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1. 发明申请

WO2008091515A3 STENTED HEART VALVE DEVICES AND METHODS FOR ATRIOVENTRICULAR VALVE REPLACEMENT 审中-公开
标题翻译：心轴瓣阀装置和用于心房瓣膜置换的方法
公开(公告)号：WO2008091515A3
公开(公告)日：2008-10-09
申请号：PCT/US2008000585
申请日：2008-01-17
申请人： MEDTRONIC INC , LASKE TIMOTHY G , HILL ALEXANDER JOHN , RYAN TIMOTHY R , MESANA THIERRY GEORGES , TOWER ALLEN J
发明人： LASKE TIMOTHY G , HILL ALEXANDER JOHN , RYAN TIMOTHY R , MESANA THIERRY GEORGES , TOWER ALLEN J
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2418 , A61F2/2433 , A61F2/82 , A61F2/852 , A61F2/958 , A61F2002/065 , A61F2002/8486 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2230/0008 , A61F2230/001 , A61F2230/0017 , A61F2230/005 , A61F2230/0054 , A61F2250/0018 , A61F2250/0036 , A61F2250/0037 , A61F2250/0039 , A61F2250/0064 , A61F2250/0069
摘要： A compressible and expandable stent assembly for implantation in a body lumen such as a mitral valve, the stent assembly including at least one stent barrel that is shaped and sized so that it allows for normal operation of adjacent heart structures. One or more stent barrels can be included in the stent assembly, where one or more of the stent barrels can include a cylinder with a tapered edge.
摘要翻译：一种用于植入诸如二尖瓣的体腔中的可压缩和可扩张支架组件，所述支架组件包括至少一个支架筒，所述支架筒的形状和尺寸设计成使得其允许相邻心脏结构的正常操作。一个或多个支架筒可以被包括在支架组件中，其中一个或多个支架筒可以包括具有锥形边缘的圆筒。

2. 发明申请

WO0027469A3 EXTRACTABLE IMPLANTABLE MEDICAL LEAD 审中-公开
标题翻译：可提取的可植入医疗领域
公开(公告)号：WO0027469A3
公开(公告)日：2000-08-31
申请号：PCT/US9926111
申请日：1999-11-04
申请人： MEDTRONIC INC , SHOBERG BRET R , PADGETT CLARE E , LASKE TIMOTHY G , WALDHAUSER STEVEN L , STEWART MARK T , TAYLOR CATHERINE E , KEENEY KENNETH W , MARSHALL MARK T
发明人： SHOBERG BRET R , PADGETT CLARE E , LASKE TIMOTHY G , WALDHAUSER STEVEN L , STEWART MARK T , TAYLOR CATHERINE E , KEENEY KENNETH W , MARSHALL MARK T
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0563
摘要： A medical electrical lead provided with a generally isodiametric lead body. The lead body includes a first elongated plastic tube and an elongated conductor mounted in the first plastic tube. A first coil electrode is mounted exterior to and around the outer surface of the first tube and is coupled to the conductor. A second elongated plastic tube having an outer diameter approximately equal to the outer diameter of the first coil electrode, is mounted exterior to and around the outer surface of the first tube adjacent the first coil electrode and extends proximally therefrom. A second coil electrode having an outer diameter approximately equal to the outer diameter of the first coil electrode may be mounted exterior to and around the first tube proximal to the first coil electrode such that the second elongated plastic tube extends to a point adjacent the second coil electrode. A third elongated plastic tube having an outer diameter approximately equal to the outer diameter of the second coil electrode may be mounted exterior to the first tube adjacent the second coil electrode and extending proximally therefrom. In a preferred embodiment, the first tube is an extruded multi-lumen tube.
摘要翻译：一个医用电线，带有一个大致等面积的铅体。引线体包括第一细长塑料管和安装在第一塑料管中的细长导体。第一线圈电极安装在第一管的外表面之外并且围绕第一管的外表面并且连接到导体。具有大致等于第一线圈电极的外径的外径的第二细长塑料管被安装在与第一线圈电极相邻并在其周围的第一管的外表面的外部和周围，并从其向近侧延伸。具有大致等于第一线圈电极的外径的外径的第二线圈电极可以安装在靠近第一线圈电极的第一管的外部和周围，使得第二细长塑料管延伸到与第二线圈相邻的点电极。具有大致等于第二线圈电极的外径的外径的第三细长塑料管可以安装在邻近第二线圈电极的第一管的外部并且从其向近侧延伸。在优选实施例中，第一管是挤出的多腔管。

3. 发明申请

WO2010123734A3 SYSTEM AND METHOD FOR CLOSURE OF AN INTERNAL OPENING IN TISSUE, SUCH AS A TRANS-APICAL ACCESS OPENING 审中-公开
标题翻译：用于关闭组织内部开放的系统和方法，例如转接开关
公开(公告)号：WO2010123734A3
公开(公告)日：2011-01-27
申请号：PCT/US2010031074
申请日：2010-04-14
申请人： MEDTRONIC INC , AHLBERG SARAH , SIMMA SARA , ROTHSTEIN PAUL T , CLEMENTS MARTIN , JELICH DAMIAN , LASKE TIMOTHY G , CLAGUE CYNTHIA , GREEN MICHAEL , IAIZZO PAUL
发明人： AHLBERG SARAH , SIMMA SARA , ROTHSTEIN PAUL T , CLEMENTS MARTIN , JELICH DAMIAN , LASKE TIMOTHY G , CLAGUE CYNTHIA , GREEN MICHAEL , IAIZZO PAUL
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B2017/00243 , A61B2017/00663 , A61B2017/00867 , A61B2017/0441 , A61B2017/0443 , A61B2017/0464 , A61B2017/1142
摘要： A method for closing an opening at a target site including bodily tissue including embedding a plurality of self-closing clips (30) into the target site in a spaced apart manner about a perimeter of the opening. Each of the clips has opposing clip ends (56,58) and an intermediate segment (50). A flexible tether (24) is coupled to the embedded clips to form a loop about the opening perimeter. A pulling force is applied onto at least one of the loop ends, thereby drawing the perimeter of the opening onto itself to completely close the opening. The loop ends are secured to maintain the target site in a closed state. In some embodiments, the target site is apical cardiac tissue, and the method is performed as part of a trans-apical access procedure.
摘要翻译：一种用于在包括身体组织的目标位置处关闭开口的方法，包括围绕开口的周边以间隔开的方式将多个自闭合夹子（30）嵌入到目标部位中。每个夹具具有相对的夹端（56,58）和中间段（50）。柔性系绳（24）联接到嵌入的夹子以形成围绕开口周界的环。将拉力施加到至少一个环端，从而将开口的周边拉到其上以完全关闭开口。环路端部被固定以将目标部位保持在关闭状态。在一些实施方案中，靶位点是心尖心脏组织，并且该方法作为跨顶部进入程序的一部分进行。

4. 发明申请

WO2005048864A3 CLINICAL TOOL FOR STRUCTURE LOCALIZATION 审中-公开
标题翻译：临床工具结构局部化
公开(公告)号：WO2005048864A3
公开(公告)日：2005-12-29
申请号：PCT/US2004037895
申请日：2004-11-12
申请人： MEDTRONIC INC , LAHM RYAN P , BAXTER WALTON W III , MORISSETTE JOSEE , LASKE TIMOTHY G
发明人： LAHM RYAN P , BAXTER WALTON W III , LASKE TIMOTHY G
IPC分类号： A61B5/05 , A61B5/06 , G06F19/00
CPC分类号： A61B5/06 , A61B5/065 , A61B5/7285
摘要： A method for localizing an internal body structure during an image-guided procedure that includes obtaining a three dimensional image of a body portion containing a targeted structure and selected reference structures; determining a set of landmark point coordinates for defining the location of each of the targeted and reference structures; computing triangulation parameters relating the location of the landmark points for the targeted structure and the reference structures; and, during an image-guided procedure, using the computed triangulation parameters to plot an estimated location of the targeted structure on an intra-operative image in which the reference structures have been identified.
摘要翻译：一种用于在图像引导过程期间定位内部身体结构的方法，该方法包括：获得包含目标结构和选择的参考结构的身体部分的三维图像; 确定用于定义每个目标和参考结构的位置的一组地标点坐标; 计算与目标结构和参考结构的界标点的位置相关的三角测量参数; 并且在图像引导过程期间，使用所计算的三角测量参数来绘制目标结构在其中参考结构已被识别的术中图像上的估计位置。

5. 发明申请

WO2004103458A2 VARIABLE EGM FILTERING AND LEAD FIXATION PREDICTION 审中-公开
标题翻译：可变的股票过滤和铅固定预测
公开(公告)号：WO2004103458A2
公开(公告)日：2004-12-02
申请号：PCT/US2004015061
申请日：2004-05-13
申请人： MEDTRONIC INC , AHERN THOMAS S , LASKE TIMOTHY G
发明人： AHERN THOMAS S , LASKE TIMOTHY G
IPC分类号： A61N1/08 , A61N
CPC分类号： A61N1/08 , A61N2001/083
摘要： An IMD includes a variable sense amplifier that can be adjusted to counteract the variability created in EGM's due to lead maturation. The effects of lead maturation are either predictively assumed or individually assessed on a given patient. The sense amplifier is then adjusted to assure positive identification of desired events and eliminate unwanted events.
摘要翻译： IMD包括可调节的可变感测放大器，以抵消由于铅成熟引起的EGM中产生的变异性。铅成熟的影响可以在给定的患者中被预测地假定或单独评估。然后调整读出放大器以确保所需事件的正确识别并消除不需要的事件。

6. 发明申请

WO2008073577A2 ELECTRONIC AND BIOLOGICAL PACEMAKER SYSTEMS 审中-公开
标题翻译：电子和生物PACEMAKER系统
公开(公告)号：WO2008073577A2
公开(公告)日：2008-06-19
申请号：PCT/US2007082089
申请日：2007-10-22
申请人： MEDTRONIC INC , SIGG DANIEL C , LASKE TIMOTHY G , SHARMA VINROD , SOYKAN ORHAN
发明人： SIGG DANIEL C , LASKE TIMOTHY G , SHARMA VINROD , SOYKAN ORHAN
IPC分类号： A61N1/362
CPC分类号： A61N1/362 , A61N1/3627
摘要： Heart pacing systems include at least one electronic or biological pacemaker as a primary pacemaker, and at least one electronic or biological pacemaker as a backup pacemaker. When implanted, the primary pacemaker(s) produce primary pacing stimuli that modulate cardiac function. The backup pacemaker(s) provide backup pacing stimuli when the electronic pacemaker is unable to modulate cardiac function at the predetermined pacing rate. The heart pacing systems are implemented by implantation in regions where they can provide pacing stimuli to cardiac tissue.
摘要翻译：心脏起搏系统包括至少一个电子或生物起搏器作为主要起搏器，以及至少一个电子或生物起搏器作为备用起搏器。当植入时，主要起搏器产生调节心脏功能的主要起搏刺激。当电子起搏器不能以预定起搏速率调节心脏功能时，备用起搏器提供备用起搏刺激。心脏起搏系统通过植入可以为心脏组织提供起搏刺激的区域来实现。

7. 发明申请

WO2008043099A2 HYBRID PACING SYSTEM 审中-公开
标题翻译：混合起飞系统
公开(公告)号：WO2008043099A2
公开(公告)日：2008-04-10
申请号：PCT/US2007080718
申请日：2007-10-08
申请人： MEDTRONIC INC , SOYKAN ORHAN , SIGG DANIEL C , LASKE TIMOTHY G
发明人： SOYKAN ORHAN , SIGG DANIEL C , LASKE TIMOTHY G
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A hybrid pacing system includes an implanted biological pacemaker and an implantable medical device providing pacing stimuli to one or more chambers of the heart. The IMD senses activity produced by the biological pacemaker, and coordinates the pacing stimuli provided by the IMD with the pacing delivered by the biological pacemaker.
摘要翻译：混合起搏系统包括植入式生物起搏器和向心脏的一个或多个腔室提供起搏刺激的可植入医疗装置。 IMD感测由生物起搏器产生的活动，并协调由IMD提供的起搏刺激与由生物起搏器递送的起搏。

8. 发明申请

WO2004028613A3 METHOD AND APPARATUS FOR PROVIDING INTRA-PERICARDIAL ACCESS 审中-公开
标题翻译：用于提供局部心脏接入的方法和设备
公开(公告)号：WO2004028613A3
公开(公告)日：2004-07-29
申请号：PCT/US0330416
申请日：2003-09-25
申请人： MEDTRONIC INC
发明人： BONNER MATTHEW D , LASKE TIMOTHY G
IPC分类号： A61B17/00 , A61B17/22 , A61B17/34 , A61B18/14 , A61M25/04 , A61N1/05
CPC分类号： A61B17/3478 , A61B17/3417 , A61B18/1492 , A61B2017/00247 , A61B2017/22077 , A61B2017/3443 , A61B2017/3484 , A61B2017/3488 , A61B2017/349 , A61B2018/00291 , A61B2018/00357 , A61B2018/00392
摘要： A method and apparatus for accessing the pericardial space is provided for stable short term or long term placement of a delivery catheter or cannula having its distal-most end fixed on the endocardial surface such that a pericardial access device including a dilator and a puncturing device may be advanced through the myocardium into the pericardial space. The catheter is provided with a distal fixation member that maintains the catheter position over the myocardial hole created by the access device allowing various medical instruments to be passed through the hole into the pericardial space. Alternatively, the catheter may be positioned against the septal wall to access a left heart chamber via a right heart chamber.
摘要翻译：提供了一种用于进入心包空间的方法和设备，用于将其最远端固定在心内膜表面上的输送导管或套管的稳定的短期或长期放置，使得包括扩张器和穿刺装置的心包进入装置可以通过心肌进入心包空间。导管设置有远侧固定构件，该远侧固定构件将导管位置保持在由进入装置产生的心肌孔上，从而允许各种医疗器械穿过孔进入心包空间。或者，导管可以靠着隔膜壁定位以经右心室进入左心室。

9. 发明申请

WO02064040A9 IMPROVED SYSTEM AND METHOD FOR PLACING AN IMPLANTABLE MEDICAL DEVICE WITHIN A BODY 审中-公开
标题翻译：用于在身体中放置可植入医疗装置的改进的系统和方法
公开(公告)号：WO02064040A9
公开(公告)日：2002-11-28
申请号：PCT/US0204013
申请日：2002-02-11
申请人： MEDTRONIC INC
发明人： IAIZZO PAUL A , LASKE TIMOTHY G , LIPSON DAVID , SOMMER JOHN L , FRANKE LINDA , STOKES KENNETH B
IPC分类号： A61B5/0215 , A61B5/029 , A61B5/042 , A61N1/05 , A61B17/00
CPC分类号： A61B5/0215 , A61B5/029 , A61B5/042 , A61N2001/0578
摘要： A system and method for positioning an implantable medical device (IMD) within a living body is disclosed. The IMD includes a flow-directed member that is deployed within the body to carry the IMD via the flow of blood. The flow-directed member may be an inflatable member such as a balloon, or a mechanical member such as a parachute structure that deploys within the body. The IMD further includes a pressure measuring device and a pressure monitor to obtain pressure measurement at one or more locations within the body adjacent the IMD. The pressure measurements are used to estimate the location of at least a portion of the IMD relative to the body to aid in positioning the IMD in the body without the use of a fluoro-visible media.
摘要翻译：公开了一种用于将可植入医疗装置（IMD）定位在生物体内的系统和方法。 IMD包括部署在身体内的流动导向的构件，以通过血流携带IMD。流动导向构件可以是可膨胀构件，例如球囊，或者在体内部署的诸如降落伞结构的机械构件。 IMD还包括压力测量装置和压力监测器，用于在与IMD相邻的身体内的一个或多个位置处获得压力测量值。压力测量用于估计IMD相对于身体的至少一部分的位置，以帮助将IMD定位在身体中而不使用荧光可见介质。

10. 发明申请

WO0224063A3 IMPROVED SYSTEM AND METHOD FOR DETERMINING TISSUE CONTACT OF AN IMPLANTABLE MEDICAL DEVICE WITHIN A BODY 审中-公开
标题翻译：用于确定身体中可植入医疗装置的组织接触的改进系统和方法
公开(公告)号：WO0224063A3
公开(公告)日：2002-06-06
申请号：PCT/US0129289
申请日：2001-09-18
申请人： MEDTRONIC INC
发明人： IAIZZO PAUL , LASKE TIMOTHY G , WOOHYEK CHOI
IPC分类号： A61N1/37 , A61B5/05 , A61B5/053 , A61N1/05 , A61N1/372
CPC分类号： A61B5/053 , A61B5/05 , A61N1/056 , A61N1/0573
摘要： An improved system for monitoring the status of an IMD such as medical electrical lead during an implant procedure is provided. The system includes a signal generator for supplying a first signal such as a constant current or voltage to the IMD. A resulting voltage or current signal is generated, respectively, and may be sensed as an indication of the impedance of a portion of the body that is proximal to one or more electrodes carried by the lead. This impedance indication is converted to an audible signal having a frequency that is proportional to the amplitude of the impedance indication. The pitch of the audible signal therefore rises when measured impedance increases, and drops as the impedance decreases. These pitch changes allow a user to determine positional information associated with the IMD, including the degree of lead tissue contact and extent of fixation of a device to tissue.
摘要翻译：提供了一种改进的系统，用于在植入程序期间监测IMD的状态，例如医疗电线。该系统包括用于向IMD提供诸如恒定电流或电压的第一信号的信号发生器。分别产生所产生的电压或电流信号，并且可以将其感测为身体接近于由引线承载的一个或多个电极的部分的阻抗的指示。该阻抗指示被转换成具有与阻抗指示的幅度成比例的频率的可听信号。因此，当测量的阻抗增加时，听觉信号的音调会上升，并随着阻抗的降低而下降。这些间距变化允许用户确定与IMD相关联的位置信息，包括铅组织接触的程度和装置固定到组织的程度。

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