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1. 发明申请

WO2009137415A2 REAGENT AND SAMPLE PREPARATION, LOADING, AND STORAGE 审中-公开
标题翻译：试剂和样品的准备，装载和储存
公开(公告)号：WO2009137415A2
公开(公告)日：2009-11-12
申请号：PCT/US2009042731
申请日：2009-05-04
申请人： ADVANCED LIQUID LOGIC INC , POLLACK MICHAEL , THWAR PRASANNA , PAMULA VAMSEE , SRINIVASAN VIJAY , ECKHARDT ALLEN , SHENDEROV ALEXANDER , ALLEN DWAYNE
发明人： POLLACK MICHAEL , THWAR PRASANNA , PAMULA VAMSEE , SRINIVASAN VIJAY , ECKHARDT ALLEN , SHENDEROV ALEXANDER , ALLEN DWAYNE
IPC分类号： G01N35/00 , G01N1/28 , G01N27/26 , G01N33/00
CPC分类号： B01L3/502784 , B01L3/502715 , B01L3/502761 , B01L7/52 , B01L2200/027 , B01L2200/0673 , B01L2300/022 , B01L2300/023 , B01L2300/024 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415 , B01L2400/0424 , B01L2400/0427 , B01L2400/043 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0683 , G01N27/44704 , G01N35/0098 , G01N2035/1046 , Y10T436/25 , Y10T436/2575
摘要： The invention provides droplet actuators and droplet actuator cassettes including reagent storage capabilities, as well as methods of making and using the droplet actuators and cassettes. The invention also provides continuous flow channel elements and techniques for using electrodes to manipulate droplets in flowing streams. The invention also discloses methods of separating compounds on a droplet actuator. Various other aspects of the invention are also disclosed.
摘要翻译：本发明提供了包括试剂储存能力的液滴致动器和液滴致动器盒，以及制造和使用液滴致动器和盒的方法。本发明还提供了用于使用电极在流动流中操纵液滴的连续流动通道元件和技术。本发明还公开了在液滴致动器上分离化合物的方法。还公开了本发明的各种其它方面。

2. 发明申请

WO2009111769A2 REAGENT AND SAMPLE PREPARATION AND LOADING ON A FLUIDIC DEVICE 审中-公开
标题翻译：试剂和样品在流体装置上的制备和装载
公开(公告)号：WO2009111769A2
公开(公告)日：2009-09-11
申请号：PCT/US2009036449
申请日：2009-03-09
申请人： ADVANCED LIQUID LOGIC INC , POLLACK MICHAEL , SISTA RAMAKRISHNAN , HUA ZHISHAN , PAMULA VAMSEE , SUDARSAN ARJUN , SRINIVASAN VIJAY , THWAR PRASANNA , SHENDEROV ALEXANDER , ALLEN DWAYNE
发明人： POLLACK MICHAEL , SISTA RAMAKRISHNAN , HUA ZHISHAN , PAMULA VAMSEE , SUDARSAN ARJUN , SRINIVASAN VIJAY , THWAR PRASANNA , SHENDEROV ALEXANDER , ALLEN DWAYNE
IPC分类号： G01N27/26
CPC分类号： B01L3/0282 , B01F13/002 , B01F13/0023 , B01F13/0071 , B01F13/0076 , B01F13/0818 , B01L3/502753 , B01L2200/0621 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2200/141 , B01L2300/0832 , B01L2300/0864 , B01L2300/0867 , B01L2400/043 , B03C1/01 , B03C1/284 , B03C1/286 , B03C2201/18 , B03C2201/26 , B03C2201/28 , Y10T436/25
摘要： Methods of concentrating beads in a droplet and/or loading beads on a fluidic device are provided, including among other things, a method of concentrating beads in a droplet, the method comprising: (a) providing a droplet actuator comprising: (i) an interior droplet operations volume; and (ii) a reservoir exterior to the interior volume; (iii) a droplet established in a liquid path extending from the reservoir into the interior volume; (b) providing magnetically responsive beads in the portion of the droplet which is in the reservoir; (c) magnetically attracting the magnetically responsive beads through the liquid path into the portion of the droplet which is in the interior volume; and (d) forming a droplet comprising one or more of the magnetically responsive beads in the interior volume.
摘要翻译：提供了将珠子集中在流体装置上的液滴和/或负载珠粒中的方法，其中包括将珠粒集中在液滴中的方法，所述方法包括：（a）提供液滴致动器，其包括：（i）内部液滴操作量; 和（ii）内部容积外部的储存器; （iii）建立在从储存器延伸到内部容积中的液体路径中的液滴; （b）在储存器中的液滴的部分中提供磁响应珠; （c）通过所述液体路径将所述磁响应珠磁吸引到位于所述内部容积中的所述液滴的所述部分中; 和（d）在内部容积中形成包含一个或多个磁响应珠的液滴。

3. 发明申请

WO2009140373A2 DROPLET ACTUATOR DEVICES, SYSTEMS, AND METHODS 审中-公开
标题翻译： DROPLET执行器装置，系统和方法
公开(公告)号：WO2009140373A2
公开(公告)日：2009-11-19
申请号：PCT/US2009043774
申请日：2009-05-13
申请人： ADVANCED LIQUID LOGIC INC , POLLACK MICHAEL , HUA ZHISHAN , ECKHARDT ALLEN , THWAR PRASANNA , SRINIVASAN VIJAY , PAMULA VAMSEE
发明人： POLLACK MICHAEL , HUA ZHISHAN , ECKHARDT ALLEN , THWAR PRASANNA , SRINIVASAN VIJAY , PAMULA VAMSEE
IPC分类号： G01N27/26 , B41J2/01 , C12Q1/68
CPC分类号： B01L3/502792 , B01L3/502753 , B01L3/502761 , B01L7/525 , B01L2200/10 , B01L2300/0816 , B01L2300/089 , B01L2400/0427 , B01L2400/043 , C12Q1/6848 , C12Q2565/629
摘要： The invention relates to certain novel approaches to reducing or eliminating the movement of contaminants from one droplet to another on a droplet actuator via liquid filler fluid. In one application, droplet actuators are used to conduct genetic analysis using polymerase chain reaction (PCR) techniques. The invention addresses the need for improved methods of performing PCR on a droplet actuator that provide for optimum amplification and detection of a sample target.
摘要翻译：本发明涉及在液滴致动器上通过液体填充液减少或消除污染物从一个液滴到另一个液滴的移动的某些新颖方法。在一个应用中，液滴致动器用于使用聚合酶链反应（PCR）技术进行遗传分析。本发明解决了对提供样品靶的最佳放大和检测的在液滴致动器上执行PCR的改进方法的需求。

4. 发明申请

WO2011002957A3 DROPLET ACTUATOR DEVICES AND METHODS 审中-公开
标题翻译：液滴驱动器装置和方法
公开(公告)号：WO2011002957A3
公开(公告)日：2011-08-04
申请号：PCT/US2010040705
申请日：2010-07-01
申请人： ADVANCED LIQUID LOGIC INC , POLLACK MICHAEL G , SRINIVASAN VIJAY , PAMULA VAMSEE K , BRACKETT GEORGE , BRAFFORD KEITH R , CLARK DARIUS , HUA ZHISHAN , NORTON SCOTT , SISTA RAMAKRISHNA , SMITH GREGORY F , STURMER RYAN A , SUDARSAN ARJUN , THWAR PRASANNA , WANG TIH-HONG , WINGER THEODORE
发明人： POLLACK MICHAEL G , SRINIVASAN VIJAY , PAMULA VAMSEE K , BRACKETT GEORGE , BRAFFORD KEITH R , CLARK DARIUS , HUA ZHISHAN , NORTON SCOTT , SISTA RAMAKRISHNA , SMITH GREGORY F , STURMER RYAN A , SUDARSAN ARJUN , THWAR PRASANNA , WANG TIH-HONG , WINGER THEODORE
IPC分类号： B41J2/06 , B41J2/175 , B41J29/38
CPC分类号： B01L3/502707 , B01F13/0071 , B01F13/0076 , B01L3/0241 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L3/502792 , B01L2200/0673 , B01L2200/0689 , B01L2300/0819 , B01L2300/0861 , B01L2300/087 , B01L2300/0874 , B01L2300/088 , B01L2300/0883 , B01L2400/0415 , B01L2400/0427 , B01L2400/0442 , B01L2400/0457 , B01L2400/0469 , B01L2400/0622 , B01L2400/0688 , B01L2400/088
摘要： The invention provides droplet actuator devices for facilitating certain droplet actuated molecular techniques. In one embodiment, the invention provides droplet actuators that facilitate droplet operations in three dimensions. In another embodiment, the invention provides for cost-effective production of droplet actuators. In another embodiment, the invention provides for replacing one or more components of a droplet actuator. In another embodiment, the invention provides droplet actuators using printed conductive inks to form electrodes and/or ground planes. In another embodiment, the invention provides a magnetic clamping fixture for assembling droplet actuators. In another embodiment, the invention provides simple, low cost power sources for use in combination with microfluidic systems. In another embodiment, the invention provides an immunoassay multiplexing platform that uses digital microfluidics and real-time imaging of flash-based chemiluminescent signals. In still another embodiment, the invention provides droplet actuator devices that are fabricated using a plasma treatment process to raise substrate surface energy.
摘要翻译：本发明提供了用于促进某些液滴致动分子技术的液滴致动器装置。在一个实施例中，本发明提供了促进三维液滴操作的液滴致动器。在另一个实施例中，本发明提供了液滴致动器的成本有效的生产。在另一个实施例中，本发明提供了替换液滴致动器的一个或多个部件。在另一个实施例中，本发明提供使用印刷导电油墨形成电极和/或接地平面的液滴致动器。在另一个实施例中，本发明提供了一种用于组装液滴致动器的磁性夹具。在另一个实施例中，本发明提供了与微流体系统结合使用的简单，低成本的电源。在另一个实施方案中，本发明提供了使用数字微流体和基于闪光的化学发光信号的实时成像的免疫测定多路复用平台。在又一个实施例中，本发明提供了使用等离子体处理工艺制造以提高衬底表面能量的液滴致动器装置。

5. 发明申请

WO2007120241A3 DROPLET-BASED BIOCHEMISTRY 审中-公开
标题翻译：基于滴灌的生物化学
公开(公告)号：WO2007120241A3
公开(公告)日：2008-08-28
申请号：PCT/US2006047486
申请日：2006-12-11
申请人： ADVANCED LIQUID LOGIC INC , UNIV DUKE , POLLACK MICHAEL G , PAMULA VAMSEE K , SRINIVASAN VIJAY , PAIK PHILIP Y , ECKHARDT ALLEN E , FAIR RICHARD B
发明人： POLLACK MICHAEL G , PAMULA VAMSEE K , SRINIVASAN VIJAY , PAIK PHILIP Y , ECKHARDT ALLEN E , FAIR RICHARD B
IPC分类号： C07K1/26 , B41J2/01 , C12M1/34 , C12Q1/68 , G01N27/26
CPC分类号： B01L3/502792 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0448 , C12Q1/6869 , G01N33/49 , C12Q2565/629 , C12Q2565/301
摘要： The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using discrete droplets. The invention includes a droplet microactuator or droplet microactuator system having one or more input reservoirs loaded with reagents for conducting biochemical reactions, such as the reagents described for use in nucleic acid amplification protocols, affinity-based assay protocols, sequencing protocols, and protocols for analyses of biological fluids.
摘要翻译：液滴微致动器技术领域本发明涉及液滴微致动器以及采用液滴微致动器来使用离散液滴执行各种协议的系统，装置和方法。本发明包括具有负载用于进行生物化学反应的试剂的一个或多个输入储存器的液滴微致动器或液滴微致动器系统，例如用于核酸扩增方案的所述试剂，基于亲和性的测定方案，测序方案和用于分析的方案的生物液体。

6. 发明申请

WO2009021173A9 USE OF ADDITIVES FOR ENHANCING DROPLET OPERATIONS 审中-公开
标题翻译：使用添加剂来增加滴灌操作
公开(公告)号：WO2009021173A9
公开(公告)日：2009-04-16
申请号：PCT/US2008072604
申请日：2008-08-08
申请人： ADVANCED LIQUID LOGIC INC , POLLACK MICHAEL , ALLEN DWAYNE , SRINIVASAN VIJAY , PAMULA VAMSEE
发明人： POLLACK MICHAEL , ALLEN DWAYNE , SRINIVASAN VIJAY , PAMULA VAMSEE
IPC分类号： B01J19/08 , B01L3/02 , G01N35/00
CPC分类号： B01L3/502792 , B01L2200/141 , B01L2300/0645 , B01L2400/0415 , G01N2035/00277
摘要： The invention relates to a droplet actuator with a substrate comprising electrodes arranged for conducting droplet operations on a droplet operations surface of the substrate; a filler fluid phase in contact with the droplet operations surface at least partially surrounding a droplet phase comprising a droplet arranged on one or more of the electrodes, the droplet comprising: (i) a target substance susceptible to loss from the droplet phase into the filler fluid phase; and (ii) an additive which reduces loss of the target substance to the filler fluid phase relative to a corresponding droplet not comprising the additive. The invention also relates to various compositions and methods.
摘要翻译：本发明涉及一种液滴致动器，其具有包括布置用于在基板的液滴操作表面上进行液滴操作的电极的基板; 与液滴操作表面接触的填充流体相，至少部分地围绕包含布置在一个或多个电极上的液滴的液滴相，所述液滴包括：（i）易受从液滴相流入填料的目标物质流体相; 和（ii）相对于不包含添加剂的相应液滴，减少目标物质对填料流体相的损失的添加剂。本发明还涉及各种组合物和方法。

7. 发明申请

WO2011020011A3 DROPLET ACTUATOR AND DROPLET-BASED TECHNIQUES 审中-公开
标题翻译： DROPLET执行器和基于DROPLET的技术
公开(公告)号：WO2011020011A3
公开(公告)日：2011-06-16
申请号：PCT/US2010045461
申请日：2010-08-13
申请人： ADVANCED LIQUID LOGIC INC , POLLACK MICHAEL G , SRINIVASAN VIJAY , ECKHARDT ALLEN E , THWAR PRASANNA , HUA ZHISHAN , SUDARSAN ARJUN , WINGER THEODORE
发明人： POLLACK MICHAEL G , SRINIVASAN VIJAY , ECKHARDT ALLEN E , THWAR PRASANNA , HUA ZHISHAN , SUDARSAN ARJUN , WINGER THEODORE
IPC分类号： C12Q1/68 , G01N33/50 , G01N35/00
CPC分类号： G01N27/447 , B01L3/502761 , B01L3/502792 , B01L7/52 , B01L2200/0668 , B01L2300/0819 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2400/0427 , B01L2400/043 , C12Q1/686 , G01N33/54326 , G01N2035/00425 , G01N2035/1058 , G01N2035/1062 , C12Q2549/101 , C12Q2527/15 , C12Q2527/107 , C12Q2561/113
摘要： The invention is directed to certain droplet actuated molecular techniques. In one embodiment, the invention provides droplet actuator methods for detection of single nucleotide polymorphisms (SNPs) in a DNA sequence using digital microfluidics, including droplet actuator-based sample preparation and SNP analysis. In another embodiment, the invention provides droplet actuator devices and methods for providing integrated sample preparation and multiplexed detection of an infectious agent, such as HIV. In yet another embodiment, the invention provides droplet actuator devices and techniques for PCR amplification and detection of specific nucleic acid sequences using digital microfluidics, including droplet actuator-based sample preparation and target nucleic acid analysis. In yet another embodiment the invention provides methods for performing hot-start PCR on a droplet actuator. In yet another embodiment, the method of the invention combines PCR amplification with pyrosequencing to investigate specific sequences.
摘要翻译：本发明涉及某些液滴致动分子技术。在一个实施方案中，本发明提供用于使用数字微流体检测DNA序列中的单核苷酸多态性（SNP）的液滴致动器方法，包括基于液滴致动器的样品制备和SNP分析。在另一个实施方案中，本发明提供了液滴致动器装置和用于提供综合样品制备和多重检测感染因子如HIV的方法。在另一个实施方案中，本发明提供了使用数字微流体（包括基于液滴致动器的样品制备和靶核酸分析）的PCR扩增和检测特异性核酸序列的液滴致动器装置和技术。在另一个实施方案中，本发明提供了在液滴致动器上进行热启动PCR的方法。在另一个实施方案中，本发明的方法将PCR扩增与焦磷酸测序结合以研究特异性序列。

8. 发明申请

WO2010077859A3 NUCLEIC ACID AMPLIFICATION AND SEQUENCING ON A DROPLET ACTUATOR 审中-公开
标题翻译：核酸激活剂的核酸扩增和测序
公开(公告)号：WO2010077859A3
公开(公告)日：2011-01-20
申请号：PCT/US2009068040
申请日：2009-12-15
申请人： ADVANCED LIQUID LOGIC INC , THWAR PRASANNA , POLLACK MICHAEL , ECKHARDT ALLEN , SRINIVASAN VIJAY
发明人： THWAR PRASANNA , POLLACK MICHAEL , ECKHARDT ALLEN , SRINIVASAN VIJAY
IPC分类号： C12Q1/68 , C12M1/00 , C12Q1/24 , G01N35/10
CPC分类号： B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L7/525 , B01L2200/10 , B01L2200/143 , B01L2300/0816 , B01L2300/0838 , B01L2400/0427 , B01L2400/043 , B01L2400/0644 , C12Q1/6869 , C12Q2565/301 , C12Q2565/626
摘要： The invention provides a droplet actuator device, as well as systems, methods and devices making use of the droplet actuator device. The droplet actuator device may include a substrate having electrodes arranged for conducting one or more droplet operations. The droplet actuator device may include a substrate having a reactor path with a wash region associated with a magnet for immobilizing beads during bead washing operations. The droplet actuator device may include nucleotide base reservoirs and dedicated nucleotide base electrode paths arranged for transporting nucleotide base droplets from nucleotide base reservoirs to the reactor path. The droplet actuator device may include one or more wash buffer reservoirs associated with electrode paths arranged for transporting wash buffer droplets from wash buffer reservoirs to the reactor path. The droplet actuator device may include one or more sample reservoirs and sample paths arranged for transporting sample droplets from the one or more sample reservoirs to the reactor path. The droplet actuator device may include one or more enzyme reservoirs and dedicated enzyme electrode paths arranged for transporting enzyme droplets from the one or more enzyme reservoirs to a detection electrode.
摘要翻译：本发明提供一种液滴致动器装置，以及利用液滴致动器装置的系统，方法和装置。液滴致动器装置可以包括具有布置用于进行一个或多个液滴操作的电极的基板。液滴致动器装置可以包括具有反应器路径的基底，具有与磁珠相关联的洗涤区域，用于在珠洗涤操作期间固定珠粒。液滴致动器装置可以包括核苷酸碱基储存器和专用核苷酸碱基电极路径，其设置用于将核苷酸碱基液滴从核苷酸碱基储存器输送到反应器路径。液滴致动器装置可以包括一个或多个洗涤缓冲液储存器，其与设置用于将洗涤缓冲液滴从洗涤缓冲液储存器运送到反应器路径的电极路径相关联。液滴致动器装置可以包括一个或多个样品储存器和样品路径，其被设置用于将样品液滴从一个或多个样品储存器输送到反应器路径。液滴致动器装置可以包括一个或多个酶储器和用于将酶液滴从一个或多个酶储存器输送到检测电极的专用酶电极路径。

9. 发明申请

WO2011106314A3 METHOD OF MAKING NUCLEIC ACID LIBRARIES 审中-公开
标题翻译：制备核酸图谱的方法
公开(公告)号：WO2011106314A3
公开(公告)日：2012-02-23
申请号：PCT/US2011025711
申请日：2011-02-22
申请人： ADVANCED LIQUID LOGIC INC , POLLACK MICHAEL G , ECKHARDT ALLEN E , SUDARSAN ARJUN , SRINIVASAN VIJAY , ROUSE JEREMY , YI UICHONG , TROTTA NICHOLAS , DHOPESHWARKAR RAHUL , THWAR PRASANNA , SMITH GREGORY F , NORTON SCOTT , LINNARTZ PETER
发明人： POLLACK MICHAEL G , ECKHARDT ALLEN E , SUDARSAN ARJUN , SRINIVASAN VIJAY , ROUSE JEREMY , YI UICHONG , TROTTA NICHOLAS , DHOPESHWARKAR RAHUL , THWAR PRASANNA , SMITH GREGORY F , NORTON SCOTT , LINNARTZ PETER
IPC分类号： C12N15/10 , C07H21/00 , C12Q1/68 , C40B40/06 , C40B50/08
CPC分类号： C12N15/1075 , B01J19/0046 , C12N15/1006 , C40B40/08 , C40B50/06
摘要： A method of preparing a nucleic acid library in droplets in contact with oil, including: (a) blunt-ending nucleic acid fragments in a droplet in the oil to yield blunt-ended nucleic acid fragments; (b) phosphorylating the blunt-ended nucleic acid fragments in a droplet in the oil to yield phosphorylated nucleic acid fragments; coupling A-tails to the phosphorylated nucleic acid fragments in a droplet in the oil to yield A-tailed nucleic acid fragments; and (d) coupling nucleic acid adapters to the A-tailed nucleic acid fragments in a droplet in the oil to yield the nucleic acid library comprising adapter-ligated nucleic acid fragments.
摘要翻译：制备与油接触的液滴核酸文库的方法，包括：（a）在油中的液滴中的平端核酸片段以产生平端核酸片段; （b）使油中的液滴中的平端核酸片段磷酸化以产生磷酸化的核酸片段; 将A尾连接到油中的液滴中的磷酸化核酸片段以产生A尾核酸片段; 和（d）将核酸衔接子偶联到油中的液滴中的A尾核酸片段，以产生包含衔接子连接的核酸片段的核酸文库。

10. 发明申请

WO2009052348A3 MANIPULATION OF BEADS IN DROPLETS 审中-公开
标题翻译：。OF。。。。。。。。。。。
公开(公告)号：WO2009052348A3
公开(公告)日：2009-07-30
申请号：PCT/US2008080264
申请日：2008-10-17
申请人： ADVANCED LIQUID LOGIC INC , ECKHARDT ALLEN , SISTA RAMAKRISHNAN , PAMULA VAMSEE , SRINIVASAN VIJAY , POLLACK MICHAEL
发明人： SISTA RAMAKRISHNAN , PAMULA VAMSEE , SRINIVASAN VIJAY , POLLACK MICHAEL
IPC分类号： G01N27/26 , B01J19/08
CPC分类号： B01L3/502792 , B01J2219/00466 , B01J2219/005 , B01J2219/00596 , B01J2219/00648 , B01J2219/00655 , B01J2219/00659 , B01L2200/0647 , B01L2200/0668 , B01L2300/0816 , B01L2300/089 , B01L2400/043
摘要： The invention provides a method of dispersing or circulating magnetically responsive beads within a droplet in a droplet actuator. The invention, in one embodiment, makes use of a droplet actuator with a plurality of droplet operations electrodes configured to transport the droplet, and a magnet field present at a portion of the plurality of droplet operations electrodes. A bead bead-containing droplet is provided on the droplet actuator in the presence of the uniform magnetic field. Beads are circulated in the droplet during incubation by conducting droplet operations on the droplet within a uniform region of the magnetic field. Other embodiments are also provided.
摘要翻译：本发明提供了一种在液滴致动器中的液滴内分散或循环磁响应珠的方法。在一个实施例中，本发明利用具有配置成输送液滴的多个液滴操作电极的液滴致动器和存在于多个液滴操作电极的一部分的磁场。在存在均匀磁场的情况下，在液滴致动器上设置有珠珠容纳液滴。在孵育期间，通过在磁场的均匀区域内的液滴上进行液滴操作，珠子在液滴中循环。还提供了其他实施例。

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