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1. 发明申请

WO1997006167A1 IMIDAZOPYRIDINE DERIVATIVES 审中-公开
标题翻译：咪唑吡啶衍生物
公开(公告)号：WO1997006167A1
公开(公告)日：1997-02-20
申请号：PCT/GB1996001849
申请日：1996-07-30
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , AYSCOUGH, Andrew, Paul , BLACKWELL, Christopher, Mark , LAUNCHBURY, Steven , WHITTAKER, Mark
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D213/36
摘要： Compounds of formula (II), wherein L, A, X, B, R , R , W, D, E, R , R , R are as defined in the specification, are dual histamine H1 and PAF receptor antagonists.
摘要翻译：式（II）化合物，其中L，A，X，B，R 2，R 3，W，D，E，R 3，R 4，R 5如规格是双组胺H1和PAF受体拮抗剂。

2. 发明申请

WO1996033997A1 BENZIMIDAZOLE DERIVATIVES BEING DUAL HISTAMINE (H1) AND PLATELET ACTIVATING FACTOR (PAF) ANTAGONISTS 审中-公开
标题翻译：苯并咪唑衍生物是双组胺（H1）和平板激活因子（PAF）拮抗剂
公开(公告)号：WO1996033997A1
公开(公告)日：1996-10-31
申请号：PCT/GB1996000680
申请日：1996-03-22
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , MARTIN, Fionna, Mitchell , FLOYD, Christopher, David , SPAVOLD, Zoe, Marie , AYSCOUGH, Andrew, Paul , WHITTAKER, Mark
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of formula (I), wherein the variable substituents and groups are as defined in the specification, are dual histamine (H1) and platelet activating factor (PAF) antagonists.
摘要翻译：其中可变取代基和基团如说明书中所定义的式（I）化合物是双组胺（H1）和血小板活化因子（PAF）拮抗剂。

3. 发明申请

WO1996005201A1 IMIDAZOPYRIDINE DERIVATIVES AS DUAL HISTAMINE (H1) AND PLATELET ACTIVATING FACTOR (PAF) ANTAGONISTS 审中-公开
标题翻译：咪达嗪衍生物作为双组胺（H1）和平板激活因子（PAF）拮抗剂
公开(公告)号：WO1996005201A1
公开(公告)日：1996-02-22
申请号：PCT/GB1995001878
申请日：1995-08-09
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , MILLER, Andrew , BOWLES, Stephen, Arthur , AYSCOUGH, Andrew, Paul , WHITTAKER, Mark
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of formula (II), wherein D is for example a group of formula (X), are dual H1/PAF antagonists.
摘要翻译：其中D是例如式（X）的基团的式（II）化合物是双重H1 / PAF拮抗剂。

4. 发明申请

WO1996026918A1 SYNTHESIS OF CARBOXYLIC AND HYDROXAMIC ACID DERIVATIVES 审中-公开
标题翻译：羧酸和羟基酸衍生物的合成
公开(公告)号：WO1996026918A1
公开(公告)日：1996-09-06
申请号：PCT/GB1996000467
申请日：1996-03-01
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , FLOYD, Christopher, David , WHITTAKER, Mark
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07C259/06
CPC分类号： C07C259/06 , C07C231/00 , Y02P20/55
摘要： A method for the preparation of carboxylic and hydroxamic acid derivatives by cocondensation in a liquid organic medium of three reaction components, namely a carboxylic acid reaction component of formula (II), an imine reaction component of formula (III), and an isonitrile reaction component of formula (IV), wherein X is hydrogen or an amino protecting group, or the residue of a solid phase reaction substrate; Y is (i) a group -CO2R5 wherein R5 is a carboxyl protecting group or the residue of a solid phase reaction substrate or (ii) a group -CONR6OR7 wherein R6 is an amino protecting group or the residue of a solid phase reaction substrate and R7 is a hydroxyl protecting group or the residue of a solid phase reaction substrate; [S1], [S2], [S3] and [S4] each represent covalently bound moieties which are substantially non reactive with the reaction components (II), (III), or (IV) defined above; provided that only one of X, R5, R6 and R7 is the residue of a solid phase reaction substrate.
摘要翻译：在三种反应组分的液体有机介质中，即式（II）的羧酸反应组分，式（III）的亚胺反应组分和异氰酸酯反应组分的缩合反应制备羧酸和异羟肟酸衍生物的方法式（Ⅳ）的化合物，其中X为氢或氨基保护基，或固相反应底物的残基; Y是（i）-CO 2 R 5基团，其中R 5是羧基保护基或固相反应底物的残基或（ii）基团-CONR 6OR 7，其中R 6是氨基保护基或固相反应底物的残基， R7是羟基保护基或固相反应底物的残基; [S1]，[S2]，[S3]和[S4]各自表示与上述定义的反应组分（II），（III）或（IV）基本上不反应的共价结合部分; 条件是X，R5，R6和R7中只有一个是固相反应底物的残基。

5. 发明申请

WO1996016931A1 METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：金属蛋白酶抑制剂
公开(公告)号：WO1996016931A1
公开(公告)日：1996-06-06
申请号：PCT/GB1995002770
申请日：1995-11-27
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , BECKETT, Raymond, Paul , WHITTAKER, Mark , MILLER, Andrew , MARTIN, Fionna, Mitchell
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07C235/70
CPC分类号： C07C237/22 , C07C259/06 , C07D333/34
摘要： Compounds of general formula (I), principally characterized in that R4 is a polyether group, are water soluble matrix metalloproteinase inhibitors.
摘要翻译：通式（I）的化合物，其主要特征在于R4是聚醚基，是水溶性基质金属蛋白酶抑制剂。

6. 发明申请

WO1996006074A1 METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：金属蛋白酶抑制剂
公开(公告)号：WO1996006074A1
公开(公告)日：1996-02-29
申请号：PCT/GB1995001971
申请日：1995-08-18
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , BECKETT, Raymond, Paul , MILLER, Andrew , WHITTAKER, Mark
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07C259/06
CPC分类号： C07D209/48 , C07C259/06 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D333/34
摘要： Compounds of formula (I) principally characterised in that R4 is an optionally substituted C3-C8 cycloalkyl group or optionally substituted C4-C8 cycloalkenyl group are inhibitors of matrix metalloproteinases.
摘要翻译：式（I）化合物主要特征在于R4是任选取代的C 3 -C 8环烷基或任选取代的C 4 -C 8环烯基是基质金属蛋白酶的抑制剂。

7. 发明申请

WO1998017655A1 METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：金属蛋白酶抑制剂
公开(公告)号：WO1998017655A1
公开(公告)日：1998-04-30
申请号：PCT/GB1997002891
申请日：1997-10-20
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , BECKETT, Raymond, Paul , MARTIN, Fionna, Mitchell , MILLER, Andrew , TODD, Richard, Simon , WHITTAKER, Mark
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07D295/18
CPC分类号： C07D295/185 , C07D295/26 , Y02P20/55
摘要： Compounds of formula (I), wherein n, V, R1, R2, R3 and R4 are as defined in the specification are matrix metalloproteinase inhibitors.
摘要翻译：式（I）化合物，其中n，V，R 1，R 2，R 3和R 4如本说明书中所定义的是基质金属蛋白酶抑制剂。

8. 发明申请

WO1995035275A1 METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：金属蛋白酶抑制剂
公开(公告)号：WO1995035275A1
公开(公告)日：1995-12-28
申请号：PCT/GB1995001464
申请日：1995-06-22
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , MILLER, Andrew , WHITTAKER, Mark , BECKETT, Raymond, Paul
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07C311/06
CPC分类号： C07D295/13 , C07C259/06 , C07C311/06 , C07C311/13 , C07C2601/14 , C07D285/06
摘要： Compounds of general formula (II) wherein X is a hydroxamic or carboxylic acid group, Y is carbonyl or sulphonyl and R1 and R2 are as defined in the claims, are matrix metalloproteinase inhibitors.
摘要翻译：通式（II）的化合物，其中X是异羟肟酸或羧酸基团，Y是羰基或磺酰基，R 1和R 2如权利要求中所定义，是基质金属蛋白酶抑制剂。

9. 发明申请

WO1995019957A1 HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：羟基酸衍生物作为金属蛋白酶抑制剂
公开(公告)号：WO1995019957A1
公开(公告)日：1995-07-27
申请号：PCT/GB1995000120
申请日：1995-01-23
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , BECKETT, Raymond, Paul , WHITTAKER, Mark , MILLER, Andrew
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07C259/06
CPC分类号： C07C259/06
摘要： The following compounds: 2S-Hydroxy-3R-[1S-(tert-butylcarbamoyl)-2,2-dimethyl-propylcarbamoyl]- 5-methyl-hexanohydroxamic acid, 2S-Hydroxy-3R-[1S-(N,N-dimethylcarbamoyl)-2,2-dimethyl-propyl-carbamoy l]-5-methyl-hexanohydroxamic acid, 2S-Hydroxy-3R-[1S-(3-hydroxy-2,2-dimethylpropylcarbamoyl)-2,2-dimethyl -propylcarbamoyl]-5-methyl-hexanohydroxamic acid, 2S-Hydroxy-3R-[1S-(methylcarbamoyl)-2,2-dimethyl-propylcarbamoyl]-6-ph enyl-hexanohydroxamic acid and 2S-Hydroxy-3R-[1S-(methylcarbamoyl)-2,2-dimethyl-butylcarbamoyl]-5-met hyl-hexanohydroxamic acid are matrix metalloproteinase inhibitors.
摘要翻译：以下化合物：2S-羟基-3R- [1S-（叔丁基氨基甲酰基）-2,2-二甲基 - 丙基氨基甲酰基] -5-甲基 - 己羟肟酸，2S-羟基-3R- [1S-（N，N-二甲基氨基甲酰基）-2,2-二甲基 - 丙基 - 氨基甲酰基l] -5-甲基 - 己羟肟酸，2S-羟基-3R- [1S-（3-羟基-2,2-二甲基丙基氨基甲酰基）-2,2-二甲基 - 丙基氨基甲酰基] -5-甲基 - 己酸异羟肟酸，2S-羟基-3R- [1S-（甲基氨基甲酰基）-2,2-二甲基 - 丙基氨基甲酰基] -6-苯基 - 己酸异羟肟酸和2S-羟基-3R- [1S-（甲基氨基甲酰基） -2,2-二甲基 - 丁基氨基甲酰基] -5-甲基己基异羟肟酸是基质金属蛋白酶抑制剂。

10. 发明申请

WO1998024759A1 METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：金属蛋白酶抑制剂
公开(公告)号：WO1998024759A1
公开(公告)日：1998-06-11
申请号：PCT/GB1997003316
申请日：1997-12-02
申请人： BRITISH BIOTECH PHARMACEUTICALS LIMITED , WHITTAKER, Mark , BECKETT, Raymond, Paul , SPAVOLD, Zoe, Marie , MARTIN, Fionna, Mitchell
发明人： BRITISH BIOTECH PHARMACEUTICALS LIMITED
IPC分类号： C07C259/06
CPC分类号： C07D213/75 , C07C237/22 , C07C259/06 , C07C2601/14 , C07D233/64 , C07D409/12
摘要： Compound of formula (I) wherein Ar represents an optionally substituted phenyl or heteroaryl group, m is 1 or 2, n is 0, 1, 2, 3 or 4, X represents -COOH or -CONHOH and R1, R3 and Y are as defined in the specification, are inhibitors of metalloproteinases involved in tissue degradation.
摘要翻译：式（I）化合物其中Ar表示任选取代的苯基或杂芳基，m为1或2，n为0,1,2,3或4，X为-COOH或-CONHOH，R1，R3和Y为在说明书中定义的是参与组织降解的金属蛋白酶的抑制剂。

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