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1. 发明申请

WO0189788A2 PATTERNING OF SURFACES UTILIZING MICROFLUIDIC STAMPS INCLUDING THREE-DIMENSIONALLY ARRAYED CHANNEL NETWORKS 审中-公开
标题翻译：使用包括三维阵列通道网络在内的微流感标记的表面图案
公开(公告)号：WO0189788A2
公开(公告)日：2001-11-29
申请号：PCT/US0117246
申请日：2001-05-25
申请人： HARVARD COLLEGE , CHILDRENS MEDICAL CENTER , CHIU DANIEL T , JEON NOO LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
发明人： CHIU DANIEL T , JEON NOO-LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
IPC分类号： B01F13/00 , B01L3/00 , B01L3/02 , B29C31/04 , B29C33/42 , B29C39/10 , B81B1/00 , B81C1/00 , C40B40/10 , C40B60/14 , G01N33/50 , B29C
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems. Specifically, the invention provides microfluidic surface patterning systems and methods for fabricating complex, discontinuous patterns on surfaces that can incorporate or deposit multiple materials onto the surfaces. The present invention also provides improved microfluidic stamps or applicators for microcontact surface patterning, which are able to pattern onto a surface arbitrary two-dimensional patterns, and which are able to pattern multiple substances onto a surface without the need for multiple steps of registration or stamping during patterning and without the need to selectively "ink" different regions of the stamp with different materials.
摘要翻译：本发明描述了改进的微流体系统和用于制造改进的微流体系统的程序，其包含一个或多个水平的微流体通道。用于制造所公开的系统的方法可以为拓扑复杂和改进的微流体系统提供方便的途径。微流体系统可以包括其中的流体流动路径的三维排列的网络，其中包括在交叉点处交叉的网络上或下方的通道，而没有物理交叉点。微流体网络可以通过使用模具主体的复制模制工艺制造，其中包括具有通过光刻形成的拓扑特征的表面。本发明还涉及在利用微流体系统的表面上制造诸如生物材料和细胞的复杂图案的微流体系统和方法。具体地，本发明提供了微流体表面图案化系统和用于在表面上制造复杂的不连续图案的方法，所述图案可以将多种材料结合或沉积到表面上。本发明还提供了用于微接触表面图案化的改进的微流体标记或涂布器，其能够将图案图案化成任意的二维图案，并且能够将多种物质图案化到表面上，而不需要多个对准或冲压的步骤在图案化期间，并且不需要使用不同材料选择性地“印刷”印模的不同区域。

2. 发明申请

WO0189788A9 PATTERNING OF SURFACES UTILIZING MICROFLUIDIC STAMPS INCLUDING THREE-DIMENSIONALLY ARRAYED CHANNEL NETWORKS 审中-公开
标题翻译：使用包括三维阵列通道网络在内的微流感标记的表面图案
公开(公告)号：WO0189788A9
公开(公告)日：2002-12-12
申请号：PCT/US0117246
申请日：2001-05-25
申请人： HARVARD COLLEGE , CHILDRENS MEDICAL CENTER , CHIU DANIEL T , JEON NOO-LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
发明人： CHIU DANIEL T , JEON NOO-LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
IPC分类号： B01F13/00 , B01L3/00 , B01L3/02 , B29C31/04 , B29C33/42 , B29C39/10 , B81B1/00 , B81C1/00 , C40B40/10 , C40B60/14 , G01N33/50 , B01J4/00 , B29C39/02
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems. Specifically, the invention provides microfluidic surface patterning systems and methods for fabricating complex, discontinuous patterns on surfaces that can incorporate or deposit multiple materials onto the surfaces. The present invention also provides improved microfluidic stamps or applicators for microcontact surface patterning, which are able to pattern onto a surface arbitrary two-dimensional patterns, and which are able to pattern multiple substances onto a surface without the need for multiple steps of registration or stamping during patterning and without the need to selectively "ink" different regions of the stamp with different materials.
摘要翻译：本发明描述了改进的微流体系统和用于制造改进的微流体系统的程序，其包含一个或多个水平的微流体通道。用于制造所公开的系统的方法可以提供拓扑复杂和改进的微流体系统的方便的途径。微流体系统可以包括其中的流体流动路径的三维排列的网络，其中包括在交叉点处交叉的网络上或下方的通道，而没有物理交叉点。微流体网络可以通过使用模具主体的复制模制工艺制造，其中包括具有通过光刻形成的拓扑特征的表面。本发明还涉及在利用微流体系统的表面上制造诸如生物材料和细胞的复杂图案的微流体系统和方法。具体地，本发明提供了微流体表面图案化系统和用于在表面上制造复杂的不连续图案的方法，所述图案可以将多种材料结合或沉积到表面上。本发明还提供了用于微接触表面图案化的改进的微流体标记或涂布器，其能够将图案图案化成任意的二维图案，并且能够将多种物质图案化到表面上，而不需要多个对准或冲压的步骤在图案化期间，并且不需要使用不同材料选择性地“印刷”印模的不同区域。

3. 发明申请

WO2004081729A3 A METHOD AND APPARATUS FOR DISPLAYING INFORMATION 审中-公开
标题翻译：一种用于显示信息的方法和装置
公开(公告)号：WO2004081729A3
公开(公告)日：2005-06-02
申请号：PCT/US2004006901
申请日：2004-03-05
申请人： CHILDRENS MEDICAL CENTER , INGBER DONALD E , HUANG SUI , EICHLER GABRIEL
发明人： INGBER DONALD E , HUANG SUI , EICHLER GABRIEL
IPC分类号： G06T11/60 , G09G5/22
CPC分类号： G06T11/60
摘要： A method for displaying large amounts of information. The method includes the steps of forming a spatial layout of tiles (Fig. 2, tiles A-I) each corresponding to a representative reference element; mapping (Fig. 3) observed elements onto the spatial layout of tiles of representative reference elements; assigning (Fig. 1, Table 1) a respective value to each respective tile of the spatial layout of the representative elements; and display (Fig. 4) an image of the spatial layout of tiles of representative elements. Each tile includes atomic attributes of representative elements. Each tile includes atomic attributes of representative elements. The invention also relates to an apparatus for displaying large amounts of information. The apparatus includes a tiler (SOM) forming a spatial layout of tiles, each corresponding to a representative reference element; a comparator (Fig. 3) mapping observed elements onto said spatial layout of tiles of representative reference elements; an assigner (Fig. 1, Table 1) assigning a respective value to each respective tile of said spatial layout of representative reference elements; and a display (Fig. 4) displaying an image of the spatial layout of tiles of representative reference elements.
摘要翻译：一种显示大量信息的方法。该方法包括以下步骤：形成每个对应于代表性参考元素的瓦片（图2，瓦片A-I）的空间布局; 将图像（图3）观察到元素到代表参考元素的瓦片的空间布局上; 将代表元素的空间布局的每个相应瓦片分配（图1，表1）相应的值; 并显示（图4）代表元素的瓦片的空间布局的图像。每个瓦片包括代表元素的原子属性。每个瓦片包括代表元素的原子属性。本发明还涉及一种用于显示大量信息的装置。该装置包括形成瓦片的空间布局的分片器（SOM），每个对应于代表参考元件; 将观察到的元素映射到代表性参考元素的瓦片的所述空间布局上的比较器（图3）分配器（图1，表1）为代表参考元件的所述空间布局的每个相应瓦片分配相应的值; 以及显示代表参考元素的瓦片的空间布局的图像的显示器（图4）。

4. 发明申请

WO0237102A3 METHODS FOR ANALYZING DYNAMIC CHANGES IN CELLULAR INFORMATICS 审中-公开
标题翻译：分析细胞动力学变化的方法
公开(公告)号：WO0237102A3
公开(公告)日：2003-03-20
申请号：PCT/US0143041
申请日：2001-10-19
申请人： CHILDRENS MEDICAL CENTER
发明人： HUANG SUI , INGBER DONALD E
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/12 , G06F19/20 , G01N33/68
CPC分类号： G01N33/5091 , G01N33/5008 , G01N33/502 , G01N33/5023 , G01N33/5038 , G01N33/5088 , G06F19/12 , G06F19/20 , G06Q50/24
摘要： Methods are provided for analyzing dynamic changes in cellular processes and for representing cellular processes as dynamic signatures or phase portraits. Methods of the invention are useful for comparing cellular processes and providing diagnostic and prognostic information. Methods of the invention are also useful for identifying important molecular components of cellular processes, for identifying targets for drug development, and in assays for identifying drug candidates and evaluating frug effectiveness.
摘要翻译：提供了用于分析细胞过程中的动态变化并将蜂窝过程表示为动态签名或相位肖像的方法。本发明的方法可用于比较细胞过程并提供诊断和预后信息。本发明的方法还可用于鉴定细胞过程的重要分子组分，用于鉴定药物开发的靶标，以及用于鉴定候选药物和评估节食效果的测定法。

5. 发明申请

WO2009089537A2 ANTI-CANCER COMPOUNDS 审中-公开
标题翻译：抗癌化合物
公开(公告)号：WO2009089537A2
公开(公告)日：2009-07-16
申请号：PCT/US2009030757
申请日：2009-01-12
申请人： UNIV NORTHWESTERN , HUANG SUI , NORTON JOHN , APPELLA DANIEL , WITSCHI MARK
发明人： HUANG SUI , NORTON JOHN , APPELLA DANIEL , WITSCHI MARK
IPC分类号： C07D215/06 , A61K31/43 , A61P35/00
CPC分类号： C07D221/14 , A61K31/43 , A61K31/473 , A61K45/06 , A61K2300/00 , C07D217/24
摘要： The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.
摘要翻译：本发明涉及抗癌化合物，其发现方法及其治疗用途。具体而言，本发明提供了已知的抗癌化合物氨氯地平的类似物以及结构和功能相关的化合物，以及使用这些化合物作为治疗剂治疗许多与过度增殖有关的病症的方法。

6. 发明申请

WO2006071805A3 PERINUCLEOLAR COMPARTMENT MARKERS FOR CANCERS 审中-公开
标题翻译：糖尿病患者的乳房标签
公开(公告)号：WO2006071805A3
公开(公告)日：2007-04-19
申请号：PCT/US2005046890
申请日：2005-12-22
申请人： UNIV NORTHWESTERN , HUANG SUI , WANG CHEN
发明人： HUANG SUI , WANG CHEN
IPC分类号： C12Q1/68
CPC分类号： G01N33/57496
摘要： The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
摘要翻译：本发明涉及癌症诊断，预后和预测的组合物和方法，包括但不限于癌症标志物。特别地，本发明提供了作为癌症标记物的周围核隔室及其驻留分子。

7. 发明申请

WO2006071805A9 PERINUCLEOLAR COMPARTMENT MARKERS FOR CANCERS 审中-公开
标题翻译：乳腺癌标签
公开(公告)号：WO2006071805A9
公开(公告)日：2006-09-14
申请号：PCT/US2005046890
申请日：2005-12-22
申请人： UNIV NORTHWESTERN , HUANG SUI , WANG CHEN
发明人： HUANG SUI , WANG CHEN
IPC分类号： G01N33/574
CPC分类号： G01N33/57496
摘要： The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
摘要翻译：本发明涉及癌症诊断，预后和预测的组合物和方法，包括但不限于癌症标志物。特别地，本发明提供了作为癌症标记物的周围核隔室及其驻留分子。

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