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1. 发明申请

WO03104439A2 ASSAY DEVICE THAT ANALYZES THE ABSORPTION, METABOLISM, PERMEABILITY AND/OR TOXICITY OF A CANDIDATE COMPOUND 审中-公开
标题翻译：分析试剂盒，分析候选化合物的吸收，代谢，渗透性和/或毒性
公开(公告)号：WO03104439A2
公开(公告)日：2003-12-18
申请号：PCT/US0307465
申请日：2003-03-12
申请人： SURFACE LOGIX INC , CAMPBELL STUART , KIM ENOCH , KIRK GREGORY L , OSTUNI EMANUELE , SCHUELLER OLIVIER , CASAGRANDE ROCCO , WANG EVELYN , SWEETNAM PAUL
发明人： CAMPBELL STUART , KIM ENOCH , KIRK GREGORY L , OSTUNI EMANUELE , SCHUELLER OLIVIER , CASAGRANDE ROCCO , WANG EVELYN , SWEETNAM PAUL
IPC分类号： C12M1/00 , C12N5/08 , C12N
CPC分类号： B82Y30/00 , C12M23/12 , C12M23/16 , C12M25/02 , C12M29/10 , C12M35/08 , C12N2503/00 , C12N2503/02 , G01N33/5014
摘要： This invention provides device for co-culturing at least two different cell types in a two-dimensional configuration, methods of patterning at least two different cell types in a two-dimensional co-culture configuration, and uses of these devices and methods for analyzing an effect of candidate compound on such cellular co-cultures. Also provided is a transmigration and extravasation device. Assay devices for analyzing the absorption, permeability, metabolism and/or toxicity of a candidate compound by a cell are provided. A microfluidic network, which is adaptable for integration with a device for coculturing is provided.
摘要翻译：本发明提供用于以二维配置共培养至少两种不同细胞类型的装置，在二维共培养构型中构图至少两种不同细胞类型的方法，以及这些装置和方法用于分析候选化合物对这种细胞共培养物的作用。还提供了一种迁移和外渗装置。提供了用于分析细胞的候选化合物的吸收，渗透性，代谢和/或毒性的测定装置。提供了适用于与用于共同培养的装置集成的微流控网络。

2. 发明申请

WO2003091730A1 DEVICE AND METHOD FOR MONITORING LEUKOCYTE MIGRATION 审中-公开
标题翻译：监测低密度脂蛋白迁移的装置和方法
公开(公告)号：WO2003091730A1
公开(公告)日：2003-11-06
申请号：PCT/US2003/012764
申请日：2003-04-24
申请人： SURFACE LOGIX, INC. , KIRK, Gregory , KIM, Enoch , OSTUNI, Emanuele , SCHUELLER, Olivier , SWEETNAM, Paul , BROWN, Matthew , AUMOND, Bernardo , BENOIT, Brian , CRUCETA, Johanna
发明人： KIRK, Gregory , KIM, Enoch , OSTUNI, Emanuele , SCHUELLER, Olivier , SWEETNAM, Paul , BROWN, Matthew , AUMOND, Bernardo , BENOIT, Brian , CRUCETA, Johanna
IPC分类号： G01N33/53
CPC分类号： G01N33/56972 , G01N33/54313 , G01N33/54366
摘要： A device for monitoring leukocyte migration is provided. The invention also provides a method of using the device to monitor leukocyte migration in the presence of physiological shear flow and therefore simulate physiological conditions of a blood vessel in vivo. The invention further provides a method of using the device to high-throughput screen a plurality of test agents. The present invention further provides a flexible assay system and numerous assays that can be used to test biological interactions and systems. Laminar flow gradients are employed mimic gradient situations present in vivo .
摘要翻译：提供了一种用于监测白细胞迁移的装置。本发明还提供了一种使用该装置在存在生理剪切流的情况下监测白细胞迁移并因此模拟体内血管生理条件的方法。本发明还提供了一种使用该设备来高通量筛选多个测试代理的方法。本发明进一步提供灵活的测定系统和可用于测试生物相互作用和系统的许多测定。采用层状流动梯度模拟体内存在的梯度情况。

3. 发明申请

WO2008024494A9 PHARMACOKINETICALLY IMPROVED COMPOUNDS 审中-公开
公开(公告)号：WO2008024494A9
公开(公告)日：2008-02-28
申请号：PCT/US2007/018784
申请日：2007-08-23
申请人： SURFACE LOGIX, INC. , CAMPBELL, Stewart , DUFFY, David , GROGAN, Michael , KATES, Steven , OSTUNI, Emanuele , SCHUELLER, Olivier , SWEETNAM, Paul
发明人： CAMPBELL, Stewart , DUFFY, David , GROGAN, Michael , KATES, Steven , OSTUNI, Emanuele , SCHUELLER, Olivier , SWEETNAM, Paul
IPC分类号： A01N43/90 , A61K31/519
摘要： A compound of formula (A) having improved non-specific binding characteristics and pharmacokinetic properties is provided or a pharmaceutically acceptable salt, stereoisomer, or hydrate thereof.

4. 发明申请

WO2008024494A3 PHARMACOKINETICALLY IMPROVED COMPOUNDS 审中-公开
公开(公告)号：WO2008024494A3
公开(公告)日：2008-02-28
申请号：PCT/US2007/018784
申请日：2007-08-23
申请人： SURFACE LOGIX, INC. , CAMPBELL, Stewart , DUFFY, David , GROGAN, Michael , KATES, Steven , OSTUNI, Emanuele , SCHUELLER, Olivier , SWEETNAM, Paul
发明人： CAMPBELL, Stewart , DUFFY, David , GROGAN, Michael , KATES, Steven , OSTUNI, Emanuele , SCHUELLER, Olivier , SWEETNAM, Paul
IPC分类号： A01N43/90 , A61K31/519
摘要： A compound of formula (A) having improved non-specific binding characteristics and pharmacokinetic properties is provided or a pharmaceutically acceptable salt, stereoisomer, or hydrate thereof.

5. 发明申请

WO2002086452A3 SELECTIVE DEPOSITION OF MATERIALS ON CONTOURED SURFACES 审中-公开
公开(公告)号：WO2002086452A3
公开(公告)日：2002-10-31
申请号：PCT/US2002/009149
申请日：2002-03-25
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHILDREN'S MEDICAL CENTER CORPORATION , OSTUNI, Emanuele , CHEN, Christopher, S. , INGBER, Donald, E. , WHITESIDES, George, M.
发明人： OSTUNI, Emanuele , CHEN, Christopher, S. , INGBER, Donald, E. , WHITESIDES, George, M.
IPC分类号： C12N11/08
摘要： A material is selectively deposited on substrate having a contoured surface including protrusions and recesses. A first fluid is applied to the surface to contact the protrusions and not the recesses, and a first material is deposited on the substrate where the substrate is in contact with the fluid. A second fluid may be applied to contact the recesses, and a second material is deposited on the substrate where the substrate is in contact with the fluid. A third fluid may be applied, and a third material having affinity for one of the first and second materials is deposited only where one of the first and second materials is deposited. The first and second material may be a protein, and the first, second and third materials may respectively be cytophobic, cytophilic and a cell. The substrate may be formed of a polymer such as polydimethylsiloxane. A cell containment device is provided containing the substrate with a cytophobic material connected to the protrusions and a cytophilic material connected to the recesses.

6. 发明申请

WO2006089275A2 METHODS OF MAKING PHARMACOKINETICALLY IMPROVED COMPOUNDS COMPRISING FUNCTIONAL RESIDUES OR GROUPS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID COMPOUNDS 审中-公开
标题翻译：制备包含功能性残留物或组合的药物动力学改进的化合物的方法和包含化合物的药物组合物
公开(公告)号：WO2006089275A2
公开(公告)日：2006-08-24
申请号：PCT/US2006006047
申请日：2006-02-21
申请人： SURFACE LOGIX INC , LUND FRANCES E , DUFFY DAVID , GROGAN MICHAEL , KATES STEVEN , OSTUNI EMANUELE , SCHUELLER OLIVIER , SWEETNAM PAUL
发明人： LUND FRANCES E , DUFFY DAVID , GROGAN MICHAEL , KATES STEVEN , OSTUNI EMANUELE , SCHUELLER OLIVIER , SWEETNAM PAUL
IPC分类号： A61K31/53
CPC分类号： A61K31/53
摘要： The present invention relates to methods of modulating the pharmacokinetic and/or pharmacodynamic properties of a compound by attaching at least one functional unit or group to the compound, thereby improving its non-specific binding characteristics and/or pharmacokinetic properties. Compounds comprising at least one functional residue are provided, as are pharmaceutical compositions comprising said compounds.
摘要翻译：本发明涉及通过将至少一个功能单元或基团连接到化合物上来调节化合物的药代动力学和/或药效学性质的方法，从而改善其非特异性结合特征和/或药代动力学性质。提供包含至少一个功能性残基的化合物，以及包含所述化合物的药物组合物。

7. 发明申请

WO2004092322A3 DEVICES AND ASSAYS FOR MONITORING/MEASURING CELLULAR DYNAMICS TO CREATE SUBJECT PROFILES FROM PRIMARY CELLS 审中-公开
标题翻译：用于监测/测量细胞动力学以从主要细胞产生主体轮廓的装置和测定
公开(公告)号：WO2004092322A3
公开(公告)日：2005-03-24
申请号：PCT/US2004011454
申请日：2004-04-14
申请人： SURFACE LOGIX INC , KIRK GREGORY L , KIM ENOCH , OSTUNI EMANUELE , SCHUELLER OLIVIER , SWEETNAM PAUL
发明人： KIRK GREGORY L , KIM ENOCH , OSTUNI EMANUELE , SCHUELLER OLIVIER , SWEETNAM PAUL
IPC分类号： C12M1/00 , C12M1/34 , C12N5/06 , G01N33/50
CPC分类号： B82Y30/00 , G01N33/5091
摘要： The present invention further relates to utilizing the above devices and methods for assaying cellular dynamics and phenotypes to create subject primary cell profiles for patients. Additionally, the present invention relates to methods of correlating primary cell profiles with a therapeutic regimen. Finally, the invention relates to methods for screening tests compounds for biological activities by measuring their effect on primary cell profiles.
摘要翻译：本发明还涉及利用上述装置和方法来测定细胞动力学和表型以产生患者的受试者原发细胞谱。另外，本发明涉及将原代细胞谱与治疗方案相关联的方法。最后，本发明涉及通过测量其对原代细胞谱的影响来筛选生物活性化合物的方法。

8. 发明申请

WO2004038368A2 DEVICE AND METHOD FOR MONITORING LEUKOCYTE MIGRATION 审中-公开
标题翻译：监测白细胞迁移的装置和方法
公开(公告)号：WO2004038368A2
公开(公告)日：2004-05-06
申请号：PCT/US2003/033177
申请日：2003-10-21
申请人： SURFACE LOGIX, INC. , KIRK, Gregory, L. , KIM, Enoch , OSTUNI, Emanuele , SCHUELLER, Olivier , SWEETNAM, Paul
发明人： KIRK, Gregory, L. , KIM, Enoch , OSTUNI, Emanuele , SCHUELLER, Olivier , SWEETNAM, Paul
IPC分类号： G01N
CPC分类号： G01N33/5029 , B01L3/5025 , B01L3/5027 , B01L2300/0681 , B01L2300/0829 , B82Y15/00 , B82Y30/00
摘要： A device for monitoring leukocyte migration is provided. The invention also provides a method of using the device to monitor leukocyte migration in the presence of physiological shear flow and therefore simulate physiological conditions of a blood vessel in vivo. The invention further provides a method of using the device to high-throughput screen a plurality of test agents. The present invention further provides a flexible assay system and numerous assays that can be used to test biological interactions and systems. Laminar flow gradients are employed mimic gradient situations present in vivo.
摘要翻译：提供了一种用于监测白细胞迁移的装置。本发明还提供了使用该装置在生理剪切流存在下监测白细胞迁移并因此模拟血管体内生理条件的方法。本发明进一步提供了使用该装置高通量筛选多个测试代理的方法。本发明进一步提供了可用于测试生物相互作用和系统的灵活测定系统和许多测定。采用层流梯度模拟体内存在的梯度情况。

9. 发明申请

WO2003053598A1 APPARATUS AND METHOD FOR HANDLING MEMBRANES 审中-公开
标题翻译：装置和处理膜的方法
公开(公告)号：WO2003053598A1
公开(公告)日：2003-07-03
申请号：PCT/US2002/040701
申请日：2002-12-18
申请人： SURFACE LOGIX, INC. , RAPHEL, Aaron , KIM, Enoch , OSTUNI, Emanuele , KIRK, Gregory , SCHUELLER, Olivier
发明人： RAPHEL, Aaron , KIM, Enoch , OSTUNI, Emanuele , KIRK, Gregory , SCHUELLER, Olivier
IPC分类号： B05D5/00
CPC分类号： B29C41/02 , B29C33/424 , B29L2031/755 , Y10T428/24802 , Y10T428/31504
摘要： A method for applying a pattern (55) to a target surface includes the steps of applying a coating of membrane material (30) over a selected portion of a substrate (20). The substrate (20) imparts a pattern to the membrane material (30) corresponding to a pattern (55) to be applied to the target surface. A support member (35) is positioned in contact with an outer portion of the membrane material(30). The support member (35) has a higher rigidity than the membrane material (30). The method may also combine the steps of curing the membrane material (30) to bond the support member (35) to the membrane. When bonded to the membrane, the support member (35) maintains at least a portion of the membrane in a substantially taut condition to prevent a portion of the membrane from folding onto itself. The membrane is then employed to impart the pattern (55) to the target surface.
摘要翻译：将图案（55）施加到目标表面的方法包括以下步骤：在衬底（20）的选定部分上涂覆膜材料（30）的涂层。基板（20）将图案赋予对应于要施加到目标表面的图案（55）的膜材料（30）。支撑构件（35）定位成与膜材料（30）的外部部分接触。支撑构件（35）具有比膜材料（30）更高的刚性。该方法还可以组合固化膜材料（30）以将支撑构件（35）结合到膜的步骤。当粘合到膜时，支撑构件（35）将膜的至少一部分保持在基本拉紧的状态，以防止膜的一部分折叠到其自身上。然后使用膜将图案（55）赋予目标表面。

10. 发明申请

WO2003012726A1 METHOD AND DEVICE FOR MONITORING CELL MOTILITY IN REAL-TIME 审中-公开
标题翻译：用于实时监测细胞动力的方法和装置
公开(公告)号：WO2003012726A1
公开(公告)日：2003-02-13
申请号：PCT/US2002/024071
申请日：2002-07-29
申请人： SURFACE LOGIX, INC. , KIM, Enoch , KIRK, Gregory, L. , SCHEULLER, Oliver , OSTUNI, Emanuele , WANG, Evelyn , RAPHEL, Aaron , BROWN, Matthew
发明人： KIM, Enoch , KIRK, Gregory, L. , SCHEULLER, Oliver , OSTUNI, Emanuele , WANG, Evelyn , RAPHEL, Aaron , BROWN, Matthew
IPC分类号： G06K9/00
CPC分类号： B82Y30/00 , B01L3/5085 , B01L2200/12 , B01L2300/0636 , B01L2300/0887 , B01L2300/0893 , C12M23/12 , C12M25/06 , C12M41/46 , G06T7/70 , G06T2207/30072
摘要： The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support (140), a first layer (150) configured to be placed in fluid-tight contact with the support, the first layer (150) having an upper surface (140a) and defining a pattern of micro-orifices (300), each micro-orifice of the pattern of micro-orifices (300) having walls (150a) and defining a micro-region on the support (140) when the first layer (150) is placed in fluid-tight contact with the support such that the walls (150a) of each micro-orifice (300) and the micro-region on the support (140) together define a micro-well (141); and a second layer (160) configured to be placed in fluid-tight contact with the upper surface of the first layer (150), the second layer (160) defining a pattern of macro-orifices (170), each macro-orifice (170) of the pattern of macro-orifices (170) having walls and defining a macro-region when the first layer is placed in fluid-tight contact with the support (140) and the second layer (160) is placed in fluid-tight contact with the first layer (150) such that the walls of the macro-orifice and the macro-region together define a macro-well (151).
摘要翻译：本发明涉及用于排列生物分子的装置，包括细胞，用于排列生物分子的方法，用于监测细胞运动的测定法和用于监测细胞运动的系统。所述装置包括支撑件（140），被配置为与所述支撑件流体密封接触的第一层（150），所述第一层（150）具有上表面（140a）并限定微孔图案 300），当所述第一层（150）与所述第一层（150）流体密封地接触时，所述微孔图案的每个微孔具有壁（150a）并且在所述支撑件（140）上限定微区域支撑，使得每个微孔（300）的壁（150a）和支撑件（140）上的微区域一起限定微孔（141）; 和配置成与第一层（150）的上表面流体密封接触的第二层（160），第二层（160）限定宏观孔（170）的图案，每个宏观孔具有壁的大孔（170）的图案的图示（170），并且当第一层被放置成与支撑件（140）流体密封接触并且第二层（160）被置于流体密封与第一层（150）接触，使得宏观孔口和宏观区域的壁一起限定了宏观井（151）。

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