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1. 发明申请

WO0222787A3 DIFFERENTIAL TREATMENT OF SELECTED PARTS OF A SINGLE CELL WITH DIFFERENT FLUID COMPONENTS 审中-公开
标题翻译：对不同流体组分的单细胞选择部分进行差异化处理
公开(公告)号：WO0222787A3
公开(公告)日：2002-07-11
申请号：PCT/US0129248
申请日：2001-09-18
申请人： HARVARD COLLEGE , TAKAYAMA SHUICHI , OSTUNI EMANUELE , LEDUC PHILIP , NARUSE KEIJI , INGBER DONALD E , WHITESIDES GEORGE M
发明人： TAKAYAMA SHUICHI , OSTUNI EMANUELE , LEDUC PHILIP , NARUSE KEIJI , INGBER DONALD E , WHITESIDES GEORGE M
IPC分类号： G01N37/00 , A61K35/12 , B81B1/00 , C12N5/00 , C12N5/071 , G01N33/50 , G01N33/52
CPC分类号： G01N33/5011 , A61K35/12 , C12N5/00 , C12N5/069 , C12N2501/48 , C12N2501/58 , C12N2503/00 , C12N2503/02 , C12N2510/00 , G01N33/5008 , G01N33/502 , G01N33/5035 , G01N33/5076 , G01N33/5079 , G01N33/528 , G01N2800/52
摘要： The present invention is directed, in certain embodiments, to improved, small scale systems and methods able to selectively treat parts of a single cell, including, in certain embodiments, portions of a main body portion of a single cell, and able, in certain embodiments, to establish long-term gradients of active substances within subcellular regions of a single cell. The present invention provides, in some embodiments, techniques for selectively contacting a portion of the surface of a biological cell with a fluid or fluid component carrying a particular potential for a physiological or biochemical interaction with the cell, and simultaneously contacting a different portion of the surface of the cell with another fluid or fluid component having a different portion of the surface of the cell with another fluid or fluid component having a different potential for the biophysical or biochemical interaction with the cell.
摘要翻译：在某些实施方案中，本发明涉及能够选择性处理单个细胞的部分的改进的小规模系统和方法，在某些实施方案中包括单个细胞的主体部分的一部分，并且能够在某些实施例，以建立单细胞的亚细胞区域内的活性物质的长期梯度。在一些实施方案中，本发明提供了用于选择性接触生物细胞表面的一部分与携带与细胞的生理或生物化学相互作用的特定可能性的流体或流体组分并且同时接触细胞的不同部分细胞表面与具有细胞表面的不同部分的另一种流体或流体成分与具有与细胞的生物物理或生物化学相互作用的不同电势的另一种流体或流体成分。

2. 发明申请

WO0189788A2 PATTERNING OF SURFACES UTILIZING MICROFLUIDIC STAMPS INCLUDING THREE-DIMENSIONALLY ARRAYED CHANNEL NETWORKS 审中-公开
标题翻译：使用包括三维阵列通道网络在内的微流感标记的表面图案
公开(公告)号：WO0189788A2
公开(公告)日：2001-11-29
申请号：PCT/US0117246
申请日：2001-05-25
申请人： HARVARD COLLEGE , CHILDRENS MEDICAL CENTER , CHIU DANIEL T , JEON NOO LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
发明人： CHIU DANIEL T , JEON NOO-LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
IPC分类号： B01F13/00 , B01L3/00 , B01L3/02 , B29C31/04 , B29C33/42 , B29C39/10 , B81B1/00 , B81C1/00 , C40B40/10 , C40B60/14 , G01N33/50 , B29C
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems. Specifically, the invention provides microfluidic surface patterning systems and methods for fabricating complex, discontinuous patterns on surfaces that can incorporate or deposit multiple materials onto the surfaces. The present invention also provides improved microfluidic stamps or applicators for microcontact surface patterning, which are able to pattern onto a surface arbitrary two-dimensional patterns, and which are able to pattern multiple substances onto a surface without the need for multiple steps of registration or stamping during patterning and without the need to selectively "ink" different regions of the stamp with different materials.
摘要翻译：本发明描述了改进的微流体系统和用于制造改进的微流体系统的程序，其包含一个或多个水平的微流体通道。用于制造所公开的系统的方法可以为拓扑复杂和改进的微流体系统提供方便的途径。微流体系统可以包括其中的流体流动路径的三维排列的网络，其中包括在交叉点处交叉的网络上或下方的通道，而没有物理交叉点。微流体网络可以通过使用模具主体的复制模制工艺制造，其中包括具有通过光刻形成的拓扑特征的表面。本发明还涉及在利用微流体系统的表面上制造诸如生物材料和细胞的复杂图案的微流体系统和方法。具体地，本发明提供了微流体表面图案化系统和用于在表面上制造复杂的不连续图案的方法，所述图案可以将多种材料结合或沉积到表面上。本发明还提供了用于微接触表面图案化的改进的微流体标记或涂布器，其能够将图案图案化成任意的二维图案，并且能够将多种物质图案化到表面上，而不需要多个对准或冲压的步骤在图案化期间，并且不需要使用不同材料选择性地“印刷”印模的不同区域。

3. 发明申请

WO0189788A9 PATTERNING OF SURFACES UTILIZING MICROFLUIDIC STAMPS INCLUDING THREE-DIMENSIONALLY ARRAYED CHANNEL NETWORKS 审中-公开
标题翻译：使用包括三维阵列通道网络在内的微流感标记的表面图案
公开(公告)号：WO0189788A9
公开(公告)日：2002-12-12
申请号：PCT/US0117246
申请日：2001-05-25
申请人： HARVARD COLLEGE , CHILDRENS MEDICAL CENTER , CHIU DANIEL T , JEON NOO-LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
发明人： CHIU DANIEL T , JEON NOO-LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
IPC分类号： B01F13/00 , B01L3/00 , B01L3/02 , B29C31/04 , B29C33/42 , B29C39/10 , B81B1/00 , B81C1/00 , C40B40/10 , C40B60/14 , G01N33/50 , B01J4/00 , B29C39/02
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems. Specifically, the invention provides microfluidic surface patterning systems and methods for fabricating complex, discontinuous patterns on surfaces that can incorporate or deposit multiple materials onto the surfaces. The present invention also provides improved microfluidic stamps or applicators for microcontact surface patterning, which are able to pattern onto a surface arbitrary two-dimensional patterns, and which are able to pattern multiple substances onto a surface without the need for multiple steps of registration or stamping during patterning and without the need to selectively "ink" different regions of the stamp with different materials.
摘要翻译：本发明描述了改进的微流体系统和用于制造改进的微流体系统的程序，其包含一个或多个水平的微流体通道。用于制造所公开的系统的方法可以提供拓扑复杂和改进的微流体系统的方便的途径。微流体系统可以包括其中的流体流动路径的三维排列的网络，其中包括在交叉点处交叉的网络上或下方的通道，而没有物理交叉点。微流体网络可以通过使用模具主体的复制模制工艺制造，其中包括具有通过光刻形成的拓扑特征的表面。本发明还涉及在利用微流体系统的表面上制造诸如生物材料和细胞的复杂图案的微流体系统和方法。具体地，本发明提供了微流体表面图案化系统和用于在表面上制造复杂的不连续图案的方法，所述图案可以将多种材料结合或沉积到表面上。本发明还提供了用于微接触表面图案化的改进的微流体标记或涂布器，其能够将图案图案化成任意的二维图案，并且能够将多种物质图案化到表面上，而不需要多个对准或冲压的步骤在图案化期间，并且不需要使用不同材料选择性地“印刷”印模的不同区域。

4. 发明申请

WO2012118956A3 THERMAL MANAGEMENT OF TRANSPARENT MEDIA 审中-公开
标题翻译：透明媒体的热管理
公开(公告)号：WO2012118956A3
公开(公告)日：2012-11-08
申请号：PCT/US2012027253
申请日：2012-03-01
申请人： HARVARD COLLEGE , INGBER DONALD E , HATTON BENJAMIN D , WHEELDON IAN R
发明人： INGBER DONALD E , HATTON BENJAMIN D , WHEELDON IAN R
IPC分类号： H05B3/84
CPC分类号： E06B3/6715 , E06B3/66323 , E06B3/66333 , E06B3/6722 , F24D17/0015 , F24J2/0433 , F24J2/20 , Y02B10/20 , Y02E10/44
摘要： A bio-inspired window can be created by applying one or more heat exchange layers to one or more surfaces of a window of a building, boat, vehicle or any other structure. The heat exchange layer can include an interconnected network or array of channels or microchannels that can be used to flow a fluid over the surface of the window. The fluid can be used to heat or cool the surface of the window panel to control the flow of heat across the window and reduce the heating or cooling energy load of building. The fluid can be heated or cooled using the ambient air in the building. The refractive index of the fluid can be adjusted to change of optical transparency properties of the window. In some embodiments, the window can appear nearly as clear as an ordinary panel of glass. In other embodiments, the window can color, block or scatter the incoming light.
摘要翻译：可以通过将一个或多个热交换层施加到建筑物，船，车辆或任何其他结构的窗户的一个或多个表面来创建生物启发的窗户。热交换层可以包括可用于使流体在窗口表面上流动的通道或微通道的互连网络或阵列。流体可用于加热或冷却窗户面板的表面，以控制跨过窗户的热量流动，并减少建筑物的加热或冷却能量负荷。流体可以使用建筑物中的环境空气进行加热或冷却。可以调节流体的折射率以改变窗口的光学透明性。在一些实施例中，窗口可以看起来像普通的玻璃板几乎一样清楚。在其他实施例中，窗口可以着色，阻挡或散射入射光。

5. 发明申请

WO2012074588A3 SHEAR CONTROLLED RELEASE FOR STENOTIC LESIONS AND THROMBOLYTIC THERAPIES 审中-公开
标题翻译：剪切控制释放用于穿透性损伤和溶栓治疗
公开(公告)号：WO2012074588A3
公开(公告)日：2012-10-11
申请号：PCT/US2011049691
申请日：2011-08-30
申请人： HARVARD COLLEGE , INGBER DONALD E , KORIN NETANEL , KANAPATHIPILLAI MATHUMAI
发明人： INGBER DONALD E , KORIN NETANEL , KANAPATHIPILLAI MATHUMAI
IPC分类号： A61K47/48
CPC分类号： A61K38/02 , A61K9/1617 , A61K9/5153 , A61K31/721 , A61K38/49
摘要： The invention provides compositions and methods for treating or imaging stenosis, stenotic lesions, occluded lumens, embolic phenomena or thrombotic disorders. The invention further provides compositions and methods for treating internal hemorrhage.
摘要翻译：本发明提供了用于治疗或成像狭窄，狭窄病变，闭塞的管腔，栓塞现象或血栓形成病症的组合物和方法。本发明进一步提供了用于治疗内出血的组合物和方法。

6. 发明申请

WO2007044642A3 DEVICE AND METHOD FOR COMBINED MICROFLUIDIC-MICROMAGNETIC SEPARATION OF MATERIAL IN CONTINUOUS FLOW 审中-公开
标题翻译：用于连续流动的材料组合微流化 - 微磁性分离的装置和方法
公开(公告)号：WO2007044642A3
公开(公告)日：2007-11-15
申请号：PCT/US2006039344
申请日：2006-10-06
申请人： HARVARD COLLEGE , INGBER DONALD E , XIA SHANNON , HUNT TOM P , WESTERVELT ROBERT M
发明人： INGBER DONALD E , XIA SHANNON , HUNT TOM P , WESTERVELT ROBERT M
IPC分类号： B01D35/06
CPC分类号： A61M1/3618 , A61M1/36 , A61M2205/0244 , A61M2206/11 , B01L3/502761 , B01L2200/0636 , B01L2200/0668 , B01L2300/06 , B01L2300/0864 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N2015/149 , Y10T436/25375
摘要： A miniaturized, integrated, microfluidic device pulls materials bound to magnetic particles from one laminar flow path to another by applying a local magnetic field gradient. The device removes microbial and mammalian cells from flowing biological fluids without any wash steps. A microfabricated high-gradient magnetic field concentrator (HGMC) is integrated at one side of a microfluidic channel. When magnetic particles are introduced into one flow path, they remain limited to that flow path. When the HGMC is magnetized, the magnetic beads are pulled from the initial flow path into the collection stream, thereby cleansing the fluid. The microdevice allows large numbers of beads and materials to be sorted simultaneously, has no capacity limit, does not lose separation efficiency as particles are removed, and is useful for cell separations from blood and other biological fluids. This on-chip separator allows cell separations to be performed in the field outside of hospitals and laboratories.
摘要翻译：小型化，集成化的微流体装置通过施加局部磁场梯度将结合到磁性粒子的材料从一个层流路径拉到另一层流路径。该装置不需要任何清洗步骤即可从流动的生物流体中去除微生物和哺乳动物细胞微制造的高梯度磁场集中器（HGMC）集成在微流体通道的一侧。当磁性颗粒被引入到一个流动路径中时，它们仍然限于该流动路径。当HGMC被磁化时，磁珠从初始流动路径被拉入收集流中，从而清洁流体。微装置允许大量的珠子和材料同时分选，没有容量限制，不会因为颗粒被去除而失去分离效率，并且可用于从血液和其他生物流体中分离细胞。这种片上分离器可以在医院和实验室以外的地方进行细胞分离。

7. 发明申请

WO2013012924A3 ENGINEERED MICROBE-TARGETING MOLECULES AND USES THEREOF 审中-公开
标题翻译：工程微型靶向分子及其应用
公开(公告)号：WO2013012924A3
公开(公告)日：2013-04-11
申请号：PCT/US2012047201
申请日：2012-07-18
申请人： HARVARD COLLEGE , INGBER DONALD E , SUPER MICHAEL , WAY JEFFREY CHARLES , CARTWRIGHT MARK J , WATTERS ALEXANDER , BERTHET JULIA B , SUPER DINAH R , ROTTMAN MARTIN M
发明人： INGBER DONALD E , SUPER MICHAEL , WAY JEFFREY CHARLES , CARTWRIGHT MARK J , BERTHET JULIA B , SUPER DINAH R , ROTTMAN MARTIN M
IPC分类号： G01N33/543 , A61K47/48 , C07K14/47 , C07K14/705 , G01N33/569
CPC分类号： C07K16/12 , A61K47/68 , A61K47/6815 , C07K14/42 , C07K2319/33 , G01N33/54353 , G01N33/56911 , G01N33/56916 , G01N33/56938 , G01N33/56961 , G01N2333/42 , G01N2333/4724
摘要： Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface. Microbe-targeting molecules and/or substrates can be regenerated after use by washing with a low pH buffer or buffer in which calcium is insoluble.
摘要翻译：本文描述了工程微生物靶向或微生物结合分子，包含其的试剂盒及其用途。微生物靶向或微生物结合分子的一些具体实施方案包括与Fc区的一部分连接的甘露糖结合凝集素的碳水化合物识别结构域或其片段。在一些实施方案中，微生物靶向分子或微生物结合分子可以与形成微生物靶向底物（例如微生物靶向磁微珠）的底物（例如磁性微珠）缀合。此类微生物靶向分子和/或底物和包含它们的试剂盒可以结合和/或捕获其微生物和/或微生物，并且因此可以用于各种应用，例如感染的诊断和/或治疗由受试者或任何环境表面中的微生物如脓毒症引起。微生物靶向分子和/或底物可以在使用后通过用钙不溶解的低pH缓冲液或缓冲液洗涤而再生。

8. 发明申请

WO2012135834A2 DIALYSIS LIKE THERAPEUTIC (DLT) DEVICE 审中-公开
标题翻译： DIALYSIS LIKE THERAPEUTIC（DLT）DEVICE
公开(公告)号：WO2012135834A2
公开(公告)日：2012-10-04
申请号：PCT/US2012031864
申请日：2012-04-02
申请人： HARVARD COLLEGE , CHILDRENS MEDICAL CENTER , YUNG CHONG WING , DOMANSKY KAREL , TERRY RICHARD , KALISH DAVID , SCHULTE ALEXA , KANG JOO HUN , INGBER DONALD E , SUPER MIKE , COOPER RYAN M
发明人： YUNG CHONG WING , DOMANSKY KAREL , TERRY RICHARD , KALISH DAVID , SCHULTE ALEXA , KANG JOO HUN , INGBER DONALD E , SUPER MIKE , COOPER RYAN M
IPC分类号： G01N33/569 , B81B1/00 , G01N35/08 , G01N35/10
CPC分类号： C12Q1/04 , A61M1/36 , A61M1/3618 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/56 , B01L2200/0652 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2400/043 , B01L2400/0487 , B03C1/002 , B03C1/01 , B03C1/0332 , B03C1/0335 , B03C1/288 , B03C2201/26
摘要： A dialysis like therapeutic (DLT) device is provided. The DLT device includes at least one source channel connected at least one collection channels by one or more transfer channels. Fluid contacting surface of the channels can be an anti-fouling surface such as slippery liquid-infused porous surface (SLIPS). Fluids can be flown at high flow rates through the channels. The target components of the source fluid can be magnetic or bound to magnetic particles using an affinity molecule. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis. The source channel and the collection channels of the microfluidic device are analogous to the splenic arterioles and venules, respectively; the transfer channels mimic the vascular sinusoids of the spleen where opsonized particles are retained. Thus, the device acts as a dialysis like therapeutic device by combining fluidics and magnetics.
摘要翻译：提供透析治疗（DLT）装置。 DLT设备包括通过一个或多个传输信道连接至少一个收集信道的至少一个源信道。通道的流体接触表面可以是防污表面，例如滑动的液体注入的多孔表面（SLIPS）。流体可以通过通道以高流速流动。源流体的目标组分可以是磁性的或使用亲和分子结合到磁性颗粒。含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。磁场梯度可以施加到源通道中的源流体，使得磁结合的目标分量通过传输通道迁移到收集通道中。收集通道可以包括收集流体以将目标组分冲洗出收集通道。随后分析目标成分进行检测和诊断。微流体装置的源通道和收集通道分别类似于脾小动脉和小静脉; 转移通道模拟脾脏的血管窦状，其中保留调理颗粒。因此，该装置通过组合流体学和磁性作为透析像治疗装置。

9. 发明申请

WO2012030805A3 A HIGH STRENGTH CHITIN COMPOSITE MATERIAL AND METHOD OF MAKING 审中-公开
标题翻译：高强度木质素复合材料及其制备方法
公开(公告)号：WO2012030805A3
公开(公告)日：2012-07-05
申请号：PCT/US2011049702
申请日：2011-08-30
申请人： HARVARD COLLEGE , INGBER DONALD E , FERNANDEZ JAVIER GOMEZ
发明人： INGBER DONALD E , FERNANDEZ JAVIER GOMEZ
IPC分类号： A61L27/20 , A61F2/02 , A61F13/00 , A61L27/22 , A61L27/34 , A61L27/54 , A61L27/56
CPC分类号： A61L27/24 , A61L15/225 , A61L15/28 , A61L15/325 , A61L15/38 , A61L15/425 , A61L15/44 , A61L15/52 , A61L27/20 , A61L27/227 , A61L27/34 , A61L27/48 , A61L27/54 , A61L27/56 , B05D3/104 , C08L1/02 , C08L3/02 , C08L5/00 , C08L5/08 , C08L5/10 , C08L89/00
摘要： The present invention is directed to a composite laminar material with high mechanical strength and methods of fabricating the material. The invention also provides a method of attaching a medical implant device to tissue.
摘要翻译：本发明涉及具有高机械强度的复合层状材料和制造该材料的方法。本发明还提供了一种将医疗植入物装置附接到组织的方法。

10. 发明申请

WO2010123545A2 ANGIOGENESIS INHIBITORS 审中-公开
标题翻译：血管生成抑制剂
公开(公告)号：WO2010123545A2
公开(公告)日：2010-10-28
申请号：PCT/US2010001121
申请日：2010-04-16
申请人： HARVARD COLLEGE , CHILDRENS MEDICAL CENTER , COREY ELIAS JAMES , CZAKO BARBARA , KUERTI LASZLO , MAMMOTO AKIKO , INGBER DONALD E
发明人： COREY ELIAS JAMES , CZAKO BARBARA , KUERTI LASZLO , MAMMOTO AKIKO , INGBER DONALD E
IPC分类号： C07J41/00 , A61K31/56 , A61P35/00 , C07J43/00
CPC分类号： C07J43/003 , C07J41/0005
摘要： Compounds of Structural Formula I or pharmaceutically acceptable salts thereof, are effective inhibitors of angiogenesis:
摘要翻译：结构式I的化合物或其药学上可接受的盐是血管生成的有效抑制剂：

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