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1. 发明申请

WO2010130811A2 METHOD OF MANUFACTURING A REACTOR AND SET OF REACTORS 审中-公开
标题翻译：制造反应器和反应器组的方法
公开(公告)号：WO2010130811A2
公开(公告)日：2010-11-18
申请号：PCT/EP2010/056597
申请日：2010-05-12
申请人： LONZA AG , ROBERGE, Dominique , KOCKMANN, Norbert , GOTTSPONER, Michael , EYHOLZER, Markus
发明人： ROBERGE, Dominique , KOCKMANN, Norbert , GOTTSPONER, Michael , EYHOLZER, Markus
IPC分类号： B01J19/00
CPC分类号： B01J19/0093 , B01J2219/00015 , B01J2219/00783 , B01J2219/00804 , B01J2219/0086 , B01J2219/00889 , B01J2219/00995 , Y10T137/0402

2. 发明申请

WO2007048641A3 REACTOR SYSTEM COMPRISING A MICROSTRUCTURED REACTOR AND A CONTACTLESS HEATING APPARATUS, AND METHOD FOR CARRYING OUT A CHEMICAL REACTION 审中-公开
标题翻译：结合实现化学反应的微结构反应器和非接触式加热和方法反应器系统
公开(公告)号：WO2007048641A3
公开(公告)日：2007-06-21
申请号：PCT/EP2006010436
申请日：2006-10-25
申请人： MEYER HEINRICH , TSCHINDER THOMAS
发明人： MEYER HEINRICH , TSCHINDER THOMAS
IPC分类号： B01J19/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00788 , B01J2219/00822 , B01J2219/00824 , B01J2219/00826 , B01J2219/00831 , B01J2219/00835 , B01J2219/00858 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00925 , B01J2219/0093 , B01J2219/00941 , B01J2219/00995 , C01C3/0225
摘要： The aim of the invention is to be able to carry out especially endothermic high-temperature chemical syntheses, particularly HCN synthesis, in a microstructured reactor with the aid of the easiest possible measures such that the desired reaction products are obtained at the greatest possible yield and at a constant quality. Said aim is achieved by means of a microstructured reactor system in which the reaction zone is heated using a contactless heating apparatus, such as an induction heater or a radiant heating system. The reactor can be embodied as a plate reactor, a shell-and-tube reactor, or a rotationally symmetrical reactor.
摘要翻译：要使用尽可能措施主要吸热化学高温的合成，特别是HCN合成，结构简单的，所述希望的反应产物以尽可能高的收率并得到一致的质量，提出了一种微结构化的反应器系统中的微结构反应器从而执行其中所述反应区是由一个非接触式加热，来诸如感应加热器或辐射加热器加热。所述反应器可以是板反应器，管式反应器或旋转对称的反应器中。

3. 发明申请

WO2003049835A1 IMPROVED CONDITIONS FOR FLUID SEPARATIONS IN MICROCHANNELS, CAPILLARY-DRIVEN FLUID SEPARATIONS, AND LAMINATED DEVICES CAPABLE OF SEPARATING FLUIDS 审中-公开
标题翻译：用于微通道，毛细管驱动的流体分离中的流体分离和能够分离流体的层压装置的改进条件
公开(公告)号：WO2003049835A1
公开(公告)日：2003-06-19
申请号：PCT/US2002/038577
申请日：2002-12-04
申请人： BATTELLE MEMORIAL INSTITUTE , TEGROTENHUIS, Ward, E. , STENKAMP, Victoria, S.
发明人： TEGROTENHUIS, Ward, E. , STENKAMP, Victoria, S.
IPC分类号： B01D19/00
CPC分类号： B01D5/0003 , B01B1/005 , B01D3/00 , B01D19/0031 , B01D53/002 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00835 , B01J2219/00873 , B01J2219/00891 , B01J2219/00905 , B01J2219/00995 , B01L3/5027 , B01L3/50273 , C01B3/384 , C01B2203/0233 , C01B2203/066 , C01B2203/0805 , C01B2203/0833 , F28D9/005 , F28F2260/02
摘要： Methods of separating fluids using capillary forces and/or improved conditions for are disclosed. The improved methods may include control of the ratio of gas and liquid Reynolds numbers relative to the Suratman number. Also disclosed are wick-containing, laminated devices that are capable of separating fluids.
摘要翻译：公开了使用毛细管力分离流体的方法和/或改进的条件。改进的方法可以包括控制相对于Suratman数的气体和液体雷诺数的比率。还公开了能够分离流体的含芯的层压装置。

4. 发明申请

WO98046438A1 CONTROLLED FLUID TRANSPORT IN MICROFABRICATED POLYMERIC SUBSTRATES 审中-公开
标题翻译：微流化聚合物基质中的控制流体输送
公开(公告)号：WO98046438A1
公开(公告)日：1998-10-22
申请号：PCT/US1998/007568
申请日：1998-04-14
IPC分类号： B01J19/00 , B01L3/00 , G01N27/447 , B44C1/22
CPC分类号： B01L3/502707 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00995 , B01L3/50273 , B01L2200/0689 , B01L2200/12 , B01L2200/147 , B01L2300/0816 , B01L2300/0887 , B01L2300/12 , B01L2400/0418 , G01N27/44791 , Y10S366/03 , Y10T29/49229 , Y10T137/2224
摘要： Microfluidic devices (202) are provided for the performance of chemical and biochemical analyses, syntheses and detection (230). The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have broad applications in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields.
摘要翻译：提供微流体装置（202）用于化学和生化分析，合成和检测（230）的性能。本发明的装置将精确的流体控制系统与微制造的聚合物基底结合在一起，以提供精确，低成本的小型化分析装置，其在化学，生物化学，生物技术，分子生物学和许多其它领域中具有广泛的应用。

5. 发明申请

WO1998007019A1 CAPILLARY MICROVALVE 审中-公开
标题翻译：毛细管
公开(公告)号：WO1998007019A1
公开(公告)日：1998-02-19
申请号：PCT/US1997011555
申请日：1997-08-12
申请人： GAMERA BIOSCIENCE CORPORATION , KELLOGG, Gregory , KIEFFER-HIGGINS, Stephen, G. , MIAN, Alec
发明人： GAMERA BIOSCIENCE CORPORATION
IPC分类号： G01N21/07
CPC分类号： B01L3/5027 , B01F5/0403 , B01F13/0059 , B01F15/0233 , B01F15/026 , B01F2215/0037 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00891 , B01J2219/0097 , B01J2219/00995 , B01L3/0268 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2200/0668 , B01L2300/0645 , B01L2300/0654 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2400/0406 , B01L2400/0409 , B01L2400/0421 , B01L2400/0655 , B01L2400/0688 , B29C59/14 , F15C1/005 , F15C5/00 , G01N21/07 , G01N27/44704 , G01N30/20 , G01N30/6095 , G01N35/00069 , G01N35/00732 , G01N35/00871 , G01N2030/326 , G01N2035/00782 , Y10T436/111666
摘要： The invention provides microvalves for controlling fluid flow from microreservoirs into transfer channels using capillary valving mechanisms. This invention provides microvalving means for use in apparatus useful for performing microanalytic and microsynthetic analyses and procedures, such as microminiaturization of genetic, biochemical and chemical processes related to analysis, synthesis and purification of biological, chemical, environmental and other compounds.
摘要翻译：本发明提供了用于控制使用毛细管阀机构从微储层流入转移通道的流体的微型阀。本发明提供了用于进行微量分析和微合成分析和程序的装置中的微型装置，例如与生物，化学，环境和其它化合物的分析，合成和纯化有关的遗传，生化和化学过程的微小化。

6. 发明申请

WO1997047390A1 ABSORPTION-ENHANCED DIFFERENTIAL EXTRACTION DEVICE 审中-公开
标题翻译：吸收增强的差异提取装置
公开(公告)号：WO1997047390A1
公开(公告)日：1997-12-18
申请号：PCT/US1997010307
申请日：1997-06-13
申请人： UNIVERSITY OF WASHINGTON
发明人： UNIVERSITY OF WASHINGTON , YAGER, Paul , BRODY, James, P.
IPC分类号： B03B05/28
CPC分类号： G01N30/0005 , A61M1/3679 , B01J19/0093 , B01J2219/00828 , B01J2219/00952 , B01J2219/00995 , B03B5/00 , G01N30/02 , G01N30/6095 , G01N2030/582 , Y10S366/01 , B01D15/3804
摘要： This invention provides an extraction device and method for extracting desired particles from a sample stream (2) containing the desired particles. The device comprises a sample stream inlet (1); an extraction stream inlet (5); an extraction channel (7) in fluid communication with the sample stream inlet (1) and the extraction stream inlet (5) for receiving a sample stream (2) from the sample stream inlet (1) in adjacent laminar flow with an extraction stream (4) from the extraction stream inlet (5); a sequestering material within the extraction channel (7) for capturing desired particles (18) in the extraction stream (9); a by-product stream outlet (15) in fluid communication with the extraction channel (7) for receiving a by-product stream (12) comprising at least a portion of the sample stream (2) from which desired particles (18) have been extracted; and a product outlet (14) in fluid communication with the extraction channel (7) for receiving a product comprising the sequestering material and at least a portion of the desired particles (18).
摘要翻译：本发明提供了一种从含有所需颗粒的样品流（2）中提取所需颗粒的提取装置和方法。该装置包括样品流入口（1）; 提取流入口（5）; 与样品流入口（1）和提取流入口（5）流体连通的提取通道（7），用于从相邻层流中的样品流入口（1）接收样品流（2），其中提取流入口 4）从提取流入口（5）中取出; 提取通道（7）内的螯合材料，用于捕获提取流（9）中的所需颗粒（18）; 与所述提取通道（7）流体连通的副产物流出口（15），用于接收副产物流（12），所述副产物流包含至少一部分样品流（2），所述样品流从所述至少一部分从所述样品流提取; 以及与所述提取通道（7）流体连通的产品出口（14），用于接收包含隔离材料和至少一部分所需颗粒（18）的产品。

7. 发明申请

WO1997021090A1 DEVICES AND METHODS FOR USING CENTRIPETAL ACCELERATION TO DRIVE FLUID MOVEMENT IN A MICROFLUIDICS SYSTEM WITH ON-BOARD INFORMATICS 审中-公开
标题翻译：在具有板上信息的微流控系统中使用中心加速驱动流体运动的装置和方法
公开(公告)号：WO1997021090A1
公开(公告)日：1997-06-12
申请号：PCT/US1996019514
申请日：1996-12-05
申请人： GAMERA BIOSCIENCE
发明人： GAMERA BIOSCIENCE , MIAN, Alec , KIEFFER-HIGGINS, Stephen, G. , COREY, George, D.
IPC分类号： G01N21/07
CPC分类号： G01N35/00732 , B01F5/0403 , B01F13/0059 , B01F15/0233 , B01F15/026 , B01F2215/0037 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00826 , B01J2219/00828 , B01J2219/00833 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00952 , B01J2219/00963 , B01J2219/00986 , B01J2219/00995 , B01L3/0268 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/10 , B01L2200/147 , B01L2300/024 , B01L2300/0645 , B01L2300/0654 , B01L2300/0806 , B01L2300/0867 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2400/0406 , B01L2400/0409 , B01L2400/0421 , B01L2400/0481 , B01L2400/0655 , B01L2400/0661 , B01L2400/0688 , B29C59/14 , F15C1/005 , F16K99/0001 , F16K99/0015 , F16K99/0017 , F16K99/0028 , F16K99/0048 , F16K99/0057 , F16K2099/0076 , F16K2099/008 , F16K2099/0084 , G01N21/07 , G01N30/20 , G01N30/6095 , G01N33/491 , G01N35/00069 , G01N35/00871 , G01N2030/326 , G01N2035/00782
摘要： This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. The microsystem platforms of the invention are also provided having system informatics and data acquisition, analysis and storage and retrieval informatics encoded on the surface of the disk opposite to the surface containing the fluidic components. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.
摘要翻译：本发明涉及用于进行微量分析和微合成分析和方法的方法和装置。本发明提供一种用于操纵平台的微系统平台和显微操纵装置，所述平台利用由平台旋转产生的向心力，以激励通过微通道的流体运动。还提供了本发明的微系统平台，其具有编码在与包含流体组分的表面相对的盘的表面上的系统信息学和数据采集，分析和存储和检索信息。提供了用于执行各种微分析或微合成方法中的任何一种的本发明装置的特异性方法。

8. 发明申请

WO1996035810A1 APPARATUS AND METHOD FOR THE GENERATION, SEPARATION, DETECTION, AND RECOGNITION OF BIOPOLYMER FRAGMENTS 审中-公开
标题翻译：生物聚合物碎片的生成，分离，检测和识别的装置和方法
公开(公告)号：WO1996035810A1
公开(公告)日：1996-11-14
申请号：PCT/US1996006579
申请日：1996-05-09
申请人： CURAGEN CORPORATION
发明人： CURAGEN CORPORATION , SIMPSON, John, W. , ROTHBERG, Jonathan, M. , WENT, Gregory, T.
IPC分类号： C12Q01/68
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00873 , B01J2219/00995 , G01N27/44708 , G01N27/44721 , G01N27/44782 , G01N27/44791 , Y10S436/80 , Y10T436/143333
摘要： This invention is an integrated instrument for the high capacity electrophoretic analysis of biopolymer samples. It comprises a specialized high-voltage, electrophoretic module in which migration lanes are formed between a bottom plate (446) and a plurality of etched grooves in a top plate (438), the module permitting concurrent separation of 80 or more separate samples. In thermal contact with the bottom plate (446) is a thermal control module incorporating a plurality of Peltier heat transfer devices for the control of temperature and gradients in the electrophoretic medium. Fragments are detected by a transmission imaging spectrograph which simultaneously spatially focuses and spectrally resolves the detection region of all the migration lanes. The spectrograph comprises a transmission dispersion element and a CCD array to detect signals. Signal analysis comprises the steps of noise filtering, comparison in a configuration space with signal prototypes, and selection of the best prototype. Optionally post-processing is done by a Monte-Carlo simulated annealing algorithm to improve results. Optionally, an array of micro-reactors can be integrated into the instrument for the generation of sequencing reaction fragments directly from crude DNA samples.
摘要翻译：本发明是用于生物聚合物样品的高容量电泳分析的集成仪器。它包括专门的高压电泳模块，其中在底板（446）和顶板（438）中的多个蚀刻凹槽之间形成迁移通道，该模块允许同时分离80个或更多个单独的样品。与底板（446）热接触是一个热控制模块，其包含多个用于控制电泳介质中的温度和梯度的珀尔帖传热装置。通过透射成像光谱仪检测片段，其同时空间聚焦并光谱地解析所有迁移通道的检测区域。该光谱仪包括用于检测信号的透射色散元件和CCD阵列。信号分析包括噪声滤波，配置空间与信号原型的比较以及最佳原型的选择的步骤。可选地，后处理通过蒙特卡罗模拟退火算法完成以改善结果。任选地，可以将微反应器阵列整合到仪器中，以直接从粗DNA样品产生测序反应片段。

9. 发明申请

WO1996012540A1 METHOD AND APPARATUS FOR DIFFUSIVE TRANSFER BETWEEN IMMISCIBLE FLUIDS 审中-公开
标题翻译：用于不可渗透流体之间的扩散转运的方法和装置
公开(公告)号：WO1996012540A1
公开(公告)日：1996-05-02
申请号：PCT/GB1995002488
申请日：1995-10-20
申请人： CENTRAL RESEARCH LABORATORIES LIMITED , SHAW, John, Edward, Andrew , SIMPSON, Richard, Iain , BULL, Adrian, James , SIMPER, Adrian, Mark , HOLMES, Robert, George, Godfrey
发明人： CENTRAL RESEARCH LABORATORIES LIMITED
IPC分类号： B01D11/04
CPC分类号： G01N1/4005 , B01D11/0403 , B01D11/0407 , B01D11/0415 , B01D11/0419 , B01D11/0426 , B01D11/043 , B01D11/0453 , B01D11/0496 , B01D61/246 , B01D61/28 , B01F13/0059 , B01F13/0093 , B01F2005/0031 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00833 , B01J2219/00844 , B01J2219/00853 , B01J2219/00907 , B01J2219/00995 , G01N1/34 , G01N25/14 , G01N27/44743 , G01N30/6069 , G01N30/6095 , G01N2001/4016
摘要： In order to facilitate diffusive transfer of an entity such as a solute between immiscible fluids and subsequent separation of the liquids without mixing, method and apparatus are disclosed having first and second flow paths (1, 2) carrying first and second immiscible fluids on opposite sides of a foraminous sheet (8) wherein the height of the apertures (10) therein are not greater than 200 micrometres (measured perpendicular to the width of the sheet and to the direction of fluid flow), and a stable interface is formed between the fluids within each aperture, with a significant amount of fluid flow immediately adjacent the interface. Diffusive transfer takes place across the interface, and subsequently the fluids flow away from the region without mixing. The width of the flow paths measured perpendicular to sheet (8) lies between 10 and 500 micrometres. The walls of each aperture may be parallel or tapered.
摘要翻译：为了便于诸如不混溶流体之间的溶质和随后分离液体而不混合的实体的扩散转移，公开了具有在相对侧上承载第一和第二不混溶流体的第一和第二流动路径（1,2）的方法和装置的多孔板（8），其中孔（10）的高度不大于200微米（垂直于片材的宽度和流体流动的方向测量），并且在流体之间形成稳定的界面在每个孔内，具有紧邻接口的大量流体流。通过界面进行扩散转移，随后流体从该区域流出而不混合。垂直于片材（8）测量的流动路径的宽度在10到500微米之间。每个孔的壁可以是平行的或锥形的。

10. 发明申请

WO2013141695A8 APPARATUS AND METHOD FOR MASS PRODUCING A MONODISPERSE MICROBUBBLE AGENT 审中-公开
标题翻译：用于大量生产单体微生物剂的装置和方法
公开(公告)号：WO2013141695A8
公开(公告)日：2014-10-16
申请号：PCT/NL2012050179
申请日：2012-03-22
申请人： UNIV TWENTE , UNIV SEVILLA , VAN HOEVE WILLEM , DE CASTRO HERNÁNDEZ ELENA , GORDILLO ARIAS DE SAVEEDRA JOSÉ MANUEL , VERSLUIS ANDREAS MICHAEL , LOHSE DETLOF
发明人： VAN HOEVE WILLEM , DE CASTRO HERNÁNDEZ ELENA , GORDILLO ARIAS DE SAVEEDRA JOSÉ MANUEL , VERSLUIS ANDREAS MICHAEL , LOHSE DETLOF
IPC分类号： B01J19/00 , B01F13/00
CPC分类号： B01F5/0602 , A61K49/223 , B01F3/0446 , B01F3/04985 , B01F13/0062 , B01F13/0064 , B01F13/0084 , B01F13/0086 , B01F2003/04858 , B01F2005/0097 , B01F2215/0034 , B01J19/0093 , B01J2219/0084 , B01J2219/0086 , B01J2219/00894 , B01J2219/00959 , B01J2219/00995
摘要： An apparatus (1) for mass producing monodisperse microbubbles, comprising a microfluidic flow focusing device (2) including a dispersed phase fluid supply channel (110) having an outlet (114) that discharges into a flow focusing junction (140); a continuous phase fluid supply channel (120, 120') having an outlet (124) that discharges into the flow focusing junction; and a bubble formation channel (130) having an inlet (132) disposed at the flow focusing junction. The configuration of the flow focusing junction (140) is such that, in operation, a flow of dispersed phase fluid (12) discharging from the outlet (114) of the dispersed phase fluid supply channel (110) is engageable in co-flow by a focusing flow of continuous phase fluid discharging from the outlet of the at least one continuous phase fluid supply channel under formation of a gradually thinning jet of dispersed phase fluid that extends into the inlet of the bubble formation channel.
摘要翻译：一种用于批量生产单分散微泡的装置（1），包括微流体聚焦装置（2），该微流体聚焦装置包括分散相流体供应通道（110），该分散相流体供应通道具有排出流入聚焦结（140）的出口（114）。连续相流体供应通道（120,120'）具有排出到流动聚焦结的出口（124）; 和具有设置在流动聚焦结处的入口（132）的气泡形成通道（130）。流动聚焦结（140）的构造使得在操作中，从分散相流体供应通道（110）的出口（114）排出的分散相流体（12）的流动可通过在至少一个连续相流体供应通道的出口处的连续相流体的聚焦流动形成逐渐变薄的分散相流体的喷射，其延伸到气泡形成通道的入口。

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