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1. 发明申请

WO2011003039A3 ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME 审中-公开
标题翻译：分析传感器及其制造方法
公开(公告)号：WO2011003039A3
公开(公告)日：2011-04-14
申请号：PCT/US2010040842
申请日：2010-07-01
申请人： DEXCOM INC , SIMPSON PETER C , BOOCK ROBERT , NEALE PAUL V , BOHM SEBASTIAN , WIGHTLIN MATTHEW , PRYOR JACK , MITCHELL JASON , JACKSON JEFF , PATEL KAUSHIK , LLEVARES ANTONIO C
发明人： SIMPSON PETER C , BOOCK ROBERT , NEALE PAUL V , BOHM SEBASTIAN , WIGHTLIN MATTHEW , PRYOR JACK , MITCHELL JASON , JACKSON JEFF , PATEL KAUSHIK , LLEVARES ANTONIO C
IPC分类号： A61B5/145 , A61B5/1468
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system (800) comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system (800) comprises first and second elongated bodies El, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer (810) that separates the conductive layer (820) from the elongated body, a membrane layer deposited on top of the elongated bodies El, E2, and working electrodes (802', 802") formed by removing portions of the conductive layer (820) and the insulating layer (810), thereby exposing electroactive surface of the elongated bodies El, E2.
摘要翻译：提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统（800）。传感器系统（800）包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成;绝缘层（810），其将导电层（820）与细长体，沉积在细长体E1，E2和通过去除导电层（820）和绝缘层（810）的部分形成的工作电极（802'，802“）之上的膜层，从而暴露电活性表面细长体E1，E2。

2. 发明申请

WO2012050926A3 ADVANCED CONTINUOUS ANALYTE MONITORING SYSTEM 审中-公开
标题翻译：先进的连续分析监测系统
公开(公告)号：WO2012050926A3
公开(公告)日：2012-06-21
申请号：PCT/US2011053777
申请日：2011-09-28
申请人： DEXCOM INC , BOHM SEBASTIAN , DERVAES MARK , JOHNSON ERIC , KAMATH APURV ULLAS , LARVENZ SHAWN , LEACH JACOB S , LIEU PHONG , MAHALINGAM AARTHI , MILLER TOM , NEALE PAUL V , PRYOR JACK , PEYSER THOMAS A , RONG DAITING , SAN VICENTE KEN , SHARIATI MOHAMMAD ALI , SIMPSON PETER C , WIGHTLIN MATTHEW
发明人： BOHM SEBASTIAN , DERVAES MARK , JOHNSON ERIC , KAMATH APURV ULLAS , LARVENZ SHAWN , LEACH JACOB S , LIEU PHONG , MAHALINGAM AARTHI , MILLER TOM , NEALE PAUL V , PRYOR JACK , PEYSER THOMAS A , RONG DAITING , SAN VICENTE KEN , SHARIATI MOHAMMAD ALI , SIMPSON PETER C , WIGHTLIN MATTHEW
IPC分类号： A61B5/145 , A61B5/157 , H04B7/24
CPC分类号： A61B5/14532 , A61B5/14507 , A61B5/1451 , G06F1/3203
摘要： The present invention relates generally to systems and methods for processing, transmitting, and displaying data received from continuous analyte sensor (10), such as a glucose sensor. In some embodiments, the continuous analyte sensor system (8) comprises a sensor electronics module (12) that includes power saving features. One feature includes a low power measurement circuit that can be switched between a measurement mode and a low power mode, in which charging circuitry continues to apply power to electrodes of a sensor during the low power mode. In addition, the sensor electronics module can be switched between in a low power storage mode higher power operational mode via a switch. The switch can include a reed switch or optical switch, for example. A validation routine can also be implemented to ensure an interrupt signal sent from the switch is valid. The continuous analyte sensor (10) can be physically connected to a sensor electronics module (12), which is in direct wireless communication with a plurality of different display devices (14, 16, 18), and/or (20).
摘要翻译：本发明一般涉及用于处理，传输和显示从诸如葡萄糖传感器的连续分析物传感器（10）接收的数据的系统和方法。在一些实施例中，连续分析物传感器系统（8）包括包括省电特征的传感器电子模块（12）。一个特征包括可在测量模式和低功率模式之间切换的低功率测量电路，其中充电电路在低功率模式期间继续向传感器的电极施加功率。此外，传感器电子模块可以通过开关在低功率存储模式较高功率操作模式之间切换。开关可以包括例如簧片开关或光开关。也可以实现验证程序，以确保从交换机发送的中断信号有效。连续的分析物传感器（10）可以物理连接到与多个不同的显示设备（14,16,18）和/或（20）直接无线通信的传感器电子模块（12）。

3. 发明申请

WO2011041463A3 TRANSCUTANEOUS ANALYTE SENSOR 审中-公开
标题翻译： TRANSCUTANEOUS分析仪传感器
公开(公告)号：WO2011041463A3
公开(公告)日：2011-07-14
申请号：PCT/US2010050788
申请日：2010-09-29
申请人： DEXCOM INC , NEALE PAUL V , BOOCK ROBERT , BOHM SEBASTIAN , SIMPSON PETER C , BRAUKER JAMES
发明人： NEALE PAUL V , BOOCK ROBERT , BOHM SEBASTIAN , SIMPSON PETER C , BRAUKER JAMES
IPC分类号： A61B5/151 , A61B5/157
CPC分类号： A61B5/14865 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/6843 , A61B5/6848 , A61B5/6849 , A61B2560/0443 , A61B2562/0209 , A61B2562/04
摘要： A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.
摘要翻译：提供了经配置以连续测量宿主中的分析物浓度的经皮传感器装置。在一些实施例中，经皮传感器装置100包括构造成用于插入主体皮肤180下方的体内部分160，以及配置成在传感器插入入口之后保留在主体的皮肤180的表面上方的离体部分170 体内部分。体内部分可以包括构造成用于刺穿主体的皮肤180的组织刺穿元件110和传感器主体120，传感器主体120包括材料或支撑构件130，材料或支撑构件130提供足够的柱强度，以允许传感器主体可在主机组织中推出而不用实质屈曲。离体部分170可以被配置为包括（或可操作地连接）传感器电子单元，并且可以包括安装单元150.此处还描述了传感器主体和组织刺穿元件的各种配置，其可以用于保护传感器体的膜。

4. 发明申请

WO2012142502A2 ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION 审中-公开
标题翻译：高级分析仪传感器校准和错误检测
公开(公告)号：WO2012142502A2
公开(公告)日：2012-10-18
申请号：PCT/US2012033645
申请日：2012-04-13
申请人： DEXCOM INC , ESTES MICHAEL J , SIMPSON PETER C , KAMATH APURV ULLAS , BOHM SEBASTIAN , RONG DAITING
发明人： ESTES MICHAEL J , SIMPSON PETER C , KAMATH APURV ULLAS , BOHM SEBASTIAN , RONG DAITING
IPC分类号： G01N33/66 , A61B5/157
CPC分类号： A61B5/1495 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/7257 , A61B5/7267 , A61B2560/0276 , G01D18/00 , G01N27/026 , G01N27/3274 , G01N33/49
摘要： Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self- calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity (110) of the analyte sensor is determined by applying an estimative algorithm (120) that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.
摘要翻译：提供了用于处理传感器数据和自校准的系统和方法。在一些实施例中，提供了能够基于初始灵敏度校准连续分析物传感器，然后在不使用或减少使用参考测量的情况下连续执行自校准的系统和方法。在某些实施例中，通过应用作为某些参数的函数的估计算法（120）来确定分析物传感器的灵敏度（110）。本文还描述了使用刺激信号来确定分析物传感器的性质的系统和方法。传感器属性可用于补偿传感器数据的灵敏度漂移，或确定与传感器相关的其他属性，如温度，传感器膜损坏，传感器电子设备中的水分进入以及缩放因子。

5. 发明申请

WO2007035564A3 MALFUNCTION DETECTION WITH DERIVATIVE CALCULATION 审中-公开
标题翻译：导数计算的失效检测
公开(公告)号：WO2007035564A3
公开(公告)日：2007-07-12
申请号：PCT/US2006036165
申请日：2006-09-18
申请人： LIFESCAN INC , KRULEVITCH PETER , BOHM SEBASTIAN , ZHAO MINGGI , ANEX DEON
发明人： KRULEVITCH PETER , BOHM SEBASTIAN , ZHAO MINGGI , ANEX DEON
IPC分类号： B01D57/02
CPC分类号： A61M5/14244 , A61M5/14248 , A61M5/1452 , A61M5/16831 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/3389
摘要： Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.
摘要翻译：讨论了检测输液泵中的闭塞和液体流失状况（例如，断开和/或泄漏）的系统和方法。例如，电动输液泵可能在流体流动路径中形成阻塞，这可能破坏从泵分散的流体的控制。同样，输液器断开连接也会导致液体损失，这可能是破坏性的。对于控制输液泵的系统而言，这种中断可能会很麻烦，例如闭环控制器。相应地，本文描述的系统和方法可用于在输注泵操作期间检测这种闭塞和流体损失状况。例如，可以使用位置传感器来监测来自输液泵的流体流量，将测量值与期望值进行比较以检测堵塞或流体损失状况。还描述了用于利用位置传感器的其他算法。

6. 发明申请

WO2007035666A3 ELECTROKINETIC INFUSION PUMP SYSTEM 审中-公开
标题翻译：电动输液泵系统
公开(公告)号：WO2007035666A3
公开(公告)日：2007-10-04
申请号：PCT/US2006036340
申请日：2006-09-18
申请人： LIFESCAN INC , KRULEVITCH PETER , BENETT WILLIAM , ROBERTS NEIL E , BOHM SEBASTIAN , SIEH ZARA
发明人： KRULEVITCH PETER , BENETT WILLIAM , ROBERTS NEIL E , BOHM SEBASTIAN , SIEH ZARA
IPC分类号： A61M31/00
CPC分类号： A61M5/14244 , A61M5/14248 , A61M5/1452 , A61M5/16831 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/3389
摘要： Various methods and devices are provided for delivering an infusion liquid using an electrokinetic infusion pump. The electrokinetic infusion pump can generally include an infusion housing having an infusion reservoir. The infusion reservoir has an infusion outlet and is capable of containing an infusion liquid. A plunger is movably coupled to the infusion housing and is adapted to be manually displaced relative to the infusion housing to load the infusion reservoir with infusion liquid. A movable partition can be disposed within the infusion housing and has a first surface in communication with an electrokinetic solution and a second surface, isolated from the first surface, in communication with the infusion reservoir. The electrokinetic infusion pump can further include an electrokinetic engine integrated within the plunger and adapted to selectively deliver electric potential across an electrokinetic porous media to cause the electrokinetic solution within the electrokinetic engine to displace the movable partition to effect delivery of at least a portion of the infusion liquid through the infusion outlet.
摘要翻译：提供用于使用电动输液泵输送输液的各种方法和装置。电动输液泵通常可以包括具有输注储器的输液罩。输注槽具有输液口，并且能够容纳输液。柱塞可移动地联接到输注壳体，并且适于相对于输注壳体手动移位以用输注液体加载输注储存器。可移动隔板可以设置在输注外壳内，并且具有与电动溶液连通的第一表面和与第一表面隔离的与输注储存器连通的第二表面。电动输液泵还可以包括集成在柱塞内的电动发动机，并适于选择性地跨电动多孔介质输送电势，以使电动发动机内的电动溶液移动可动隔板，从而实现至少一部分输液通过输液口。

7. 发明申请

WO2007035563A2 MALFUNCTION DETECTION VIA PRESSURE PULSATION 审中-公开
标题翻译：通过压力脉冲进行故障检测
公开(公告)号：WO2007035563A2
公开(公告)日：2007-03-29
申请号：PCT/US2006036164
申请日：2006-09-18
申请人： LIFESCAN INC , KRULEVITCH PETER , BOHM SEBASTIAN , ZHAO MINGQI , ANEX DEON
发明人： KRULEVITCH PETER , BOHM SEBASTIAN , ZHAO MINGQI , ANEX DEON
IPC分类号： A61M1/00
CPC分类号： A61M5/14244 , A61M5/14248 , A61M5/1452 , A61M5/16831 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/3389
摘要： Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.
摘要翻译：讨论了检测输液泵中的闭塞和液体流失状况（例如，断开和/或泄漏）的系统和方法。例如，电动输液泵可能在流体流动路径中形成阻塞，这可能破坏从泵分散的流体的控制。同样，输液器断开连接也会导致液体损失，这可能是破坏性的。对于控制输液泵的系统而言，这种中断可能会很麻烦，例如闭环控制器。相应地，本文描述的系统和方法可用于在输注泵操作期间检测这种闭塞和流体损失状况。例如，可以使用位置传感器来监测来自输液泵的流体流量，将测量值与期望值进行比较以检测堵塞或流体损失状况。还描述了用于利用位置传感器的其他算法。

8. 发明申请

WO2013152090A3 TRANSCUTANEOUS ANALYTE SENSORS, APPLICATORS THEREFOR, AND ASSOCIATED METHODS 审中-公开
标题翻译： TRANSCUTANEOUS分析仪传感器，其应用者及相关方法
公开(公告)号：WO2013152090A3
公开(公告)日：2014-01-03
申请号：PCT/US2013035097
申请日：2013-04-03
申请人： DEXCOM INC
发明人： PRYOR JACK , BOHM SEBASTIAN , DERENZY DAVID , HALAC JASON , KLINE DANIEL S , LIEU PHONG , LIVINGSTON ADAM J , MASTERSON STEVE , NEALE PAUL V , SIMPSON PETER C , UBACH ANTONIO JOAO
IPC分类号： A61B5/00 , A61B5/145
CPC分类号： A61B5/14503 , A61B5/0004 , A61B5/0031 , A61B5/14532 , A61B5/6833 , A61B5/6849 , A61B2560/0412 , A61B2560/0443
摘要： The present embodiments relate generally to systems and methods for measuring an analyte in a host. More particularly, the present embodiments provide sensor applicators and methods of use with pushbutton activation that implant the sensor, withdraw the insertion needle, engage the transmitter with the housing, and disengage the applicator from the housing, all in one smooth motion. Some embodiments contemplate engagement of the transmitter with the housing after release of the applicator.
摘要翻译：本实施例一般涉及用于测量主机中的分析物的系统和方法。更具体地，本实施例提供了传感器施加器和使用按钮按钮的方法，该按钮激活植入传感器，撤回插入针，使发射器与壳体接合，并且使得施加器与壳体脱离，全部以一个平滑的运动。一些实施例考虑了在释放施加器之后发射器与壳体的接合。

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