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    • 2. 发明申请
    • LIPOSOMALLY ENCAPSULATED HYBRID ADENOVIRUS-SEMLIKI FOREST VIRUS (SFV) VECTORS CARRYING RNAI CONSTRUCTS AND THERAPEUTIC GENES FOR USE AGAINST CANCER TARGETS AND OTHER DISEASES
    • 脂质体包裹的杂交腺病毒--SEMLIKI森林病毒(SFV)载体携带RNAi构建体和治疗性基因,用于抗癌目标和其他疾病
    • WO2008026015A3
    • 2008-07-17
    • PCT/GR2007000044
    • 2007-09-03
    • BOULIKAS PARTHENIOSROBERTS MICHAEL
    • BOULIKAS PARTHENIOSROBERTS MICHAEL
    • C12N15/86C12N15/861
    • C12N7/00A61K2039/5256C12N15/86C12N2710/10343C12N2710/10344C12N2770/36143
    • A hybrid adenovirus Semliki Forest Virus (SFV) vector is provided which has a structure as shown in Figure 1, which may comprise 3' and 5' inverted terminal repeat (ITR) of adenovirus the packaging signal of adenovirus, the structural genes encoding the adenovirus hexon and penton proteins, fiber and knob proteins and which may be deleted in the E4 region, E2 region or in the both the E2 and E4 regions. The adenovirus vector may not require a helper virus coinfection for propagation in producer cell lines. The hybrid vector may comprise a eukaryotic promoter controlling expression of the 42S genome of SFV comprising the nonstructural genes 1-4 endowed with enhanced cytotoxicity after infection of target cells and retaining the ability to replicate the 42S genome, which also comprises the therapeutic mRNA, in the cytoplasm or the hybrid vector may comprise a eukaryotic promoter controlling expression of the 42S genome of SFV comprising the nonstructural genes 1-4 containing two point mutations. In use, the hybrid vector further comprises cDNA encoding for microRNA (miRNA) and hairpin loops of short interfering RNA (siRNA) or cDNA encoding for double-stranded RNA (dsRNA).
    • 提供了具有如图1所示结构的杂种腺病毒塞姆利基森林病毒(SFV)载体,其可以包含腺病毒的3'和5'反向末端重复序列(ITR),腺病毒的包装信号,编码腺病毒的结构基因 六邻体和五邻体蛋白,纤维蛋白和球蛋白,并且可以在E4区域,E2区域或E2和E4区域中删除。 腺病毒载体可能不需要辅助病毒共感染以在生产细胞系中繁殖。 杂交载体可包含控制SFV 42S基因组表达的真核启动子,所述真核启动子控制SFV的42S基因组的表达,所述真核启动子包含在感染靶细胞后具有增强的细胞毒性并且保留了在42℃下还包含治疗性mRNA的42S基因组的复制能力的非结构基因1-4 细胞质或杂交载体可以包含控制SFV 42S基因组表达的真核启动子,其包含含有两个点突变的非结构基因1-4。 在使用中,杂交载体还包含编码微RNA(miRNA)和短干扰RNA(siRNA)的发夹环或编码双链RNA(dsRNA)的cDNA的cDNA。
    • 3. 发明申请
    • IMPROVED EXPANDABLE WRITING INSTRUMENT
    • 改进的可扩展写字仪
    • WO2011136873A1
    • 2011-11-03
    • PCT/US2011027560
    • 2011-03-08
    • ATX INT INCGREGORY REBECCAREEKIE GEORGEROBERTS MICHAELSANTOS DONALDTORNGREN FRANK
    • GREGORY REBECCAREEKIE GEORGEROBERTS MICHAELSANTOS DONALDTORNGREN FRANK
    • B43K24/02
    • B43K7/005B43K8/003B43K23/00B43K24/02B43K25/026
    • An expandable writing instrument has a writing end body section and a rear body section mounted to the writing end body section for relative axial and non-rotational movement between an extended position with the rear body section spaced away from the writing end body section, and a retracted position with the rear body section closer to the writing end body section. A spring in the writing end body section biases the cartridge upwardly. A helix cylinder is mounted for rotation and axial movement in the rear body section with a peg of the rear body section sliding in a track of the helix cylinder. The track is a closed loop with left and right hand helixes so that axial movement of the rear body section causes rotation of the helix cylinder continuously in one rotational direction. A shuttle receives a cartridge body and is mounted for axial movement in the helix cylinder. A shuttle cam on the shuttle is mounted for axial non- rotational movement to the writing end body section. Shuttle cam surfaces slidably engage cam surfaces of the helix cylinder and the cam surfaces include a high point that engages a flat portion of another cam surface for moving the shuttle with rotation of the helix cylinder, to project a writing tip of a cartridge out of the bottom opening in the extended position.
    • 可扩展书写工具具有书写端主体部分和后体部分,安装到书写端主体部分,用于在与书写端主体部分间隔开的延伸位置与后主体部分之间进行相对的轴向和非旋转运动;以及 缩回位置,后体部分靠近书写端主体部分。 书写端主体部分中的弹簧将盒向上偏置。 螺旋缸被安装成用于在后体部分中的旋转和轴向运动,后体部分的钉在螺旋缸的轨道中滑动。 轨道是具有左右螺旋线的闭环,使得后体部分的轴向运动导致螺旋缸在一个旋转方向上连续旋转。 梭子接收盒体并安装成在螺旋缸中轴向移动。 梭子上的穿梭凸轮被安装用于轴向非旋转运动到书写端本体部分。 梭形凸轮表面可滑动地接合螺旋圆柱体的凸轮表面,并且凸轮表面包括接合另一个凸轮表面的平坦部分的高点,用于随着旋转圆柱体的旋转而使梭子移动,从而使墨盒的书写尖端突出 底部开口处于延伸位置。
    • 4. 发明申请
    • POS PRINTING TRIGGERED BY PHARMACY PRESCRIPTION ORDERS
    • POS打印通过药品处理订单触发
    • WO2008149251A2
    • 2008-12-11
    • PCT/IB2008051766
    • 2008-05-07
    • CATALINA MARKETING CORPROBERTS MICHAELEBERT MICHAEL
    • ROBERTS MICHAELEBERT MICHAEL
    • G06Q10/00
    • G06F19/3456G06Q20/202G06Q20/209G06Q30/06G06Q50/24G07G5/00
    • The invention provides a computer implemented system and method for printing at a POS, comprising: determining in a PM CS of a pharmacy of a retail store a payloadID to association with a prescription order for a prescription ordered from said pharmacy; filling, in said pharmacy, said prescription, to provide a filled prescription; first printing, using a PM CS printer in said pharmacy, a first print that encodes first information associated with said filled prescription; attaching or physically associating with hardware or adhesive said first print with said filled prescription; during a purchase transaction in which said prescription is being purchased at a POS terminal of a POS CS of said retail store, reading said first print to determine said first information associated with said filled prescription; during said purchase transaction, using data lines for retrieving second information associated with said first information; and during said purchase transaction, second printing, using a printer at a POS of said POS CS, a second print including said second information in human understandable form. RAN Date/Time code: April 8, 2008 (3:12pm) Y:\Clients\Catalina\PIP-194-ROBE\PIP194ROBEU-US\Drafts\Specification_PIP194ROBEU-U S_4-30-2007.wpd
    • 本发明提供了一种用于在POS打印的计算机实现的系统和方法,包括:在零售商店的药店的PM CS中确定与所述药房订购的处方的处方订单相关联的有效载荷ID; 填写,在药房说处方,提供一个充满处方; 首先在所述药店中使用PM CS打印机打印第一印刷品,其对与所述填充处方相关联的第一信息进行编码; 将所述第一印刷品与所述填充的处方附接或物理上与硬件或粘合剂相关联; 在购买交易中,在所述零售商店的POS CS的POS终端处购买所述处方,读取所述第一打印以确定与所述填写的处方相关联的所述第一信息; 在所述购买交易期间,使用数据线来检索与所述第一信息相关联的第二信息; 并且在所述购买交易期间,在所述POS CS的POS处使用打印机进行第二次打印,包括以人可理解的形式包括所述第二信息的第二打印。 RAN日期/时间码:2008年4月8日(3:12 pm)Y:\ Clients \ Catalina \ PIP-194-ROBE \ PIP194ROBEU-US \ Drafts \ Specification_PIP194ROBEU-U S_4-30-2007.wpd
    • 6. 发明申请
    • CELL SEARCH IN A CELLULAR COMMUNICATIONS SYSTEM
    • 细胞在细胞通信系统中的搜索
    • WO2008086648A8
    • 2009-03-05
    • PCT/CN2007000037
    • 2007-01-08
    • HUAWEI TECH CO LTDBAKHUIZEN MARTINOLOFSSON HENRIKROBERTS MICHAEL
    • BAKHUIZEN MARTINOLOFSSON HENRIKROBERTS MICHAEL
    • H04W48/08H04W48/16H04W48/18H04W48/20
    • H04W48/16H04J11/0069H04W16/32H04W48/08H04W48/18
    • The invention concerns a method for cell search of the type performed in conjunction with selecting a Public Land Mobile Network (PLMN) in a cellular communications system, wherein the cellular communications system includes at least one terminal and at least two cells, the method including:- said at least one terminal obtaining, in any of said at least two cells, data on at least one candidate camping cell, - using said data for cell search. The method is distinguished by:- in said step of obtaining data, obtaining data including information on preference for at least one of said at least one candidate camping cell,- in said step of cell search, searching a cell based on said information on preference. The invention also concerns a terminal, a base station and a cellular communications system.
    • 本发明涉及一种在蜂窝通信系统中结合选择公共陆地移动网络(PLMN)执行的类型的小区搜索的方法,其中蜂窝通信系统包括至少一个终端和至少两个小区,该方法包括: - 所述至少一个终端在所述至少两个小区中的任一个中获得至少一个候选野营小区上的数据, - 使用所述用于小区搜索的数据。 该方法的特征在于: - 在所述获得数据的步骤中,获得包括关于所述至少一个候选野营小区中的至少一个的偏好的信息的数据, - 在所述小区搜索步骤中,基于所述关于优先级的信息来搜索小区 。 本发明还涉及终端,基站和蜂窝通信系统。