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1. 发明申请

WO2008026015A3 LIPOSOMALLY ENCAPSULATED HYBRID ADENOVIRUS-SEMLIKI FOREST VIRUS (SFV) VECTORS CARRYING RNAI CONSTRUCTS AND THERAPEUTIC GENES FOR USE AGAINST CANCER TARGETS AND OTHER DISEASES 审中-公开
标题翻译：脂质体包裹的杂交腺病毒--SEMLIKI森林病毒（SFV）载体携带RNAi构建体和治疗性基因，用于抗癌目标和其他疾病
公开(公告)号：WO2008026015A3
公开(公告)日：2008-07-17
申请号：PCT/GR2007000044
申请日：2007-09-03
申请人： BOULIKAS PARTHENIOS , ROBERTS MICHAEL
发明人： BOULIKAS PARTHENIOS , ROBERTS MICHAEL
IPC分类号： C12N15/86 , C12N15/861
CPC分类号： C12N7/00 , A61K2039/5256 , C12N15/86 , C12N2710/10343 , C12N2710/10344 , C12N2770/36143
摘要： A hybrid adenovirus Semliki Forest Virus (SFV) vector is provided which has a structure as shown in Figure 1, which may comprise 3' and 5' inverted terminal repeat (ITR) of adenovirus the packaging signal of adenovirus, the structural genes encoding the adenovirus hexon and penton proteins, fiber and knob proteins and which may be deleted in the E4 region, E2 region or in the both the E2 and E4 regions. The adenovirus vector may not require a helper virus coinfection for propagation in producer cell lines. The hybrid vector may comprise a eukaryotic promoter controlling expression of the 42S genome of SFV comprising the nonstructural genes 1-4 endowed with enhanced cytotoxicity after infection of target cells and retaining the ability to replicate the 42S genome, which also comprises the therapeutic mRNA, in the cytoplasm or the hybrid vector may comprise a eukaryotic promoter controlling expression of the 42S genome of SFV comprising the nonstructural genes 1-4 containing two point mutations. In use, the hybrid vector further comprises cDNA encoding for microRNA (miRNA) and hairpin loops of short interfering RNA (siRNA) or cDNA encoding for double-stranded RNA (dsRNA).
摘要翻译：提供了具有如图1所示结构的杂种腺病毒塞姆利基森林病毒（SFV）载体，其可以包含腺病毒的3'和5'反向末端重复序列（ITR），腺病毒的包装信号，编码腺病毒的结构基因六邻体和五邻体蛋白，纤维蛋白和球蛋白，并且可以在E4区域，E2区域或E2和E4区域中删除。腺病毒载体可能不需要辅助病毒共感染以在生产细胞系中繁殖。杂交载体可包含控制SFV 42S基因组表达的真核启动子，所述真核启动子控制SFV的42S基因组的表达，所述真核启动子包含在感染靶细胞后具有增强的细胞毒性并且保留了在42℃下还包含治疗性mRNA的42S基因组的复制能力的非结构基因1-4 细胞质或杂交载体可以包含控制SFV 42S基因组表达的真核启动子，其包含含有两个点突变的非结构基因1-4。在使用中，杂交载体还包含编码微RNA（miRNA）和短干扰RNA（siRNA）的发夹环或编码双链RNA（dsRNA）的cDNA的cDNA。

2. 发明申请

WO2007099377A3 CANCER TREATMENTS 审中-公开
标题翻译：癌症治疗
公开(公告)号：WO2007099377A3
公开(公告)日：2008-04-17
申请号：PCT/GR2007000015
申请日：2007-03-05
申请人： BOULIKAS PARTHENIOS
发明人： BOULIKAS PARTHENIOS
IPC分类号： A61K9/127 , A61K31/555 , A61P35/00
CPC分类号： A61K9/1075 , A61K9/1271 , A61K31/555
摘要： The present invention relates to liposome comprising encapsulated oxaliplatin and methods for making encapsulated oxaliplatin. The invention also relates to liposomes comprising oxaliplatin and another anticancer drug. The liposome sof the invention are useful in cancer treatments.
摘要翻译：本发明涉及包含奥沙利铂的脂质体和制备包封的奥沙利铂的方法。本发明还涉及包含奥沙利铂和另一种抗癌药物的脂质体。本发明的脂质体可用于癌症治疗。

3. 发明申请

WO2008026015A2 LIPOSOMALLY ENCAPSULATED HYBRID ADENOVIRUS-SEMLIKI FOREST VIRUS (SFV) VECTORS CARRYING RNAI CONSTRUCTS AND THERAPEUTIC GENES FOR USE AGAINST CANCER TARGETS AND OTHER DISEASES 审中-公开
标题翻译：携带RNAI构建体和治疗癌基因用于癌症目标和其他疾病的感染性混合性ADENOVIRUS-SEMLIKI FOREST VIRUS（SFV）载体
公开(公告)号：WO2008026015A2
公开(公告)日：2008-03-06
申请号：PCT/GR2007/000044
申请日：2007-09-03
申请人： BOULIKAS, Parthenios , ROBERTS, Michael
发明人： BOULIKAS, Parthenios , ROBERTS, Michael
IPC分类号： C12N15/09
CPC分类号： C12N7/00 , A61K2039/5256 , C12N15/86 , C12N2710/10343 , C12N2710/10344 , C12N2770/36143
摘要： A hybrid adenovirus Semliki Forest Virus (SFV) vector is provided which has a structure as shown in Figure 1, which may comprise 3' and 5' inverted terminal repeat (ITR) of adenovirus the packaging signal of adenovirus, the structural genes encoding the adenovirus hexon and penton proteins, fiber and knob proteins and which may be deleted in the E4 region, E2 region or in the both the E2 and E4 regions. The adenovirus vector may not require a helper virus coinfection for propagation in producer cell lines. The hybrid vector may comprise a eukaryotic promoter controlling expression of the 42S genome of SFV comprising the nonstructural genes 1-4 endowed with enhanced cytotoxicity after infection of target cells and retaining the ability to replicate the 42S genome, which also comprises the therapeutic mRNA, in the cytoplasm or the hybrid vector may comprise a eukaryotic promoter controlling expression of the 42S genome of SFV comprising the nonstructural genes 1-4 containing two point mutations. In use, the hybrid vector further comprises cDNA encoding for microRNA (miRNA) and hairpin loops of short interfering RNA (siRNA) or cDNA encoding for double-stranded RNA (dsRNA).
摘要翻译：提供了具有如图1所示结构的杂合腺病毒塞姆利基森林病毒（SFV）载体，其可以包含腺病毒的3'和5'反向末端重复（ITR），腺病毒的包装信号，编码腺病毒的结构基因六邻体和penton蛋白质，纤维和旋钮蛋白质，并且其可在E4区域，E2区域或E2和E4区域中缺失。腺病毒载体可能不需要辅助病毒共感染用于在生产细胞系中繁殖。杂交载体可以包含控制SFV的42S基因组表达的真核启动子，其包含在靶细胞感染后具有增强的细胞毒性的非结构基因1-4，并且保留复制还含有治疗性mRNA的42S基因组的能力细胞质或杂交载体可以包含控制SFV的42S基因组表达的真核启动子，其包含含有两个点突变的非结构基因1-4。在使用中，杂交载体还包含编码微小RNA（miRNA）的cDNA和短干扰RNA（siRNA）的发夹环或编码双链RNA（dsRNA）的cDNA。

4. 发明申请

WO2007099377A2 CANCER TREATMENTS 审中-公开
标题翻译：癌症治疗
公开(公告)号：WO2007099377A2
公开(公告)日：2007-09-07
申请号：PCT/GR2007/000015
申请日：2007-03-05
申请人： BOULIKAS, Parthenios
发明人： BOULIKAS, Parthenios
IPC分类号： A61K9/127
CPC分类号： A61K9/1075 , A61K9/1271 , A61K31/555
摘要： The present invention relates to liposome comprising encapsulated oxaliplatin and methods for making encapsulated oxaliplatin. The invention also relates to liposomes comprising oxaliplatin and another anticancer drug. The liposome sof the invention are useful in cancer treatments.
摘要翻译：本发明涉及包含奥沙利铂的脂质体和用于制备包封的奥沙利铂的方法。本发明还涉及包含奥沙利铂和另一种抗癌药物的脂质体。本发明的脂质体可用于癌症治疗。

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