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1. 发明申请

WO2006082588A2 METHOD AND DEVICE FOR OPHTHALMIC ADMINISTRATION OF ACTIVE PHARMACEUTICAL INGREDIENTS 审中-公开
标题翻译：活性药物成分的眼科药物治疗方法和装置
公开(公告)号：WO2006082588A2
公开(公告)日：2006-08-10
申请号：PCT/IL2006/000145
申请日：2006-02-06
申请人： PHARMALIGHT INC. , GROSS, Yossi , HERZOG, Rafi , KOEVARY, Steven, B.
发明人： GROSS, Yossi , HERZOG, Rafi , KOEVARY, Steven, B.
IPC分类号： A61K9/00
CPC分类号： A61K47/46 , A61K9/0048 , A61K9/12 , A61K31/138 , A61K31/165 , A61K31/192 , A61K31/222 , A61K31/382 , A61K31/4168 , A61K31/4178 , A61K31/433 , A61K31/4704 , A61K31/496 , A61K31/498 , A61K31/5377 , A61K31/542 , A61K31/5575 , A61K31/573 , A61K31/575 , A61K31/661 , A61K38/00 , A61K45/06
摘要： ABSTRACT Disclosed is the use of a mist of a pharmaceutical composition for ophthalmic delivery of a protein or peptide active pharmaceutical ingredient, a related method of treatment and a device useful in implementing the use and method. Disclosed is also the use of a mist for ophthalmic delivery of a pharmaceutical composition including a highly irritating penetration enhancer and an ophthalmically acceptable carrier, a related method of treatment and a device useful in implementing the use and method. Disclosed is also a device for ophthalmic administration configured to direct a mist of a pharmaceutical composition to the eye only when the eye is open. Disclosed is also a self-sterlizing device for ophthalmic administration. Disclosed is also a device and a method for increasing the bioavailability of an ophthalmically administered API in a pharmaceutical composition.
摘要翻译：摘要公开了一种药物组合物雾用于蛋白质或肽活性药物成分的眼部递送，相关治疗方法和用于实施使用和方法的装置。还公开了使用雾剂用于药物组合物的眼科递送，所述药物组合物包括高度刺激性的渗透增强剂和眼科可接受的载体，相关的治疗方法和用于实施使用和方法的装置。还公开了一种用于眼部给药的装置，其被配置为仅在眼睛打开时将药物组合物的雾引导到眼睛。还公开了一种用于眼科给药的自动灭菌装置。还公开了一种用于增加药物组合物中眼用API的生物利用度的装置和方法。

2. 发明申请

WO2010046865A2 OPHTHALMIC ADMINISTRATION OF A COMPOSITION INCLUDING BRIMONIDINE AS A MIST 审中-公开
标题翻译：包括作为雾化剂的嘧啶酮的组合物的眼科管理
公开(公告)号：WO2010046865A2
公开(公告)日：2010-04-29
申请号：PCT/IB2009/054656
申请日：2009-10-21
申请人： PHARMALIGHT INC. , FEKE, Gilbert T. , KOEVARY, Steven B. , GROSS, Yossi
发明人： FEKE, Gilbert T. , KOEVARY, Steven B. , GROSS, Yossi
CPC分类号： A61K31/498 , A61K9/0048
摘要： Disclosed are methods of treatment including administration of a pharmaceutical composition including brimonidine to an eye as a mist, the composition devoid of a penetration enhancer.
摘要翻译：公开了治疗方法，包括向眼睛施用包含溴莫尼定的药物组合物作为雾，所述组合物没有渗透促进剂。

3. 发明申请

WO2005043224A3 LIQUID-CRYSTAL EYEGLASS SYSTEM 审中-公开
公开(公告)号：WO2005043224A3
公开(公告)日：2005-05-12
申请号：PCT/IL2004/001008
申请日：2004-11-03
申请人： OPHTHOCARE LTD , HERZOG, Rafi , BEN-EZRA, Omry , GROSS, Yossi
发明人： HERZOG, Rafi , BEN-EZRA, Omry , GROSS, Yossi
IPC分类号： G02F1/1335
摘要： An electronically controlled, liquid-crystal eyeglass system is provided, designed for intermittent occlusion, while exercising the eyes of a user, through combined occlusion-and-exercising sessions, wherein the eyeglass system includes features to improve and monitor compliance. Specifically, features to improve compliance include an ordinary eyeglass design, wherein the electronic components are miniaturized and hidden, and a reflective coating on the exterior surfaces of the lenses, for identical exterior appearance, even when the two lenses operate at different opacity levels. In this manner, the liquid-crystal eyeglass system does not attract attention. Additionally, a fashionable design, and possibly also, a fashionable designer's brand name may be employed. In order to monitor compliance, the times, dates, and durations of the occlusion-and-exercising sessions that took place are recorded by the system. A computerized implement is provided, to present feedback to the user, preferably, in a playful manner. The liquid-crystal eyeglass system may be used in the treatment of amblyopia, strabismus, and a weak eye, and may be integrated with sunglasses and (or) with glasses for corrective vision.

4. 发明申请

WO2009109900A1 STIMULATION OF OCULAR RETROBULBAR FLOW USING OCULAR IRRITANTS 审中-公开
标题翻译：使用眼科激光刺激OCARAR RETROBOLBAR流动
公开(公告)号：WO2009109900A1
公开(公告)日：2009-09-11
申请号：PCT/IB2009/050834
申请日：2009-03-02
申请人： PHARMALIGHT INC. , GROSS, Yossi , KOEVARY, Steve B.
发明人： GROSS, Yossi , KOEVARY, Steve B.
IPC分类号： A61K9/00 , A61K9/12 , A61K31/135 , A61K31/704
CPC分类号： A61K31/135 , A61K9/0048 , A61K9/12 , A61K31/704
摘要： Disclosed are uses of an ocular irritant such as saponin in stimulating the retrobulbar blood flow of an eye. Disclosed are also methods of treatment including administration of a pharmaceutical composition including an ocular irritant to an eye, for example as a mist, in order to stimulate the retrobulbar blood flow. In some embodiments, the stimulation of the retrobulbar blood flow has a beneficial effect.
摘要翻译：公开了刺激眼球后血流的眼刺激剂如皂角苷的用途。还公开了治疗方法，包括给予眼睛刺激眼睛的药物组合物，例如雾化，以刺激眼球后血液。在一些实施例中，眼球后血流的刺激具有有益效果。

5. 发明申请

WO2013035092A2 WIRELESS ENDOVASCULAR STENT-BASED ELECTRODES 审中-公开
标题翻译：无电极基底静脉电极
公开(公告)号：WO2013035092A2
公开(公告)日：2013-03-14
申请号：PCT/IL2012/000336
申请日：2012-09-09
申请人： ENOPACE BIOMEDICAL LTD. , DAGAN, Amir , ELAZAR, Moshe , HANANI, Nitai , ARIAV, Gal , MEIRI, Oded , GINDIN, Igor , BERNSHTEIN, Vadim , ARMONY, Nir , GROSS, Yossi , REISNER, Yotam , GLASBERG, Offer
发明人： DAGAN, Amir , ELAZAR, Moshe , HANANI, Nitai , ARIAV, Gal , MEIRI, Oded , GINDIN, Igor , BERNSHTEIN, Vadim , ARMONY, Nir , GROSS, Yossi , REISNER, Yotam , GLASBERG, Offer
CPC分类号： A61N1/40 , A61B5/0215 , A61B5/04 , A61B5/0402 , A61B5/0816 , A61F2/82 , A61F2/915 , A61F2002/8483 , A61F2002/91541 , A61F2002/91558 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , A61F2250/0002 , A61F2250/0018 , A61N1/05 , A61N1/0514 , A61N1/0558 , A61N1/056 , A61N1/057 , A61N1/36053 , A61N1/3756 , A61N2001/0585
摘要： Apparatus and methods are provided for use with a blood vessel of a subject, including a stent (20) configured to be placed in the blood vessel. The stent includes at least first (32), second (34), and third (36) strut portions disposed along the stent. The first and second strut portions are coupled to one another at a first junction (37A) that facilitates bending of the first and second strut portions with respect to one another. The second and third strut portions are coupled to one another at a second junction (37B) that facilitates bending of the second and third strut portions with respect to one another. At least one electrode (22) is disposed on at least an outer surface of the stent. Other applications are also described.
摘要翻译：提供了与被检体的血管一起使用的装置和方法，包括构造成放置在血管中的支架（20）。所述支架包括沿支架设置的至少第一（32），第二（34）和第三（36）支柱部分。第一和第二支柱部分在促进第一和第二支柱部分相对于彼此的弯曲的第一接合部（37A）处彼此联接。第二和第三支柱部分在促进第二和第三支柱部分相对于彼此的弯曲的第二接合部（37B）处彼此联接。至少一个电极（22）设置在支架的至少外表面上。还描述了其它应用。

6. 发明申请

WO2012073239A3 TECHNIQUES FOR USE WITH A NAIL PENETRATION DEVICE 审中-公开
公开(公告)号：WO2012073239A3
公开(公告)日：2012-06-07
申请号：PCT/IL2011/000916
申请日：2011-12-01
申请人： GROSS, Yossi , GELBER, Moshe , AMIT, Noah , ALON, Ruth
发明人： GROSS, Yossi , GELBER, Moshe , AMIT, Noah , ALON, Ruth
IPC分类号： A61M99/00
摘要： Apparatus and methods are described for generating a hole in a subject's nail. A nail penetration device (20) has a nail-contacting surface (26), a first electrode (29) being disposed on the surface. A skin-contact sensor unit (27) detects contact between the surface and the nail bed, the sensor unit including a pair of second electrodes (31) disposable on the subject's skin. A control unit (33) generates a hole in the subject's nail by moving the surface, while the surface is in contact with the nail. The control unit drives current having a given set of parameters via the first electrode, and detects a voltage between the second electrodes. The control unit does not move the surface, in response to detecting a change in the voltage between the second electrodes that is indicative of the current having travelled to the pair of second electrodes.

7. 发明申请

WO2011083456A1 ALVEOLAR RIDGE AUGMENTATION 审中-公开
标题翻译：爱尔兰骑士队
公开(公告)号：WO2011083456A1
公开(公告)日：2011-07-14
申请号：PCT/IL2010/000975
申请日：2010-11-22
申请人： RAINBOW MEDICAL LTD. , BETTER, Hadar , FOSTICK, Gideon , GROSS, Yossi
发明人： BETTER, Hadar , FOSTICK, Gideon , GROSS, Yossi
IPC分类号： A61B17/32
CPC分类号： A61C8/0006 , A61B17/24 , A61B17/32 , A61B17/3209 , A61B18/14 , A61B18/20 , A61B2017/0647 , A61B2017/0648 , A61B2017/3225 , A61B2018/144 , A61B2018/1467 , A61N7/02
摘要： Apparatus is provided for use with a gingival periosteum (230) lining a bone. The apparatus comprises a periosteal mesher (200), which comprises a mesher surface (210), and a plurality of cutting elements (212) distributed over the mesher surface (210), which are configured to cut the gingival periosteum (230) to increase flexibility thereof. Other embodiments are also described.
摘要翻译：设置用于与骨衬里的牙龈骨膜（230）一起使用。该装置包括骨膜网（200），其包括网状物表面（210）和分布在所述网状物表面（210）上的多个切割元件（212），其被配置为切割牙龈骨（230）以增加灵活性。还描述了其它实施例。

8. 发明申请

WO2010128503A2 DEPLOYMENT TECHNIQUES FOR ANNULOPLASTY RING AND OVER-WIRE ROTATION TOOL 审中-公开
标题翻译：用于静脉曲张和超线性旋转工具的部署技术
公开(公告)号：WO2010128503A2
公开(公告)日：2010-11-11
申请号：PCT/IL2010/000358
申请日：2010-05-04
申请人： VALTECH CARDIO, LTD. , ZIPORY, Yuval , CABIRI, Oz , GROSS, Yossi , HAMMER, Tal , GROSS, Amir , MAISANO, Francesco , MILLER, Eran , WEITZMAN, Yoseph , AYVAZIAN, Aram
发明人： ZIPORY, Yuval , CABIRI, Oz , GROSS, Yossi , HAMMER, Tal , GROSS, Amir , MAISANO, Francesco , MILLER, Eran , WEITZMAN, Yoseph , AYVAZIAN, Aram
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/068 , A61B17/072 , A61B2017/00243 , A61B2017/0409 , A61B2017/0414 , A61B2017/0441 , A61B2017/0443 , A61B2017/0464 , A61B2017/0496 , A61B2017/0647 , A61B2017/0648 , A61B2017/0649 , A61B2017/12095 , A61B2017/2923 , A61F2/2409 , A61F2/2412 , A61F2/2445 , A61F2/2451 , A61F2/2457 , A61F2/2466 , A61F2002/30537 , A61F2220/0016 , A61F2250/0004
摘要： Apparatus is provided including an implant structure (22, 500), which includes a contracting mechanism (40), which comprises a rotatable structure (46, 810, 936), arranged such that rotation of the rotatable structure (46, 810, 936) contracts the implant structure (22, 500). A longitudinal member (86) is coupled to the contracting mechanism (40). A tool (80) for rotating the rotatable structure (46, 810, 936) is configured to be guided along the longitudinal member (86), to engage the rotatable structure (46, 810, 936), and to rotate the rotatable structure (46, 810, 936) in response to a rotational force applied to the tool (80). Other applications are also described.
摘要翻译：提供了包括植入结构（22,500）的设备，其包括收缩机构（40），该收缩机构包括可旋转结构（46,810,936），其可旋转结构（46,810,936）收缩植入物结构（22,500）。纵向构件（86）联接到收缩机构（40）。用于旋转可旋转结构（46,810,936）的工具（80）被构造成沿着纵向构件（86）被引导以接合可旋转结构（46,810,936），并且使可旋转结构（ 46,810,936）响应于施加到工具（80）的旋转力。还描述了其它应用。

9. 发明申请

WO2010029556A1 A DEVICE FOR ULTRASOUND TREATMENT AND MONITORING TISSUE TREATMENT 审中-公开
标题翻译：一种用于超声治疗和监测组织治疗的装置
公开(公告)号：WO2010029556A1
公开(公告)日：2010-03-18
申请号：PCT/IL2009/000894
申请日：2009-09-13
申请人： SLENDER MEDICAL, LTD. , AZHARI, Haim , TSOREF, Liat , GROSS, Yossi , BENARIE, Jacob
发明人： AZHARI, Haim , TSOREF, Liat , GROSS, Yossi , BENARIE, Jacob
IPC分类号： A61B8/00 , A61H1/00
CPC分类号： A61B8/08 , A61B8/0825 , A61B18/18 , A61B18/20 , A61B2017/00084 , A61B2017/00106 , A61B2018/00011 , A61B2018/00642 , A61B2090/378 , A61H23/0245 , A61N7/02 , A61N2007/0008 , A61N2007/0039 , A61N2007/0056 , A61N2007/0065 , A61N2007/0078 , A61N2007/027
摘要： Apparatus is provided, including first and second support structures (30, 32) for placement on skin of a subject. At least one of the first and second structures (30, 32) is moveable with respect to the other so as to draw a portion (122) of the skin and underlying tissue of the subject between respective lateral surfaces (51, 53) of the support structures (30, 32). At least one ultrasound transducer (40) is moveably coupled to the first support structure (30) along an axis of the structure (30) that is not parallel to the lateral surface (51) of the structure (30). The ultrasound transducer (40) is configured to transmit toward the portion (122) of skin and underlying tissue one or more forms of acoustic radiation energy, including treatment energy. At least one acoustic element (42) is coupled to the second support structure (32). Other applications are also described.
摘要翻译：提供了包括用于放置在受试者皮肤上的第一和第二支撑结构（30,32）的装置。所述第一和第二结构（30,32）中的至少一个可相对于另一个结构（30,32）移动，以便在所述第一和第二结构（30,32）的相应的侧表面（51,53）之间绘制所述皮肤的部分（122）和所述对象的下方组织支撑结构（30,32）。至少一个超声换能器（40）沿着不平行于结构（30）的侧表面（51）的结构（30）的轴线可移动地联接到第一支撑结构（30）。超声换能器（40）被配置为向皮肤部分（122）和下面的组织传递一种或多种形式的声辐射能量，包括治疗能量。至少一个声学元件（42）联接到第二支撑结构（32）。还描述了其它应用。

10. 发明申请

WO2009095918A2 PERISTALTIC PUMP FOR TREATMENT OF ERECTILE DYSFUNCTION 审中-公开
标题翻译：用于治疗溃疡性功能障碍的尿液泵
公开(公告)号：WO2009095918A2
公开(公告)日：2009-08-06
申请号：PCT/IL2009/000115
申请日：2009-01-29
申请人： RAINBOW MEDICAL LTD. , GROSS, Yossi
发明人： GROSS, Yossi
IPC分类号： A61F5/00
CPC分类号： A61F2/26 , A61N1/0408 , A61N1/0476 , A61N1/0492 , A61N1/05 , A61N1/321 , A61N1/36007
摘要： In some embodiments of the present invention, apparatus is provided for treating erectile dysfunction of a subject. The apparatus includes one or more electrodes (22) configured to be coupled to a vicinity of a blood vessel (50) that carries blood into or out of a penis (52) of the subject, and a control unit (24) configured to facilitate erection of the penis by peristaltically pumping blood in the blood vessel by stimulating nitric oxide (NO) production in the vicinity, by driving the electrodes to drive a current into the vicinity. Additional embodiments are also described.
摘要翻译：在本发明的一些实施方案中，提供了用于治疗受试者勃起功能障碍的装置。该装置包括一个或多个电极（22），其被配置为耦合到携带血液进入或离开受试者的阴茎（52）的血管（50）附近;以及控制单元（24），其被配置为便于通过驱动电极驱动电流进入附近，通过刺激附近的一氧化氮（NO）生成，通过蠕动地抽血血液来竖立阴茎。还描述了另外的实施例。

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