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1. 发明申请

WO2005084263A3 REAGENT DELIVERY SYSTEM, DISPENSING DEVICE AND CONTAINER FOR A BIOLOGICAL STAINING APPARATUS 审中-公开
公开(公告)号：WO2005084263A3
公开(公告)日：2005-09-15
申请号：PCT/US2005/006383
申请日：2005-02-28
申请人： DAKOCYTOMATION DENMARK A/S , FAVUZZI, John, A. , BUCHANAN, Kristopher , MARTIN, Merritt, M., Jr. , BLAND, Loren, L. , SWEDA, Jonathan, R. , LATHROP, Robert, L. , VAN BOSCH, John, E.
发明人： FAVUZZI, John, A. , BUCHANAN, Kristopher , MARTIN, Merritt, M., Jr. , BLAND, Loren, L. , SWEDA, Jonathan, R. , LATHROP, Robert, L. , VAN BOSCH, John, E.
IPC分类号： G01N1/10
摘要： The invention concerns reagent delivery system for an apparatus for processing of biological samples arranged on microscope slides, comprising a reagent section having one or more reagent containers; a slide section in which at least one microscope slide is arranged; a probe for dispensing a portion of reagent onto a predetermined microscope slide, and means for handling the probe. The probe comprises a continuous prove tubing element extending through a rigid probe member and connecting the probe tip to a pneumatic pressure regulation device. The reagent containers are adapted for cooperation with the probe tip. In this manner a high though-put and a very low carry over of fluid tresidues is achieved since there is no assembled parts making up the inside volume of the probe in which the fluid may be retained.

2. 发明申请

WO2003049861A1 EXTENDABLE SEGMENTED SAMPLE CARRIER SYSTEM 审中-公开
标题翻译：可扩展的SEGMEN样本载体系统
公开(公告)号：WO2003049861A1
公开(公告)日：2003-06-19
申请号：PCT/US2002/039471
申请日：2002-12-09
申请人： DAKOCYTOMATION DENMARK A/S , BUCHANAN, Kristopher, S. , BAHJAT, Keith, S. , FOX, Nathan, M.
发明人： BUCHANAN, Kristopher, S. , BAHJAT, Keith, S. , FOX, Nathan, M.
IPC分类号： B01L3/00
CPC分类号： B01L3/50855 , B01L9/06 , B01L9/523 , B01L9/54 , B01L2200/022 , B01L2300/0829 , G01N35/026 , G01N2035/0427
摘要： A sample carrier system (11) with spatially adjustable configuration provides variable positioning as to the relative location of a plurality of sample containment elements (1). In a preferred embodiment, a slidably reconfigurable sampling system in which a matrix type, row-by-row arrangement of receptacles or sample retention elements (1) for specimen carriers such as cuvettes, test tubes and beakers, or the like (40), or for samples (41), may be reconfigured into a substantially linear arrangement of individual specimen carriers along with the entrained material contents, providing more accurate testing processes and more reliable test results.
摘要翻译：具有空间可调配置的样品载体系统（11）提供关于多个样品容纳元件（1）的相对位置的可变定位。在优选实施例中，可滑动地重新配置的采样系统，其中用于样本载体（如比色皿，试管和烧杯等）的容器或样品保留元件（1）的逐排排列，或对于样品（41），可以重新配置成单个样品载体的基本线性布置以及夹带的材料含量，提供更准确的测试过程和更可靠的测试结果。

3. 发明申请

WO0140765A3 IMPROVED FLOW CYTOMETER NOZZLE AND FLOW CYTOMETER SAMPLE HANDLING METHODS 审中-公开
标题翻译：改进的流量计方程式喷嘴和流量计流量计样品处理方法
公开(公告)号：WO0140765A3
公开(公告)日：2002-02-14
申请号：PCT/US0042350
申请日：2000-11-29
申请人： XY INC , BUCHANAN KRISTOPHER S , HERICKHOFF LISA
发明人： BUCHANAN KRISTOPHER S , HERICKHOFF LISA
IPC分类号： A01K67/02 , A61D19/00 , C12M1/00 , C12Q1/02 , G01N1/00 , G01N15/00 , G01N15/14
CPC分类号： G01N15/1404 , G01N2015/0065 , G01N2015/1006 , G01N2015/1409 , G01N2015/1413 , G01N2015/1415 , G01N2015/149 , Y10T436/101666
摘要： An improved nozzle system for a flow cytometer and accompanying methods have been invented for a high efficiency orientation and sorting process of a flat sample and dedicates items such as equine or bovine sperm cells. This improved nozzle system comprises a nozzle (16) with a novel interior surface geometry that can both gently accelerate the cells and can include an elliptical-like, single torsional interior surface element within (c) the nozzle, i.e., a single torsional orientation nozzle (6). The elliptical-like, single torsional interior surface element (e.g.) (8, 9, 10) may have a laminar flow surface and may produce the simplest flow path for applying minimal forces which act in either an accelerative nature or orienting hydrodynamic forces, namely, the single torsional orientation forces, to orient a flat sample (16) such as animal sperm cells into a proper direction for an analyzing and efficiently sorting process in clinical use, for research and for the animal insemination industry.
摘要翻译：已经发明了一种用于流式细胞仪的改进的喷嘴系统和相关方法，用于平坦样品的高效取向和分选过程，并且专用诸如马或牛精子细胞的物品。这种改进的喷嘴系统包括具有新颖的内表面几何形状的喷嘴（16），其可以轻轻地加速细胞并且可以在（c）喷嘴内包括椭圆形的单个扭转内表面元件，即，单个扭转定向喷嘴（6）。椭圆形单个扭转内表面元件（例如）（8,9,10）可以具有层流表面并且可以产生最简单的流动路径，用于施加以加速性质或取向的流体动力作用的最小力，即单一的扭转取向力将诸如动物精子细胞的平坦样品（16）定向到适当的方向，用于临床使用中的分析和有效分选过程，用于研究和动物授精行业。

4. 发明申请

WO2005084263A2 REAGENT DELIVERY SYSTEM, DISPENSING DEVICE AND CONTAINER FOR A BIOLOGICAL STAINING APPARATUS 审中-公开
标题翻译：试剂递送系统，生物染色装置的分配装置和容器
公开(公告)号：WO2005084263A2
公开(公告)日：2005-09-15
申请号：PCT/US2005006383
申请日：2005-02-28
申请人： DAKOCYTOMATION DENMARK AS , FAVUZZI JOHN A , BUCHANAN KRISTOPHER , MARTIN MERRITT M JR , BLAND LOREN L , SWEDA JONATHAN R , LATHROP ROBERT L , VAN BOSCH JOHN E
发明人： FAVUZZI JOHN A , BUCHANAN KRISTOPHER , MARTIN MERRITT M JR , BLAND LOREN L , SWEDA JONATHAN R , LATHROP ROBERT L , VAN BOSCH JOHN E
IPC分类号： B01L3/00 , G01N1/31 , G01N35/10
CPC分类号： G01N1/30 , B01L3/508 , G01N1/312 , G01N35/1002 , G01N35/109 , Y10T436/2575
摘要： The invention concerns reagent delivery system for an apparatus for processing of biological samples arranged on microscope slides, comprising a reagent section having one or more reagent containers; a slide section in which at least one microscope slide is arranged; a probe for dispensing a portion of reagent onto a predetermined microscope slide, and means for handling the probe. The probe comprises a continuous prove tubing element extending through a rigid probe member and connecting the probe tip to a pneumatic pressure regulation device. The reagent containers are adapted for cooperation with the probe tip. In this manner a high though-put and a very low carry over of fluid tresidues is achieved since there is no assembled parts making up the inside volume of the probe in which the fluid may be retained.
摘要翻译：本发明涉及用于处理布置在显微镜载片上的生物样品的装置的试剂递送系统，包括具有一个或多个试剂容器的试剂部分; 其中布置有至少一个显微镜载玻片的滑动部分; 用于将一部分试剂分配到预定显微镜载玻片上的探针和用于处理探针的装置。探针包括连续证明管道元件，其延伸穿过刚性探针构件并将探针尖端连接到气动调压装置。试剂容器适于与探针尖端配合。以这种方式，由于没有组装部件构成探针的内部容积，可以保持流体，所以实现了很高的保持和非常低的流体滞留输送。

5. 发明申请

WO2003062796A1 ENVIRONMENTAL CONTAINMENT SYSTEM FOR A FLOW CYTOMETER 审中-公开
标题翻译：流量计的环境容纳系统
公开(公告)号：WO2003062796A1
公开(公告)日：2003-07-31
申请号：PCT/US2003/001972
申请日：2003-01-22
申请人： DAKOCYTOMATION DENMARK A/S , HALL, Brian, R. , BUCHANAN, Kristopher, S. , KAANTA, Benjamin, H. , FOX, Nathan, M.
发明人： HALL, Brian, R. , BUCHANAN, Kristopher, S. , KAANTA, Benjamin, H. , FOX, Nathan, M.
IPC分类号： G01N1/00
CPC分类号： B01L1/50 , B01L9/52 , B01L2300/10 , G01N15/1456 , G01N15/1459 , G01N2015/149 , G01N2015/1497 , G01N2035/00277 , Y10T436/25 , Y10T436/25875
摘要： An environmental containment system (16) for a flow cytometer (21) which provides a adjustably controllable environment in which biological particles can be differentiated and droplets separated into collection container (15).
摘要翻译：一种用于流式细胞仪（21）的环境容纳系统（16），其提供可调节的可控制的环境，其中生物颗粒可以被分化并且液滴分离成收集容器（15）。

6. 发明申请

WO2004059287A3 SYSTEMS AND METHODS OF SAMPLE PROCESSING AND TEMPERATURE CONTROL 审中-公开
公开(公告)号：WO2004059287A3
公开(公告)日：2004-07-15
申请号：PCT/US2003/040880
申请日：2003-12-22
申请人： DAKOCYTOMATION DENMARK A/S , BUCHANAN, Kristopher , KEY, Marc , FAVUZZI, John , WELCHER, Rosanne , GUGGENHEIMER, Benno , CLARK, Robert , BARBER, Michael , LATHROP, Bob
发明人： BUCHANAN, Kristopher , KEY, Marc , FAVUZZI, John , WELCHER, Rosanne , GUGGENHEIMER, Benno , CLARK, Robert , BARBER, Michael , LATHROP, Bob
IPC分类号： G05B13/02
摘要： Systems and methods of sample processing and temperature control are disclosed. Specifically, the present invention provides temperature control in relation to sample processing systems and methods of processing samples. Some embodiments provides temperature control for sample carriers and processing materials, such as reagents. Corresponding systems and devices are disclosed, including sample processing systems (1) (Fig. 10), sample carrier temperature regulation systems, reagent temperature regulation systems, sample processing control systems, and temperature regulation devices. The present invention in particular applicability to the fields of immunohistochemistry, in-situ hybridization, fluorescent in-situ hybridization, special staining, such as special staining of histological samples, microarray sample processing, and cytology, as well as other chemical and biological applications.

7. 发明申请

WO2004059284A2 APPARATUS FOR AUTOMATED PROCESSING BIOLOGICAL SAMPLES 审中-公开
标题翻译：自动处理生物样品的设备
公开(公告)号：WO2004059284A2
公开(公告)日：2004-07-15
申请号：PCT/US2003/040520
申请日：2003-12-19
申请人： DAKOCYTOMATION DENMARK A/S , WINTHER, Lars , KEY, Marc , BUCHANAN, Kristopher , FAVUZZI, John , GUGGENHEIMER, Benno
发明人： WINTHER, Lars , KEY, Marc , BUCHANAN, Kristopher , FAVUZZI, John , GUGGENHEIMER, Benno
IPC分类号： G01N
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
摘要翻译：本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件如载玻片上的至少一种生物样品的装置，所述装置包括：一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。

8. 发明申请

WO2004059287A2 SYSTEMS AND METHODS OF SAMPLE PROCESSING AND TEMPERATURE CONTROL 审中-公开
标题翻译：样品加工和温度控制系统与方法
公开(公告)号：WO2004059287A2
公开(公告)日：2004-07-15
申请号：PCT/US0340880
申请日：2003-12-22
申请人： DAKOCYTOMATION DENMARK AS , BUCHANAN KRISTOPHER , KEY MARC , FAVUZZI JOHN , WELCHER ROSANNE , GUGGENHEIMER BENNO , CLARK ROBERT , BARBER MICHAEL , LATHROP BOB
发明人： BUCHANAN KRISTOPHER , KEY MARC , FAVUZZI JOHN , WELCHER ROSANNE , GUGGENHEIMER BENNO , CLARK ROBERT , BARBER MICHAEL , LATHROP BOB
IPC分类号： B01L3/02 , B32B5/02 , G01M1/38 , G01N1/10 , G01N1/30 , G01N1/31 , G01N15/06 , G01N35/00 , G01N35/02 , G05B21/00 , G01N
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： Systems and methods of sample processing and temperature control are disclosed. The invention may especially relate to temperature control, and may in some embodiments be methods of temperature control of an automated sample processing system and methods of automated sample processing. Specifically, the present invention provides temperature control in relation to sample processing systems and methods of processing samples, and in some embodiments provides temperature control in relation to sample carriers and processing materials such as reagents. Corresponding systems and devices are disclosed, including sample processing systems (1), sample carrier temperature regulation systems (60), reagent temperature regulation systems, sample processing control systems, and temperature regulation devices, among other embodiments. Scientific fields to which the present invention may have particular applicability include immunohistochemistry, in-situ hybridization, fluorescent in-situ hybridization, special staining, such as special staining of histological samples, microarray sample processing, and cytology, as well as potentially other chemical and biological applications.
摘要翻译：公开了样品处理和温度控制的系统和方法。本发明可以特别涉及温度控制，并且在一些实施例中可以是自动化样品处理系统的温度控制方法和自动样品处理方法。具体地，本发明提供了与样品处理系统和处理样品的方法相关的温度控制，并且在一些实施例中提供了与样品载体和加工材料如试剂相关的温度控制。公开了相应的系统和装置，包括样品处理系统（1），样品载体温度调节系统（60），试剂温度调节系统，样品处理控制系统和温度调节装置。本发明可能具有特定适用性的科学领域包括免疫组织化学，原位杂交，荧光原位杂交，特殊染色，例如组织学样品的特殊染色，微阵列样品处理和细胞学，以及潜在的其它化学和生物应用。

9. 发明申请

WO2004058950A1 A METHOD AND APPARATUS FOR AUTOMATIC STAINING OF TISSUE SAMPLES 审中-公开
标题翻译：一种用于组织样品自动染色的方法和装置
公开(公告)号：WO2004058950A1
公开(公告)日：2004-07-15
申请号：PCT/US2003/040518
申请日：2003-12-19
申请人： DAKOCYTOMATION DENMARK A/S , SWEET, Doug , KEY, Mark , FEINGOLD, Gordon , BUCHANAN, Kristopher , LATHROP, Bob , FAVUZZI, John
发明人： SWEET, Doug , KEY, Mark , FEINGOLD, Gordon , BUCHANAN, Kristopher , LATHROP, Bob , FAVUZZI, John
IPC分类号： C12N1/04
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus (1) for staining tissue samples, said apparatus (1) including a reagent section (2) or reagent containers (3); at least one staining section or tissue samples, a robotic head (22) or robotic element (20) that may move reagent to a predetermined tissue sample, said robotic element (20) being moveable above the reagent and the staining sections, a control element (85) that may manage a staining process, a 2-D optical sensor (86) to detect two-dimensional image data of a relevant property and that can feed the captured image data to the control element (86). By providing the robotic element (20) with a 2-D optical sensor (86), a common image processor may be provided having multiple functions. By using a 2-D optical image processing system, the control system of the apparatus may easily be adapted to read various types of data presentations, just as actual images for sections of the apparatus may be identified in order to assess the condition of the apparatus. The optical sensor may be used to automatically identify the slides and the reagent containers present in the apparatus, just as the optical sensor may be used for checking if a slide is misplaced at or absent from a slide position, etc.
摘要翻译：本发明涉及一种用于染色组织样本的装置（1），所述装置（1）包括试剂部分（2）或试剂容器（3）; 至少一个染色部分或组织样本，可将试剂移动到预定组织样品的机器人头部（22）或机器人元件（20），所述机器人元件（20）可在试剂和染色部分上方移动，控制元件（85），其可以管理染色过程; 2-D光学传感器（86），用于检测相关属性的二维图像数据，并且可以将捕获的图像数据馈送到控制元件（86）。通过向机器人元件（20）提供2-D光学传感器（86），可以提供具有多个功能的公共图像处理器。通过使用2-D光学图像处理系统，装置的控制系统可以容易地适于读取各种类型的数据呈现，就像可以识别装置的部分的实际图像以便评估装置的状况。光学传感器可以用于自动识别设备中存在的滑块和试剂容器，就像光学传感器可用于检查滑块是否位于滑动位置或不存在滑动位置等。

10. 发明申请

WO2004059284A3 APPARATUS FOR AUTOMATED PROCESSING BIOLOGICAL SAMPLES 审中-公开
标题翻译：自动处理生物样品的设备
公开(公告)号：WO2004059284A3
公开(公告)日：2004-11-25
申请号：PCT/US0340520
申请日：2003-12-19
申请人： DAKOCYTOMATION DENMARK AS , WINTHER LARS , KEY MARC , BUCHANAN KRISTOPHER , FAVUZZI JOHN , GUGGENHEIMER BENNO
发明人： WINTHER LARS , KEY MARC , BUCHANAN KRISTOPHER , FAVUZZI JOHN , GUGGENHEIMER BENNO
IPC分类号： B01L3/02 , B32B5/02 , G01M1/38 , G01N1/10 , G01N1/30 , G01N1/31 , G01N15/06 , G01N35/00 , G01N35/02 , G05B21/00 , G01N31/00
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus (1) for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by (7) applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus (1) comprising; a housing frame (4); at least one processing section for accommodating at least one slide (7), wherein the at least one processing section is provided within the housing (4); a hood cover protecting the at least one processing section in said housing (4); wherein the hood cover (40) completely encloses the processing section defining an interior space (120); and wherein the apparatus (1) further comprises climate control device (121) provided to control the environment within the interior space (120).
摘要翻译：本发明涉及一种用于通过（7）根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件（例如载玻片）上的至少一种生物样品的装置（1），所述装置 1）包括壳体框架（4）; 至少一个处理部分，用于容纳至少一个滑块（7），其中所述至少一个处理部分设置在所述壳体（4）内; 保护所述壳体（4）中的至少一个处理部分的罩盖; 其中所述罩盖（40）完全包围限定内部空间（120）的所述处理部分; 并且其中所述设备（1）还包括设置用于控制所述内部空间（120）内的环境的气候控制装置（121）。

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