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1. 发明申请

WO2006065686A3 SPIRO DERIVATIVES AS LIPOXYGENASE INHIBITORS 审中-公开
标题翻译： SPIRO衍生物作为LIPOXYGENASE抑制剂
公开(公告)号：WO2006065686A3
公开(公告)日：2006-08-24
申请号：PCT/US2005044768
申请日：2005-12-09
申请人： GALILEO PHARMACEUTICALS INC , CHU DANIEL T W , CHEN JIAN , CONG QIANG , JAMES DONALD R , LI XIANFENG , SONG JIANGAO , WANG BING , ZHANG WEI
发明人： CHU DANIEL T W , CHEN JIAN , CONG QIANG , JAMES DONALD R , LI XIANFENG , SONG JIANGAO , WANG BING , ZHANG WEI
IPC分类号： C07D311/96 , A61K31/352 , A61K31/382 , A61K31/4747 , A61P35/00 , C07D221/20 , C07D335/04 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D407/04 , C07D413/04 , C07D417/04
CPC分类号： C07D221/20 , C07D311/96 , C07D335/04 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D407/04 , C07D413/04 , C07D417/04
摘要： The present invention is concerned with certain novel spiro substituted heterocyclic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenase. They may also be useful in the manufacture of pharmaceutical formulations for the treatment of lipoxygenase-mediated disorders.
摘要翻译：本发明涉及一些新的螺取代杂环衍生物。这些化合物可用于制备用于治疗由脂氧合酶介导的病症的药物组合物。它们也可用于制备用于治疗脂氧合酶介导的病症的药物制剂。

2. 发明申请

WO2006093547A3 NOVEL LIPOXYGENASE INHIBITORS 审中-公开
标题翻译：新型LIPOXYGENASE抑制剂
公开(公告)号：WO2006093547A3
公开(公告)日：2007-02-22
申请号：PCT/US2005044360
申请日：2005-12-09
申请人： GALILEO PHARMACEUTICALS INC , ZHANG WEI , CHEN JIAN
发明人： ZHANG WEI , CHEN JIAN
IPC分类号： C07D207/10 , A61K31/40 , A61K31/445 , C07D211/60
CPC分类号： A61K8/498 , A61K31/353 , A61K2800/782 , A61Q19/00 , C07D311/22 , C07D311/68 , C07D311/70 , C07D335/06
摘要： The present invention is concerned with certain novel derivatives of Formula (I): wherein X and R 1 to R 10 are as described in the specification, and where either R 5 is OH, -NR d OR a or NR d -NR b R c , or R 7 is -NR d OR a or NR d -NR b R c , or C=R 7 R 8 is C=NOR a or C=N-NR b R c , which may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful in the manufacture of pharmaceutical formulations for the treatment of lipoxygenase mediated disorders.
摘要翻译：本发明涉及式（I）的某些新型衍生物：其中X和R 1至R 10如说明书所述，并且其中R 0 > 5 是OH，-NR d，或O，或NR d，-NR b，或者R 7是-NR 11或-NR 11或-NR 11 或者C = R 7 R 8是C = NOR a S / O， >或C = N-NR B，其可用于制备用于治疗由脂肪氧合酶介导的病症的药物组合物。它们也可用于制备用于治疗脂氧合酶介导的病症的药物制剂。

3. 发明申请

WO2008124703A3 DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY 审中-公开
标题翻译：使用单一化学物质开发碳氢化合物IX的分子成像探针
公开(公告)号：WO2008124703A3
公开(公告)日：2009-02-05
申请号：PCT/US2008059599
申请日：2008-04-07
申请人： SIEMENS MEDICAL SOLUTIONS , KOLB HARTMUTH C , WALSH JOSEPH C , KASI DHANALAKSHMI , MOCHARLA VANI , WANG BING , GANGADHARMATH UMESH B , DUCLOS BRIAN A , CHEN KAI , ZHANG WEI , CHEN GANG , PADGETT HENRY CLIFTON , KARIMI FARHAD , SCOTT PETER J H , GAO ZHIYONG , LIANG QIANWA , COLLIER THOMAS LEE , ZHAO TIEMING , XIA CHUNFANG
发明人： KOLB HARTMUTH C , WALSH JOSEPH C , KASI DHANALAKSHMI , MOCHARLA VANI , WANG BING , GANGADHARMATH UMESH B , DUCLOS BRIAN A , CHEN KAI , ZHANG WEI , CHEN GANG , PADGETT HENRY CLIFTON , KARIMI FARHAD , SCOTT PETER J H , GAO ZHIYONG , LIANG QIANWA , COLLIER THOMAS LEE , ZHAO TIEMING , XIA CHUNFANG
IPC分类号： C07D249/04 , A61K31/4192 , A61P35/00 , C07D249/06 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D417/14 , G01N33/532
CPC分类号： C07D417/04 , C07D249/04 , C07D249/06 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14 , C12Q1/485 , G01N2500/04 , G01N2500/10
摘要： The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.
摘要翻译：本申请公开了使用点击化学法鉴定对碳酸酐酶IX（CA-IX）酶具有高结合亲和力的抑制剂的方法，并将其候选用作正电子发射断层摄影（PET）成像剂。

4. 发明申请

WO2005016270A2 METHODS FOR TREATMENT OF DERMATOLOGICAL CONDITIONS 审中-公开
标题翻译：治疗皮肤病的方法
公开(公告)号：WO2005016270A2
公开(公告)日：2005-02-24
申请号：PCT/US2004025128
申请日：2004-08-02
申请人： GALILEO PHARMACEUTICALS INC
发明人： WANG BING , BODDUPALLI SEKHAR , LI XIANFENG , MAHMOOD KHALID , MILLER GUY , ZHANG WEI
IPC分类号： A61K8/44 , A61K8/49 , A61K31/135 , A61K31/195 , A61K31/40 , A61K31/44 , A61K31/66 , A61K45/06 , A61Q19/00 , A61Q19/08 , A61K
CPC分类号： A61K45/06 , A61K8/44 , A61K8/49 , A61K8/498 , A61K31/135 , A61K31/195 , A61K31/40 , A61K31/44 , A61K31/66 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： A method of reducing the appearance of skin conditions associated with loss of skin tightness, skin firmness, or dark circles under the eyes with topical compositions comprising compounds of any of the Formulae (I) or (Ia) as described herein, is disclosed.
摘要翻译：公开了用包含如本文所述的任何式（I）或（Ia）的化合物的局部用组合物来减少与眼睛下方的皮肤紧度丧失，皮肤紧致度或黑眼圈相关的皮肤病状的出现的方法。

5. 发明申请

WO2015084681A3 AUTOMATED BREAST ULTRASOUND EQUIPMENT AND METHODS USING ENHANCED NAVIGATOR AIDS 审中-公开
标题翻译：自动乳房超声波设备和使用增强导航器艾滋病的方法
公开(公告)号：WO2015084681A3
公开(公告)日：2015-10-29
申请号：PCT/US2014067758
申请日：2014-11-26
申请人： QVIEW MEDICAL INC , ZHANG WEI , SCHEIDER ALEXANDER , WANG SHIH-PING , ROMSDAHL HARLAN , NEFF THOMAS
发明人： ZHANG WEI , SCHEIDER ALEXANDER , WANG SHIH-PING , ROMSDAHL HARLAN , NEFF THOMAS
IPC分类号： A61B8/00
CPC分类号： A61B8/085 , A61B8/0825 , A61B8/403 , A61B8/4405 , A61B8/5223
摘要： A method and system acquiring, processing and displaying breast ultrasound images in a way that makes breast ultrasound screening more practical and thus more widely used, and reduces the occurrence of missing cancers in screening and diagnosis, using automated scanning of chestwardly compressed breasts with ultrasound. Enhanced, whole-breast navigator overview images are produced from scanning breasts with ultrasound that emphasize abnormalities in the breast while excluding obscuring influences of non-breast structures, particularly those external to the breast such as ribs and chest wall, and differentiating between likely malignant and likely benign abnormalities and otherwise enhancing the navigator overview image and other images, thereby reducing the time to read, screen, and/or diagnose to practical time limits and also reduce screening or diagnostic errors.
摘要翻译：一种方法和系统采用乳房超声检查更加实用，因此更广泛使用的方式获取，处理和显示乳房超声图像，并通过使用超声波胸部压缩乳房进行自动扫描，减少筛查和诊断中遗漏的癌症的发生。增强的全乳头导航仪概述图像是通过扫描具有强调乳房异常的超声波的乳房产生的，同时排除非乳房结构的模糊影响，特别是胸部以外的肋骨和胸壁，以及可能的恶性和可能是良性异常，否则增强导航仪概览图像和其他图像，从而减少读取，屏幕和/或诊断到实际时间限制的时间，并且还减少筛查或诊断错误。

6. 发明申请

WO2012096825A3 HYBRID SPECTROPHOTOMETRIC MONITORING OF BIOLOGICAL CONSTITUENTS 审中-公开
标题翻译：生物组分的混合分光光度法监测
公开(公告)号：WO2012096825A3
公开(公告)日：2012-09-07
申请号：PCT/US2012020319
申请日：2012-01-05
申请人： O2 MEDTECH INC , ZHANG WEI , YU ZENGPIN , WANG SHIH-PING
发明人： ZHANG WEI , YU ZENGPIN , WANG SHIH-PING
IPC分类号： A61B5/1477
CPC分类号： A61B5/1455
摘要： Systems, methods, and related computer program products for non-invasive NIR spectrophotometric (NIRS) monitoring of total blood hemoglobin levels and/or other blood constituent levels based on a hybrid combination of phase modulation spectrophotometry (PMS) and continuous wave spectrophotometry (CWS) are described. PMS-based measurements including both amplitude and phase information used in the determination of a non-pulsatile component of an absorption property for each of at least three distinct wavelengths are processed to compute PMS-derived intermediate information at least partially representative of a scattering characteristic. CWS-based measurements including amplitude information is processed in conjunction with the PMS-derived intermediate information to compute a pulsatile component of the absorption property. A metric representative of at least one chromophore level, such as the total blood hemoglobin level, is computed from the pulsatile component of the absorption property at the at least three wavelengths and displayed on an output display.
摘要翻译：基于相位调制分光光度法（PMS）和连续波分光光度法（CWS）的混合组合，用于非侵入式近红外分光光度（NIRS）监测总血红蛋白水平和/或其他血液成分水平的系统，方法和相关计算机程序产品，被描述。处理包括用于确定至少三个不同波长中的每一个的吸收特性的非脉动分量的振幅和相位信息的基于PMS的测量值，以计算至少部分表示散射特性的PMS导出的中间信息。结合PMS导出的中间信息处理包括幅度信息的基于CWS的测量值，以计算吸收特性的脉动分量。从至少三个波长处的吸收特性的脉动分量计算代表至少一个发色团水平的量度，例如总血红蛋白水平，并显示在输出显示器上。

7. 发明申请

WO2012003989A3 DETERMINING THE CONCENTRATION OF A BLOOD CONSTITUENT IN TUBING 审中-公开
标题翻译：测定血液成分的浓度在软管组件
公开(公告)号：WO2012003989A3
公开(公告)日：2012-03-08
申请号：PCT/EP2011003401
申请日：2011-07-08
申请人： FRESENIUS MEDICAL CARE DE GMBH , ZHANG WEI
发明人： ZHANG WEI
IPC分类号： A61B5/1455
CPC分类号： A61B5/14557 , G01N21/31 , G01N21/359 , G01N21/51 , G01N33/49 , G01N2021/3144 , G01N2021/3181
摘要： The invention relates to a method and a device for determining the concentration of a blood constituent in tubing, in particular tubing (5) of an extracorporal blood circuit (I) of an extracorporal blood treatment unit. The invention also relates to an extracorporal blood treatment device comprising a device (11) for determining the concentration of a blood constituent. The claimed method and the claimed device relate to the correction of the influence of the tubing on the determination of the concentration of the blood constituent. In order to determine the correction factor k, a reference measurement is carried out with a liquid other than blood, in order to be able to determine the correlation between the intensity of emitted electromagnetic radiation in tubing which is filled with blood containing the blood constituent in a defined concentration, and in tubing which is filled with a liquid other than blood. The correction factor is then determined on the basis of the previously determined correlation between the intensity of the emitted electromagnetic radiation in tubing filled with blood and in tubing filled with a liquid other than blood and on the basis of the previously measured intensity of the electromagnetic radiation which is emitted by the tubing filled with a liquid other than blood.
摘要翻译：本发明涉及一种用于确定血液的成分的浓度中的软管线，在体外血液处理装置的体外血液回路（I）的特定的软管管线（5）的方法和装置。此外，本发明涉及一种具有用于确定血液成分的浓度的装置（11）的体外血液处理的设备。本发明的方法和本发明的装置是基于所述软管线到血液成分的浓度的确定的影响的校正。为了确定校正因子K，参考测量与液体以外的血液进行以在一个管道，其填充有含有给定浓度的血液成分的血液的软管线输出耦合的电磁辐射的强度之间的关系，并填充有血液以外的液体，可以被确定。校正因子的确定，然后在输出耦合的电磁辐射的强度之间预先确定的关系的基础上进行了血液填充，并用比在一方面与电磁辐射的从先前测量的强度的基础上，血管线以外的液体填充填充比血管线之外的液体耦合。

8. 发明申请

WO2009050588A3 POWER CONTROL IN COGNITIVE RADIO SYSTEMS BASED ON SPECTRUM SENSING SIDE INFORMATION 审中-公开
标题翻译：基于频谱侧面信息的认知无线电系统功率控制
公开(公告)号：WO2009050588A3
公开(公告)日：2009-07-23
申请号：PCT/IB2008003360
申请日：2008-04-10
申请人： UNIV HONG KONG SCIENCE & TECHN , HAMDI KARAMA , ZHANG WEI , BEN LETAIEF KHALED
发明人： HAMDI KARAMA , ZHANG WEI , BEN LETAIEF KHALED
IPC分类号： H04W52/24 , H04B7/00
CPC分类号： H04W52/26 , H04W16/14 , H04W52/242 , H04W52/243 , H04W52/246 , H04W52/265 , H04W52/283 , H04W64/00
摘要： For cognitive radio systems, the transmit power of a cognitive radio device is controlled so that the cognitive, unlicensed radio device does not interfere with the use of a shared spectrum by a primary, licensed device. Controlling the transmit power includes determining a distance, or a function of the distance, between a primary transmitter of the primary device and the cognitive radio device based on sensing information from a spectrum sensing process. The maximum transmit power of the cognitive radio device is then dynamically controlled based on the distance, or the function of the distance, while considering a worst case scenario of an underlying cognitive radio model, to guarantee a quality of service requirement of the primary device.
摘要翻译：对于认知无线电系统，认知无线电设备的发射功率被控制，使得认知的，未许可的无线电设备不干扰主要许可设备对共享频谱的使用。控制发射功率包括基于来自频谱感测过程的感测信息来确定主装置的主发射器与认知无线电装置之间的距离或距离的函数。然后基于距离或距离的函数动态控制认知无线电设备的最大发射功率，同时考虑底层认知无线电模型的最坏情况，以保证主设备的服务质量要求。

9. 发明申请

WO2009044292A3 CLUSTER-BASED COOPERATIVE SPECTRUM SENSING IN COGNITIVE RADIO SYSTEMS 审中-公开
标题翻译：认知无线电系统中基于聚类的合作频谱感知
公开(公告)号：WO2009044292A3
公开(公告)日：2009-05-22
申请号：PCT/IB2008003432
申请日：2008-04-08
申请人： UNIV HONG KONG SCIENCE & TECHN , SUN CHUNHUA , ZHANG WEI , BEN LETAIEF KHALED
发明人： SUN CHUNHUA , ZHANG WEI , BEN LETAIEF KHALED
IPC分类号： H04B7/26 , H04W16/14 , H04W84/18
CPC分类号： H04W16/14 , H04W84/18
摘要： Cluster-based cooperative spectrum sensing is provided for cognitive radio systems. For each cluster of cognitive users, a cluster head is determined. Each cluster head collects energies of a reporting channel measured by the cognitive users within the cluster and decides whether a primary user is absent from a given spectrum. A common receiver then aggregates the cluster-level decisions made by the cluster heads, and makes a decision across multiple, or all of, the clusters whether the primary user is absent based on a fusion function of the cluster-level decisions. If the primary (licensed) user is absent, then secondary (unlicensed) users may utilize the spectrum.
摘要翻译：为认知无线电系统提供了基于簇的协作频谱感知。对于每个认知用户集群，确定集群头。每个簇头收集由群集内的认知用户测量的报告信道的能量，并且确定主用户是否不在给定的频谱中。然后，公共接收器聚合由簇头做出的集群级决策，并且基于聚类级别决策的融合功能，通过多个或全部群集来决定主用户是否不存在。如果主（许可）用户不存在，则次要（未许可）用户可以利用频谱。

10. 发明申请

WO2007109326A3 METHODS AND MATERIALS USEFUL FOR CHIP STACKING, CHIP AND WAFER BONDING 审中-公开
标题翻译：用于芯片堆叠，芯片和波形结合的方法和材料
公开(公告)号：WO2007109326A3
公开(公告)日：2008-07-17
申请号：PCT/US2007007029
申请日：2007-03-21
申请人： PROMERUS LLC , APANIUS CHRIS , SHICK ROBERT A , NG HENDRA , BELL ANDREW , ZHANG WEI , NEAL PHIL
发明人： APANIUS CHRIS , SHICK ROBERT A , NG HENDRA , BELL ANDREW , ZHANG WEI , NEAL PHIL
IPC分类号： H01L21/98 , H01L25/065
CPC分类号： H01L24/29 , C08F32/00 , C08G64/0208 , C09D145/00 , H01L24/13 , H01L24/73 , H01L24/81 , H01L24/83 , H01L25/0657 , H01L25/50 , H01L2224/05568 , H01L2224/05573 , H01L2224/131 , H01L2224/16145 , H01L2224/16225 , H01L2224/16227 , H01L2224/274 , H01L2224/29 , H01L2224/29101 , H01L2224/2919 , H01L2224/29298 , H01L2224/32145 , H01L2224/32225 , H01L2224/33181 , H01L2224/48091 , H01L2224/48227 , H01L2224/48472 , H01L2224/73103 , H01L2224/73203 , H01L2224/73204 , H01L2224/73265 , H01L2224/81191 , H01L2224/81903 , H01L2224/83191 , H01L2224/83193 , H01L2224/83203 , H01L2224/838 , H01L2225/0651 , H01L2225/06513 , H01L2225/06517 , H01L2225/06575 , H01L2924/00013 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01019 , H01L2924/01023 , H01L2924/01024 , H01L2924/01025 , H01L2924/01033 , H01L2924/01041 , H01L2924/01047 , H01L2924/01051 , H01L2924/01055 , H01L2924/01058 , H01L2924/01073 , H01L2924/01082 , H01L2924/014 , H01L2924/0665 , H01L2924/10253 , H01L2924/12041 , H01L2924/14 , H01L2924/1433 , H01L2924/1461 , H01L2924/19042 , H01L2924/00 , H01L2924/3512 , H01L2924/00012 , H01L2224/29099 , H01L2224/29199 , H01L2224/29299 , H01L2224/2929 , H01L2224/05599
摘要： Materials, and methods that use such materials, that are useful for forming chip stacks, chip and wafer bonding and wafer thinning are disclosed. Such methods and materials provide strong bonds while also being readily removed with little or no residues.
摘要翻译：公开了使用这种材料的材料和方法，其可用于形成芯片堆叠，芯片和晶片接合以及晶片薄化。这样的方法和材料提供强的键，同时也很少或没有残留物容易地除去。

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