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1. 发明申请

WO2002072631A3 MHC MOLECULE CONSTRUCTS AND THEIR USESFOR DIAGNOSIS AND THERAPY 审中-公开
公开(公告)号：WO2002072631A3
公开(公告)日：2002-09-19
申请号：PCT/DK2002/000169
申请日：2002-03-13
申请人： DAKOCYTOMATION DENMARK A/S , DYNAL BIOTECH ASA , WINTHER, Lars , PETERSEN, Lars, Oestergaard , BUUS, Soeren , SCHOELLER, Joergen , RUUD, Erik , AAMELLEM, Oeystein
发明人： WINTHER, Lars , PETERSEN, Lars, Oestergaard , BUUS, Soeren , SCHOELLER, Joergen , RUUD, Erik , AAMELLEM, Oeystein
IPC分类号： C07K14/705
摘要： Novel compounds carrying ligands capable of ligating to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as in various methods. In particular, novel MHC molecule constructs comprising one or more MHC molecules are disclosed. The affinity and avidity of the MHC molecules of the constructs are surprisingly high. The possibility of presenting to the target cells a plurality of MHC molecules makes the MHC molecule constructs an extremely powerful tool e.g. in the field of diagnosis. The invention relates in general to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC molecules, MHC molecule multimers, and MHC molecule constructs.

2. 发明申请

WO2002072631A2 NOVEL MHC MOLECULE CONSTRUCTS, AND METHODS OF EMPLOYING THESE CONSTRUCTS FOR DIAGNOSIS AND THERAPY, AND USES OF MHC MOLECULES 审中-公开
标题翻译：新型MHC分子构建体，以及使用这些构建体进行诊断和治疗的方法以及MHC分子的用途
公开(公告)号：WO2002072631A2
公开(公告)日：2002-09-19
申请号：PCT/DK2002/000169
申请日：2002-03-13
申请人： DAKO A/S , DYNAL BIOTECH ASA , WINTHER, Lars , PETERSEN, Lars, Oestergaard , BUUS, Soeren , SCHOELLER, Joergen , RUUB, Erik , AAMELLEM, Oeystein
发明人： WINTHER, Lars , PETERSEN, Lars, Oestergaard , BUUS, Soeren , SCHOELLER, Joergen , RUUB, Erik , AAMELLEM, Oeystein
IPC分类号： C07K14/705
CPC分类号： B82Y5/00 , A61K38/00 , B82Y10/00 , C07K14/70539
摘要： Novel compounds carrying ligands capable of ligating to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as in various methods. In particular, novel MHC molecule constructs comprising one or more MHC molecules are disclosed. The affinity and avidity of the MHC molecules of the constructs are surprisingly high. The possibility of presenting to the target cells a plurality of MHC molecules makes the MHC molecule constructs an extremely powerful tool e.g. in the field of diagnosis. The invention relates in general to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC molecules, MHC molecule multimers, and MHC molecule constructs.
摘要翻译：公开了新型化合物，其携带能够连接到相关靶细胞上的反向受体的配体。这些化合物具有许多有利的特征，使它们非常适用于广泛的应用，包括用作检测系统，检测相关靶细胞以及各种方法。具体而言，公开了包含一种或多种MHC分子的新型MHC分子构建体。构建体的MHC分子的亲和力和亲和力出人意料地高。向目标细胞提供多个MHC分子的可能性使得MHC分子构建了非常强大的工具，例如，在诊断领域。本发明一般涉及治疗领域，包括治疗方法和治疗组合物。本发明还包括MHC分子，MHC分子多聚体和MHC分子构建体的样品安装用途。

3. 发明申请

WO2005054860A1 METHODS AND COMPOSITIONS FOR IMMUNO-HISTOCHEMICAL DETECTION 审中-公开
标题翻译：免疫组织化学检测的方法和组合
公开(公告)号：WO2005054860A1
公开(公告)日：2005-06-16
申请号：PCT/US2004/039911
申请日：2004-11-30
申请人： DAKOCYTOMATION DENMARK A/S , WINTHER, Lars , KNOLL, Anthony, Lionel , WECKWORTH, Kelly, Ann , LOVBORG, Uffe
发明人： WINTHER, Lars , KNOLL, Anthony, Lionel , WECKWORTH, Kelly, Ann , LOVBORG, Uffe
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , G01N33/543 , G01N33/58
摘要： In certain embodiments the invention relates to methods and compositions for detecting a biological marker in a sample. In certain embodiments the biological markers are detected immunologically.
摘要翻译：在某些实施方案中，本发明涉及用于检测样品中生物标志物的方法和组合物。在某些实施方案中，免疫学检测生物学标记。

4. 发明申请

WO2005003773A1 STANDARD 审中-公开
标题翻译：标准
公开(公告)号：WO2005003773A1
公开(公告)日：2005-01-13
申请号：PCT/IB2004/002682
申请日：2004-07-08
申请人： DAKOCYTOMATION DENMARK A/S , WINTHER, Lars , PII, Kurt
发明人： WINTHER, Lars , PII, Kurt
IPC分类号： G01N33/543
CPC分类号： G01N33/5005 , C12Q1/6841 , G01N1/36 , G01N33/54346 , G01N33/54353 , G01N33/54386 , G01N33/96 , G01N2001/2893 , G01N2496/00 , C12Q2545/113
摘要： We disclose a reference standard for a detectable entity, the reference standard comprising a support medium, preferably an embedding medium, a compact particle having a compact shape with a quantity of detectable entity coupled thereto and supported by the medium, in which the compact particle is a biological, preferably cellular compact particle, preferably a cellular compact particle. We also disclose a reference standard for a detectable entity, the reference standard comprising a support medium, preferably an embedding medium, a compact particle having a compact shape with a quantity of detectable entity coupled thereto and supported by the medium, in which the compact particle is a non-biological compact particle, preferably a non-cellular compact particle having cell-like dimensions, preferably less than 1.5 mm.
摘要翻译：我们公开了可检测实体的参考标准，参考标准包括支持介质，优选包埋介质，具有紧凑形状的致密颗粒，其具有耦合到其上并由介质支持的可检测实体的量，其中紧密颗粒是生物的，优选细胞致密的颗粒，优选细胞致密颗粒。我们还公开了可检测实体的参考标准，参考标准包括支持介质，优选包埋介质，具有紧凑形状的致密颗粒，其具有与其连接并由介质支持的可检测实体的量，其中致密颗粒是非生物致密颗粒，优选具有细胞样尺寸，优选小于1.5mm的非细胞致密颗粒。

5. 发明申请

WO2006004739A2 METHOD OF PRE-TREATMENT AND STAINING OF AND SUPPORT DEVICE FOR A BIOLOGICAL SAMPLE 审中-公开
标题翻译：用于生物样品的预处理和染色和支持装置的方法
公开(公告)号：WO2006004739A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/022907
申请日：2005-06-28
申请人： DAKOCYTOMATION DENMARK A/S , BLAND, Loren, L. , KEY, Marc, E. , WINTHER, Lars , STANFORTH, David, A. , LINDBERG, Martin, N.
发明人： BLAND, Loren, L. , KEY, Marc, E. , WINTHER, Lars , STANFORTH, David, A. , LINDBERG, Martin, N.
IPC分类号： G01N1/30 , G01N33/48 , G06F19/00 , G01N33/50
CPC分类号： G01N1/30 , B01L3/545 , B01L2300/023 , B01L2300/024 , B01L2300/0822 , G01N1/312 , G01N35/00732 , G01N2035/00782 , Y10T436/255
摘要： There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or, within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information.
摘要翻译：公开了根据方案对设置在载体表面上的生物样品进行预处理和染色的方法，所述方法包括以下步骤：将与至少一个方案步骤相关的至少一个参数记录在非 - 位于载体上或载体内的易失性存储器或包含载体的装置。还公开了一种装置，包括：非易失性存储器; 所述装置的表面适于携带生物样品; 以及电连接到存储器的通信装置，用于使能到外部设备的数据传输。还公开了一种控制设置在载体上的生物样品的处理的方法，包括：在载体或保持载体的装置的一侧或之下提供具有与样品处理优先级或方案有关的信息的非易失性存储器; 阅读信息; 并基于该信息调度处理。

6. 发明申请

WO2005066327A1 APPARATUS AND METHODS FOR PROCESSING BIOLOGICAL SAMPLES AND A RESERVOIR THEREFORE 审中-公开
标题翻译：用于处理生物样品和储存器的装置和方法
公开(公告)号：WO2005066327A1
公开(公告)日：2005-07-21
申请号：PCT/DK2005/000003
申请日：2005-01-06
申请人： DAKOCYTOMATION DENMARK A/S , TESTA, Gregory, A. , POULSEN, Tim, Svenstrup , MATTHIESEN, Steen, Hauge , RASMUSSEN, Ole, Feldballe , WINTHER, Lars
发明人： TESTA, Gregory, A. , POULSEN, Tim, Svenstrup , MATTHIESEN, Steen, Hauge , RASMUSSEN, Ole, Feldballe , WINTHER, Lars
IPC分类号： C12M1/22
CPC分类号： C12Q1/6841 , B01L3/508 , B01L7/52 , B01L2200/142 , B01L2300/043 , B01L2300/069 , B01L2300/0822 , B01L2300/10 , B01L2300/1822 , B01L2300/1844 , C12M41/14 , C12M41/36 , G01N1/312 , Y10T436/143333
摘要： An apparatus for processing biological samples comprising means for processing at least one biological sample accommodated on at least one carrier member (15) in a chamber, characterised in that at least one reservoir (18) able to accommodate a fluid is arranged on a surface inside the chamber adjacent to and/or facing a substantial part of the at least one biological sample. Preferably the apparatus comprises a bottom member (12) arranged to support at least one carrier member (15) carrying at least one biological sample and a lid (14) including at least one fluid reservoir (18). The reservoir filled with water provides humidity to the chamber and impedes drying out of the sample.
摘要翻译：一种用于处理生物样品的装置，包括用于处理容纳在室中的至少一个载体构件（15）上的至少一个生物样品的装置，其特征在于，能够容纳流体的至少一个储存器（18）布置在内部的表面邻近和/或面向至少一个生物样品的主要部分的腔室。优选地，该装置包括底部构件（12），该底部构件（12）布置成支撑承载至少一个生物样品的至少一个承载构件（15）和包括至少一个流体储存器（18）的盖子（14）。充满水的储存器对室提供湿气并阻止样品干燥。

7. 发明申请

WO2004077057A1 STANDARD FOR IMMUNOHISTOCHEMISTRY, IMMUNOCYTOCHEMISTRY AND MOLECULAR CYTOGENETICS 审中-公开
标题翻译：免疫组织化学，免疫组织化学和分子细胞化学标准
公开(公告)号：WO2004077057A1
公开(公告)日：2004-09-10
申请号：PCT/IB2004/001173
申请日：2004-02-27
申请人： DAKOCYTOMATION DENMARK A/S , WINTHER, Lars
发明人： WINTHER, Lars
IPC分类号： G01N33/53
CPC分类号： G01N15/1468 , C12Q1/6841 , G01N1/06 , G01N1/36 , G01N2001/2893 , G01N2015/1472
摘要： We describe a method comprising: (a) providing a reference standard or a planar section thereof, the reference standard comprising (i) a support medium; and (ii) a quantity of a detectable entity supported by the support medium; in which the detectable entity has an elongate path; in which a predetermined amount of the detectable entity is present in a defined region in a cross section of the reference standard; (b) obtaining a first reference signal indicative of the presence or quantity of detectable entity in the reference standard, planar section thereof, or the defined region; (c) providing a biological sample and obtaining a second signal indicative of the presence or quantity of detectable entity in the biological sample, or a component thereof; and (d) comparing the reference signal obtained in (b) against the second signal obtained in (c). Preferably, the method is used to indicate the presence, quantity or concentration of a detectable entity in a biological sample.
摘要翻译：我们描述了一种方法，包括：（a）提供参考标准或其平面部分，所述参考标准包括（i）支撑介质; 和（ii）由支持媒介支持的可检测实体的数量; 其中可检测实体具有细长路径; 其中预定量的可检测实体存在于参考标准的横截面中的限定区域中; （b）获得指示参考标准，其平面部分或限定区域中可检测实体的存在或数量的第一参考信号; （c）提供生物样品并获得指示生物样品或其组分中可检测实体的存在或数量的第二信号; 和（d）将（b）中获得的参考信号与（c）中获得的第二信号进行比较。优选地，该方法用于指示生物样品中可检测实体的存在，数量或浓度。

8. 发明申请

WO2004059284A2 APPARATUS FOR AUTOMATED PROCESSING BIOLOGICAL SAMPLES 审中-公开
标题翻译：自动处理生物样品的设备
公开(公告)号：WO2004059284A2
公开(公告)日：2004-07-15
申请号：PCT/US2003/040520
申请日：2003-12-19
申请人： DAKOCYTOMATION DENMARK A/S , WINTHER, Lars , KEY, Marc , BUCHANAN, Kristopher , FAVUZZI, John , GUGGENHEIMER, Benno
发明人： WINTHER, Lars , KEY, Marc , BUCHANAN, Kristopher , FAVUZZI, John , GUGGENHEIMER, Benno
IPC分类号： G01N
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
摘要翻译：本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件如载玻片上的至少一种生物样品的装置，所述装置包括：一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。

9. 发明申请

WO2003016872A1 PROCESS AND APPARATUS FOR PREPARING AND PRESENTING A TISSUE SAMPLE FOR HISTOLOGICAL STUDY 审中-公开
标题翻译：制备和提供组织学研究的组织样品的方法和装置
公开(公告)号：WO2003016872A1
公开(公告)日：2003-02-27
申请号：PCT/DK2002/000532
申请日：2002-08-12
申请人： DAKOCYTOMATION DENMARK A/S , HUANG, Dennis, Shihchang , WINTHER, Lars
发明人： HUANG, Dennis, Shihchang , WINTHER, Lars
IPC分类号： G01N1/36
CPC分类号： G01N1/36 , G01N1/06 , G01N1/30 , Y10T436/2525
摘要： An apparatus and method for preserving cytological specimens for histological or histopathological use. A cytological sample from a biological tissue such as a tumor or a tumor cell line is dehydrated, disbursed and evenly distributed throughout a volume of molten material. The molten material is then drawn into a tubular member such as a pipette and allowed to solidify. Upon solidification, the cylindrical specimen is partially or completely extrudedfrom the tube for further processing, including fixation, dehydration and molten paraffin infiltration and embedding as required for presentation to a sectioning device such as a microtome. Thin circular slices of the cylindrical specimen are removed from the cylindrical specimen and transferred to a slide, fixed and stained as desired. The device and method enable the production of a slide bearing a spatially homogeneous distribution of cytological material for microscopic examination.
摘要翻译：一种用于保留细胞学标本用于组织学或组织病理学用途的装置和方法。来自生物组织如肿瘤细胞系的细胞学样品被脱水，分散并均匀分布在一定体积的熔融材料中。然后将熔融的材料拉入诸如移液管的管状构件中并使其固化。固化后，将圆筒形样品从管中部分或完全挤出，用于进一步加工，包括固定，脱水和熔融石蜡渗透，并根据需要将其包埋到切片装置如切片机上。将圆柱形试样的圆形圆形切片从圆柱形样品中取出并转移到载玻片上，固定并根据需要进行染色。该装置和方法使得能够生产具有用于显微镜检查的细胞学材料的空间均匀分布的载玻片。

10. 发明申请

WO2010128033A2 METHOD FOR PURIFICATION OF TARGET POLYPEPTIDES 审中-公开
标题翻译：目标多肽的纯化方法
公开(公告)号：WO2010128033A2
公开(公告)日：2010-11-11
申请号：PCT/EP2010/056010
申请日：2010-05-04
申请人： NOVOZYMES A/S , KYHSE-ANDERSEN, Jan , WINTHER, Lars
发明人： KYHSE-ANDERSEN, Jan , WINTHER, Lars
IPC分类号： C07K14/435 , C07K1/22
CPC分类号： C07K1/22 , C07K1/32 , C07K1/36
摘要： The present invention relates to a process for purification of a target molecule, comprising the steps: (a) contacting a target molecule, and a population of target binding polypeptides (TBP), in solution for a sufficient time to allow complex formation; and (b) isolating the target from the complex from (a) by subsequent purification steps, wherein (i) the target binding polypeptides have at least two binding functionalities; a first binding functionality towards the target and a second binding functionality towards a catching ligand comprised in a solid support; and (ii) the first binding functionality comprises at least two binding sites for the target, and the target com¬ prises at least two binding sites for the TBP.
摘要翻译：本发明涉及一种纯化靶分子的方法，包括以下步骤：（a）在溶液中使目标分子和靶结合多肽（TBP）群体接触足够的时间以允许复合物形成; 和（b）通过随后的纯化步骤从（a）分离所述复合物中的靶，其中（i）靶结合多肽具有至少两个结合官能团; 针对靶的第一结合功能和朝向包含在固体支持物中的捕获性配体的第二结合功能; 和（ii）第一结合功能包含靶的至少两个结合位点，并且靶标包含TBP的至少两个结合位点。

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