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1. 发明申请

WO2006082588A3 METHOD AND DEVICE FOR OPHTHALMIC ADMINISTRATION OF ACTIVE PHARMACEUTICAL INGREDIENTS 审中-公开
标题翻译：用于活性药物成分的眼科管理的方法和装置
公开(公告)号：WO2006082588A3
公开(公告)日：2007-01-04
申请号：PCT/IL2006000145
申请日：2006-02-06
申请人： PHARMALIGHT INC , GROSS YOSSI , HERZOG RAFI , KOEVARY STEVEN B
发明人： GROSS YOSSI , HERZOG RAFI , KOEVARY STEVEN B
IPC分类号： B05B3/08
CPC分类号： A61K47/46 , A61K9/0048 , A61K9/12 , A61K31/138 , A61K31/165 , A61K31/192 , A61K31/222 , A61K31/382 , A61K31/4168 , A61K31/4178 , A61K31/433 , A61K31/4704 , A61K31/496 , A61K31/498 , A61K31/5377 , A61K31/542 , A61K31/5575 , A61K31/573 , A61K31/575 , A61K31/661 , A61K38/00 , A61K45/06
摘要： Disclosed is the use of a mist of a pharmaceutical composition for ophthalmic delivery of a protein or peptide active pharmaceutical ingredient, a related method of treatment and a device useful in implementing the use and method. Disclosed is also the use of a mist for ophthalmic delivery of a pharmaceutical composition including a highly irritating penetration enhancer and an ophthalmically acceptable carrier, a related method of treatment and a device useful in implementing the use and method. Disclosed is also a device for ophthalmic administration configured to direct a mist of a pharmaceutical composition to the eye only when the eye is open. Disclosed is also a self-sterlizing device for ophthalmic administration. Disclosed is also a device and a method for increasing the bioavailability of an ophthalmically administered API in a pharmaceutical composition.
摘要翻译：公开了使用药物组合物的雾用于蛋白质或肽活性药物成分的眼部递送，相关的治疗方法和用于实施使用和方法的装置。还公开了使用雾剂用于药物组合物的眼部递送，所述药物组合物包括高度刺激性的渗透增强剂和眼科可接受的载体，相关的治疗方法和可用于实施使用和方法的装置。还公开了一种用于眼用给药的装置，其仅在眼睛打开时将药物组合物的雾引导到眼睛。还公开了一种用于眼科给药的自动灭菌装置。还公开了一种用于增加药物组合物中眼用API的生物利用度的装置和方法。

2. 发明申请

WO2012029008A1 ORTHOPEDIC IMPLANT FOR TREATMENT OF BONE DEFORMITIES 审中-公开
标题翻译：用于治疗骨质疏松的手术植入物
公开(公告)号：WO2012029008A1
公开(公告)日：2012-03-08
申请号：PCT/IB2011/053763
申请日：2011-08-28
申请人： BONFIX LTD. , HERZOG, Rafi , BARKAI, Nir , SHAHAR, Mark , ROBINSON, Dror , SCHON, Lew
发明人： HERZOG, Rafi , BARKAI, Nir , SHAHAR, Mark , ROBINSON, Dror , SCHON, Lew
IPC分类号： A61B17/68
CPC分类号： A61B17/683 , A61B17/68 , A61B17/7291 , A61B17/842 , A61B17/844 , A61B2017/565 , A61B2017/681
摘要： An implantable device (20) includes a first anchor (22), configured to be implanted inside a first bone (24), and a second anchor (26), configured to be implanted inside a second bone (28), adjacent to the first bone. A cord (30) connects the first and second anchors. A shock absorber (42) contained within at least one of the first and second anchors is coupled to the cord so as to deform in response to a force exerted on the cord. The shock absorber may also include a force adjuster (48). The device may include an adjustment mechanism (44), which is operable, after implantation of the first and second anchors in the first and second bones, to adjust a length of the cord extending between the first and second anchors.
摘要翻译：可植入装置（20）包括构造成植入在第一骨骼（24）内的第一锚固件（22）和构造成植入第二骨骼（28）内部的第二锚固件（26），邻近第一骨。线（30）连接第一和第二锚。包含在第一和第二锚定件中的至少一个中的减震器（42）联接到绳索，以便响应于施加在绳索上的力而变形。减震器还可以包括力调节器（48）。该装置可以包括调节机构（44），其可以在将第一和第二锚固件植入第一和第二骨中之后调节在第一和第二锚定件之间延伸的绳索的长度。

3. 发明申请

WO2006082588A2 METHOD AND DEVICE FOR OPHTHALMIC ADMINISTRATION OF ACTIVE PHARMACEUTICAL INGREDIENTS 审中-公开
标题翻译：活性药物成分的眼科药物治疗方法和装置
公开(公告)号：WO2006082588A2
公开(公告)日：2006-08-10
申请号：PCT/IL2006/000145
申请日：2006-02-06
申请人： PHARMALIGHT INC. , GROSS, Yossi , HERZOG, Rafi , KOEVARY, Steven, B.
发明人： GROSS, Yossi , HERZOG, Rafi , KOEVARY, Steven, B.
IPC分类号： A61K9/00
CPC分类号： A61K47/46 , A61K9/0048 , A61K9/12 , A61K31/138 , A61K31/165 , A61K31/192 , A61K31/222 , A61K31/382 , A61K31/4168 , A61K31/4178 , A61K31/433 , A61K31/4704 , A61K31/496 , A61K31/498 , A61K31/5377 , A61K31/542 , A61K31/5575 , A61K31/573 , A61K31/575 , A61K31/661 , A61K38/00 , A61K45/06
摘要： ABSTRACT Disclosed is the use of a mist of a pharmaceutical composition for ophthalmic delivery of a protein or peptide active pharmaceutical ingredient, a related method of treatment and a device useful in implementing the use and method. Disclosed is also the use of a mist for ophthalmic delivery of a pharmaceutical composition including a highly irritating penetration enhancer and an ophthalmically acceptable carrier, a related method of treatment and a device useful in implementing the use and method. Disclosed is also a device for ophthalmic administration configured to direct a mist of a pharmaceutical composition to the eye only when the eye is open. Disclosed is also a self-sterlizing device for ophthalmic administration. Disclosed is also a device and a method for increasing the bioavailability of an ophthalmically administered API in a pharmaceutical composition.
摘要翻译：摘要公开了一种药物组合物雾用于蛋白质或肽活性药物成分的眼部递送，相关治疗方法和用于实施使用和方法的装置。还公开了使用雾剂用于药物组合物的眼科递送，所述药物组合物包括高度刺激性的渗透增强剂和眼科可接受的载体，相关的治疗方法和用于实施使用和方法的装置。还公开了一种用于眼部给药的装置，其被配置为仅在眼睛打开时将药物组合物的雾引导到眼睛。还公开了一种用于眼科给药的自动灭菌装置。还公开了一种用于增加药物组合物中眼用API的生物利用度的装置和方法。

4. 发明申请

WO2005043224A2 LIQUID-CRYSTAL EYEGLASS SYSTEM 审中-公开
标题翻译：液晶晶体系统
公开(公告)号：WO2005043224A2
公开(公告)日：2005-05-12
申请号：PCT/IL2004001008
申请日：2004-11-03
申请人： OPHTHOCARE LTD , HERZOG RAFI , BEN-EZRA OMRY , GROSS YOSSI
发明人： HERZOG RAFI , BEN-EZRA OMRY , GROSS YOSSI
IPC分类号： G02F20060101 , G02F1/1335 , G02F
CPC分类号： G02F1/133553 , G02B27/017 , G02B2027/014 , G02C7/101 , G02C7/104
摘要： An electronically controlled, liquid-crystal eyeglass system is provided, designed for intermittent occlusion, while exercising the eyes of a user, through combined occlusion-and-exercising sessions, wherein the eyeglass system includes features to improve and monitor compliance. Specifically, features to improve compliance include an ordinary eyeglass design, wherein the electronic components are miniaturized and hidden, and a reflective coating on the exterior surfaces of the lenses, for identical exterior appearance, even when the two lenses operate at different opacity levels. In this manner, the liquid-crystal eyeglass system does not attract attention. Additionally, a fashionable design, and possibly also, a fashionable designer's brand name may be employed. In order to monitor compliance, the times, dates, and durations of the occlusion-and-exercising sessions that took place are recorded by the system. A computerized implement is provided, to present feedback to the user, preferably, in a playful manner. The liquid-crystal eyeglass system may be used in the treatment of amblyopia, strabismus, and a weak eye, and may be integrated with sunglasses and (or) with glasses for corrective vision.
摘要翻译：提供了一种电子控制的液晶眼镜系统，其设计用于通过组合的闭合和运动会话而对使用者的眼睛进行间歇闭塞，其中眼镜系统包括改善和监视顺应性的特征。具体地，即使在两个透镜在不同的不透明度水平下操作时，具有改善柔顺性的特征也包括普通的眼镜设计，其中电子部件被小型化和隐藏，并且在透镜的外表面上具有相同外观的反射涂层。以这种方式，液晶眼镜系统不引起注意。此外，可以采用时尚的设计，也可能采用时尚的设计师的品牌名称。为了监测合规性，发生的闭塞和锻炼会话的时间，日期和持续时间由系统记录。提供了一种计算机化的工具，以优选地以俏皮的方式向用户呈现反馈。液晶眼镜系统可用于治疗弱视，斜视和弱眼，并可与太阳镜和（或）与眼镜结合以进行矫正视力。

5. 发明申请

WO2005043224A3 LIQUID-CRYSTAL EYEGLASS SYSTEM 审中-公开
公开(公告)号：WO2005043224A3
公开(公告)日：2005-05-12
申请号：PCT/IL2004/001008
申请日：2004-11-03
申请人： OPHTHOCARE LTD , HERZOG, Rafi , BEN-EZRA, Omry , GROSS, Yossi
发明人： HERZOG, Rafi , BEN-EZRA, Omry , GROSS, Yossi
IPC分类号： G02F1/1335
摘要： An electronically controlled, liquid-crystal eyeglass system is provided, designed for intermittent occlusion, while exercising the eyes of a user, through combined occlusion-and-exercising sessions, wherein the eyeglass system includes features to improve and monitor compliance. Specifically, features to improve compliance include an ordinary eyeglass design, wherein the electronic components are miniaturized and hidden, and a reflective coating on the exterior surfaces of the lenses, for identical exterior appearance, even when the two lenses operate at different opacity levels. In this manner, the liquid-crystal eyeglass system does not attract attention. Additionally, a fashionable design, and possibly also, a fashionable designer's brand name may be employed. In order to monitor compliance, the times, dates, and durations of the occlusion-and-exercising sessions that took place are recorded by the system. A computerized implement is provided, to present feedback to the user, preferably, in a playful manner. The liquid-crystal eyeglass system may be used in the treatment of amblyopia, strabismus, and a weak eye, and may be integrated with sunglasses and (or) with glasses for corrective vision.

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