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1. 发明申请

WO2006073453A2 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可植入分析传感器
公开(公告)号：WO2006073453A2
公开(公告)日：2006-07-13
申请号：PCT/US2005014696
申请日：2005-05-02
申请人： DEXCOM INC , GOODE JR PAUL V , HOLMQUIST ARNOLD L , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , BRAUKER JAMES H , NEALE PAUL V , MCCLURE JASON D , BRISTER MARK , SIMPSON PETER C , RHODES RATHBUN K
发明人： GOODE JR PAUL V , HOLMQUIST ARNOLD L , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , BRAUKER JAMES H , NEALE PAUL V , MCCLURE JASON D , BRISTER MARK , SIMPSON PETER C , RHODES RATHBUN K
IPC分类号： A61B5/07 , A61B5/00 , A61B5/05 , H04B1/03
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B2560/04 , A61B2560/0462 , H04B1/03 , Y10T29/49117
摘要： An implantable analyte sensor (12) including a sensor body substantially formed from a water vapor permeable material and electrical components encapsulated within the sensor body, wherein the electrical components comprise RF circuitry (38) and an antenna (42) adapted for RF transmission from the sensor (12) in vivo to a receiver (14) ex vivo, wherein the RF circuitry (38) is spaced a fixed distance from the sensor body so as to support a dielectric constant that enables RF transmission between the sensor (12) in vivo to the receiver (14) ex vivo.
摘要翻译：一种可植入分析物传感器（12），其包括基本由水蒸气可渗透材料形成的传感器主体和封装在传感器主体内的电子部件，其中电子部件包括RF电路（38）和适于从传感器（12）在体内与接收器（14）离体接触，其中所述RF电路（38）与所述传感器主体间隔固定距离，以支持介电常数，所述介电常数使所述传感器（12）能够在体内到体外的接收器（14）。

2. 发明申请

WO2005019795A3 ELECTROCHEMICAL SENSORS INCLUDING ELECTRODE SYSTEMS WITH INCREASED OXYGEN GENERATION 审中-公开
标题翻译：包括电极系统在内的电化学传感器与增加的氧气发生
公开(公告)号：WO2005019795A3
公开(公告)日：2006-03-16
申请号：PCT/US2004023650
申请日：2004-07-21
申请人： DEXCOM INC , SIMPSON PETER C , GOODE PAUL , TAPSAK MARK A , CARR-BRENDEL VICTORIA
发明人： SIMPSON PETER C , GOODE PAUL , TAPSAK MARK A , CARR-BRENDEL VICTORIA
IPC分类号： A61B5/00 , C12Q1/00 , G01N33/487 , G01N27/327
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , C12Q1/003 , G01N27/3272
摘要： The present invention relates generally to systems and methods for increasing oxygen generation in electrochemical sensors (10) in order to overcome the oxygen limitations. The preferred embodiments employ electrode systems (16b) with at least two electrodes in relatively close proximity to each other; wherein at least one electrode is configured to generate oxygen and at least one other electrode is configured to sense an analyte or a product of a reaction indicative of the concentration of analyte. The oxygen generated by the oxygen-generating electrode is available to the catalyst within a membrane system and/or the counter electrode, thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. The electrochemical sensor (10) can include a body with a sensing region (14), and a membrane system (18) disposed over the electroactive surfaces of the electrode system (16b).
摘要翻译：本发明一般涉及用于增加电化学传感器（10）中的氧气产生的系统和方法，以克服氧的限制。优选实施例采用电极系统（16b），其中至少两个电极彼此相对靠近; 其中至少一个电极被配置为产生氧，并且至少一个其它电极被配置为感测分析物或指示分析物浓度的反应的产物。由氧发生电极产生的氧气可用于膜系统和/或对电极中的催化剂，从而使得优选实施方案的电化学传感器能够在缺血条件下起作用。电化学传感器（10）可以包括具有感测区域（14）的主体和设置在电极系统（16b）的电活性表面之上的膜系统（18）。

3. 发明申请

WO2013152090A3 TRANSCUTANEOUS ANALYTE SENSORS, APPLICATORS THEREFOR, AND ASSOCIATED METHODS 审中-公开
标题翻译： TRANSCUTANEOUS分析仪传感器，其应用者及相关方法
公开(公告)号：WO2013152090A3
公开(公告)日：2014-01-03
申请号：PCT/US2013035097
申请日：2013-04-03
申请人： DEXCOM INC
发明人： PRYOR JACK , BOHM SEBASTIAN , DERENZY DAVID , HALAC JASON , KLINE DANIEL S , LIEU PHONG , LIVINGSTON ADAM J , MASTERSON STEVE , NEALE PAUL V , SIMPSON PETER C , UBACH ANTONIO JOAO
IPC分类号： A61B5/00 , A61B5/145
CPC分类号： A61B5/14503 , A61B5/0004 , A61B5/0031 , A61B5/14532 , A61B5/6833 , A61B5/6849 , A61B2560/0412 , A61B2560/0443
摘要： The present embodiments relate generally to systems and methods for measuring an analyte in a host. More particularly, the present embodiments provide sensor applicators and methods of use with pushbutton activation that implant the sensor, withdraw the insertion needle, engage the transmitter with the housing, and disengage the applicator from the housing, all in one smooth motion. Some embodiments contemplate engagement of the transmitter with the housing after release of the applicator.
摘要翻译：本实施例一般涉及用于测量主机中的分析物的系统和方法。更具体地，本实施例提供了传感器施加器和使用按钮按钮的方法，该按钮激活植入传感器，撤回插入针，使发射器与壳体接合，并且使得施加器与壳体脱离，全部以一个平滑的运动。一些实施例考虑了在释放施加器之后发射器与壳体的接合。

4. 发明申请

WO2011041463A3 TRANSCUTANEOUS ANALYTE SENSOR 审中-公开
标题翻译： TRANSCUTANEOUS分析仪传感器
公开(公告)号：WO2011041463A3
公开(公告)日：2011-07-14
申请号：PCT/US2010050788
申请日：2010-09-29
申请人： DEXCOM INC , NEALE PAUL V , BOOCK ROBERT , BOHM SEBASTIAN , SIMPSON PETER C , BRAUKER JAMES
发明人： NEALE PAUL V , BOOCK ROBERT , BOHM SEBASTIAN , SIMPSON PETER C , BRAUKER JAMES
IPC分类号： A61B5/151 , A61B5/157
CPC分类号： A61B5/14865 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/6843 , A61B5/6848 , A61B5/6849 , A61B2560/0443 , A61B2562/0209 , A61B2562/04
摘要： A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.
摘要翻译：提供了经配置以连续测量宿主中的分析物浓度的经皮传感器装置。在一些实施例中，经皮传感器装置100包括构造成用于插入主体皮肤180下方的体内部分160，以及配置成在传感器插入入口之后保留在主体的皮肤180的表面上方的离体部分170 体内部分。体内部分可以包括构造成用于刺穿主体的皮肤180的组织刺穿元件110和传感器主体120，传感器主体120包括材料或支撑构件130，材料或支撑构件130提供足够的柱强度，以允许传感器主体可在主机组织中推出而不用实质屈曲。离体部分170可以被配置为包括（或可操作地连接）传感器电子单元，并且可以包括安装单元150.此处还描述了传感器主体和组织刺穿元件的各种配置，其可以用于保护传感器体的膜。

5. 发明申请

WO2011003035A3 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2011003035A3
公开(公告)日：2011-04-14
申请号：PCT/US2010040838
申请日：2010-07-01
申请人： DEXCOM INC , SIMPSON PETER C , BOOCK ROBERT , KAMATH APURV ULLAS , WIGHTLIN MATTHEW , ESTES MICHAEL J
发明人： SIMPSON PETER C , BOOCK ROBERT , KAMATH APURV ULLAS , WIGHTLIN MATTHEW , ESTES MICHAEL J
IPC分类号： A61B5/145 , A61B5/1468
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system (180) is provided having a first working electrode (150) comprising a first sensor element (102) and a second working electrode (160) comprising a second sensor element (104), and a reference electrode (108) for providing a reference value for measuring the working electrode potential of the sensor elements (102, 104).
摘要翻译：提供了用于连续测量分析物浓度的装置和方法。该装置可以包括具有多个传感器元件的传感器，每个传感器元件具有与装置的其它传感器不同的至少一个特性。在一些实施例中，多个传感器元件各自被调谐以测量分析物浓度的不同范围，从而为器件提供在生理学相关范围内实现基本一致的测量精度水平的能力。在其他实施例中，该装置包括多个传感器元件，每个传感器元件在插入或植入之后的不同时间期间被调整以测量，从而为传感器提供在宽范围的时间段内连续且精确地测量分析物浓度的能力。例如，提供传感器系统（180），其具有包括第一传感器元件（102）的第一工作电极（150）和包括第二传感器元件（104）的第二工作电极（160）和参考电极（108）），用于提供用于测量传感器元件（102,104）的工作电极电位的参考值。

6. 发明申请

WO2010033724A3 PARTICLE-CONTAINING MEMBRANE AND PARTICULATE ELECTRODE FOR ANALYTE SENSORS 审中-公开
标题翻译：用于分析仪传感器的颗粒包含膜和颗粒电极
公开(公告)号：WO2010033724A3
公开(公告)日：2010-05-20
申请号：PCT/US2009057347
申请日：2009-09-17
申请人： DEXCOM INC , SIMPSON PETER C , BOOCK ROBERT J , WIGHTLIN MATTHEW , SCHULTS MARK
发明人： SIMPSON PETER C , BOOCK ROBERT J , WIGHTLIN MATTHEW , SCHULTS MARK
IPC分类号： G01N27/26 , G01N27/30 , G01N33/48
CPC分类号： A61B5/1473 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/6848 , A61B2562/028
摘要： Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporealIy implanted. In a preferred embodiment, the sensor includes a membrane 32 having an electrode domain 43, an interference domain 44, and enzyme domain 46, a diffusion resistance domain 48, and a particle-containing domain 50 wrapped around a working electrode 38.
摘要翻译：提供涉及具有含颗粒结构域的传感器的系统和使用方法用于在主机中进行连续的分析物测量。在一些实施例中，连续分析物测量系统被配置为完全，经皮，血管内或体外植入。在优选实施例中，传感器包括具有电极结构域43，干涉区域44和酶结构域46，扩散阻力结构域48和缠绕在工作电极38周围的含颗粒结构域50的膜32。

7. 发明申请

WO2005051170A3 INTEGRATED RECEIVER FOR CONTINUOUS ANALYTE SENSOR 审中-公开
标题翻译：用于连续分析仪传感器的集成接收器
公开(公告)号：WO2005051170A3
公开(公告)日：2009-04-02
申请号：PCT/US2004038724
申请日：2004-11-17
申请人： DEXCOM INC , RASDAL ANDREW , BRAUKER JAMES , NEALE PAUL , SIMPSON PETER C
发明人： RASDAL ANDREW , BRAUKER JAMES , NEALE PAUL , SIMPSON PETER C
IPC分类号： A61B5/05 , A61B20060101 , A61B5/00 , A61B13/00 , A61K49/00
CPC分类号： A61B5/1495 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B5/7203 , A61B2560/0456 , A61B2562/247
摘要： A system is provided for monitoring glucose in a host, including a continuous glucose sensor (10) that produces a data stream indicative of a host's glucose concentration and an integrated receiver (12) that receives the data stream from the continuous glucose sensor (10) and calibrates the data stream using a single point glucose monitor (14) that is integral with the integrated receiver (12). The integrated receiver (12) obtains a glucose value from the single point glucose monitor (14), calibrates the sensor data stream received from the continuous glucose sensor (10), and displays one or both of the single point glucose measurement values and the calibrated continuous glucose sensor values on the user interface (16).
摘要翻译：提供了一种用于监测主机中的葡萄糖的系统，包括产生指示宿主葡萄糖浓度的数据流的连续葡萄糖传感器（10）和从连续葡萄糖传感器（10）接收数据流的集成接收器（12）并且使用与集成接收器（12）集成的单点葡萄糖监测器（14）来校准数据流。集成接收器（12）从单点葡萄糖监测器（14）获得葡萄糖值，校准从连续葡萄糖传感器（10）接收的传感器数据流，并显示单点葡萄糖测量值和校准后的一个或两个用户界面上连续的葡萄糖传感器值（16）。

8. 发明申请

WO2005057168A3 CALIBRATION TECHNIQUES FOR A CONTINUOUS ANALYTE SENSOR 审中-公开
标题翻译：连续分析仪传感器的校准技术
公开(公告)号：WO2005057168A3
公开(公告)日：2007-03-22
申请号：PCT/US2004040476
申请日：2004-12-03
申请人： DEXCOM INC , KAMATH APURV ULLAS , SIMPSON PETER C , BRAUKER JAMES H , GOODE JR PAUL V
发明人： KAMATH APURV ULLAS , SIMPSON PETER C , BRAUKER JAMES H , GOODE JR PAUL V
IPC分类号： A61B5/05 , A61B5/00 , G01N20060101
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1495 , A61B5/7203 , A61B5/742 , A61B2560/0223 , B33Y70/00 , B33Y80/00
摘要： Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the sensor. Furthermore, baseline and/or sensitivity measurements may be used to trigger events such as digital filtering of data or suspending display of data.
摘要翻译：本文公开了用于校准连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。一个这样的系统利用一个或多个电极来测量另外的分析物。这样的测量可以提供用于校准传感器的基线或灵敏度测量。此外，可以使用基线和/或灵敏度测量来触发诸如数字数字滤波或暂停显示数据的事件。

9. 发明申请

WO2015066051A2 ADAPTIVE INTERFACE FOR CONTINUOUS MONITORING DEVICES 审中-公开
标题翻译：用于连续监测设备的自适应接口
公开(公告)号：WO2015066051A2
公开(公告)日：2015-05-07
申请号：PCT/US2014062687
申请日：2014-10-28
申请人： DEXCOM INC
发明人： MAYOU PHIL , BHAVARAJU NARESH C , BOWMAN LEIF N , CARLTON ALEXANDRA LYNN , DUNN LAURA J , GRUBSTEIN KATHERINE YERRE , MAHALINGAM AARTHI , REIHMAN ELI , SIMPSON PETER C
IPC分类号： G06F19/00
CPC分类号： G09B5/02 , A61B5/01 , A61B5/1112 , A61B5/1118 , A61B5/14532 , A61B5/14552 , A61B5/165 , A61B5/7275 , A61B5/7282 , A61B5/742 , A61B5/746 , G06F19/3406 , G06F19/3418 , G06F19/3487 , G09B19/00 , G16H15/00 , G16H40/63 , H04L67/12
摘要： Systems and methods that continuously adapt aspects of a continuous monitoring device based on collected information to provide an individually tailored configuration are described. The adaptations may include adapting the user interface, the alerting, the motivational messages, the training, and the like. Such adaptation can allow a patient to more readily identify and understand the information provided by/via the device.
摘要翻译：描述了基于收集的信息连续地适应连续监视设备的各个方面以提供单独定制的配置的系统和方法。修改可以包括调整用户界面，警报，激励消息，训练等。这种适应可以允许患者更容易地识别和理解由/经由设备提供的信息。

10. 发明申请

WO2012142502A2 ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION 审中-公开
标题翻译：高级分析仪传感器校准和错误检测
公开(公告)号：WO2012142502A2
公开(公告)日：2012-10-18
申请号：PCT/US2012033645
申请日：2012-04-13
申请人： DEXCOM INC , ESTES MICHAEL J , SIMPSON PETER C , KAMATH APURV ULLAS , BOHM SEBASTIAN , RONG DAITING
发明人： ESTES MICHAEL J , SIMPSON PETER C , KAMATH APURV ULLAS , BOHM SEBASTIAN , RONG DAITING
IPC分类号： G01N33/66 , A61B5/157
CPC分类号： A61B5/1495 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/7257 , A61B5/7267 , A61B2560/0276 , G01D18/00 , G01N27/026 , G01N27/3274 , G01N33/49
摘要： Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self- calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity (110) of the analyte sensor is determined by applying an estimative algorithm (120) that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.
摘要翻译：提供了用于处理传感器数据和自校准的系统和方法。在一些实施例中，提供了能够基于初始灵敏度校准连续分析物传感器，然后在不使用或减少使用参考测量的情况下连续执行自校准的系统和方法。在某些实施例中，通过应用作为某些参数的函数的估计算法（120）来确定分析物传感器的灵敏度（110）。本文还描述了使用刺激信号来确定分析物传感器的性质的系统和方法。传感器属性可用于补偿传感器数据的灵敏度漂移，或确定与传感器相关的其他属性，如温度，传感器膜损坏，传感器电子设备中的水分进入以及缩放因子。

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