专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1996026223A1 SYNTHESIS OF HYDROXAMIC ACID DERIVATIVES 审中-公开
标题翻译：羟基酸衍生物的合成
公开(公告)号：WO1996026223A1
公开(公告)日：1996-08-29
申请号：PCT/GB1996000428
申请日：1996-02-26
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , FLOYD, Christopher, David , LEWIS, Christopher, Norman
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C08F08/30
CPC分类号： C07K1/04 , C07K1/003 , C08F8/30 , Y02P20/55
摘要： A solid phase reaction component comprising a solid substrate, substantially insoluble in aqueous or organic reaction media, carrying a plurality of covalently bound hydroxylamine or protected hydroxylamine groups of formula (A) or (B), wherein P1 is hydrogen or an amino protecting group and P2 is hydrogen or a hydroxyl protecting group, and the bond designated (a) is one which covalently links the group (A) or (B) to the residue of the solid substrate and is cleavable under acid conditions or by photolysis. Such components are useful in the solid phase synthesis of, for example, compounds which are matrix metalloproteinase inhibitors.
摘要翻译：固相反应组分，其包含基本上不溶于水或有机反应介质的固体底物，其携带多个共价键合的式（A）或（B）的羟胺或被保护的羟胺基，其中P1是氢或氨基保护基， P2是氢或羟基保护基，并且指定为（a）的键是将基团（A）或（B）共价连接到固体底物的残基上的键，并且在酸性条件下或通过光解可分解。这些组分可用于例如作为基质金属蛋白酶抑制剂的化合物的固相合成。

2. 发明申请

WO1997018183A1 PREPARATION OF ALLYL SUCCINATE DERIVATIVES AND STARTING MATERIALS THEREFOR 审中-公开
标题翻译：制备ALLYL SUCCINATE衍生物及其起始材料
公开(公告)号：WO1997018183A1
公开(公告)日：1997-05-22
申请号：PCT/GB1996002531
申请日：1996-10-16
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , MARTIN, Fionna, Mitchell , LEWIS, Christopher, Norman , BOWLES, Stephen, Arthur , TODD, Richard, Simon
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07C67/343
CPC分类号： C07C67/343 , Y02P20/55 , C07C69/593
摘要： A process for the preparation of a compound of formula (I) wherein R2 is a (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, phenyl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, cycloalkyl(C1-C6)alkyl or cycloalkenyl(C1-C6)alkyl group, any one of which may be optionally substituted by one or more substituents selected from (C1-C6)alkyl, -O(C1-C6)alkyl, -S(C1-C6)alkyl, halo and cyano (-CN); and R7 is a carboxylic acid protecting group, which process comprises the internal molecular rearrangement of an allyl carboxylate compound of formula (II) wherein R2 and R7 are as defined in relation to formula (I) to form the desired compound of formula (I). Compounds (I) are intermediates for the preparation of Matrix metaloproteinase inhibitors.
摘要翻译：制备式（I）化合物的方法，其中R2是（C1-C6）烷基，（C2-C6）烯基，（C2-C6）炔基，苯基（C1-C6）烷基，杂芳基（C1- C 1 -C 6）烷基或环烯基（C 1 -C 6）烷基，其中任何一个可以任选地被一个或多个选自（C 1 -C 6）烷基，-O（C 1 -C 6）烷基，烷基，-S（C 1 -C 6）烷基，卤素和氰基（-CN）; 并且R 7是羧酸保护基，该方法包括式（II）的烯丙基羧酸酯化合物的内部分子重排，其中R 2和R 7如关于式（I）所定义，以形成所需的式（I）化合物，。化合物（I）是制备基质金属蛋白酶抑制剂的中间体。

3. 发明申请

WO1997019053A1 METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：金属蛋白酶抑制剂
公开(公告)号：WO1997019053A1
公开(公告)日：1997-05-29
申请号：PCT/GB1996002877
申请日：1996-11-21
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , MARTIN, Fionna, Mitchell , LEWIS, Christopher, Norman , WHITTAKER, Mark
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07C237/22
CPC分类号： C07D213/75 , C07C237/22 , C07C259/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D211/34 , C07D277/46 , C07D333/24
摘要： Compounds of general formula (I) wherein X ia a -CO2H, -NH(OH)CHO or -CONHOH group; R1 is a cylcoalkyl, cycloalkenyl or non-aromatic heterocyclic ring containing up to 3 heteroatoms, any of which may be (i) substituted by one ore more substituents selected from C1-C6 alkyl, C2-C6 alkenyl, halo, cyano (-CN), -CO2H, -CO2R, -CONH2, -CONHR, -CON(R)2, -OH, -OR, oxo-, -SH, -SR, -NHCOR, and -NHCO2R wherein R is C1-C6 alkyl or benzyl and/or (ii) fused to a cycloalky or heterocyclic ring; and R2, R3. R4 and R5 are as defined in the specification are matrix metalloproteinase inhibitors.
摘要翻译：通式（I）的化合物，其中X a a -CO 2 H，-NH（OH）CHO或-CONHOH基团; R 1是含有至多3个杂原子的环烷基，环烯基或非芳族杂环，其中任何一个可以（i）被一个或多个选自C 1 -C 6烷基，C 2 -C 6烯基，卤素，氰基（-CN）），-CO 2 H，-CO 2 R，-CONH 2，-CONHR，-CON（R）2，-OH，-OR，氧代 - ，-SH，-SR，-NHCOR和-NHCO 2 R，其中R是C 1 -C 6烷基或苄基和/或（ii）与环烷或杂环稠合; 和R2，R3。 R4和R5如本说明书中所定义的是基质金属蛋白酶抑制剂。

4. 发明申请

WO1996026918A1 SYNTHESIS OF CARBOXYLIC AND HYDROXAMIC ACID DERIVATIVES 审中-公开
标题翻译：羧酸和羟基酸衍生物的合成
公开(公告)号：WO1996026918A1
公开(公告)日：1996-09-06
申请号：PCT/GB1996000467
申请日：1996-03-01
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , FLOYD, Christopher, David , WHITTAKER, Mark
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07C259/06
CPC分类号： C07C259/06 , C07C231/00 , Y02P20/55
摘要： A method for the preparation of carboxylic and hydroxamic acid derivatives by cocondensation in a liquid organic medium of three reaction components, namely a carboxylic acid reaction component of formula (II), an imine reaction component of formula (III), and an isonitrile reaction component of formula (IV), wherein X is hydrogen or an amino protecting group, or the residue of a solid phase reaction substrate; Y is (i) a group -CO2R5 wherein R5 is a carboxyl protecting group or the residue of a solid phase reaction substrate or (ii) a group -CONR6OR7 wherein R6 is an amino protecting group or the residue of a solid phase reaction substrate and R7 is a hydroxyl protecting group or the residue of a solid phase reaction substrate; [S1], [S2], [S3] and [S4] each represent covalently bound moieties which are substantially non reactive with the reaction components (II), (III), or (IV) defined above; provided that only one of X, R5, R6 and R7 is the residue of a solid phase reaction substrate.
摘要翻译：在三种反应组分的液体有机介质中，即式（II）的羧酸反应组分，式（III）的亚胺反应组分和异氰酸酯反应组分的缩合反应制备羧酸和异羟肟酸衍生物的方法式（Ⅳ）的化合物，其中X为氢或氨基保护基，或固相反应底物的残基; Y是（i）-CO 2 R 5基团，其中R 5是羧基保护基或固相反应底物的残基或（ii）基团-CONR 6OR 7，其中R 6是氨基保护基或固相反应底物的残基， R7是羟基保护基或固相反应底物的残基; [S1]，[S2]，[S3]和[S4]各自表示与上述定义的反应组分（II），（III）或（IV）基本上不反应的共价结合部分; 条件是X，R5，R6和R7中只有一个是固相反应底物的残基。

5. 发明申请

WO1998023588A1 METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：金属蛋白酶抑制剂
公开(公告)号：WO1998023588A1
公开(公告)日：1998-06-04
申请号：PCT/GB1997003258
申请日：1997-11-27
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , FLOYD, Christopher, David
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07D209/48
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/0606
摘要： Compounds of formula (I) wherein R2 is a group -(Alk)m-(Q)n-(Alk )p-Ar wherein m, n and p are independently 0 or 1, Alk and Alk each independently represents a divalent (C1-C3)alkylene group, Q represents -O-, -S-, -SO-, or -SO2-, and Ar represents an optionally substituted phenyl or heteroaryl group; R1 is hydrogen or acyl; R21 is a group -(CH2)t-W wherein t represents 1, 2, 3 or 4 and W represents a 5- or 6-membered N-heterocyclic ring as defined in the specification; Z is either (a) a saturated 5- to 8-membered monocyclic or bridged N-heterocyclic ring as defined in the specification, or (b) a radical of formula (IB) wherein R3 is the side chain of a natural or non-natural alpha -amino acid in which any functional groups may be protected; R4 is one of a variety of groups defined in the specification; and R5 is hydrogen or a (C1-C6)alkyl group. The compounds are matrix metalloproteinase inhibitors.
摘要翻译：其中R2是基团 - （Alk）m-（Q）n-（Alk 1）p-Ar的式（I）化合物其中m，n和p各自独立地为0或1，Alk和Alk 1各自独立地为独立地表示二价（C1-C3）亚烷基，Q表示-O - ， - S-，-SO-或-SO2-，Ar表示任选取代的苯基或杂芳基; R1是氢或酰基; R 21是基团 - （CH 2）t-W，其中t表示1,2,3或4，W表示说明书中定义的5-或6-元N-杂环; Z是（a）如说明书中定义的饱和的5-至8-元单环或桥连的N-杂环，或（b）式（IB）的基团，其中R 3是天然或非 - 任何官能团可被保护的天然α-氨基酸; R4是规范中定义的各种组之一; 并且R 5是氢或（C 1 -C 6）烷基。这些化合物是基质金属蛋白酶抑制剂。

6. 发明申请

WO1997003783A1 METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：金属蛋白酶抑制剂
公开(公告)号：WO1997003783A1
公开(公告)日：1997-02-06
申请号：PCT/GB1996001737
申请日：1996-07-22
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , FLOYD, Christopher, David , BECKETT, Raymond, Paul , WHITTAKER, Mark , MILLER, Andrew
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： B23K01/00
CPC分类号： C07K5/0606 , A61K38/00 , C07K5/0207 , C07K5/021 , C07K5/06043 , C07K5/06191
摘要： A compound of general formula (I), wherein X is a group of formula (II) or (III), R2, R1, R21, R3, R4, and R5 being as defined in the specification are matrix metalloproteinase inhibitors.
摘要翻译：通式（I）的化合物，其中X是式（II）或（III）的基团，R2，R1，R21，R3，R4和R5如说明书中所定义的是基质金属蛋白酶抑制剂。

7. 发明申请

WO1996033997A1 BENZIMIDAZOLE DERIVATIVES BEING DUAL HISTAMINE (H1) AND PLATELET ACTIVATING FACTOR (PAF) ANTAGONISTS 审中-公开
标题翻译：苯并咪唑衍生物是双组胺（H1）和平板激活因子（PAF）拮抗剂
公开(公告)号：WO1996033997A1
公开(公告)日：1996-10-31
申请号：PCT/GB1996000680
申请日：1996-03-22
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , MARTIN, Fionna, Mitchell , FLOYD, Christopher, David , SPAVOLD, Zoe, Marie , AYSCOUGH, Andrew, Paul , WHITTAKER, Mark
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of formula (I), wherein the variable substituents and groups are as defined in the specification, are dual histamine (H1) and platelet activating factor (PAF) antagonists.
摘要翻译：其中可变取代基和基团如说明书中所定义的式（I）化合物是双组胺（H1）和血小板活化因子（PAF）拮抗剂。

8. 发明申请

WO1998017655A1 METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：金属蛋白酶抑制剂
公开(公告)号：WO1998017655A1
公开(公告)日：1998-04-30
申请号：PCT/GB1997002891
申请日：1997-10-20
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , BECKETT, Raymond, Paul , MARTIN, Fionna, Mitchell , MILLER, Andrew , TODD, Richard, Simon , WHITTAKER, Mark
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07D295/18
CPC分类号： C07D295/185 , C07D295/26 , Y02P20/55
摘要： Compounds of formula (I), wherein n, V, R1, R2, R3 and R4 are as defined in the specification are matrix metalloproteinase inhibitors.
摘要翻译：式（I）化合物，其中n，V，R 1，R 2，R 3和R 4如本说明书中所定义的是基质金属蛋白酶抑制剂。

9. 发明申请

WO1998013495A1 HUMAN RANTES MUTANTS INCAPABLE OF AGGREGATE FORMATION 审中-公开
标题翻译：人类吞噬突变体不能形成聚集体
公开(公告)号：WO1998013495A1
公开(公告)日：1998-04-02
申请号：PCT/GB1997002605
申请日：1997-09-24
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , CZAPLEWSKI, Lloyd, George , HUNTER, Michael, George , EDWARDS, Richard, Mark , DAWSON, Keith, Martyn
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C12N15/19
CPC分类号： C07K14/523 , A61K38/00
摘要： This invention relates to mutants of human RANTES (hRANTES) which, relative to the wild-type molecule, have a reduced tendency to aggregate into large multimeric complexes at physiological ionic strength and pH, and are less pro-inflammatory.
摘要翻译：本发明涉及人RANTES（hRANTES）的突变体，其相对于野生型分子在生理离子强度和pH下具有降低的聚集成大多聚体复合物的趋势，并且较少促炎症。

10. 发明申请

WO1997006167A1 IMIDAZOPYRIDINE DERIVATIVES 审中-公开
标题翻译：咪唑吡啶衍生物
公开(公告)号：WO1997006167A1
公开(公告)日：1997-02-20
申请号：PCT/GB1996001849
申请日：1996-07-30
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , AYSCOUGH, Andrew, Paul , BLACKWELL, Christopher, Mark , LAUNCHBURY, Steven , WHITTAKER, Mark
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D213/36
摘要： Compounds of formula (II), wherein L, A, X, B, R , R , W, D, E, R , R , R are as defined in the specification, are dual histamine H1 and PAF receptor antagonists.
摘要翻译：式（II）化合物，其中L，A，X，B，R 2，R 3，W，D，E，R 3，R 4，R 5如规格是双组胺H1和PAF受体拮抗剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式