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1. 发明申请

WO9856956A8 APPARATUS AND METHODS FOR CORRECTING FOR VARIABLE VELOCITY IN MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：用于校正微流体系统中可变速度的装置和方法
公开(公告)号：WO9856956A8
公开(公告)日：1999-09-16
申请号：PCT/US9811969
申请日：1998-06-08
申请人： CALIPER TECHN CORP , KOPF SILL ANNE R , CHOW ANDREA W , COHEN CLAUDIA B , SUNDBERG STEVEN A , PARCE JOHN WALLACE
发明人： KOPF-SILL ANNE R , CHOW ANDREA W , COHEN CLAUDIA B , SUNDBERG STEVEN A , PARCE JOHN WALLACE
IPC分类号： B01J19/00 , B01L3/00 , B01L9/00 , G01N27/447 , G01N33/557 , C12Q1/70
CPC分类号： G01N33/557 , B01J19/0093 , B01J2219/0095 , B01J2219/0097 , B01J2219/00995 , B01L3/5027 , B01L3/50273 , B01L3/502746 , B01L3/563 , B01L9/527 , B01L2200/14 , B01L2200/143 , B01L2300/0627 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , G01N27/447 , G01N27/44726 , G01N27/44791 , Y10S435/81 , Y10S436/805 , Y10S436/809
摘要： Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and products in a reaction in electrokinetic microfluidic devices are also provided. These microfluidic devices can have substrates with channels, depressions, and/or wells for moving, mixing and monitoring precise amounts of analyte fluids.
摘要翻译：提供了具有用于校正电动效果的计算机的电动装置。还提供了通过在电动微流体装置中确定反应物和产物在反应中的速度来校正电动效应的方法。这些微流体装置可以具有用于移动，混合和监测精确量的分析物流体的通道，凹陷和/或孔的基底。

2. 发明申请

WO0149414A2 ULTRA HIGH THROUGHPUT SAMPLING AND ANALYSIS SYSTEMS AND METHODS 审中-公开
标题翻译：超高压采样和分析系统及方法
公开(公告)号：WO0149414A2
公开(公告)日：2001-07-12
申请号：PCT/US0035658
申请日：2000-12-28
申请人： CALIPER TECHN CORP , WOLK JEFFREY A , BIONDI SHERRI ANN , PARCE JOHN WALLACE , JENSEN MORTEN J , KOPF SILL ANNE R
发明人： WOLK JEFFREY A , BIONDI SHERRI ANN , PARCE JOHN WALLACE , JENSEN MORTEN J , KOPF-SILL ANNE R
IPC分类号： B01J19/00 , B01L3/00 , B01L3/02 , C40B40/06 , C40B60/14 , G01N1/02 , G01N21/64 , G01N35/10
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01L3/02 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2200/143 , B01L2300/0819 , B01L2300/0861 , B01L2400/022 , B01L2400/0406 , C12Q2565/629 , C40B40/06 , C40B60/14 , G01N35/10 , G01N2001/028 , G01N2035/1034 , G01N2035/1037 , G01N2035/1039 , Y10T436/25 , Y10T436/2575
摘要： Systems and method of sampling compounds into a microfluidic channel, comprising: providing a plurality of different compounds reversibly immobilized on a first surface of substrate; providing a capillary element having a capillary channel disposed therethrough, the capillary element having at least one open end, and a volume of solubilizing fluid present at the open end of the capillary element; moving the solubilizing fluid at the open end of the capillary element into contact with a fist compound on the surface of the substrate; sensing when the solubilizing fluid contacts the surface of the substrate, the solubilizing fluid dissolving at least a portion of the first compound; and drawing at least a portion of the dissolved first compound into the capillary element.
摘要翻译：将化合物取样成微流体通道的系统和方法，包括：提供可逆地固定在基材的第一表面上的多种不同的化合物; 提供毛细管元件，其具有穿过其中的毛细通道，所述毛细管元件具有至少一个开口端，以及存在于毛细管元件的开口端的增溶液体积; 将毛细管元件的开口端处的增溶液移动到与基底表面上的第一化合物接触; 当增溶流体接触基底的表面时，感测溶解至少一部分第一化合物的溶解流体; 并将至少一部分溶解的第一化合物吸入毛细管元件中。

3. 发明申请

WO0046594A9 METHODS, DEVICES AND SYSTEMS FOR CHARACTERIZING PROTEINS 审中-公开
标题翻译：用于表征蛋白质的方法，装置和系统
公开(公告)号：WO0046594A9
公开(公告)日：2001-11-15
申请号：PCT/US0002680
申请日：2000-02-02
申请人： CALIPER TECHN CORP , DUBROW ROBERT S , BLOXSOM CHRISTOPHER , CHOW CALVIN Y H , PARCE JOHN WALLACE
发明人： DUBROW ROBERT S , BLOXSOM CHRISTOPHER , CHOW CALVIN Y H , PARCE JOHN WALLACE
IPC分类号： G01N27/447 , G01N37/00 , G01N27/26
CPC分类号： G01N27/44747 , G01N27/44791
摘要： A method of characterizing a polypeptide, comprising providing a first capillary channel (104) having a separation buffer disposed within, wherein the separation buffer comprises a non-crosslinked polymer solution, a buffering agent, a detergent, and a lipophilic dye. The separation buffer is provided such that, at the time of detection, the detergent concentration in the buffer is not above the critical micelle concentration. The polypeptide is introduced into one end of the capillary channel. An electric field is applied across the polymer solution at different rates. The polypeptide is then detected as it passes a point (176) along the length of the capillary channel.
摘要翻译：一种表征多肽的方法，包括提供其中设置有分离缓冲液的第一毛细通道（104），其中所述分离缓冲液包含非交联聚合物溶液，缓冲剂，洗涤剂和亲脂性染料。提供分离缓冲液，使得在检测时，缓冲液中的洗涤剂浓度不高于临界胶束浓度。将多肽引入毛细管通道的一端。以不同的速率在整个聚合物溶液上施加电场。然后当毛细通道沿着毛细通道的长度通过点（176）时，检测多肽。

4. 发明申请

WO2011028296A3 SEQUENCE DETERMINATION BY USE OF OPPOSING FORCES 审中-公开
标题翻译：通过使用反作用力确定序列
公开(公告)号：WO2011028296A3
公开(公告)日：2011-08-25
申请号：PCT/US2010002451
申请日：2010-09-07
申请人： CAERUS MOLECULAR DIAGNOSTICS INC , FARINAS JAVIER , CHOW ANDREA , PARCE JOHN WALLACE
发明人： FARINAS JAVIER , CHOW ANDREA , PARCE JOHN WALLACE
IPC分类号： C12Q1/68 , G01N27/00 , G01N33/48
CPC分类号： C12Q1/6872 , C12Q1/6874
摘要： The present teachings relate to systems, methods, and the like, for analyzing biological polymers, by use of opposing forces. Among other things, the present teachings can be used to determine sequence information, such as in genetic sequencing and genotyping applications. Various embodiments are described for efficient, high throughput sequencing of nucleic-acid molecules, such as DNA. Various embodiments are described wherein nucleic-acid sequence information is determined without the need or use of extrinsic labels. As well various embodiments of methods, systems, and the like, are described, which can provide long and accurate read lengths for low-cost nucleic acid sequencing.
摘要翻译：本教导涉及通过使用反作用力来分析生物聚合物的系统，方法等。除其他之外，本教导可以用于确定序列信息，例如在基因测序和基因分型应用中。描述了核酸分子如DNA的高效，高通量测序的各种实施方案。描述了其中核酸序列信息被确定而不需要或不使用外在标记的各种实施方案。描述了方法，系统等的各种实施例，其可以为低成本的核酸测序提供长且准确的读取长度。

5. 发明申请

WO2011053894A3 METHODS AND APPARATUS FOR BINDING ASSAYS 审中-公开
标题翻译：用于结合测定的方法和装置
公开(公告)号：WO2011053894A3
公开(公告)日：2011-09-29
申请号：PCT/US2010054904
申请日：2010-10-31
申请人： CAERUS MOLECULAR DIAGNOSTICS INC , FARINAS JAVIER , CHOW ANDREA , PARCE JOHN WALLACE
发明人： FARINAS JAVIER , CHOW ANDREA , PARCE JOHN WALLACE
IPC分类号： G01N33/53 , C12Q1/68 , G01N33/52 , G01N33/58
CPC分类号： C12Q1/6825 , C12Q1/6834 , G01N33/54346 , C12Q2565/107 , C12Q2523/303 , C12Q2565/607
摘要： The present teachings relate to methods, systems, and apparatus for low cost label-free assay detection. The present teachings, in a variety of embodiments, employ opposing forces to detect signals which depend on the number of charges on and/or the size of a particle. The particle, which can be subjected to opposing forces, can have specific capture probes at its surface. As analytes of interest are captured by the particle, the number of charges on the particle surface and/or the size of the particle is changed. A particle parameter or kinematic property such as the position, velocity, acceleration or force of/on the particle can be measured, and results obtained relating, for example, to the present, absence, quantity, and such, of one or more analytes of interest. Various embodiments are described for efficient, high throughput assays of samples potentially including one or more analytes of interest, such as bioanalytes. As well, various embodiments are described wherein binding assays can be carried out without the need or use of extrinsic labels. A number of embodiments provide, for example, methods, systems, and apparatus for detecting analytes (such as nucleic acids, proteins, cells and other entities, particulates, and the like) in one or more samples. Also described are: detection of a single copy of a target biomolecule, such as DNA, captured onto a trapped (e.g., tethered) bead; protocols for fabricating encoded bead arrays for multiplex assays; and methods, systems and apparatus for efficient and specific capture of pathogen biomolecular markers onto bead-bound capture probes, as well as detection and measurement of such capture events.
摘要翻译：本教导涉及用于低成本无标记测定检测的方法，系统和设备。在各种实施例中，本教导使用相反的力来检测取决于粒子上的电荷数量和/或粒子大小的信号。可受到相反作用力的颗粒可在其表面具有特定的捕获探针。当感兴趣的分析物被颗粒捕获时，颗粒表面上的电荷数量和/或颗粒的大小发生改变。可以测量粒子参数或运动学性质，例如粒子上的位置，速度，加速度或力，以及获得的结果例如与一种或多种分析物的存在，不存在，数量等有关利益。描述了潜在包括一种或多种感兴趣分析物（例如生物分析物）的样品的高效，高通量测定的各种实施方案。同样，描述了各种实施方案，其中可以进行结合测定而不需要或使用外在标记。多个实施例提供了例如用于检测一个或多个样本中的分析物（例如核酸，蛋白质，细胞和其他实体，微粒等）的方法，系统和设备。还描述了：检测捕获到捕获的（例如系留的）珠子上的目标生物分子例如DNA的单拷贝; 用于制造用于多重测定的编码微珠阵列的方案; 以及用于有效和特异性捕获病原体生物分子标记到珠子结合的捕获探针上的方法，系统和装置，以及这种捕获事件的检测和测量。

6. 发明申请

WO2011028296A9 SEQUENCE DETERMINATION BY USE OF OPPOSING FORCES 审中-公开
标题翻译：使用对手的序列确定
公开(公告)号：WO2011028296A9
公开(公告)日：2011-07-07
申请号：PCT/US2010002451
申请日：2010-09-07
申请人： CAERUS MOLECULAR DIAGNOSTICS INC , FARINAS JAVIER , CHOW ANDREA , PARCE JOHN WALLACE
发明人： FARINAS JAVIER , CHOW ANDREA , PARCE JOHN WALLACE
IPC分类号： C12Q1/68 , G01N27/00 , G01N33/48
CPC分类号： C12Q1/6872 , C12Q1/6874
摘要： The present teachings relate to systems, methods, and the like, for analyzing biological polymers, by use of opposing forces. Among other things, the present teachings can be used to determine sequence information, such as in genetic sequencing and genotyping applications. Various embodiments are described for efficient, high throughput sequencing of nucleic-acid molecules, such as DNA. Various embodiments are described wherein nucleic-acid sequence information is determined without the need or use of extrinsic labels. As well various embodiments of methods, systems, and the like, are described, which can provide long and accurate read lengths for low-cost nucleic acid sequencing.
摘要翻译：本教导涉及通过使用相反的力分析生物聚合物的系统，方法等。除其他之外，本教导可用于确定序列信息，例如在遗传测序和基因分型应用中。描述了用于核酸分子（例如DNA）的有效，高通量测序的各种实施方案。描述了其中确定核酸序列信息而不需要或使用外在标记的各种实施方案。还描述了方法，系统等的各种实施方案，其可以为低成本核酸测序提供长且准确的读取长度。

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