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1. 发明申请

WO2017095428A1 MODULATORS OF ACTIVIN AND METHODS FOR MODULATING IMMUNE RESPONSES AND T FOLLICULAR HELPER CELLS 审中-公开
标题翻译：活化素调节因子及调节免疫应答和T辅助细胞的方法
公开(公告)号：WO2017095428A1
公开(公告)日：2017-06-08
申请号：PCT/US2015/063827
申请日：2015-12-03
申请人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , NOVARTIS AG , MILLER, Andrew, Todd
发明人： MILLER, Andrew, Todd , CROTTY, Shane , LOCCI, Michela
IPC分类号： A61K38/18 , A61K39/00 , A61P37/04 , A61P37/06 , C07K16/26
CPC分类号： C07K16/28 , A61P37/06 , C07K16/22 , C07K2317/70 , C07K2317/76
摘要： The invention provides methods and uses for stimulating, inducing, increasing or enhancing Tfh (follicular helper) cell differentiation, germinal center B cell development or an antibody response, and an immune response by administering activin or a subsequence thereof, or an activator of activin receptor, in an amount effective to stimulate, induce, increase or enhance Tfh (follicular helper) cell differentiation, germinal center B cell development or an antibody response, and an immune response, respectively. Also provided are peptides comprising or consisting of a subsequence of human activin sequence, in which the activin sequence or subsequence stimulates, induces, increases or enhances development of Tfh (follicular helper) cell differentiation, germinal center B cell development, an antibody response, an immune response and/or an immune response induced by a vaccine.
摘要翻译：本发明提供了通过施用激活素或子序列来刺激，诱导，增加或增强Tfh（滤泡辅助细胞）分化，生发中心B细胞发育或抗体应答以及免疫应答的方法和用途或刺激素受体激活剂，其量可分别有效刺激，诱导，增加或增强Tfh（滤泡辅助细胞）分化，生发中心B细胞发育或抗体应答和免疫应答。还提供了包含或由人活化素序列的子序列组成的肽，其中活化素序列或子序列刺激，诱导，增加或增强Tfh（滤泡辅助细胞）分化，生发中心B细胞发育，抗体应答，免疫应答和/或疫苗诱导的免疫应答。

2. 发明申请

WO2016090035A2 MODULATORS OF ACTIVIN AND METHODS FOR MODULATING IMMUNE RESPONSES AND T FOLLICULAR HELPER CELLS 审中-公开
标题翻译：活化剂的调节剂和用于调节免疫应答和T细胞帮助细胞的方法
公开(公告)号：WO2016090035A2
公开(公告)日：2016-06-09
申请号：PCT/US2015063500
申请日：2015-12-02
申请人： JOLLA INST ALLERGY IMMUNOLOG , NOVARTIS AG , MILLER ANDREW TOOD
发明人： MILLER ANDREW TOOD , CROTTY SHANE , LOCCI MICHELA
IPC分类号： A61K48/00 , A61K39/395
CPC分类号： C07K16/22 , C07K2317/70 , C07K2317/76
摘要： The invention provides methods and uses for stimulating, inducing, increasing or enhancing Tfh (follicular helper) cell differentiation, Germinal center B cell development or an antibody response, and an immune response by administering activin or a subsequence thereof, or an activator of activin Receptor, in an amount effective to stimulate, induce, increase or enhance Tfh (follicular helper) cell differentiation, Germinal center B cell development or an antibody response, and an immune response, respectively. Also provided are peptides comprising or consisting of a subsequence of human activin sequence, in which the activin sequence or subsequence stimulates, induces, increases or enhances development of Tfh (follicular helper) cell differentiation, Germinal center B cell development, an antibody response, an immune response and/or an immune response induced by a vaccine.
摘要翻译：本发明提供了刺激，诱导，增加或增强Tfh（滤泡辅助细胞）细胞分化，生发中心B细胞发育或抗体应答以及通过施用激活素或其子序列或激活素受体的激活剂的免疫应答的方法和用途，有效刺激，诱导，增加或增强Tfh（滤泡辅助细胞）细胞分化，生发中心B细胞发育或抗体应答以及免疫应答的量。还提供了包含人活化素序列的亚序列或由其组成的肽，其中所述激活素序列或亚序列刺激，诱导，增加或增强Tfh（滤泡辅助细胞）分化，生发中心B细胞发育，抗体应答，免疫应答和/或由疫苗诱导的免疫应答。

3. 发明申请

WO2013162741A1 ENGAGEMENT DEVICE AND METHOD FOR DEPLOYMENT OF ANASTOMOTIC CLIPS 审中-公开
标题翻译：接触装置和方法用于分解解锁
公开(公告)号：WO2013162741A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/031279
申请日：2013-03-14
申请人： THORATEC CORPORATION , HOARAU, Carine , REICHENBACH, Steven, H. , HSU, George , HARRINGTON, James, N. , MILLER, Andrew, R. , HAARSTAD, Philip , SUNQUIST, Stephen Kenneth
发明人： HOARAU, Carine , REICHENBACH, Steven, H. , HSU, George , HARRINGTON, James, N. , MILLER, Andrew, R. , HAARSTAD, Philip , SUNQUIST, Stephen Kenneth
IPC分类号： A61B17/11 , A61B17/128 , A61B17/10
CPC分类号： A61B17/11 , A61B17/0644 , A61B17/115 , A61B2017/00252 , A61B2017/00867 , A61B2017/0647 , A61B2017/1107 , A61B2017/308 , A61B2090/309
摘要： A coupling system includes an applicator tool, an anastomotic prosthesis mounted on the applicator tool, and an engagement device. The applicator tool deploys a securement through the prosthesis and tissue which leaves the prosthesis attached to the tissue. The engagement device selectively engages the applicator tool onto the tissue, with the use of suction, in order to facilitate accurate placement of the prosthesis on the tissue and facilitate deployment of the securement into the tissue. The applicator tool and the tissue are able to move together while the engagement device prevents or inhibits relative movement between the applicator tool and the tissue. A method for securing an anastomotic prosthesis to tissue includes applying of suction to engage an applicator tool to the tissue while a securement is deployed out of the applicator tool and into the prosthesis and the tissue.
摘要翻译：耦合系统包括施用工具，安装在施用工具上的吻合假体和接合装置。涂抹器工具通过假体和组织展开固定，所述假体和组织离开假体附着到组织。接合装置通过使用抽吸选择性地将施用工具接合到组织上，以便于将假体准确地放置在组织上并且便于将固定件部署到组织中。施用工具和组织能够一起移动，同时接合装置防止或抑制施用工具和组织之间的相对运动。用于将吻合假体固定到组织的方法包括施加抽吸以将施用器工具接合到组织，同时将固定部署到施用工具外并进入假体和组织。

4. 发明申请

WO2012116376A1 COUPLING SYSTEM, APPLICATOR TOOL, ATTACHMENT RING AND METHOD FOR CONNECTING A CONDUIT TO BIOLOGICAL TISSUE 审中-公开
标题翻译：联系系统，应用工具，附件环和连接到生物组织的方法
公开(公告)号：WO2012116376A1
公开(公告)日：2012-08-30
申请号：PCT/US2012/026838
申请日：2012-02-27
申请人： THORATEC CORPORATION , HOARAU, Carine , REICHENBACH, Steven, H. , MILLER, Andrew, R. , HILL, J., Donald , BOIADJIEVA, Nina , HAARSTAD, Philip , BADIA, James , CHANG, Shuo-Hsiu , HSU, George, Chao-Chih , SUNDQUIST, Stephen, Kenneth , STANESCU, Olga, M.
发明人： HOARAU, Carine , REICHENBACH, Steven, H. , MILLER, Andrew, R. , HILL, J., Donald , BOIADJIEVA, Nina , HAARSTAD, Philip , BADIA, James , CHANG, Shuo-Hsiu , HSU, George, Chao-Chih , SUNDQUIST, Stephen, Kenneth , STANESCU, Olga, M.
IPC分类号： A61B17/064
CPC分类号： A61B17/064 , A61B17/072 , A61B17/07292 , A61B17/10 , A61B17/1155 , A61B2017/00867 , A61B2017/0441 , A61B2017/0443 , A61B2017/0647 , A61B2017/0649 , A61B2017/1107 , A61M1/1008 , A61M1/101 , A61M1/1087 , A61M1/1096 , A61M1/1098 , A61M1/122
摘要： A coupling system includes an applicator tool and an attachment ring mounted on the applicator tool. Clips are contained within the applicator tool and are deployed through the attachment ring in order to anchor the attachment ring to biological tissue. When deployed, tips of the clips follow a curved trajectory through an annular cuff of the attachment ring and through the underlying tissue. The tips loop back out of the tissue and to a location where they are later trapped or clamped by the attachment ring. While the tips are trapped or clamped, the applicator tool cinches the clips by pulling rear segments of the clips. Thereafter, the applicator tool disconnects from the attachment ring which remains anchored to the tissue and serves as a coupling for a cannula. The cannula can have movable lock members that secure it to the attachment ring.
摘要翻译：联接系统包括涂抹器工具和安装在涂抹器工具上的附接环。夹子被包含在施用器工具内并且通过附接环展开，以便将附接环锚定到生物组织。当部署时，夹子的尖端沿着弯曲的轨迹穿过连接环的环形箍并穿过下面的组织。尖端环绕回组织并移动到随后由附接环捕获或夹持的位置。当尖端被夹住或夹紧时，涂抹器工具通过拉动夹子的后部片段来夹紧夹子。此后，涂抹器工具与保持锚定到组织的附接环断开，并用作插管的联接器。套管可以具有将其固定到附接环的可移动的锁定构件。

5. 发明申请

WO2012040025A2 LIGHT WEIGHT PROPPANT WITH IMPROVED STRENGTH AND METHODS OF MAKING SAME 审中-公开
标题翻译：具有改进的强度的轻重量助剂及其制备方法
公开(公告)号：WO2012040025A2
公开(公告)日：2012-03-29
申请号：PCT/US2011051712
申请日：2011-09-15
申请人： OXANE MATERIALS INC , WU SHANGHUA , PHAM JODY , XIE YUMING , CHATTERJEE DILIP K , MILLER ANDREW , COKER CHRISTOPHER E
发明人： WU SHANGHUA , PHAM JODY , XIE YUMING , CHATTERJEE DILIP K , MILLER ANDREW , COKER CHRISTOPHER E
IPC分类号： C04B35/01 , C03B19/06 , C04B35/10 , C04B35/185 , C04B35/65
CPC分类号： C09K8/805 , C04B35/117 , C04B35/185 , C04B35/6261 , C04B35/62807 , C04B35/803 , C04B38/0615 , C04B2235/3217 , C04B2235/322 , C04B2235/3418 , C04B2235/3472 , C04B2235/36 , C04B2235/3817 , C04B2235/3826 , C04B2235/526 , C04B2235/5264 , C04B2235/5268 , C04B2235/5276 , C04B2235/528 , C04B2235/5409 , C04B2235/5445 , C04B2235/6028 , C04B2235/724 , C04B2235/77 , C04B2235/80 , C04B2235/94 , C04B2235/96 , C09K8/80 , C04B38/0054 , C04B38/0074
摘要： Methods are described to make strong, tough, and lightweight whisker-reinforced glass-ceramic composites through a self-toughening structure generated by viscous reaction sintering of a complex mixture of oxides. The invention further relates to strong, tough, and lightweight glass-ceramic composites that can be used as proppants and for other uses.
摘要翻译：描述了通过由复杂的氧化物混合物的粘性反应烧结产生的自增韧结构来制造坚固，坚韧且轻质的晶须增强玻璃陶瓷复合材料的方法。本发明进一步涉及可用作支撑剂和用于其他用途的坚固，坚韧且轻质的玻璃陶瓷复合材料。

6. 发明申请

WO2011139273A1 4 SUBSTITUTED PYRAZOLOPYRIMIDINES USEFUL AS PKC-THETA INHIBITORS 审中-公开
标题翻译： 4作为PKC-THETA抑制剂有用的取代的吡唑并嘧啶
公开(公告)号：WO2011139273A1
公开(公告)日：2011-11-10
申请号：PCT/US2010/033711
申请日：2010-05-05
申请人： VERTEX PHARMACEUTICALS INCORPORATED , JIMENEZ, Juan-miguel , MILLER, Andrew
发明人： JIMENEZ, Juan-miguel , MILLER, Andrew
IPC分类号： C07D487/04 , A61K31/519 , A61P37/00
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formulae (I) and (IA) useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译：本发明涉及可用作蛋白激酶抑制剂的式（I）和（IA）化合物。本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。本发明还提供了制备本发明化合物的方法。

7. 发明申请

WO2011094290A1 PYRAZOLOPYRIMIDINE KINASE INHIBITORS 审中-公开
标题翻译：吡唑并嘧啶激酶抑制剂
公开(公告)号：WO2011094290A1
公开(公告)日：2011-08-04
申请号：PCT/US2011/022547
申请日：2011-01-26
申请人： VERTEX PHARMACEUTICALS INCORPORATED , JIMENEZ, Juan-Miguel , SETTIMO, Luca , FRAYSSE, Damien , BRENCHLEY, Guy , DAVIS, John, Christopher , MILLER, Andrew, W.
发明人： JIMENEZ, Juan-Miguel , SETTIMO, Luca , FRAYSSE, Damien , BRENCHLEY, Guy , DAVIS, John, Christopher , MILLER, Andrew, W.
IPC分类号： C07D487/04 , A61K31/519 , A61P31/00
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译：本发明涉及可用作蛋白激酶抑制剂的化合物。本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。本发明还提供了制备本发明化合物的方法。

8. 发明申请

WO2011094288A1 PYRAZOLOPYRAZINE KINASE INHIBITORS 审中-公开
标题翻译：吡唑并吡啶激酶抑制剂
公开(公告)号：WO2011094288A1
公开(公告)日：2011-08-04
申请号：PCT/US2011/022543
申请日：2011-01-26
申请人： VERTEX PHARMACEUTICALS INCORPORATED , JIMENEZ, Juan-Miguel , SETTIMO, Luca , FRAYSSE, Damien , BRENCHLEY, Guy , DAVIS, John, Christopher , MILLER, Andrew, W.
发明人： JIMENEZ, Juan-Miguel , SETTIMO, Luca , FRAYSSE, Damien , BRENCHLEY, Guy , DAVIS, John, Christopher , MILLER, Andrew, W.
IPC分类号： C07D487/04 , A61K31/4985 , A61P37/00 , A61P29/00
CPC分类号： C07D487/04
摘要： The present invention relates to pyrazolopyrazine compounds useful as inhibitors of protein kinase specially PKC theta. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译：本发明涉及可用作蛋白激酶特异性PKCθ抑制剂的吡唑并吡嗪化合物。本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。本发明还提供了制备本发明化合物的方法。

9. 发明申请

WO2011060386A9 ATTACHMENT SYSTEM, DEVICE AND METHOD 审中-公开
标题翻译：附件系统，装置和方法
公开(公告)号：WO2011060386A9
公开(公告)日：2011-07-07
申请号：PCT/US2010056751
申请日：2010-11-15
申请人： THORATEC CORP , REICHENBACH STEVEN H , HOARAU CARINE , NGUYEN JOHN DUC , COSTA RUTH ELEANOR , BADIA JAMES , HANNULA DONALD LEE , MILLER ANDREW ROSS
发明人： REICHENBACH STEVEN H , HOARAU CARINE , NGUYEN JOHN DUC , COSTA RUTH ELEANOR , BADIA JAMES , HANNULA DONALD LEE , MILLER ANDREW ROSS
IPC分类号： A61M1/10
CPC分类号： A61M1/10 , A61M1/1008 , A61M1/101 , A61M1/1098 , A61M1/122
摘要： A ventricular assist system and a method of implanting the system are disclosed. The system can have a pump, an inflow conduit, an outflow conduit, attachment ring, ring clamp, and a valvular structure. The attachment ring can be attached to the apex of the heart. The valvular structure can have a flexible, one-way valve in a rigid housing. The inflow conduit can be passed through the valvular structure and the attachment ring into a beating heart with minimal loss of blood. Devices such as slitting tool, coring knife, and/or C-clamp and use of the devices can form part of the system and method for implanting the ventricular assist device.
摘要翻译：公开了一种心室辅助系统和植入该系统的方法。该系统可以具有泵，流入导管，流出导管，附接环，环形夹和瓣膜结构。附件环可以连接到心脏的顶点。瓣膜结构可以在刚性外壳中具有柔性的单向阀。流入导管可以通过瓣膜结构和附着环进入跳动心脏，血液损失最小。诸如切割工具，取芯刀和/或C形夹具之类的设备以及这些设备的使用可以形成植入心室辅助装置的系统和方法的一部分。

10. 发明申请

WO2011060386A3 ATTACHMENT SYSTEM, DEVICE AND METHOD 审中-公开
标题翻译：附件系统，装置和方法
公开(公告)号：WO2011060386A3
公开(公告)日：2011-05-19
申请号：PCT/US2010/056751
申请日：2010-11-15
申请人： THORATEC CORPORATION , REICHENBACH, Steven, H. , HOARAU, Carine , NGUYEN, John Duc , COSTA, Ruth, Eleanor , BADIA, James , HANNULA, Donald, Lee , MILLER, Andrew, Ross
发明人： REICHENBACH, Steven, H. , HOARAU, Carine , NGUYEN, John Duc , COSTA, Ruth, Eleanor , BADIA, James , HANNULA, Donald, Lee , MILLER, Andrew, Ross
IPC分类号： A61M1/10
摘要： A ventricular assist system (13) and a method of implanting the system (13) are disclosed. The system (13) can have a pump (8), an inflow conduit (10), an outflow conduit (2), attachment ring (22), ring clamp (24), and a valvular structure (12). The attachment ring (22) can be attached to the apex of the heart. The valvular structure (12) can have a flexible, one-way valve in a rigid housing. The inflow conduit (10) can be passed through the valvular structure (12) and the attachment ring (22) into a beating heart with minimal loss of blood. Devices such as slitting tool (300), coring knife (140), and/or C-clamp (600) and use of the devices can form part of the system (13) and method for implanting the ventricular assist device.
摘要翻译：公开了一种心室辅助系统（13）和植入该系统（13）的方法。系统13可以具有泵8，流入导管10，流出导管2，附接环22，环形夹24和阀结构12。连接环（22）可以连接到心脏的顶点。瓣膜结构（12）可以在刚性外壳中具有柔性的单向阀。流入导管（10）可以通过瓣膜结构（12）和附接环（22）而以最小的血液损失进入跳动的心脏。诸如纵切工具（300），取芯刀（140）和/或C形夹具（600）之类的装置以及这些装置的使用可形成用于植入心室辅助装置的系统（13）和方法的一部分。

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