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1. 发明申请

WO2009087380A3 MULTISTANDARD VIDEO MOTION COMPENSATION 审中-公开
标题翻译：多媒体视频运动补偿
公开(公告)号：WO2009087380A3
公开(公告)日：2009-10-15
申请号：PCT/GB2009000040
申请日：2009-01-08
申请人： IMAGINATION TECH LTD , GAO ZHIYONG JOHN
发明人： GAO ZHIYONG JOHN
IPC分类号： H04N7/26 , H04N7/36 , H04N7/50
CPC分类号： H04N19/523 , H04N19/117 , H04N19/134 , H04N19/43 , H04N19/436 , H04N19/61 , H04N19/82
摘要： A method and apparatus are provided for video motion compensation suitable for use in decoding compressed video. An input buffer receives lines of blocks of video data and outputs lines of these to a first block transpose unit (52). This can selectively transpose the lines and columns of an input block of pixels. A vertical line filtering unit (58) is coupled to the block transpose unit for producing an output line of interpolated pixel samples. A first selector with inputs coupled to the output of the vertical line filtering unit and to the output of the input block transpose unit is able to select between an un-interpolated output line of pixels and an interpolated output line of pixel samples. A second selector (62) with inputs coupled to the outputs of the first block transpose unit and to the vertical line filtering unit is able to select between lines of pixels from the first input block transpose unit and from the vertical line filtering unit and provides these to a horizontal line filtering unit (66). The first and second selectors (60), (62) receive control signals related to motion vectors in an incoming stream of data.
摘要翻译：提供了适用于解码压缩视频的视频运动补偿的方法和装置。输入缓冲器接收视频数据块的行并将其输出到第一块转置单元（52）。这可以选择性地转置输入像素块的行和列。垂直线滤波单元（58）耦合到块转置单元，用于产生插值像素采样的输出线。具有耦合到垂直线滤波单元的输出和输入块转置单元的输出的输入的第一选择器能够在未内插的像素输出线和像素采样的内插输出线之间进行选择。具有耦合到第一块转置单元和垂直线滤波单元的输出的输入的第二选择器（62）能够从第一输入块转置单元和垂直线滤波单元的像素行之间进行选择，并且提供这些到水平线滤波单元（66）。第一和第二选择器（60），（62）接收与输入的数据流中的运动矢量有关的控制信号。

2. 发明申请

WO2009102498A1 NOVEL IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION 审中-公开
标题翻译：用于检测神经功能障碍的新型成像剂
公开(公告)号：WO2009102498A1
公开(公告)日：2009-08-20
申请号：PCT/US2009/000961
申请日：2009-02-17
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , KOLB, Hartmuth C. , WALSH, Joseph C. , LIANG, Qianwa , DUCLOS, Brian A. , ZHANG, Wei , SCOTT, Peter J.h. , CHEN, Kai , GAO, Zhiyong , ZHAO, Tieming , MOCHARLA, Vani P. , KASI, Dhanalakshmi , CHEN, Gang , WANG, Eric , SINHA, Anjana , XIA, Chunfang , PADGETT, Henry Clifton , KARIMI, Farhad
发明人： KOLB, Hartmuth C. , WALSH, Joseph C. , LIANG, Qianwa , DUCLOS, Brian A. , ZHANG, Wei , SCOTT, Peter J.h. , CHEN, Kai , GAO, Zhiyong , ZHAO, Tieming , MOCHARLA, Vani P. , KASI, Dhanalakshmi , CHEN, Gang , WANG, Eric , SINHA, Anjana , XIA, Chunfang , PADGETT, Henry Clifton , KARIMI, Farhad
IPC分类号： C07B59/00
CPC分类号： C07B59/002
摘要： Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease
摘要翻译：本文公开了在哺乳动物中诊断阿尔茨海默病或其倾向的化合物和方法，所述方法包括向哺乳动物施用诊断有效量的放射性标记的化合物，其中所述化合物选自放射性标记的黄酮，香豆素，咔唑，喹啉酮，色烯酮，咪唑和三唑衍生物，使化合物分布到脑组织中，并使脑组织成像，其中与正常对照结合水平相比，化合物与脑组织的结合增加指示哺乳动物患有或有发生阿尔茨海默病的风险

3. 发明申请

WO2010011964A3 IMAGING AGENTS USEFUL FOR IDENTIFYING AD PATHOLOGY 审中-公开
标题翻译：成像剂有助于鉴别AD病理
公开(公告)号：WO2010011964A3
公开(公告)日：2010-08-26
申请号：PCT/US2009051748
申请日：2009-07-24
申请人： SIEMENS MEDICAL SOLUTIONS , KOLB HARTMUTH C , WALSH JOSEPH C , ZHANG WEI , GANGADHARMATH UMESH B , KASI DHANALAKSHMI , CHEN KAI , SINHA ANJANA , WANG ERIC , CHEN GANG , MOCHARLA VANI P , SCOTT PETER J H , PADGETT HENRY CLIFTON , LIANG QIANWA , GAO ZHIYONG , ZHAO TIEMING , XIA CHUNFANG
发明人： KOLB HARTMUTH C , WALSH JOSEPH C , ZHANG WEI , GANGADHARMATH UMESH B , KASI DHANALAKSHMI , CHEN KAI , SINHA ANJANA , WANG ERIC , CHEN GANG , MOCHARLA VANI P , SCOTT PETER J H , PADGETT HENRY CLIFTON , LIANG QIANWA , GAO ZHIYONG , ZHAO TIEMING , XIA CHUNFANG
IPC分类号： A61K51/04 , C07D498/14 , C07D513/04 , C07D513/14
CPC分类号： C07D417/14 , A61K51/0406 , A61K51/0453 , A61K51/0455 , A61K51/0459 , C07D277/64 , C07D277/68 , C07D417/04 , C07D471/04 , C07D498/14 , C07D513/04 , C07D513/14
摘要： Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders.. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.
摘要翻译：本文提供了包含本文公开的化学式的化合物和组合物，其中所述化合物是淀粉样蛋白结合化合物。根据本发明的结合淀粉样蛋白的化合物可以以适于淀粉样蛋白沉积物的体内成像的量施用于患者，并区分具有淀粉样蛋白沉积物的神经组织和正常神经组织。本发明的淀粉状蛋白探针可用于检测和定量疾病中的淀粉状蛋白沉积物，所述疾病包括例如唐氏综合征，家族性阿尔茨海默氏病。在另一个实施方案中，所述化合物可用于治疗或预防神经变性疾病。本文还提供了使化合物分布到脑组织中并使脑组织成像的方法，其中所述化合物与与正常对照水平的结合相比，脑组织指示该哺乳动物患有神经退行性疾病或处于发展神经退行性疾病的风险中。

4. 发明申请

WO2010011964A2 IMAGING AGENTS USEFUL FOR IDENTIFYING AD PATHOLOGY 审中-公开
标题翻译：成像代理有助于识别广泛的病理学
公开(公告)号：WO2010011964A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/051748
申请日：2009-07-24
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , KOLB, Hartmuth, C. , WALSH, Joseph, C. , ZHANG, Wei , GANGADHARMATH, Umesh B. , KASI, Dhanalakshmi , CHEN, Kai , SINHA, Anjana , WANG, Eric , CHEN, Gang , MOCHARLA, Vani, P. , SCOTT, Peter J.H. , PADGETT, Henry, Clifton , LIANG, Qianwa , GAO, Zhiyong , ZHAO, Tieming , XIA, Chunfang
发明人： KOLB, Hartmuth, C. , WALSH, Joseph, C. , ZHANG, Wei , GANGADHARMATH, Umesh B. , KASI, Dhanalakshmi , CHEN, Kai , SINHA, Anjana , WANG, Eric , CHEN, Gang , MOCHARLA, Vani, P. , SCOTT, Peter J.H. , PADGETT, Henry, Clifton , LIANG, Qianwa , GAO, Zhiyong , ZHAO, Tieming , XIA, Chunfang
IPC分类号： A61K51/04 , C07D498/14 , C07D513/04 , C07D513/14
CPC分类号： C07D417/14 , A61K51/0406 , A61K51/0453 , A61K51/0455 , A61K51/0459 , C07D277/64 , C07D277/68 , C07D417/04 , C07D471/04 , C07D498/14 , C07D513/04 , C07D513/14
摘要： Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders.. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.
摘要翻译：本文提供了包含本文公开的式的化合物和组合物，其中所述化合物是淀粉样蛋白结合化合物。根据本发明的淀粉样蛋白结合化合物可以以适于淀粉样蛋白沉积物的体内成像的量施用于患者，并且可以区分具有淀粉样沉积物的神经组织和正常神经组织。本发明的淀粉样蛋白探针可用于检测和定量疾病中的淀粉样蛋白沉积物，包括例如唐氏综合症，家族性阿尔茨海默氏病。在另一个实施方案中，所述化合物可用于治疗或预防神经变性疾病。本文还提供了允许化合物分布于脑组织和成像脑组织的方法，其中化合物与脑组织与正常对照水平的结合相比表明哺乳动物患有或有发展为神经变性疾病的风险。

5. 发明申请

WO2008124703A2 DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY 审中-公开
标题翻译：使用单一化学物质开发碳氢化合物IX的分子成像探针
公开(公告)号：WO2008124703A2
公开(公告)日：2008-10-16
申请号：PCT/US2008/059599
申请日：2008-04-07
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , KOLB, Hartmuth C , WALSH, Joseph C. , KASI, Dhanalakshmi , MOCHARLA, Vani , WANG, Bing , GANGADHARMATH, Umesh B. , DUCLOS, Brian A. , CHEN, Kai , ZHANG, Wei , CHEN, Gang , PADGETT, Henry Clifton , KARIMI, Farhad , SCOTT, Peter J. H. , GAO, Zhiyong , LIANG, Qianwa , COLLIER, Thomas Lee , ZHAO, Tieming , XIA, Chunfang
发明人： KOLB, Hartmuth C , WALSH, Joseph C. , KASI, Dhanalakshmi , MOCHARLA, Vani , WANG, Bing , GANGADHARMATH, Umesh B. , DUCLOS, Brian A. , CHEN, Kai , ZHANG, Wei , CHEN, Gang , PADGETT, Henry Clifton , KARIMI, Farhad , SCOTT, Peter J. H. , GAO, Zhiyong , LIANG, Qianwa , COLLIER, Thomas Lee , ZHAO, Tieming , XIA, Chunfang
IPC分类号： C07D249/04 , C07D249/06 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D417/14 , A61P35/00 , A61K31/4192 , G01N33/532
CPC分类号： C07D417/04 , C07D249/04 , C07D249/06 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14 , C12Q1/485 , G01N2500/04 , G01N2500/10
摘要： The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.
摘要翻译：本申请公开了使用点击化学法鉴定对碳酸酐酶IX（CA-IX）酶具有高结合亲和力的抑制剂的方法，并将其候选用作正电子发射断层摄影（PET）成像剂。

6. 发明申请

WO2009087380A2 VIDEO MOTION COMPENSATION 审中-公开
标题翻译：视频运动补偿
公开(公告)号：WO2009087380A2
公开(公告)日：2009-07-16
申请号：PCT/GB2009/000040
申请日：2009-01-08
申请人： IMAGINATION TECHNOLOGIES LIMITED , GAO, Zhiyong, John
发明人： GAO, Zhiyong, John
CPC分类号： H04N19/523 , H04N19/117 , H04N19/134 , H04N19/43 , H04N19/436 , H04N19/61 , H04N19/82
摘要： A method and apparatus are provided for video motion compensation suitable for use in decoding compressed video. An input buffer receives lines of blocks of video data and outputs lines of these to a first block transpose unit (52). This can selectively transpose the lines and columns of an input block of pixels. A vertical line filtering unit (58) is coupled to the block transpose unit for producing an output line of interpolated pixel samples. A first selector with inputs coupled to the output of the vertical line filtering unit and to the output of the input block transpose unit is able to select between an un-interpolated output line of pixels and an interpolated output line of pixel samples. A second selector (62) with inputs coupled to the outputs of the first block transpose unit and to the vertical line filtering unit is able to select between lines of pixels from the first input block transpose unit and from the vertical line filtering unit and provides these to a horizontal line filtering unit (66). The first and second selectors (60), (62) receive control signals related to motion vectors in an incoming stream of data.
摘要翻译：提供了适用于解码压缩视频的视频运动补偿的方法和装置。输入缓冲器接收视频数据块的行并将其输出到第一块转置单元（52）。这可以选择性地转置输入像素块的行和列。垂直线滤波单元（58）耦合到块转置单元，用于产生插值像素采样的输出线。具有耦合到垂直线滤波单元的输出和输入块转置单元的输出的输入的第一选择器能够在未内插的像素输出线和像素采样的内插输出线之间进行选择。具有耦合到第一块转置单元和垂直线滤波单元的输出的输入的第二选择器（62）能够从第一输入块转置单元和垂直线滤波单元的像素行之间进行选择，并且提供这些到水平线滤波单元（66）。第一和第二选择器（60），（62）接收与输入的数据流中的运动矢量有关的控制信号。

7. 发明申请

WO2008124651A2 NITRO-IMIDAZOLE HYPOXIA IMAGING AGENTS 审中-公开
标题翻译： NITRO-IMIDAZOLE HYPOXIA成像剂
公开(公告)号：WO2008124651A2
公开(公告)日：2008-10-16
申请号：PCT/US2008059505
申请日：2008-04-04
申请人： SIEMENS MEDICAL SOLUTIONS , KOLB HARTMUTH C , WALSH JOSEPH C , GANGADHARMATH UMESH B , KARIMI FARHAD , PADGETT HENRY CLIFTON , KASI DHANALAKSHMI , GAO ZHIYONG , LIANG QIANWA , COLLIER THOMAS LEE , DUCLOS BRIAN A , ZHAO TIEMING
发明人： KOLB HARTMUTH C , WALSH JOSEPH C , GANGADHARMATH UMESH B , KARIMI FARHAD , PADGETT HENRY CLIFTON , KASI DHANALAKSHMI , GAO ZHIYONG , LIANG QIANWA , COLLIER THOMAS LEE , DUCLOS BRIAN A , ZHAO TIEMING
CPC分类号： C07D403/06 , C07B59/002 , C07D403/12
摘要： The present invention relates to novel radioactively labeled bioreducible tracers of Formula (I) useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.
摘要翻译：本发明涉及用于体内检测缺氧性肿瘤或缺血组织的式（I）的新型放射性标记生物可还原示踪剂。在一个实施方案中，示踪剂由2-硝基咪唑部分，三唑，具有药代动力学增强取代基的代谢稳定接头和放射性同位素组成。优选的体内成像模式是正电子发射断层摄影。

8. 发明申请

WO2008124703A3 DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY 审中-公开
标题翻译：使用单一化学物质开发碳氢化合物IX的分子成像探针
公开(公告)号：WO2008124703A3
公开(公告)日：2009-02-05
申请号：PCT/US2008059599
申请日：2008-04-07
申请人： SIEMENS MEDICAL SOLUTIONS , KOLB HARTMUTH C , WALSH JOSEPH C , KASI DHANALAKSHMI , MOCHARLA VANI , WANG BING , GANGADHARMATH UMESH B , DUCLOS BRIAN A , CHEN KAI , ZHANG WEI , CHEN GANG , PADGETT HENRY CLIFTON , KARIMI FARHAD , SCOTT PETER J H , GAO ZHIYONG , LIANG QIANWA , COLLIER THOMAS LEE , ZHAO TIEMING , XIA CHUNFANG
发明人： KOLB HARTMUTH C , WALSH JOSEPH C , KASI DHANALAKSHMI , MOCHARLA VANI , WANG BING , GANGADHARMATH UMESH B , DUCLOS BRIAN A , CHEN KAI , ZHANG WEI , CHEN GANG , PADGETT HENRY CLIFTON , KARIMI FARHAD , SCOTT PETER J H , GAO ZHIYONG , LIANG QIANWA , COLLIER THOMAS LEE , ZHAO TIEMING , XIA CHUNFANG
IPC分类号： C07D249/04 , A61K31/4192 , A61P35/00 , C07D249/06 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D417/14 , G01N33/532
CPC分类号： C07D417/04 , C07D249/04 , C07D249/06 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14 , C12Q1/485 , G01N2500/04 , G01N2500/10
摘要： The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.
摘要翻译：本申请公开了使用点击化学法鉴定对碳酸酐酶IX（CA-IX）酶具有高结合亲和力的抑制剂的方法，并将其候选用作正电子发射断层摄影（PET）成像剂。

9. 发明申请

WO2008124651A3 NITRO-IMIDAZOLE HYPOXIA IMAGING AGENTS 审中-公开
公开(公告)号：WO2008124651A3
公开(公告)日：2008-10-16
申请号：PCT/US2008/059505
申请日：2008-04-04
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , KOLB, Hartmuth C , WALSH, Joseph C. , GANGADHARMATH, Umesh B. , KARIMI, Farhad , PADGETT, Henry Clifton , KASI, Dhanalakshmi , GAO, Zhiyong , LIANG, Qianwa , COLLIER, Thomas Lee , DUCLOS, Brian A. , ZHAO, Tieming
发明人： KOLB, Hartmuth C , WALSH, Joseph C. , GANGADHARMATH, Umesh B. , KARIMI, Farhad , PADGETT, Henry Clifton , KASI, Dhanalakshmi , GAO, Zhiyong , LIANG, Qianwa , COLLIER, Thomas Lee , DUCLOS, Brian A. , ZHAO, Tieming
IPC分类号： C07D403/06 , C07D403/12 , C07B59/00 , A61K31/4192
摘要： The present invention relates to novel radioactively labeled bioreducible tracers of Formula (I) useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.

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