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1. 发明申请

WO2010104425A1 ISCHEMIC STATUS MONITORING 审中-公开
标题翻译： ISCHEMIC状态监测
公开(公告)号：WO2010104425A1
公开(公告)日：2010-09-16
申请号：PCT/SE2009/000140
申请日：2009-03-13
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , SVENSSON, Tomas , BROOME, Michael , JÄRVERUD, Karin , HJELM, Stefan
发明人： HEDBERG, Sven-Erik , SVENSSON, Tomas , BROOME, Michael , JÄRVERUD, Karin , HJELM, Stefan
IPC分类号： A61B5/02 , A61B5/00 , A61N1/37 , A61B5/053
CPC分类号： A61B5/0452 , A61B5/026 , A61B5/053 , A61B5/1116 , A61B5/1118 , A61B5/4836 , A61B5/6846 , A61B5/7405 , A61B5/7455 , A61N1/3702
摘要： An ischemia monitoring system (100) comprises detectors (110, 120, 130) for detecting the onset of an ischemic event of a tissue (10) in subject (1), the end of the ischemic event and the end of a following recovery from the ischemic event, respectively. A time processor (130) determines the duration of the ischemic event and the recovery period based on the detected onset and end times. A status processor 150 co-processes the two determined time durations for the purpose of monitoring the ischemic status of the subject and detecting any deterioration in ischemic status for the latest ischemic event as compared to previous ischemic events that have occurred in the subject's tissue (10).
摘要翻译：缺血监测系统（100）包括检测器（110,120,130），用于检测受试者（1）中组织（10）的缺血事件的发作，缺血事件的结束和从缺血事件。时间处理器（130）基于检测到的起始和结束时间来确定缺血事件的持续时间和恢复时段。状态处理器150协调处理两个确定的时间持续时间，用于监测受试者的缺血状态并检测与在受试者组织中发生的先前缺血事件相比最新缺血事件的缺血状态的任何恶化（10 ）。

2. 发明申请

WO2010024739A1 AN IMPLANTABLE HEART MONITORING DEVICE AND METHOD 审中-公开
标题翻译：可植入心脏监测装置及方法
公开(公告)号：WO2010024739A1
公开(公告)日：2010-03-04
申请号：PCT/SE2008/000490
申请日：2008-08-29
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas , BROOME, Michael
发明人： BLOMQVIST, Andreas , BROOME, Michael
IPC分类号： A61B5/029 , A61N1/37 , A61B5/024 , A61B5/0245
CPC分类号： A61B5/026 , A61B5/0245 , A61B5/029 , A61B5/042 , A61B5/0452 , A61B5/053 , A61B5/6846 , A61N1/3627 , A61N1/36585
摘要： The invention concerns an implantable heart monitoring device (10) with which the status of the heart, in particular concerning a diastolic dysfunction, may be monitored. The device (10) comprises at least one memory (15) and a control circuit (14) configured to be able to carry out the following steps: a) detect the heart rate, b) derive said information correlated to the stroke volume at said detected heart rate, and c) store the detected heart rate and the derived information correlated to the stroke volume in said memory (15), wherein said control circuit (14) is configured to automatically carry out steps a) to c) at a plurality of different occasions at different, naturally varying, heart rates, such that said memory (15) comprises information that indicates the stroke volume as a function of the heart rate. The invention also concerns a corresponding method.
摘要翻译：本发明涉及可植入式心脏监测装置（10），其可以监测心脏的状态，特别是关于舒张功能障碍。设备（10）包括至少一个存储器（15）和控制电路（14），其被配置为能够执行以下步骤：a）检测心率，b）导出与所述检测心率，以及c）将检测到的心率和与行程量相关的导出信息存储在所述存储器（15）中，其中所述控制电路（14）被配置为自动地执行多个步骤a）至c）在不同的，自然变化的心率不同的场合，使得所述存储器（15）包括指示作为心率的函数的行程体积的信息。本发明还涉及一种相应的方法。

3. 发明申请

WO2008105698A1 DEVICE AND METHOD OF A MEDICAL IMPLANT FOR MONITORING PROGRESSION OF HEART FAILURE IN A HUMAN HEART 审中-公开
标题翻译：用于监测人心脏心脏衰竭进展的医用植入物的装置和方法
公开(公告)号：WO2008105698A1
公开(公告)日：2008-09-04
申请号：PCT/SE2007/000855
申请日：2007-09-27
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , ÖHLANDER, Malin , ERIKSSON, Tom , ECKERDAL, Johan , LÖNN, Urban , NILSSON, Kenth , TUVSTEDT, Cecilia , SVAHN, Johan , JOHANSSON, Anna-Karin , NOREN, Kjell , BROOME, Michael
发明人： BJÖRLING, Anders , ÖHLANDER, Malin , ERIKSSON, Tom , ECKERDAL, Johan , LÖNN, Urban , NILSSON, Kenth , TUVSTEDT, Cecilia , SVAHN, Johan , JOHANSSON, Anna-Karin , NOREN, Kjell , BROOME, Michael
IPC分类号： A61N1/372 , A61B5/0205 , A61B5/145
CPC分类号： A61B5/14542 , A61B5/0031 , A61B5/076 , A61B5/1459 , A61B2562/0219 , A61N1/3627 , A61N1/36542 , A61N1/36557 , A61N1/36585
摘要： A device and method of a medical implant for monitoring progression of heart failure in a human heart. An activity sensor provides information related to the activity level of a patient and an oxygen sensor provides information related to the level of oxygen content in venous blood. A determined level of venous oxygen content at a determined activity level is obtained, and that level of venous oxygen content is compared to stored values at a corresponding activity level. The result of the comparison is used as a basis for determining a degree of heart failure.
摘要翻译：用于监测人类心脏心脏衰竭进展的医用植入物的装置和方法。活动传感器提供与患者的活动水平相关的信息，氧传感器提供与静脉血中氧含量水平相关的信息。在确定的活性水平获得确定水平的静脉氧含量，并将静脉氧含量的水平与在相应活动水平的储存值进行比较。将比较结果用作确定心力衰竭程度的基础。

4. 发明申请

WO2010126404A1 IMPLANTABLE CORONARY PERFUSION MONITORING DEVICE 审中-公开
标题翻译：可植入冠脉灌注监测装置
公开(公告)号：WO2010126404A1
公开(公告)日：2010-11-04
申请号：PCT/SE2009/000223
申请日：2009-04-29
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas , JARVERUD, Karin , BROOME, Michael
发明人： BLOMQVIST, Andreas , JARVERUD, Karin , BROOME, Michael
IPC分类号： A61B5/0215 , A61B5/053
CPC分类号： A61B5/02158 , A61B5/02007 , A61B5/02028 , A61B5/02125 , A61B5/0295 , A61B5/053
摘要： An implantable coronary perfusion monitoring device for in- vivo determination of a coronary perfusion index ( CPI ) indicative of the coronary perfusion of a heart. The device comprises a time measurement unit to determine a blood pressure reflection wave measure t indicating the timely position in the heart cycle of the maximum of a reflected blood pressure wave and being a time period starting at a preset point of time in systole and ending at a local maximum of blood pressure following aortic valve closure; a diastolic peak pressure measurement unit adapted to determine a diastolic peak blood pressure measure DPP related to diastolic aortic peak pressure; a systolic arterial pressure measurement unit adapted to determine a systolic arterial blood pressure measure SAP related to systolic arterial pressure, and a coronary perfusion index calculating unit adapted to determine said coronary perfusion index CPI as ( t . DPP ) / SAP .
摘要翻译：一种用于体内确定冠状动脉灌注指数（CPI）的植入式冠状动脉灌注监测装置，其指示心脏的冠状动脉灌注。该装置包括时间测量单元，用于确定表示心脏周期中及时反映血压波的最大值的血压反射波测量t，并且是从收缩期的预设时间点开始的时间段，并且以主动脉瓣关闭后局部最大血压; 舒适峰值压力测量单元，其适于确定与舒张主动脉峰值压力相关的舒张峰值血压测量DPP; 用于确定与收缩期动脉压相关的收缩期动脉血压测量SAP的收缩期动脉压测量单元和适于将所述冠状动脉灌注指数CPI确定为（t.DPP）/ SAP的冠状动脉灌注指数计算单元。

5. 发明申请

WO2010071488A1 IMPLANTABLE MEDICAL DEVICE AND METHOD FOR MONITORING SYNCHRONICITY OF THE VENTRICLES OF A HEART 审中-公开
标题翻译：用于监测心脏通气道的同步性的可植入医疗装置和方法
公开(公告)号：WO2010071488A1
公开(公告)日：2010-06-24
申请号：PCT/SE2008/000720
申请日：2008-12-17
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , LJUNGSTRÖM, Karin , BROOME, Michael , EMANUELSSON, Cecilia
发明人： HOLMSTRÖM, Nils , LJUNGSTRÖM, Karin , BROOME, Michael , EMANUELSSON, Cecilia
IPC分类号： A61N1/362 , A61N1/365 , A61B5/053 , A61B5/08 , A61B5/11 , A61N1/368 , A61N1/372
CPC分类号： A61N1/3627 , A61B5/053 , A61B5/0538 , A61B5/0816 , A61B5/11 , A61B5/7239 , A61B5/7289 , A61N1/36521 , A61N1/36578 , A61N1/3684 , A61N1/3686
摘要： The present invention generally relates to the field of implantable heart stimulation devices, such as pacemakers, and similar cardiac stimulation devices that also are capable of monitoring and detecting electrical activities and events within the heart. More specifically, the present invention relates to an implantable medical device and a method for monitoring ventricular synchronicity of a heart. In particular, the present invention comprises measuring impedance signals that reflects septal wall movements and detecting impedance amplitude peaks in the impedance signal. A synchronicity index indicating a degree of synchronicity is determined based on detected impedance peaks, wherein at least two impedance peaks detected within a predetermined time window including a cardiac cycle or a part of a cardiac cycle indicates an increased dyssynchronicity in the ventricular contractions. The system also selects an optimal electrode configuration based on a minimum synchronicity index obtained by testing several electrode configurations.
摘要翻译：本发明一般涉及可植入的心脏刺激装置领域，例如起搏器和类似的心脏刺激装置，其也能够监测和检测心脏内的电活动和事件。更具体地，本发明涉及可植入医疗装置和用于监测心脏的心室同步性的方法。特别地，本发明包括测量反射隔壁移动的阻抗信号和检测阻抗信号中的阻抗幅度峰值。基于检测到的阻抗峰值确定表示同步度的同步性指标，其中在包括心动周期或心动周期的一部分的预定时间窗口内检测到的至少两个阻抗峰值表示心室收缩中增加的不同步性。该系统还基于通过测试多个电极配置获得的最小同步性指数来选择最佳电极配置。

6. 发明申请

WO2009136817A1 AN IMPLANTABLE MEDICAL DEVICE AND METHOD FOR CLASSIFYING ARRHYTHMIA EVENTS 审中-公开
标题翻译：一种可植入的医疗装置和分类ARRHYTHMIA事件的方法
公开(公告)号：WO2009136817A1
公开(公告)日：2009-11-12
申请号：PCT/SE2008/000312
申请日：2008-05-07
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , BHARMI, Rupinder , BROOME, Michael , JÄRVERUD, Karin
发明人： BJÖRLING, Anders , BHARMI, Rupinder , BROOME, Michael , JÄRVERUD, Karin
IPC分类号： A61N1/362 , A61B5/046 , A61B5/0464 , A61N1/37 , A61N1/39
CPC分类号： A61B5/0464 , A61B5/0809 , A61B5/7264 , A61N1/3622 , A61N1/36585 , A61N1/395 , A61N1/3987
摘要： The present invention generally relates to the field of implantable devices. More specifically, the present invention relates to an implantable medical device, for example, an implantable cardiac defibrillator and a method for classifying arrhythmia events. IEGM signals are analysed to detect an arrhythmia event and a respiratory pattern of the patient is sensed. At least one respiratory parameter reflecting characteristics of the respiratory pattern of the patient is determined based on the sensed respiratory pattern and a respiratory measure corresponding to a change of a rate of change of the at least one respiratory parameter is calculated. The detected arrhythmia event is classified based on the respiratory measure and the IEGM signals, wherein arrhythmia events that satisfy at least a first criterion is classified as an arrhythmia event requiring therapy.
摘要翻译：本发明一般涉及可植入装置领域。更具体地，本发明涉及可植入医疗装置，例如可植入心脏除颤器和用于分类心律失常事件的方法。分析IEGM信号以检测心律失常事件并感测患者的呼吸模式。基于感测到的呼吸模式来确定反映患者呼吸模式特征的至少一个呼吸参数，并且计算与至少一个呼吸参数的变化率的变化相对应的呼吸测量。基于呼吸测量和IEGM信号对所检测到的心律失常事件进行分类，其中满足至少第一标准的心律失常事件被分类为需要治疗的心律失常事件。

7. 发明申请

WO2009002237A1 A METHOD AND DEVICE FOR DETECTING REM SLEEP 审中-公开
标题翻译：一种用于检测休眠的方法和装置
公开(公告)号：WO2009002237A1
公开(公告)日：2008-12-31
申请号：PCT/SE2007/000631
申请日：2007-06-27
申请人： St. JUDE MEDICAL AB , BLOMQVIST, Andreas , BROOME, Michael
发明人： BLOMQVIST, Andreas , BROOME, Michael
IPC分类号： A61N1/362 , A61B5/053
CPC分类号： A61N1/37282 , A61B5/02405 , A61B5/053 , A61B5/076 , A61B5/4812 , A61N1/36521 , A61N1/36585 , A61N1/3702
摘要： In a method and device an efficient REM sleep detector using an impedance signal as input signal, and which hence can detect REM sleep using only sensor signals present in an implantable medical device and which hence enables REM sleep detection of a patient carrying an implantable medical device such as an implanted pacemaker or a cardioverter/defibrillator.
摘要翻译：在方法和装置中，使用阻抗信号作为输入信号的有效的REM睡眠检测器，并且因此可以仅使用存在于可植入医疗装置中的传感器信号来检测REM睡眠，并且因此能够进行携带植入式医疗装置的患者的REM睡眠检测例如植入式心脏起搏器或心律转复/除颤器。

8. 发明申请

WO2009002238A1 A METHOD AND DEVICE FOR COLLECTING REM SLEEP DATA 审中-公开
标题翻译：一种用于收集休眠数据的方法和装置
公开(公告)号：WO2009002238A1
公开(公告)日：2008-12-31
申请号：PCT/SE2007/000632
申请日：2007-06-27
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas , BROOME, Michael
发明人： BLOMQVIST, Andreas , BROOME, Michael
IPC分类号： A61N1/362 , A61B5/053
CPC分类号： A61N1/3702 , A61B5/02405 , A61B5/053 , A61B5/076 , A61B5/4812 , A61B5/7275 , A61N1/36521 , A61N1/36585 , A61N1/37282 , G06F19/00
摘要： In a method and a device a REM sleep detector is provide to enable better trending and prediction of monitored conditions or diseases. REM sleep data is separated from other data whereby stable and uniform conditions for data collection are achieved. The REM sleep detector can advantageously be provided inside an implantable medical device.
摘要翻译：在一种方法和装置中，提供REM睡眠检测器以使得能够更好地趋向并预测所监视的病症或疾病。 REM睡眠数据与其他数据分离，从而实现数据收集的稳定和统一的条件。 REM睡眠检测器可以有利地设置在可植入医疗装置的内部。

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