翻译：一种可植入医疗装置和一种包含检测和分类静脉曲张虫的手段的方法
公开(公告)号：WO2008153450A1
公开(公告)日：2008-12-18
申请号：PCT/SE2007/000581
申请日：2007-06-13
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , BLOMQVIST, Andreas , HEDBERG, Sven-Erik , ÖHLANDER, Malin
发明人： HOLMSTRÖM, Nils , BLOMQVIST, Andreas , HEDBERG, Sven-Erik , ÖHLANDER, Malin
IPC分类号： A61N1/362 , A61N1/365 , A61N1/37 , A61N1/372 , A61N1/38
CPC分类号： A61N1/3702 , A61B5/0464 , A61B5/053 , A61B5/7264
摘要： The invention relates to ventricular tachyarrhythmia detection and classification. Upon detection of a ventricular tachyarrhythmia based on an electrocardiogram signal, cardiogenic impedance data representative of ventricular volume dynamics are collected and used for classifying the detected tachyarrhythmia as stable or unstable. In the latter case but typically not in the former case, defibrillation shocks or other forms of therapy are applied to combat the unstable ventricular tachyarrhythmia.
摘要翻译：本发明涉及室性快速性心律失常检测和分类。在基于心电图信号检测到心室快速性心律失常时，收集代表心室体积动力学的心源阻抗数据，并用于将检测到的快速性心律失常分类为稳定或不稳定。在后一种情况下，但通常不是在前一种情况下，应用除颤电击或其他形式的治疗来对抗不稳定性室性快速性心律失常。

10. 发明申请

WO2012084044A1 METHOD AND SYSTEM FOR OPTIMIZING CARDIAC PACING SETTINGS 审中-公开
标题翻译：优化心脏瓣膜设置的方法和系统
公开(公告)号：WO2012084044A1
公开(公告)日：2012-06-28
申请号：PCT/EP2010/070640
申请日：2010-12-23
申请人： ST. JUDE MEDICAL AB , GUSTAFSSON, John , KARLSSON, Andreas , BLOMQVIST, Andreas , HEDBERG, Sven-Erik , HOLMSTRÖM, Nils
发明人： GUSTAFSSON, John , KARLSSON, Andreas , BLOMQVIST, Andreas , HEDBERG, Sven-Erik , HOLMSTRÖM, Nils
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368 , A61B5/0205 , A61B5/0215 , A61B8/04
CPC分类号： A61N1/36571 , A61B5/02028 , A61B5/0215 , A61B5/028 , A61B5/029 , A61B5/0472 , A61B5/0538 , A61B5/1116 , A61B5/686 , A61B8/06 , A61B2562/0219 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3682
摘要： The present invention relates generally to methods and systems for optimizing stimulation of a heart of a patient. More specifically, hemodynamical index signals reflecting a mechanical functioning of a heart of a patient are recorded at different hemodynamical states. Further, corresponding hemodynamical reference signals at corresponding hemodynamical states are recorded. Further, at least one hemodynamical index parameter is extracted from the recorded hemodynamical index signals, the at least one hemodynamical index parameter being a measure of the mechanical functioning of the heart and a hemodynamical index model is created, wherein the hemodynamical index model is based on the at least one hemodynamical index parameter and a comparison between output results from the hemodynamical index model and corresponding hemodynamical reference signals. From this hemodynamical index model, a hemodynamical index can be derived, which then can be used in determining patient customized cardiac pacing settings of the cardiac stimulator.
摘要翻译：本发明一般涉及优化患者心脏的刺激的方法和系统。更具体地，反映患者心脏的机械功能的血液动力学指标信号记录在不同的血液动力学状态。此外，记录相应的血流动力学状态下的相应血液动力学参考信号。此外，从记录的血液动力学指标信号中提取至少一个血液动力学指标参数，所述至少一个血液动力学指数参数是心脏的机械功能的量度，并且产生血液动力学指标模型，其中血液动力学指数模型基于所述至少一个血液动力学指标参数以及来自血液动力学指标模型的输出结果与相应的血液动力学参考信号之间的比较。从该血液动力学指标模型可以得出血流动力学指标，然后可以用于确定心脏刺激器患者定制的心脏起搏设置。

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