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1. 发明申请

WO2005074026A3 TIN-BASED COATING OF ELECTRONIC COMPONENT 审中-公开
标题翻译：电子元件的锡基涂层
公开(公告)号：WO2005074026A3
公开(公告)日：2005-10-06
申请号：PCT/US2005001999
申请日：2005-01-21
申请人： ENTHONE , XU CHEN , ZHANG YUN , FAN CHONGLUN , KHASELEV OSCAR , ABYS JOSEPH A , WALCH ERIC , KLEINFELD MARLIES , ECKERT HANS ULLRICH
发明人： XU CHEN , ZHANG YUN , FAN CHONGLUN , KHASELEV OSCAR , ABYS JOSEPH A , WALCH ERIC , KLEINFELD MARLIES , ECKERT HANS ULLRICH
IPC分类号： C25D5/12 , H01L23/495 , H01R4/02 , H01R13/03 , H05K3/34
CPC分类号： H01L23/49582 , C25D5/12 , H01L2224/48247 , H01L2224/48465 , H01L2224/49171 , H01L2924/00014 , H01L2924/01327 , H01L2924/15747 , H01L2924/19041 , H01R4/02 , H01R13/03 , H05K3/3426 , H05K2201/10909 , Y02P70/613 , Y10T428/12722 , H01L2224/45099 , H01L2924/00
摘要： A method for reducing whisker formation and preserving solderability in tin coatings over metal features of electronic components. The tin coating has internal tensile stress and is between about 0.5 m and about 4.0 m in thickness. There is a nickel-based layer under the tin coating.
摘要翻译：一种减少电子部件的金属特征的方法，用于减少锡涂层中的晶须形成和保持锡涂层的可焊性。锡涂层具有内部拉伸应力，厚度在约0.5μm至约4.0μm之间。在锡涂层下面有一个镍基层。

2. 发明申请

WO2007065027A3 CARBONIC ANHYDRASE IX (G250) ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：碳氢化合物IX（G250）抗体及其使用方法
公开(公告)号：WO2007065027A3
公开(公告)日：2008-09-25
申请号：PCT/US2006046350
申请日：2006-12-04
申请人： DANA FARBER CANCER INST INC , MARASCO WAYNE A , LO AGNES , XU CHEN
发明人： MARASCO WAYNE A , LO AGNES , XU CHEN
IPC分类号： C07K16/30 , A61K39/395 , A61K47/48 , A61P35/00 , C07K16/40
CPC分类号： C07K16/40 , A61K38/2013 , A61K39/3955 , A61K51/1045 , A61K51/1075 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76
摘要： The invention provides scFv antibodies and monoclonal antibodies that bind to and decrease an activity of Carbonic Anhydrase IX (G250). Also provided are methods of treating and/or preventing cancer, such as renal clear cell cancer. Also provided are methods of identifying a carbonic anhydrase IX (G250) protein. The invention additionally provides methods of modifying immune effector cells, and the immune effector cells modified thereby.
摘要翻译：本发明提供结合并降低碳酸酐酶IX（G250）的活性的scFv抗体和单克隆抗体。还提供了治疗和/或预防癌症的方法，例如肾透明细胞癌。还提供了鉴定碳酸酐酶IX（G250）蛋白质的方法。本发明另外提供了修饰免疫效应细胞和由此修饰的免疫效应细胞的方法。

3. 发明申请

WO2007139787A3 METHOD AND APPARATUS PROVIDING DARK CURRENT REDUCTION IN AN ACTIVE PIXEL SENSOR 审中-公开
标题翻译：在主动像素传感器中提供暗电流减少的方法和装置
公开(公告)号：WO2007139787A3
公开(公告)日：2008-03-27
申请号：PCT/US2007012167
申请日：2007-05-22
申请人： MICRON TECHNOLOGY INC , XU CHEN
发明人： XU CHEN
IPC分类号： H04N5/225 , H04N5/361 , H04N5/369
CPC分类号： H04N5/37452 , H01L27/14609 , H04N5/361
摘要： An imager has one or more pixel circuits arranged to receive negatively biased control signals at one or more gates associated with charge holding regions to reduce dark current generation and flow.
摘要翻译：成像器具有一个或多个像素电路，其布置成在与电荷保持区域相关联的一个或多个栅极处接收负偏置的控制信号，以减少暗电流产生和流动。

4. 发明申请

WO2008066829A3 ANTIBLOOMING IMAGING APPARATUS, SYSTEMS, AND METHODS 审中-公开
标题翻译：防止成像设备，系统和方法
公开(公告)号：WO2008066829A3
公开(公告)日：2008-07-17
申请号：PCT/US2007024479
申请日：2007-11-28
申请人： MICRON TECHNOLOGY INC , XU CHEN , AGRANOV GENNADIY , KARASEV IGOR
发明人： XU CHEN , AGRANOV GENNADIY , KARASEV IGOR
IPC分类号： H01L27/14 , H04N5/359 , H04N5/374
CPC分类号： H04N5/378 , H04N5/3594 , H04N5/3745
摘要： Apparatus, systems and methods are described to assist in reducing dark current in an active pixel sensor. A potential barrier arrangement is configured to block the flow of charge carriers generated outside a photosensitive region. In various embodiments, a potential well-potential barrier arrangement is formed to direct charge carriers away from the photosensitive region during an integration time.
摘要翻译：描述了装置，系统和方法以帮助减少有源像素传感器中的暗电流。势垒布置被配置为阻挡在感光区域外产生的电荷载流子的流动。在各种实施例中，形成势阱势垒布置，以在积分时间期间使电荷载流子远离光敏区域。

5. 发明申请

WO2007111845A9 METHOD AND APPARATUS FOR PROVIDING A ROLLING DOUBLE RESET TIMING FOR GLOBAL STORAGE IN IMAGE SENSORS 审中-公开
公开(公告)号：WO2007111845A9
公开(公告)日：2007-12-27
申请号：PCT/US2007006597
申请日：2007-03-16
申请人： MICRON TECHNOLOGY INC , XU CHEN , ALTICE PARKER
发明人： XU CHEN , ALTICE PARKER
IPC分类号： H04N5/359 , H04N5/361 , H04N5/3745
CPC分类号： H04N5/3745 , H01L27/14609 , H04N5/359 , H04N5/361 , H04N5/363 , H04N5/374
摘要： An apparatus for and a method of operating an array of pixels of an image sensor, where each pixel includes at least a photosensor, an associated storage device and a floating diffusion region and the array of pixels is configured in a plurality of rows and columns. The photosensors associated with the pixels are reset and charges are accumulated in the photosensor. The accumulated charges are then globally transferred to storage devices associated with the pixels. A rolling double reset is used to reduce the deleterious effects on the accumulated charges stored in the storage devices. The accumulated charges stored in the storage devices are transferred to floating diffusion regions associated with the pixels and the charges residing in the floating diffusion region are read out. In a second embodiment the storage device is eliminated and the rolling double reset is used to reduce the deleterious effects on the accumulated charges stored in the floating diffusion region.

6. 发明申请

WO2008100432A3 METHOD, APPARATUS, AND SYSTEM PROVIDING MULTIPLE PIXEL INTEGRATION PERIODS 审中-公开
标题翻译：方法，装置和系统提供多个像素集成期
公开(公告)号：WO2008100432A3
公开(公告)日：2009-01-08
申请号：PCT/US2008001703
申请日：2008-02-08
申请人： APTINA IMAGING CORP , XU CHEN
发明人： XU CHEN
CPC分类号： H04N5/3592 , H04N5/3532 , H04N5/35554 , H04N5/374
摘要： A method, apparatus and system providing high dynamic range operation for an image sensor by using signals from multiple pixels having different integration times.
摘要翻译：一种通过使用来自具有不同积分时间的多个像素的信号为图像传感器提供高动态范围操作的方法，装置和系统。

7. 发明申请

WO2008010893A2 METHOD, APPARATUS AND SYSTEM FOR CHARGE INJECTION SUPPRESSION IN ACTIVE PIXEL SENSORS 审中-公开
标题翻译：有源像素传感器中充电注入抑制方法，装置和系统
公开(公告)号：WO2008010893A2
公开(公告)日：2008-01-24
申请号：PCT/US2007014730
申请日：2007-06-26
申请人： MICRON TECHNOLOGY INC , ALTICE PETER PARKER , XU CHEN , LADD JOHN , LI XIANGLI
发明人： ALTICE PETER PARKER , XU CHEN , LADD JOHN , LI XIANGLI
IPC分类号： H04N5/359 , H04N5/374
CPC分类号： H04N5/374 , H04N5/355 , H04N5/3575 , H04N5/3594 , H04N5/3597
摘要： A method and apparatus are provided for operation of an image sensor during signal readout. During a reset operation the gate of a reset transistor coupled to the storage node receives a voltage greater than a threshold voltage to produce a reset of the storage node. During a period where photogenerated charges stored at the storage node are read out the gate of the reset transistor receives a voltage V RST_LOW greater than ground, but less than a maximum voltage which can be stored at the storage node.
摘要翻译：提供了一种在信号读出期间操作图像传感器的方法和装置。在复位操作期间，耦合到存储节点的复位晶体管的栅极接收大于阈值电压的电压，以产生存储节点的复位。在存储节点存储的光生电荷被读出的期间，重置晶体管的栅极接收比地大的电压V RST_LOW，但小于可存储在存储节点处的最大电压。

8. 发明申请

WO2012064571A2 LARGE-SCALE LATERAL NANOWIRE ARRAYS NANOGENERATORS 审中-公开
标题翻译：大规模的横向纳米级阵列纳米器件
公开(公告)号：WO2012064571A2
公开(公告)日：2012-05-18
申请号：PCT/US2011059044
申请日：2011-11-03
申请人： GEORGIA TECH RES INST , WANG ZHONG L , XU CHEN , QIN YONG , ZHU GUANG , YANG RUSEN , HU YOUFAN , ZHANG YAN
发明人： WANG ZHONG L , XU CHEN , QIN YONG , ZHU GUANG , YANG RUSEN , HU YOUFAN , ZHANG YAN
IPC分类号： H02N2/18
CPC分类号： H01L41/316 , H02N2/18
摘要： In a method of making a generating device (100), a plurality of spaced apart elongated seed members (114) are deposited onto a surface of a flexible non-conductive substrate (110). An elongated conductive layer (118) is applied to a top surface and a first side of each seed member (114), thereby leaving an exposed second side opposite the first side. A plurality of elongated piezoelectric nanostructures (122) is grown laterally from the second side of each seed member (114). A second conductive material (126) is deposited onto the substrate (110) adjacent each elongated first conductive layer (118) so as to be coupled the distal end of each of the plurality of elongated piezoelectric nanostructures (122). The second conductive material (126) is selected so as to form a Schottky barrier between the second conductive material (126) and the distal end of each of the plurality of elongated piezoelectric nanostructures (122) and so as to form an electrical contact with the first conductive layer (118).
摘要翻译：在制造发生装置（100）的方法中，将多个间隔开的细长种子构件（114）沉积到柔性非导电衬底（110）的表面上。细长导电层（118）被施加到每个种子构件（114）的顶表面和第一侧，从而留下与第一侧相对的暴露的第二侧。多个细长的压电纳米结构（122）从每个种子构件（114）的第二侧横向生长。邻近每个细长的第一导电层（118）将第二导电材料（126）沉积到衬底（110）上，以便耦合到多个细长的压电纳米结构（122）中的每一个的远端。选择第二导电材料（126）以在第二导电材料（126）和多个细长压电纳米结构（122）中的每一个的远端之间形成肖特基势垒，以便形成与第一导电层（118）。

9. 发明申请

WO2008063419A1 METHOD, APPARATUS AND SYSTEM PROVIDING MEMORY CELLS ASSOCIATED WITH A PIXEL ARRAY 审中-公开
标题翻译：提供与像素阵列相关的存储单元的方法，装置和系统
公开(公告)号：WO2008063419A1
公开(公告)日：2008-05-29
申请号：PCT/US2007023462
申请日：2007-11-08
申请人： MICRON TECHNOLOGY INC , HOLTZCLAW KARL , XU CHEN , MAURITZSON RICHARD A , CHEN YANGDON , BRUCE JEFFREY , LI XIANGLI , SOLHUSVIK JOHANNES
发明人： HOLTZCLAW KARL , XU CHEN , MAURITZSON RICHARD A , CHEN YANGDON , BRUCE JEFFREY , LI XIANGLI , SOLHUSVIK JOHANNES
IPC分类号： H04N5/335
CPC分类号： H04N5/335 , H01L23/5252 , H01L27/112 , H01L27/11206 , H01L27/14643 , H01L2924/0002 , H01L2924/00
摘要： A method, apparatus, and system are disclosed providing an imaging device with memory cells containing anti-fuse elements located with or outside a pixel array. The memory cells are read out using control signal lines which are used to readout imaging pixels.
摘要翻译：公开了一种方法，装置和系统，其提供具有包含位于像素阵列之外或位于像素阵列之外的反熔丝元件的存储器单元的成像装置。使用用于读出成像像素的控制信号线读出存储单元。

10. 发明申请

WO2006089141A2 ANTIBODIES AGAINST CXCR4 AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗CXCR4的抗体及其使用方法
公开(公告)号：WO2006089141A2
公开(公告)日：2006-08-24
申请号：PCT/US2006005691
申请日：2006-02-15
申请人： DANA FARBER CANCER INST INC , MARASCO WAYNE A , SUI JIANHUA , XU CHEN
发明人： MARASCO WAYNE A , SUI JIANHUA , XU CHEN
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/005 , C07K2317/21 , C07K2317/622
摘要： The invention provides human monoclonal antibodies, scFv antibodies, scFv-Fc fusions, a dAb (domain antibodies), F ab , F ab' and F (ab')2 fragments, single chain antibodies and/or minibodies that specifically bind to CXCR4. Also provided are methods of treating and/or preventing a CXCR4 disease or disorder such as cancer and X4-tropic HIV-I infection as well as uses of such antibodies and antibody fragments in the manufacture of a medicament for the treatment or prevention of a CXCR4 disorder. The invention also provides methods of preventing diseases or disorders associated with CXCR4 function or expression. The invention further provides for the use of the antibodies (or fragments thereof) of the invention in the manufacture of a medicament for the prevention of diseases or disorders associated with CXCR4 expression. Also provided are methods of treating or preventing cancer metastasis in a patient suffering from a cancer involving tumor cells that express CXCR4. The invention also encompasses the use of such antibodies and antibody fragments in the manufacture of a medicament for the treatment or prevention of cancer metastasis. The invention also includes methods of treating or preventing cancer metastasis in a patient suffering from a hypoxic tumor, such as any solid tumor characterized by HIF- dependent CXCR4 activation. The antibodies and fragments disclosed herein can be used in the manufacture of a medicament for the prevention of cancer metastasis in a patient suffering from a hypoxic tumor. The invention additionally provides methods of mobilizing CD34 + stem cells from the bone marrow as wells methods of blocking chemotaxis of CXCR4-expressing cells in response to SDF-1. Also provided are methods of treating or preventing graft-versus-host disease as well as the use of the antibodies and fragments thereof in the manufacture of a medicament for the prevention or treatment of GVHD. Finally, the invention also provides methods of inhibiting the formation of new tumor blood vessels and/or inhibiting tumor cell angiogenesis.
摘要翻译：本发明提供了人单克隆抗体，scFv抗体，scFv-Fc融合蛋白，dAb（结构域抗体），F ab，ab F和ab F（ab' ）2片段，与CXCR4特异性结合的单链抗体和/或微型抗体。还提供了治疗和/或预防CXCR4疾病或病症例如癌症和X4向性HIV-1感染的方法以及这些抗体和抗体片段在制备用于治疗或预防CXCR4的药物中的用途紊乱。本发明还提供了预防与CXCR4功能或表达相关的疾病或病症的方法。本发明还提供了本发明的抗体（或其片段）在制备用于预防与CXCR4表达相关的疾病或病症的药物中的用途。还提供了治疗或预防患有涉及表达CXCR4的肿瘤细胞的癌症的患者的癌症转移的方法。本发明还包括这些抗体和抗体片段在制备用于治疗或预防癌症转移的药物中的用途。本发明还包括治疗或预防患有缺氧肿瘤的患者例如以HIF依赖性CXCR4活化为特征的任何实体瘤的癌症转移的方法。本文公开的抗体和片段可以用于制造用于预防患有低氧肿瘤的患者中的癌症转移的药物。本发明另外提供了从骨髓动员CD34 + / +干细胞以及阻断SDF-1响应CXCR4表达细胞的趋化性的方法。还提供了治疗或预防移植物抗宿主病的方法以及抗体和其片段在制备用于预防或治疗GVHD的药物中的用途。最后，本发明还提供了抑制新肿瘤血管形成和/或抑制肿瘤细胞血管生成的方法。

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