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1. 发明申请

WO2004076857A2 METHOD AND APPARATUS FOR LOW-COST ELECTROKINETIC PUMP MANUFACTURING 审中-公开
标题翻译：低成本电动泵制造方法与装置
公开(公告)号：WO2004076857A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/002855
申请日：2004-01-29
申请人： COOLIGY, INC. , LOVETTE, James , MUNCH, Mark , SHOOK, James, Gill , ZENG, Shulin , DOUGLAS, Werner , CICHOCKI, Zbigniew , LIN, Tien-Chih, Eric
发明人： LOVETTE, James , MUNCH, Mark , SHOOK, James, Gill , ZENG, Shulin , DOUGLAS, Werner , CICHOCKI, Zbigniew , LIN, Tien-Chih, Eric , KENNY, Thomas, W., Jr.
IPC分类号： F04B
CPC分类号： F04B17/00 , F28D15/0266 , F28F19/006 , H01L23/473 , H01L2924/0002 , H01L2924/09701 , H01L2924/00
摘要： An electroosmotic pump used in a closed loop cooling system. The pump includes a fluid chamber, a pumping element, an inlet electrode, an outlet electrode, and means for providing electrical voltage to the inlet electrode and the outlet electrode to produce an electrical field therebetween. The pumping element is configured to pump fluid therethrough, and the pumping element is positioned to segment the fluid chamber into an inlet chamber including a fluid inlet port and an outlet chamber including a fluid outlet port. The size of the inlet chamber is proportional to a predetermined residence time of the inlet chamber. The inlet electrode is positioned within the inlet chamber and a predetermined distance from a first surface of the pumping element. The outlet electrode is positioned within the outlet chamber and a predetermined distance from a second surface of the pumping element.
摘要翻译：用于闭环冷却系统的电渗泵。泵包括流体室，泵送元件，入口电极，出口电极以及用于向入口电极和出口电极提供电压以在其间产生电场的装置。泵送元件构造成泵送流体通过其中，并且泵送元件被定位成将流体室分割成包括流体入口端口和包括流体出口的出口室的入口室。入口室的尺寸与入口室的预定停留时间成比例。入口电极定位在入口室内并与泵送元件的第一表面预定距离。出口电极定位在出口室内并且距离泵送元件的第二表面预定的距离。

2. 发明申请

WO2004071139A2 REMEDIES TO PREVENT CRACKING IN A LIQUID SYSTEM 审中-公开
标题翻译：补救措施以防止液体系统中的破裂
公开(公告)号：WO2004071139A2
公开(公告)日：2004-08-19
申请号：PCT/US2004/001047
申请日：2004-01-14
申请人： COOLIGY, INC. , MUNCH, Mark , GOODSON, Kenneth , CORBIN, Dave , ZENG, Shulin , KENNY, Thomas, W., Jr. , SHOOK, James, Gill
发明人： MUNCH, Mark , GOODSON, Kenneth , CORBIN, Dave , ZENG, Shulin , KENNY, Thomas, W., Jr. , SHOOK, James, Gill
IPC分类号： H05K
CPC分类号： H01L23/473 , F04B17/00 , F28D15/00 , F28F19/006 , F28F2245/02 , F28F2250/08 , H01L2924/0002 , H01L2924/00
摘要： A liquid cooling system utilizing minimal size and volume enclosures, air pockets, compressible objects, and flexible objects is provided to protect against expansion of water-based solutions when frozen. In such a system, pipes, pumps, and heat exchangers are designed to prevent cracking of their enclosures and chambers. Also described are methods of preventing cracking in a liquid cooling system. In all these cases, the system must be designed to tolerate expansion when water is frozen.
摘要翻译：提供使用最小尺寸和体积的外壳，气穴，可压缩物体和柔性物体的液体冷却系统，以防止冻结时水性溶液的膨胀。在这种系统中，管道，泵和热交换器被设计成防止其外壳和腔室的破裂。还描述了防止液体冷却系统中的裂纹的方法。在所有这些情况下，系统必须设计成在水被冻结时容忍膨胀。

3. 发明申请

WO2008005322A3 SYSTEM AND METHOD FOR RAPID THERMAL CYCLING 审中-公开
公开(公告)号：WO2008005322A3
公开(公告)日：2008-01-10
申请号：PCT/US2007/015106
申请日：2007-06-29
申请人： CANON U.S. LIFE SCIENCES, INC. , ZENG, Shulin , HASSON, Kenton C. , DALE, Gregory A. , KEADY, John
发明人： ZENG, Shulin , HASSON, Kenton C. , DALE, Gregory A. , KEADY, John
IPC分类号： C12M1/34 , C12M3/00
摘要： At least one exemplary embodiment is directed to an apparatus that includes a microfluidic channel and at least one energy absorbing element, where the energy absorbing element is configured to absorb at least a portion of an incident electromagnetic radiation. The absorption of the radiation by the energy absorbing element varies the temperature of a sample in the microfluidic channel.

4. 发明申请

WO2008005321A2 SYSTEMS AND METHODS FOR REAL-TIME PCR 审中-公开
标题翻译：用于实时PCR的系统和方法
公开(公告)号：WO2008005321A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/015104
申请日：2007-06-29
申请人： CANON U.S. LIFE SCIENCES, INC. , OWEN, Gregory H. , DALE, Gregory A. , HASSON, Kenton C. , ZENG, Shulin , WARFIELD, Dwayne W.
发明人： OWEN, Gregory H. , DALE, Gregory A. , HASSON, Kenton C. , ZENG, Shulin , WARFIELD, Dwayne W.
IPC分类号： C12Q1/68 , G06T7/20 , C12M3/00
CPC分类号： B01L7/525 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L2200/10 , B01L2200/143 , B01L2300/0627 , B01L2300/0654 , B01L2300/0829 , B01L2300/18 , B01L2300/1811 , B01L2300/1822 , B01L2300/1827 , B01L2300/1877 , B01L2400/0487 , C12Q1/686 , G01N21/71 , G01N35/08 , G06T7/0012 , G06T7/11 , G06T2207/10004 , G06T2207/30072 , Y10T436/115831 , Y10T436/117497 , C12Q2565/629 , C12Q2561/113
摘要： In one aspect, the present invention provides a systems and methods for the real-time amplification and analysis of a sample of DNA.
摘要翻译：一方面，本发明提供了用于实时扩增和分析DNA样品的系统和方法。

5. 发明申请

WO2010002797A1 SYSTEM AND METHOD FOR MICROFLUIDIC FLOW CONTROL 审中-公开
标题翻译：微流控流的系统与方法
公开(公告)号：WO2010002797A1
公开(公告)日：2010-01-07
申请号：PCT/US2009/049073
申请日：2009-06-29
申请人： CANON U.S. LIFE SCIENCES, INC. , ZENG, Shulin , DALE, Gregory, A.
发明人： ZENG, Shulin , DALE, Gregory, A.
IPC分类号： F15C1/04
CPC分类号： B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/10 , B01L2300/0861 , B01L2300/0867 , B01L2300/12 , B01L2300/14 , B01L2400/049 , B01L2400/0666 , F16K99/0001 , F16K2099/0084 , F16K2099/0086 , Y10T137/0396 , Y10T137/2191 , Y10T137/86083 , Y10T137/87249
摘要： A system and method for controlling fluid flow within a microchannel includes a fluid circuit comprising a fluid outlet well and one or more fluid inlet wells, all in communication with a microchannel. A negative pressure differential is applied to the outlet well and fluid flow from an inlet well into the microchannel is controlled by opening or closing the inlet well to atmospheric pressure. To stop fluid flow from the inlet well, a negative pressure differential may be applied to the inlet well to equalize pressure between the inlet and outlet wells. By sequentially opening and closing different inlet wells to atmosphere, controlled amounts of different reagents can be serially introduced into the microchannel.
摘要翻译：用于控制微通道内的流体流动的系统和方法包括流体回路，流体回路包括流体出口井和一个或多个流体入口井，全部与微通道连通。对出口井施加负压差，并且通过将入口井打开或关闭到大气压力来控制从入口井到微通道的流体流动。为了阻止流体从入口井流出，负压差可以施加到入口井以平衡入口和出口孔之间的压力。通过依次打开和关闭不同的入口孔到大气中，控制量的不同试剂可以连续地引入微通道。

6. 发明申请

WO2008005323A2 COMBINED THERMAL DEVICES FOR THERMAL CYCLING 审中-公开
标题翻译：用于热循环的组合热装置
公开(公告)号：WO2008005323A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/015109
申请日：2007-06-29
申请人： CANON U.S. LIFE SCIENCES, INC. , DALE, Gregory A. , ZENG, Shulin , HASSON, Kenton C.
发明人： DALE, Gregory A. , ZENG, Shulin , HASSON, Kenton C.
IPC分类号： C12Q1/68 , G06T7/20 , C12M3/00
CPC分类号： B01L7/525 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L2200/10 , B01L2200/143 , B01L2300/0627 , B01L2300/0654 , B01L2300/0829 , B01L2300/18 , B01L2300/1811 , B01L2300/1822 , B01L2300/1827 , B01L2300/1877 , B01L2400/0487 , C12Q1/686 , G01N21/71 , G01N35/08 , G06T7/0012 , G06T7/11 , G06T2207/10004 , G06T2207/30072 , Y10T436/115831 , Y10T436/117497 , C12Q2565/629 , C12Q2561/113
摘要： The invention relates to systems and methods including a combination of thermal generating device technologies to achieve more efficiency and accuracy in PCR temperature cycling of nucleic samples undergoing amplification.
摘要翻译：本发明涉及包括热生成装置技术的组合的系统和方法，以实现经历扩增的核酸样品的PCR温度循环中的更高效率和准确度。

7. 发明申请

WO2006121510A3 POINT-OF-CARE FLUIDIC SYSTEMS AND USES THEREOF 审中-公开
公开(公告)号：WO2006121510A3
公开(公告)日：2006-11-16
申请号：PCT/US2006/011090
申请日：2006-03-24
申请人： THERANOS, INC. , HOLMES, Elizabeth A. , ROY, Shaunak , HOWARD, John , WANG, Chengwang , GIBBONS, Ian , KEMP, Tim , TODD, Chris , ORAL, Ron , ZENG, Shulin , FENTON, Jeff , QI, Shize Daniel
发明人： HOLMES, Elizabeth A. , ROY, Shaunak , HOWARD, John , WANG, Chengwang , GIBBONS, Ian , KEMP, Tim , TODD, Chris , ORAL, Ron , ZENG, Shulin , FENTON, Jeff , QI, Shize Daniel
IPC分类号： C12Q1/68 , G01N15/06 , G01N33/00 , G01N33/48 , G01N35/00 , B23P17/04
摘要： This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

8. 发明申请

WO2010118427A1 FLUID INTERFACE CARTRIDGE FOR A MICROFLUIDIC CHIP 审中-公开
标题翻译：用于微流控芯片的流体接口盒
公开(公告)号：WO2010118427A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/030762
申请日：2010-04-12
申请人： CANON U.S. LIFE SCIENCES, INC. , TSAO, Ray , INOUE, Hiroshi , ZENG, Shulin , MURPHY, Brian , HASSON, Kenton, C.
发明人： TSAO, Ray , INOUE, Hiroshi , ZENG, Shulin , MURPHY, Brian , HASSON, Kenton, C.
IPC分类号： G01N1/10 , B01J19/00
CPC分类号： B01L3/502715 , B01L3/502723 , B01L9/527 , B01L2200/021 , B01L2200/027 , B01L2300/0816 , B01L2300/0867 , G01N35/1095 , G01N2035/1034
摘要： An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.
摘要翻译：用于微流控芯片的接口盒，具有微流程工艺通道和在工艺通道的相对端处的流体连接孔，提供辅助流体结构，包括流体流动通道和输入和/或废气井，其将反应流体混合和/或输送到流体连接孔并进入微流体芯片的过程通道。

9. 发明申请

WO2010033338A1 SYSTEMS AND METHODS FOR THE AMPLIFICATION OF DNA 审中-公开
标题翻译：用于扩增DNA的系统和方法
公开(公告)号：WO2010033338A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/054578
申请日：2009-08-21
申请人： CANON U.S. LIFE SCIENCES, INC. , ZENG, Shulin , HASSON, Kenton, C. , DALE, Gregory, A.
发明人： ZENG, Shulin , HASSON, Kenton, C. , DALE, Gregory, A.
IPC分类号： C12P19/34
CPC分类号： C12P19/34 , B01L3/502715 , B01L7/525 , B01L2200/147 , B01L2300/0816 , B01L2300/0883 , B01L2300/1822 , B01L2300/1827 , B01L2300/1838 , B01L2400/0487 , C12Q1/686 , C12Q2527/101
摘要： A system for amplifying nucleic acids is disclosed which, in one embodiment, includes a fluidic device having a sample channel and a heat exchange channel disposed sufficiently close to the sample channel such that a heat exchange fluid in the heat exchange channel can cause a sample in the sample channel to gain or lose heat at desired levels. In one illustrative embodiment, the system further includes three reservoirs coupled to the heat exchange channel and a temperature control system configured to heat fluids stored in the respective reservoirs at different temperatures. One or more pumps and a controller are configured to cause fluid stored in the reservoirs to enter and flow through the heat exchange channel at different times.
摘要翻译：公开了用于扩增核酸的系统，其在一个实施方案中包括具有样品通道和设置成足够接近样品通道的热交换通道的流体装置，使得热交换通道中的热交换流体可导致样品样品通道以所需的水平获得或失去热量。在一个示例性实施例中，系统还包括耦合到热交换通道的三个储存器和被配置为在不同温度下加热存储在各个储存器中的流体的温度控制系统。一个或多个泵和控制器构造成使存储在储存器中的流体在不同时间进入和流过热交换通道。

10. 发明申请

WO2010002811A1 SYSTEM AND METHOD TO PREVENT CROSS-CONTAMINATION IN ASSAYS PERFORMED IN A MICROFLUDIC CHANNEL 审中-公开
标题翻译：用于防止在微波通道中进行的测定中的交叉污染的系统和方法
公开(公告)号：WO2010002811A1
公开(公告)日：2010-01-07
申请号：PCT/US2009/049100
申请日：2009-06-29
申请人： CANON U.S. LIFE SCIENCES, INC. , ZENG, Shulin
发明人： ZENG, Shulin
IPC分类号： G01N33/00
CPC分类号： B01L3/50273 , B01L2200/141 , B01L2300/0816 , B01L2300/0877 , B01L2400/0487
摘要： The present application discloses systems and methods for preventing contamination in assays performed in microfluidic channels. In one embodiment, a buffer of non-reactive fluid is provided between an input port and a microchannel in which assays are performed during such times that flow from the input port is stopped. In general, an amount of non-reactive fluid is drawn into a channel connecting the stopped input port to the microchannel. Thus, any seepage, or diffusion, from the channel connecting the stopped input port to the microchannel will be of the non-reactive fluid, not the reagent, or other potentially-contaminating fluid, introduced through the input port. In one embodiment, microvalves and a negative pressure differential source control flow of reagents into the microchannel and the flow of non-reactive fluid into the inlet conduits.
摘要翻译：本申请公开了用于防止在微流体通道中进行的分析中的污染的系统和方法。在一个实施例中，在输入端口和微通道之间提供非反应性流体的缓冲液，其中在从输入端口的流动停止的时间期间进行测定。通常，一定量的非反应流体被吸入连接停止的输入端口到微通道的通道中。因此，从连接停止的输入端口到微通道的通道的任何渗流或扩散将是通过输入端口引入的非反应性流体，而不是试剂或其它潜在污染的流体。在一个实施例中，微阀和负压差压源控制试剂进入微通道的流动以及非反应流体流入入口导管。

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