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1. 发明申请

WO2013040504A2 SRPX FOR TREATMENT OF CANCER 审中-公开
标题翻译： SRPX治疗癌症
公开(公告)号：WO2013040504A2
公开(公告)日：2013-03-21
申请号：PCT/US2012/055641
申请日：2012-09-14
申请人： UNIVERSITY OF MASSACHUSETTS , GREEN, Michael , GAO, Guangping , SANTRA, Manas Kumar , BHATNAGAR, Sanchita
发明人： GREEN, Michael , GAO, Guangping , SANTRA, Manas Kumar , BHATNAGAR, Sanchita
IPC分类号： A61K38/16 , A61K38/17 , A61K48/00 , A61P35/00
CPC分类号： A61K38/1709 , A61K35/12 , A61K38/16 , A61K48/00 , A61K48/005 , C12N9/0065
摘要： Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an SRPX.
摘要翻译：在受试者中治疗肿瘤的方法包括鉴定患有肿瘤，有患病风险或疑似患有肿瘤的受试者，并向受试者施用有效量的SRPX。

2. 发明申请

WO2012054404A3 SYSTEMS, METHODS AND APPARATUSES FOR DEWATERING, FLOCCULATING AND HARVESTING ALGAE CELLS 审中-公开
标题翻译：用于脱水，絮凝和收集细胞的系统，方法和装置
公开(公告)号：WO2012054404A3
公开(公告)日：2012-07-26
申请号：PCT/US2011056586
申请日：2011-10-17
申请人： ORIGINOIL INC , GREEN MICHAEL , ECKELBERRY NICHOLAS , FRASER SCOTT , GOODALL BRIAN
发明人： GREEN MICHAEL , ECKELBERRY NICHOLAS , FRASER SCOTT , GOODALL BRIAN
IPC分类号： C11B1/10 , C11B1/04 , C11B3/00
CPC分类号： C11B1/02 , B03C3/0175 , C11B1/04 , C11B1/06 , C11B1/10 , C12M21/02 , C12M47/10
摘要： Described herein are systems, methods and apparatuses, for dewatering, flocculating and harvesting microorganisms. In various implementations, at least one intracellular product from the microorganisms is recovered and processed according to methods disclosed herein. In some implementations, an electromagnetic field is applied to an aqueous suspension of microorganisms thereby causing flocculation of the microorganisms. In various implementations, the microorganisms are harvested, such as by causing the microorganisms to flocculate and sink to the bottom of a container. Alternatively, the microorganisms are caused to flocculate and float to the surface of the aqueous medium where they can be recovered by skimming. In other implementations, the microorganisms are lysed as they are passed through a second electromagnetic field to release intracellular products, among other desired components of the microorganisms. In some implementations, the intracellular contents of the microorganisms, as well as cellular mass and debris, are recovered and utilized as useful products.
摘要翻译：本文描述了用于脱水，絮凝和收获微生物的系统，方法和装置。在各种实施方案中，根据本文公开的方法回收和处理来自微生物的至少一种细胞内产物。在一些实施方案中，电磁场被施加到微生物的水性悬浮液，从而引起微生物的絮凝。在各种实施方案中，收获微生物，例如通过使微生物絮凝并沉降到容器的底部。或者，使微生物絮凝并漂浮到水性介质的表面，在那里它们可以通过撇去来回收。在其他实施方案中，当微生物通过第二电磁场以释放微生物的其它所需组分中的细胞内产物时，微生物被裂解。在一些实施方案中，微生物的细胞内含量以及细胞质量和碎片被回收并用作有用的产物。

3. 发明申请

WO2009036188A3 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 7 FOR TREATMENT OF CANCER 审中-公开
标题翻译：胰岛素样生长因子结合蛋白7用于治疗癌症
公开(公告)号：WO2009036188A3
公开(公告)日：2012-03-01
申请号：PCT/US2008076043
申请日：2008-09-11
申请人： UNIV MASSACHUSETTS , GREEN MICHAEL , WAJAPEYEE NARENDRA
发明人： GREEN MICHAEL , WAJAPEYEE NARENDRA
IPC分类号： A61K38/00
CPC分类号： A61K38/1754 , C12Q1/6886 , G01N33/5743
摘要： Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an IGFBP7 agent if the tumor has increased Ras-BRAF-MEK-Erk signaling, is dependent for growth and/or survival upon the Ras-BRAF-MEK-Erk signaling pathway, and/or expresses an activated or oncogenic BRAF or RAS.
摘要翻译：治疗受试者肿瘤的方法包括鉴定具有肿瘤风险或怀疑患有肿瘤的受试者，并且如果肿瘤具有增加的Ras-BRAF-MEK-Erk信号传导，则向受试者施用有效量的IGFBP7药物依赖于Ras-BRAF-MEK-Erk信号传导途径的生长和/或存活，和/或表达活化的或致癌的BRAF或RAS。

4. 发明申请

WO2012021831A2 PROCEDURE FOR EXTRACTING OF LIPIDS FROM ALGAE WITHOUT CELL SACRIFICE 审中-公开
标题翻译：在没有细胞刺激的情况下从脂肪提取脂肪的程序
公开(公告)号：WO2012021831A2
公开(公告)日：2012-02-16
申请号：PCT/US2011047627
申请日：2011-08-12
申请人： ORIGIN OIL INC , REEP PAUL , GREEN MICHAEL
发明人： REEP PAUL , GREEN MICHAEL
IPC分类号： C11B1/10 , A61K36/02
CPC分类号： C12M47/06 , C12N13/00 , C12P7/6463
摘要： A system and method are disclosed for extracting lipids from algal cells. In the method, lipids are extracted from algal cells by exposing the algal cells in an aqueous medium to an electric field sufficient to cause release of lipids from said cells. In the system, an electric field is formed between two electrodes connected with an electrical power supply and configured such that during use an aqueous medium containing the algal cells passes between the electrodes to extract lipids therefrom.
摘要翻译：公开了从藻类细胞中提取脂质的系统和方法。在该方法中，通过将水性介质中的藻类细胞暴露于足以引起脂质从所述细胞释放的电场，从藻类细胞中提取脂质。在该系统中，在与电源连接的两个电极之间形成电场，并配置为使得在使用期间，含有藻类细胞的水性介质在电极之间通过以从其中提取脂质。

5. 发明申请

WO2011022429A2 PROCESS FOR THE PREPARATION OF (S)-2-AMINO-5-CYCLOPROPYL-4,4-DIFLUOROPENTANOIC ACID AND ALKYL ESTERS AND ACID SALTS THEREOF 审中-公开
标题翻译：制备（S）-2-氨基-5-环丙基-4,4-二氟戊酸及其烷基酯及其盐酸盐的方法
公开(公告)号：WO2011022429A2
公开(公告)日：2011-02-24
申请号：PCT/US2010/045799
申请日：2010-08-17
申请人： VIROBAY, INC. , HART, Barry , DENER, Jeffrey M. , GREEN, Michael J. , STANDEN, Michael , KOCIAN, Oldrich
发明人： HART, Barry , DENER, Jeffrey M. , GREEN, Michael J. , STANDEN, Michael , KOCIAN, Oldrich
IPC分类号： C07C213/08 , C07C219/18 , C07C303/26 , C07C309/65 , C07C69/608
CPC分类号： C07C53/23 , C07B2200/07 , C07C67/307 , C07C67/347 , C07C69/635 , C07C227/18 , C07C309/65 , C07C2601/02 , C07C229/28
摘要： The present invention relates to a process for the preparation of alkyl esters of (S) 2-amino-5-cyclopropyl-4,4-difluoropentanoic acid, which are intermediates useful in the synthesis of (S)- N -(1-cyanocyclopropyl)-5-cyclopropyl-4,4-difluoro-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide and related compounds, which are compounds that are cysteine protease inhibitors.
摘要翻译：（S）2-氨基-5-环丙基-4,4-二氟戊酸的烷基酯的制备方法本发明涉及制备（S）2-氨基-5-环丙基-4,4-二氟戊酸的烷基酯的方法，） - 名词的 - （1-氰基环丙基）-5-环丙基-4,4-二氟-2 - （（S）-2,2,2-三氟-1-（4-氟苯基）乙基氨基）戊酰胺和相关化合物，它们是半胱氨酸蛋白酶抑制剂的化合物。

6. 发明申请

WO2010123734A2 SYSTEM AND METHOD FOR CLOSURE OF AN INTERNAL OPENING IN TISSUE, SUCH AS A TRANS-APICAL ACCESS OPENING 审中-公开
标题翻译：用于关闭组织内部开放的系统和方法，例如转接开关
公开(公告)号：WO2010123734A2
公开(公告)日：2010-10-28
申请号：PCT/US2010/031074
申请日：2010-04-14
申请人： MEDTRONIC INC. , AHLBERG, Sarah , SIMMA, Sara , ROTHSTEIN, Paul T. , CLEMENTS, Martin , JELICH, Damian , LASKE, Timothy G. , CLAGUE, Cynthia , GREEN, Michael , IAIZZO, Paul
发明人： AHLBERG, Sarah , SIMMA, Sara , ROTHSTEIN, Paul T. , CLEMENTS, Martin , JELICH, Damian , LASKE, Timothy G. , CLAGUE, Cynthia , GREEN, Michael , IAIZZO, Paul
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B2017/00243 , A61B2017/00663 , A61B2017/00867 , A61B2017/0441 , A61B2017/0443 , A61B2017/0464 , A61B2017/1142
摘要： A method for closing an opening at a target site including bodily tissue including embedding a plurality of self-closing clips into the target site in a spaced apart manner about a perimeter of the opening. Each of the clips has opposing clip ends and an intermediate segment. A flexible tether is coupled to the embedded clips to form a loop about the opening perimeter. A pulling force is applied onto at least one of the loop ends, thereby drawing the perimeter of the opening onto itself to completely close the opening. The loop ends are secured to maintain the target site in a closed state. In some embodiments, the target site is apical cardiac tissue, and the method is performed as part of a trans-apical access procedure.
摘要翻译：一种用于在包括身体组织在内的目标位置处关闭开口的方法，包括围绕开口的周边以间隔开的方式将多个自闭合夹子嵌入目标部位。每个夹子具有相对的夹子端部和中间部分。柔性系绳联接到嵌入的夹子上以围绕开口周边形成环。将拉力施加到至少一个环端，从而将开口的周边拉到其上以完全关闭开口。环路端部被固定以将目标部位保持在关闭状态。在一些实施方案中，靶位点是心尖心脏组织，并且该方法作为跨顶部进入程序的一部分进行。

7. 发明申请

WO2010077973A3 APPARATUS FOR FILTERING A BODY LUMEN 审中-公开
标题翻译：用于过滤身体的装置的装置
公开(公告)号：WO2010077973A3
公开(公告)日：2010-08-26
申请号：PCT/US2009068301
申请日：2009-12-16
申请人： SHRIVASTAVA SANJAY , OBRADOVIC MILISAV , TANG NIE , BREGULLA RAINER , GREEN MICHAEL
发明人： SHRIVASTAVA SANJAY , OBRADOVIC MILISAV , TANG NIE , BREGULLA RAINER , GREEN MICHAEL
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2002/8486 , A61F2230/0006 , A61F2230/008 , A61F2250/0067
摘要： An implantable lumen filter (200) is described. The implantable lumen filter includes a body (202) having a proximal end (202a), a distal end (202b), and a generally tapered outer surface (204). The outer surface is formed by a plurality of struts (206a, 206b). The plurality of struts forms a plurality of apertures (210). The apertures are dimensioned to inhibit and/or to lyse particulates of a selected size from passing through the apertures. The body (202) is transitionable from a collapsed state toward a deployed state. The implantable lumen filter includes an engaging portion (220) having a proximal end (220a) and a distal end (220b). The proximal end of the engaging portion is connected to a distal end of the body. The engaging portion has a generally annular shape and is configured to engage an inner surface of a body lumen.
摘要翻译：描述可植入管腔过滤器（200）。可植入管腔过滤器包括具有近端（202a），远端（202b）和大致锥形的外表面（204）的主体（202）。外表面由多个支柱（206a，206b）形成。多个支柱形成多个孔（210）。孔的尺寸被设计成抑制和/或裂解选定尺寸的颗粒通过孔。主体（202）可以从折叠状态向展开状态转换。可植入管腔过滤器包括具有近端（220a）和远端（220b）的接合部分（220）。接合部分的近端连接到主体的远端。接合部分具有大致环形的形状并且构造成接合体腔的内表面。

8. 发明申请

WO2010077973A2 METHODS AND APPARATUS FOR FILTERING A BODY LUMEN 审中-公开
标题翻译：用于过滤身体的方法和装置
公开(公告)号：WO2010077973A2
公开(公告)日：2010-07-08
申请号：PCT/US2009/068301
申请日：2009-12-16
申请人： SHRIVASTAVA, Sanjay , OBRADOVIC, Milisav , TANG, Nie , BREGULLA, Rainer , GREEN, Michael
发明人： SHRIVASTAVA, Sanjay , OBRADOVIC, Milisav , TANG, Nie , BREGULLA, Rainer , GREEN, Michael
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2002/8486 , A61F2230/0006 , A61F2230/008 , A61F2250/0067
摘要： An implantable lumen filter is described. The implantable lumen filter may include a body having a proximal end, a distal end, and a generally tapered outer surface. The outer surface may be formed by a plurality of struts. The plurality of struts may form a plurality of apertures. The apertures may be dimensioned to inhibit and/or to lyse particulates of a selected size from passing through the apertures. The body may be transitionable from a collapsed state toward a deployed state. The implantable lumen filter may include an engaging portion having a proximal end and a distal end. The proximal end of the engaging portion may be connected to a distal end of the body. The engaging portion may have a generally annular shape and may be configured to engage an inner surface of a body lumen. Methods for using the same are described.
摘要翻译：描述了可植入管腔滤器。可植入管腔过滤器可以包括具有近端，远端和大致锥形的外表面的主体。外表面可以由多个支柱形成。多个支柱可以形成多个孔。孔的尺寸可以被限定以抑制和/或裂解选定尺寸的颗粒通过孔。身体可以从折叠状态向展开状态转变。可植入管腔过滤器可以包括具有近端和远端的接合部分。接合部分的近端可以连接到主体的远端。接合部分可以具有大致环形的形状，并且可以被配置为接合体腔的内表面。对其使用方法进行说明。

9. 发明申请

WO2010047934A2 METHODS AND SYSTEMS FOR TREATING CANCER USING EXTERNAL BEAM RADIATION 审中-公开
标题翻译：使用外部束辐射治疗癌症的方法和系统
公开(公告)号：WO2010047934A2
公开(公告)日：2010-04-29
申请号：PCT/US2009059303
申请日：2009-10-02
申请人： VARIAN MED SYS INC , ZDASIUK GEORGE , CLAYTON JAMES , STAR-LACK JOSH , HUMBER DAVID , VIRSHUP GARY , GREEN MICHAEL
发明人： ZDASIUK GEORGE , CLAYTON JAMES , STAR-LACK JOSH , HUMBER DAVID , VIRSHUP GARY , GREEN MICHAEL
IPC分类号： A61N5/10 , A61B6/00 , A61N5/01
CPC分类号： H05H7/04 , A61N5/1043 , A61N5/1081 , A61N2005/1087 , A61N2005/1089 , G21K1/093 , G21K5/00 , H01J37/1475 , H05G2/00
摘要： A radiation system employs magnetic field to move particle beams and radiation sources. The radiation system includes a source operable to produce a particle beam, a scanning magnet operable to scan the particle beam, and a target configured to be impinged by at least a portion of the scanned particle beam to produce radiation.
摘要翻译：辐射系统采用磁场来移动粒子束和辐射源。辐射系统包括可操作以产生粒子束的源，可操作以扫描粒子束的扫描磁体，以及配置成由至少一部分扫描粒子束照射以产生辐射的靶。

10. 发明申请

WO2009154790A2 NOVEL METASTASIS SUPPRESOR GENES AND USES THEREOF 审中-公开
标题翻译：新型METASTASIS抑制基因及其用途
公开(公告)号：WO2009154790A2
公开(公告)日：2009-12-23
申请号：PCT/US2009/003688
申请日：2009-06-19
申请人： UNIVERSITY OF MASSACHUSETTS , GREEN, Michael, R. , GOBEIL, Stephane
发明人： GREEN, Michael, R. , GOBEIL, Stephane
IPC分类号： C12Q1/68 , C12N15/11 , A61K48/00
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178
摘要： The invention relates to methods for detecting a metastatic cancer, methods for inhibiting tumor metastatic properties, methods for treating tumor metastasis, methods for identifying agents for the treatment of tumor metastasis, and methods for screening for modulators of tumor metastatic properties.
摘要翻译：本发明涉及用于检测转移性癌症的方法，用于抑制肿瘤转移性质的方法，用于治疗肿瘤转移的方法，用于鉴定肿瘤转移治疗剂的方法，以及用于筛选肿瘤转移性质的调节剂的方法。

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