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1. 发明申请

WO2018200479A1 TISSUE FIXATION SYSTEMS 审中-公开
公开(公告)号：WO2018200479A1
公开(公告)日：2018-11-01
申请号：PCT/US2018/029080
申请日：2018-04-24
申请人： MELSHEIMER, Jeffry , LENTS, Gordon
发明人： MELSHEIMER, Jeffry , LENTS, Gordon
IPC分类号： A61B17/04 , A61B17/24
CPC分类号： A61F2/20 , A61B17/04 , A61B17/24 , A61B2017/044 , A61F2220/0016 , A61F2240/001 , A61F2250/0067
摘要： Tissue fixation systems and associated methods and kits are described herein. An example embodiment of a tissue fixation system includes a locking screw and a tissue manipulator. The locking screw has a locking screw lengthwise axis and a locking screw main body that defines a locking screw exterior thread that extends in a first direction around the locking screw lengthwise axis and a locking screw interior thread that extends in a second direction around the locking screw lengthwise axis that is the same as the first direction. The tissue manipulator has a tissue manipulator lengthwise axis, a shaft, and a coil. The shaft has a shaft main body that defines a shaft exterior thread that extends in a third direction around the tissue manipulator lengthwise axis that is the same as the first direction. The coil extends from the shaft in a fourth direction around the tissue manipulator lengthwise axis that is different than the first direction.

2. 发明申请

WO2018160790A1 TRANSCATHETER MITRAL VALVE DESIGN 审中-公开
公开(公告)号：WO2018160790A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/020370
申请日：2018-03-01
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： MOORE, Brandon L.
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/2454 , A61F2/2457 , A61F2220/0016 , A61F2230/0008 , A61F2230/0013 , A61F2230/0023 , A61F2230/0054 , A61F2250/0037 , A61F2250/0063
摘要： A prosthetic mitral valve (200) includes a collapsible and expandable stent (250) extending from an inflow end (210) to an outflow end (212). A collapsible and expandable valve assembly is disposed within the stent. The valve assembly includes a plurality of anterior leaflets (238a-c) and one posterior leaflet (236). The posterior leaflet has a larger surface area than any of the anterior leaflets. When implanted in the native mitral valve annulus, the smaller size of the anterior leaflets and the corresponding smaller size of an anterior portion of the stent (228) reduce the likelihood of interference with blood flowing through the native aortic valve (140), while also reducing the likelihood of ventricular fibrillation.

3. 发明申请

WO2018077145A1 一种自适应的心脏瓣膜假体审中-公开
公开(公告)号：WO2018077145A1
公开(公告)日：2018-05-03
申请号：PCT/CN2017/107382
申请日：2017-10-23
申请人：宁波健世生物科技有限公司
发明人：徐志云 , 陆方林 , 李毅斌 , 陈志 , 李佳楠
IPC分类号： A61F2/24
CPC分类号： A61F2/24 , A61F2/2409 , A61F2220/0016 , A61F2220/0025
摘要：一种自适应的心脏瓣膜假体（100，200，300，400，500），包括支架（110，210，310）和人工瓣膜（120，520），支架包括防漏环（111，211，311，411，511）和瓣膜缝制段（112，212，312，412，512，612），防漏环（111，211，311，411，511）与瓣膜缝制段（112，212，312，412，512，612）相连，人工瓣膜（120，520）被固定连接在瓣膜缝制段（112，212，312，412，512，612）上，瓣膜缝制段（112，212，312，412，512，612）至少部分位于患者自体瓣叶之间，在垂直于人工瓣膜（120，520）中轴线的横截面上，瓣膜缝制段（112，212，312，412，512，612）的横截面积小于患者自体瓣膜瓣环的横截面积，使得瓣膜缝制段（112，212，312，412，512，612）不会直接径向扩张患者自体瓣膜瓣环，在自由状态下，防漏环（111，211，311，411，511）的横截面积大于患者自体瓣膜瓣环的横截面积，防漏环（111，211，311，411，511）能够顺应心房腔壁或患者自身瓣膜瓣环的不均匀轮廓。

4. 发明申请

WO2018022416A1 MESH POSITIONING SYSTEM FOR LAPAROSCOPIC VENTRAL HERNIA REPAIR 审中-公开
标题翻译：腹腔镜胃肠道修复的网格定位系统
公开(公告)号：WO2018022416A1
公开(公告)日：2018-02-01
申请号：PCT/US2017/043040
申请日：2017-07-20
申请人： ETHICON, INC.
发明人： GUO, Jianxin , COHN, Simon , CARDINALE, Michael , SOULS, Doug
IPC分类号： A61F2/00
CPC分类号： A61F2/0063 , A61B1/313 , A61B17/06004 , A61B2017/00951 , A61F2002/0072 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/0058 , A61F2250/0059
摘要： Mesh implant positioning systems for use in laparoscopic body wall defect repairs, such as hernia defects, are disclosed. The systems utilize one or more bar members combined with surgical sutures and needles to position a mesh implant adjacent to a body wall defect without the need for stay sutures. Also disclosed are assemblies of the positioning systems with surgical mesh repair implants, and methods of repairing body wall defects such as hernias with the assemblies.
摘要翻译：公开了用于腹腔镜体壁缺陷修复例如疝缺陷的网状植入物定位系统。该系统利用与手术缝合线和针结合的一个或多个杆构件将网状植入物定位在体壁缺陷附近而不需要留置缝合线。还公开了具有外科手术网修复植入物的定位系统的组件，以及用该组件修复诸如疝气之类的体壁缺陷的方法。

5. 发明申请

WO2017117560A1 MITRAL LEAFLET TETHERING 审中-公开
公开(公告)号：WO2017117560A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/069567
申请日：2016-12-30
申请人： PIPELINE MEDICAL TECHNOLOGIES, INC.
发明人： BOLLING, Steven, F. , LASHINSKI, Randall, T.
IPC分类号： A61F2/24 , A61F2/00 , A61B17/04
CPC分类号： A61B17/04 , A61F2/2457 , A61F2/2466 , A61F2220/0016 , A61F2230/0091
摘要： This disclosure includes apparatuses and techniques to access the right ventricle via trans-femoral vein threading a catheter or catheters to the apex or bottom of the right ventricle. Piercing through the venous or right side of the heart in the interventricular septal wall to access the left ventricle a catheter can be passed to turn upward pointing to the mitral valve. From this access point in the left ventricle the flail mitral leaflet can be sutured and tethered pulling it back into position and reattached with a grounding anchor in the right ventricle or imbedding the anchor into the septal wall. The interventricular septal wall crossing technique could include the passing of a coaxial catheter through the first access catheter where the first access catheter could guide to direct the internal or second coaxial catheter toward the flail mitral leaflet.
摘要翻译：本公开包括经由穿过一个或多个导管至右心室的顶点或底部的股静脉来进入右心室的装置和技术。通过室间隔壁的静脉或心脏右侧进入左心室，可以通过导管向上转动，指向二尖瓣。从左心室的这个进入点，可以缝合拴系二尖瓣小叶并将其拉回到位，并用右心室中的接地锚再次附接或将锚插入隔膜壁中。室间隔壁横穿技术可以包括使同轴导管通过第一进入导管，其中第一进入导管可以引导将内部或第二同轴导管朝向肱二尖瓣小叶引导。

6. 发明申请

WO2017087424A1 IMPLANTABLE DEVICE AND DELIVERY SYSTEM FOR RESHAPING A HEART VALVE ANNULUS 审中-公开
标题翻译：用于重置心瓣膜环的可植入装置和输送系统
公开(公告)号：WO2017087424A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062107
申请日：2016-11-15
申请人： MILLIPEDE, INC.
发明人： LASHINSKI, Randall , KRISTOFFERSEN, Kristian , RUST, Matthew , GLENN, Richard , DANIELS, Terry, Wayne , LEE, Michael , MACAULAY, Patrick
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61B17/064 , A61B2017/0647 , A61B2017/0649 , A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2/2466 , A61F2220/0016 , A61F2250/001
摘要： Systems, devices and methods related to various heart valve implants and for delivery of those heart valve implants are described. The implants may be used to re-size a native valve annulus or to replace a native heart valve. The implants include a re-sizable frame having angled struts. Anchors secure the implant to tissue and collars are used to decrease the angle between the struts and contract the frame. The implant thus expands from a first size inside of a delivery catheter, to a second and larger deployed size inside the heart to engage and anchor with the tissue, and then to a third and contracted size to re-size the annulus and/or provide a secure fit for a replacement heart valve. Various delivery systems including imaging capabilities for precise delivery, positioning and anchoring of the various implants are further described.
摘要翻译：描述了与各种心脏瓣膜植入物有关并用于输送那些心脏瓣膜植入物的系统，装置和方法。植入物可用于重新调整天然瓣膜环的尺寸或替换天然心脏瓣膜。植入物包括具有成角度支柱的可调整尺寸的框架。锚固件将植入物固定到组织上，并使用套环来减小支柱之间的角度并收缩框架。因此，植入物从输送导管内部的第一尺寸扩张到心脏内的第二和更大的展开尺寸，以与组织接合并锚定，然后扩张到第三和收缩尺寸以重新调整瓣环尺寸和/或提供安全适合更换心脏瓣膜。进一步描述了各种输送系统，包括用于精确输送，定位和锚定各种植入物的成像能力。

7. 发明申请

WO2017062548A2 LEAFLET SUPPORT DEVICES AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译： LEAFLET支持装置及其制造和使用方法
公开(公告)号：WO2017062548A2
公开(公告)日：2017-04-13
申请号：PCT/US2016/055644
申请日：2016-10-06
申请人： W. L. GORE & ASSOCIATES, INC
发明人： BRUCHMAN, William, C.
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2403 , A61F2/2442 , A61F2/2454 , A61F2/2463 , A61F2220/0008 , A61F2220/0016 , A61F2240/001 , A61F2250/0018 , A61F2250/0039 , A61L27/14 , A61L27/16 , A61L27/40 , C08L27/12
摘要： Described embodiments are directed toward centrally-opening leaflet support devices having a frame and one or more support leaflets coupled to the frame forming a hinge where coupled. The described support leaflets have one or more stiffer regions that facilitate the function of a support leaflet to decrease or prevent prolapse of a native valve leaflet. Methods of making and using such valve devices are also described amongst others.
摘要翻译：所描述的实施例涉及具有框架的中心开启的小叶支撑装置，以及耦合到框架的一个或多个支撑小叶形成联接的铰链。所描述的支撑小叶具有一个或多个较硬的区域，其便于支撑小叶的功能以减少或防止天然瓣膜的脱垂。还描述了制造和使用这种阀装置的方法。

8. 发明申请

WO2017035434A1 PROSTHETIC VALVE SYSTEM HAVING A DOCKING COMPONENT AND A PROSTHETIC VALVE COMPONENT 审中-公开
标题翻译：具有锁定部件和前置阀部件的前置阀系统
公开(公告)号：WO2017035434A1
公开(公告)日：2017-03-02
申请号：PCT/US2016/048880
申请日：2016-08-26
申请人： MEDTRONIC VASCULAR INC.
发明人： HAREWOOD, Frank
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/07 , A61F2/2412 , A61F2/2418 , A61F2220/0016 , A61F2250/0063
摘要： A two-component valve prosthesis system (100) includes a docking component (102) and a prosthetic valve component (104) that is configured to be delivered separately from the docking component. The docking component has a compressed configuration for percutaneous delivery within a vasculature and an expanded configuration for deployment within a native heart valve. The docking component includes a tubular skirt, a first annular scaffold attached to a first end of the tubular skirt and a second annular scaffold attached to a second end of the tubular skirt. The first and second annular scaffolds are independent from each other. An intermediate portion of the tubular skirt is unsupported such that neither of the first or second annular scaffolds surrounds the intermediate portion of the tubular skirt. The prosthetic valve component has a compressed configuration for percutaneous delivery within a vasculature and an expanded configuration for deployment within the intermediate portion of the docking component.
摘要翻译：双组分阀门假体系统（100）包括对接部件（102）和被配置为与对接部件分离地递送的假体阀部件（104）。对接组件具有压缩配置，用于脉管系统内的经皮输送和用于部署在天然心脏瓣膜内的扩展配置。对接部件包括管状裙部，附接到管状裙部的第一端的第一环形支架和连接到管状裙部的第二端的第二环形支架。第一和第二环形支架彼此独立。管状裙部的中间部分是不支撑的，使得第一或第二环形支架都不包围管状裙部的中间部分。假体瓣膜部件具有用于脉管系统内的经皮输送的压缩构型和用于展开在对接部件的中间部分内的扩展构型。

9. 发明申请

WO2016201024A1 HEART VALVE REPAIR AND REPLACEMENT 审中-公开
标题翻译：心瓣膜修复和更换
公开(公告)号：WO2016201024A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/036560
申请日：2016-06-09
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.
发明人： BRAIDO, Peter N. , FAHIM, Mina S. , BENSON, Thomas M. , DALE, Theodore P. , PARA, Andrea N. , KRANZ, Mark , GLIMSDALE, Mathias C.
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2469 , A61F2220/0008 , A61F2220/0016 , A61F2230/0006 , A61F2230/0069
摘要： A prosthetic heart valve having an inflow end and an outflow end includes a collapsible and expandable stent having a plurality of commissure features, a plurality of first struts and a plurality of second struts. The plurality of first struts define a substantially cylindrical portion and the plurality of second struts have first ends attached to the cylindrical portion and free ends projecting radially outward from the cylindrical portion and configured to couple to adjacent heart tissue to anchor the stent. A collapsible and expandable valve assembly disposed within the stent has a plurality of leaflets coupled to the commissure features.
摘要翻译：具有流入端和流出端的假体心脏瓣膜包括具有多个连合特征的多个第一支柱和多个第二支柱的可收缩且可扩张的支架。多个第一支柱限定基本上圆柱形的部分，并且多个第二支柱具有附接到圆柱形部分的第一端部和从圆柱形部分径向向外突出的自由端并且构造成联接到相邻的心脏组织以锚定支架。设置在支架内的可折叠和可膨胀的阀组件具有耦合到连合件特征的多个传单。

10. 发明申请

WO2016161135A1 IMPROVED TISSUE FIXATION DEVICES 审中-公开
标题翻译：改进的组织固定装置
公开(公告)号：WO2016161135A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/025305
申请日：2016-03-31
申请人： ABBOTT CARDIOVASCULAR SYSTEMS, INC.
发明人： WEI, Michael F.
IPC分类号： A61B17/122
CPC分类号： A61F2/2454 , A61B17/083 , A61B17/122 , A61B17/1227 , A61B2017/00243 , A61B2017/00526 , A61B2017/00867 , A61B2017/00964 , A61B2017/081 , A61F2/246 , A61F2220/0016
摘要： The present disclosure describes tissue gripping devices, systems, and methods for gripping mitral valve tissue during treatment of a mitral valve and while a tissue fixation device is implanted in the mitral valve. The tissue gripping device includes a flexible member and one or more tissue gripping members coupled to one or more arms of the flexible member. The flexible member is formed from a shape-memory material, such as nitinol, and the tissue gripping member(s) are formed from a material that is more rigid than the shape-memory material. The tissue gripping member(s) are attached to the flexible member by threading or looping suture lines around and/or through the tissue gripping member(s) and the flexible member and/or by applying a cover material to the tissue gripping device to hold the tissue gripping member(s) against the flexible member.
摘要翻译：本公开描述了在治疗二尖瓣期间以及组织固定装置植入二尖瓣中时用于夹持二尖瓣组织的组织夹持装置，系统和方法。组织夹持装置包括柔性构件和联接到柔性构件的一个或多个臂的一个或多个组织夹持构件。柔性构件由诸如镍钛诺的形状记忆材料形成，并且组织夹持构件由比形状记忆材料更刚性的材料形成。组织夹持构件通过将组合夹持构件和柔性构件周围和/或穿过组合夹持构件和/或通过将覆盖材料施加到组织夹持装置以将其保持组织夹持构件抵靠柔性构件。

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