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1. 发明申请

WO2011002957A3 DROPLET ACTUATOR DEVICES AND METHODS 审中-公开
标题翻译：液滴驱动器装置和方法
公开(公告)号：WO2011002957A3
公开(公告)日：2011-08-04
申请号：PCT/US2010040705
申请日：2010-07-01
申请人： ADVANCED LIQUID LOGIC INC , POLLACK MICHAEL G , SRINIVASAN VIJAY , PAMULA VAMSEE K , BRACKETT GEORGE , BRAFFORD KEITH R , CLARK DARIUS , HUA ZHISHAN , NORTON SCOTT , SISTA RAMAKRISHNA , SMITH GREGORY F , STURMER RYAN A , SUDARSAN ARJUN , THWAR PRASANNA , WANG TIH-HONG , WINGER THEODORE
发明人： POLLACK MICHAEL G , SRINIVASAN VIJAY , PAMULA VAMSEE K , BRACKETT GEORGE , BRAFFORD KEITH R , CLARK DARIUS , HUA ZHISHAN , NORTON SCOTT , SISTA RAMAKRISHNA , SMITH GREGORY F , STURMER RYAN A , SUDARSAN ARJUN , THWAR PRASANNA , WANG TIH-HONG , WINGER THEODORE
IPC分类号： B41J2/06 , B41J2/175 , B41J29/38
CPC分类号： B01L3/502707 , B01F13/0071 , B01F13/0076 , B01L3/0241 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L3/502792 , B01L2200/0673 , B01L2200/0689 , B01L2300/0819 , B01L2300/0861 , B01L2300/087 , B01L2300/0874 , B01L2300/088 , B01L2300/0883 , B01L2400/0415 , B01L2400/0427 , B01L2400/0442 , B01L2400/0457 , B01L2400/0469 , B01L2400/0622 , B01L2400/0688 , B01L2400/088
摘要： The invention provides droplet actuator devices for facilitating certain droplet actuated molecular techniques. In one embodiment, the invention provides droplet actuators that facilitate droplet operations in three dimensions. In another embodiment, the invention provides for cost-effective production of droplet actuators. In another embodiment, the invention provides for replacing one or more components of a droplet actuator. In another embodiment, the invention provides droplet actuators using printed conductive inks to form electrodes and/or ground planes. In another embodiment, the invention provides a magnetic clamping fixture for assembling droplet actuators. In another embodiment, the invention provides simple, low cost power sources for use in combination with microfluidic systems. In another embodiment, the invention provides an immunoassay multiplexing platform that uses digital microfluidics and real-time imaging of flash-based chemiluminescent signals. In still another embodiment, the invention provides droplet actuator devices that are fabricated using a plasma treatment process to raise substrate surface energy.
摘要翻译：本发明提供了用于促进某些液滴致动分子技术的液滴致动器装置。在一个实施例中，本发明提供了促进三维液滴操作的液滴致动器。在另一个实施例中，本发明提供了液滴致动器的成本有效的生产。在另一个实施例中，本发明提供了替换液滴致动器的一个或多个部件。在另一个实施例中，本发明提供使用印刷导电油墨形成电极和/或接地平面的液滴致动器。在另一个实施例中，本发明提供了一种用于组装液滴致动器的磁性夹具。在另一个实施例中，本发明提供了与微流体系统结合使用的简单，低成本的电源。在另一个实施方案中，本发明提供了使用数字微流体和基于闪光的化学发光信号的实时成像的免疫测定多路复用平台。在又一个实施例中，本发明提供了使用等离子体处理工艺制造以提高衬底表面能量的液滴致动器装置。

2. 发明申请

WO2010006166A3 BEAD MANIPULATION TECHNIQUES 审中-公开
标题翻译： BEAD操作技术
公开(公告)号：WO2010006166A3
公开(公告)日：2010-04-29
申请号：PCT/US2009050101
申请日：2009-07-09
申请人： ADVANCED LIQUID LOGIC INC , PAMULA VAMSEE , THWAR PRASANNA , SUDARSAN ARJUN , SISTA RAMAKRISHNA , SULLIVAN MICHAEL , NORTON SCOTT
发明人： PAMULA VAMSEE , THWAR PRASANNA , SUDARSAN ARJUN , SISTA RAMAKRISHNA , SULLIVAN MICHAEL , NORTON SCOTT
IPC分类号： G01N33/543 , G01N27/00
CPC分类号： B03C5/028 , B03C5/005
摘要： The invention provides a method of redistributing magnetically responsive beads in a droplet. The method may include providing a droplet including magnetically responsive beads. The droplet may be provided within a region of a magnetic field having sufficient strength to attract the magnetically responsive beads to an edge of the droplet or towards an edge of the droplet, or otherwise regionalize or aggregate beads within the droplet. The method may also include conducting on a droplet operations surface one or more droplet operations using the droplet without removing the magnetically responsive beads from the region of the magnetic field. The droplet operations may in some cases be electrode -mediated. The droplet operations may redistribute and/or circulate the magnetically responsive beads within the droplet. In some cases, the droplet may include a sample droplet may include a target analyte. The redistributing of the magnetically responsive beads may cause target analyte to bind to the magnetically responsive beads. In some cases, the droplet may include unbound substances in a wash buffer. The redistributing of the magnetically responsive beads causes unbound substances to be freed from interstices of an aggregated set or subset of the magnetically responsive beads.
摘要翻译：本发明提供了在液滴中重新分布磁响应珠的方法。该方法可以包括提供包括磁响应珠的液滴。可以在具有足够强度的磁场的区域内提供液滴，以将磁响应珠吸引到液滴的边缘或朝向液滴的边缘，或以其他方式使液滴区域化或聚集在液滴内。该方法还可以包括使用液滴在液滴操作表面上进行一个或多个液滴操作，而不从磁场的区域移除磁响应珠。液滴操作在某些情况下可能是电极介导的。液滴操作可以重新分配和/或循环液滴内的磁响应珠。在一些情况下，液滴可以包括样品液滴可以包括目标分析物。磁响应珠粒的重新分布可以使目标分析物结合到磁响应珠粒上。在一些情况下，液滴可以包含洗涤缓冲液中的未结合物质。磁响应珠粒的重新分布导致未结合的物质从磁性响应珠粒的聚集组或亚组的空隙释放。

3. 发明申请

WO2008014223A3 ASSAY PARTICLE CONCENTRATION AND IMAGING APPARATUS AND METHOD 审中-公开
标题翻译：测定颗粒浓度和成像装置及方法
公开(公告)号：WO2008014223A3
公开(公告)日：2008-04-03
申请号：PCT/US2007074161
申请日：2007-07-24
申请人： OXONICA INC , NORTON SCOTT M , HOLLAND EDWARD ROBERT , WALTON IAN D , CROMER REMY , STOERMER REBECCA LOUISE
发明人： NORTON SCOTT M , HOLLAND EDWARD ROBERT , WALTON IAN D , CROMER REMY , STOERMER REBECCA LOUISE
IPC分类号： G01J3/00 , G01J3/44
CPC分类号： G01N21/658 , B01L3/5082 , B82Y15/00 , B82Y25/00 , G01N1/40 , G01N35/0098 , G01N2015/0092 , G01N2021/651 , G01N2035/00524
摘要： An assay apparatus having a sample vessel within which an assay may be performed. The apparatus further includes a holder having a receptacle, socket or other device configured to operatively receive the sample vessel in a precise and easily repeated location with respect to the holder. A magnet may be operatively associated with the holder such that a magnetic field generated by the magnet intersects a portion of the sample vessel defining a magnetic concentration region within the sample vessel. A separate or integrated detection or interrogation instrument, typically a spectrometer, may be provided.
摘要翻译：一种具有其中可以进行测定的样品容器的测定装置。该装置还包括具有容器，插座或其他装置的保持器，其被构造成相对于保持器以精确且容易重复的位置操作地接收样品容器。磁体可以与保持器可操作地相关联，使得由磁体产生的磁场与在样品容器内限定磁性浓度区域的样品容器的一部分相交。可以提供单独的或集成的检测或询问仪器，通常是光谱仪。

4. 发明申请

WO2001026038A1 METHODS OF IMAGING COLLOIDAL ROD PARTICLES AS NANOBAR CODES 审中-公开
标题翻译：将胶体颗粒作为纳豆代谢物的成像方法
公开(公告)号：WO2001026038A1
公开(公告)日：2001-04-12
申请号：PCT/US2000/027121
申请日：2000-10-02
申请人： THE PENN STATE RESEARCH FOUNDATION , SURROMED, INC. , NATAN, Michael, J. , WALTON, Ian , DIETZ, Louis, J. , NORTON, Scott , KEATING, Christine, D.
发明人： NATAN, Michael, J. , WALTON, Ian , DIETZ, Louis, J. , NORTON, Scott , KEATING, Christine, D.
IPC分类号： G06K9/00
CPC分类号： G06K9/3233 , B01J13/0047 , B01J13/0091 , B01J19/0046 , B01J2219/005 , B01J2219/00502 , B01J2219/00513 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00596 , B01J2219/00657 , B01J2219/0072 , B01J2219/00722 , B01L3/545 , B22F1/004 , B22F2999/00 , B82B1/00 , B82Y25/00 , B82Y30/00 , C25D1/04 , C40B40/06 , C40B70/00 , G01N33/54346 , H01F1/0081 , B22F2207/01
摘要： Methods for imaging colloidal rod particles as nanobar codes is described in which imaging or reading free-standing particles comprising a plurality of segments of length from 10 nm to 50 μm and width from 5 nm to 50 μm is performed. The segments of particles may be comprised of any material including metal, allow, a metal allow, a metal nitride, a metal chalcogenide, a metal oxide, a metal sulfide, a metal selenide, a metal telluride, polymeric materials, crystalline or non-crystalline materials.
摘要翻译：描述了将胶体棒粒子作为纳米棒代码成像的方法，其中进行包括长度为10nm至50μm，宽度为5nm至50μm的多个片段的成像或读取独立粒子。颗粒的段可以由包括金属，允许金属允许金属氮化物，金属硫族化物，金属氧化物，金属硫化物，金属硒化物，金属碲化物，聚合物材料，结晶或非金属，结晶材料。

5. 发明申请

WO2011106314A2 METHOD OF MAKING NUCLEIC ACID LIBRARIES 审中-公开
标题翻译：制备核酸图谱的方法
公开(公告)号：WO2011106314A2
公开(公告)日：2011-09-01
申请号：PCT/US2011/025711
申请日：2011-02-22
申请人： ADVANCED LIQUID LOGIC, INC. , POLLACK, Michael, G. , ECKHARDT, Allen, E. , SUDARSAN, Arjun , SRINIVASAN, Vijay , ROUSE, Jeremy , YI, Uichong , TROTTA, Nicholas , DHOPESHWARKAR, Rahul , THWAR, Prasanna , SMITH, Gregory, F. , NORTON, Scott , LINNARTZ, Peter
发明人： POLLACK, Michael, G. , ECKHARDT, Allen, E. , SUDARSAN, Arjun , SRINIVASAN, Vijay , ROUSE, Jeremy , YI, Uichong , TROTTA, Nicholas , DHOPESHWARKAR, Rahul , THWAR, Prasanna , SMITH, Gregory, F. , NORTON, Scott , LINNARTZ, Peter
IPC分类号： C12N15/10 , C40B50/08 , C40B40/06 , C07H21/00 , C12Q1/68
CPC分类号： C12N15/1075 , B01J19/0046 , C12N15/1006 , C40B40/08 , C40B50/06
摘要： A method of preparing a nucleic acid library in droplets in contact with oil, including: (a) blunt-ending nucleic acid fragments in a droplet in the oil to yield blunt-ended nucleic acid fragments; (b) phosphorylating the blunt-ended nucleic acid fragments in a droplet in the oil to yield phosphorylated nucleic acid fragments; coupling A-tails to the phosphorylated nucleic acid fragments in a droplet in the oil to yield A-tailed nucleic acid fragments; and (d) coupling nucleic acid adapters to the A-tailed nucleic acid fragments in a droplet in the oil to yield the nucleic acid library comprising adapter-ligated nucleic acid fragments.
摘要翻译：制备与油接触的液滴核酸文库的方法，包括：（a）在油中的液滴中的平端核酸片段以产生平端核酸片段; （b）使油中的液滴中的平端核酸片段磷酸化以产生磷酸化的核酸片段; 将A尾连接到油中的液滴中的磷酸化核酸片段以产生A尾核酸片段; 和（d）将核酸衔接子偶联到油中的液滴中的A尾核酸片段，以产生包含衔接子连接的核酸片段的核酸文库。

6. 发明申请

WO2008014223A2 ASSAY PARTICLE CONCENTRATION AND IMAGING APPARATUS AND METHOD 审中-公开
标题翻译：测定颗粒浓度和成像装置及方法
公开(公告)号：WO2008014223A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/074161
申请日：2007-07-24
申请人： OXONICA, INC. , NORTON, Scott, M. , HOLLAND, Edward, Robert , WALTON, Ian, D. , CROMER, Remy , STOERMER, Rebecca, Louise
发明人： NORTON, Scott, M. , HOLLAND, Edward, Robert , WALTON, Ian, D. , CROMER, Remy , STOERMER, Rebecca, Louise
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , B01L3/5082 , B82Y15/00 , B82Y25/00 , G01N1/40 , G01N35/0098 , G01N2015/0092 , G01N2021/651 , G01N2035/00524
摘要： An assay apparatus having a sample vessel within which an assay may be performed. The apparatus further includes a holder having a receptacle, socket or other device configured to operatively receive the sample vessel in a precise and easily repeated location with respect to the holder. A magnet may be operatively associated with the holder such that a magnetic field generated by the magnet intersects a portion of the sample vessel defining a magnetic concentration region within the sample vessel. A separate or integrated detection or interrogation instrument, typically a spectrometer, may be provided.
摘要翻译：具有可在其中进行测定的样品器皿的测定装置。该设备进一步包括具有容器，插座或其它装置的保持器，该保持器被构造成在相对于保持器精确且容易重复的位置中可操作地接收样品器皿。磁体可以可操作地与保持器相关联，使得由磁体产生的磁场与限定样品器皿内的磁性集中区域的样品器皿的一部分相交。可以提供单独的或集成的检测或询问仪器，通常是光谱仪。

7. 发明申请

WO2011106314A3 METHOD OF MAKING NUCLEIC ACID LIBRARIES 审中-公开
标题翻译：制备核酸图谱的方法
公开(公告)号：WO2011106314A3
公开(公告)日：2012-02-23
申请号：PCT/US2011025711
申请日：2011-02-22
申请人： ADVANCED LIQUID LOGIC INC , POLLACK MICHAEL G , ECKHARDT ALLEN E , SUDARSAN ARJUN , SRINIVASAN VIJAY , ROUSE JEREMY , YI UICHONG , TROTTA NICHOLAS , DHOPESHWARKAR RAHUL , THWAR PRASANNA , SMITH GREGORY F , NORTON SCOTT , LINNARTZ PETER
发明人： POLLACK MICHAEL G , ECKHARDT ALLEN E , SUDARSAN ARJUN , SRINIVASAN VIJAY , ROUSE JEREMY , YI UICHONG , TROTTA NICHOLAS , DHOPESHWARKAR RAHUL , THWAR PRASANNA , SMITH GREGORY F , NORTON SCOTT , LINNARTZ PETER
IPC分类号： C12N15/10 , C07H21/00 , C12Q1/68 , C40B40/06 , C40B50/08
CPC分类号： C12N15/1075 , B01J19/0046 , C12N15/1006 , C40B40/08 , C40B50/06
摘要： A method of preparing a nucleic acid library in droplets in contact with oil, including: (a) blunt-ending nucleic acid fragments in a droplet in the oil to yield blunt-ended nucleic acid fragments; (b) phosphorylating the blunt-ended nucleic acid fragments in a droplet in the oil to yield phosphorylated nucleic acid fragments; coupling A-tails to the phosphorylated nucleic acid fragments in a droplet in the oil to yield A-tailed nucleic acid fragments; and (d) coupling nucleic acid adapters to the A-tailed nucleic acid fragments in a droplet in the oil to yield the nucleic acid library comprising adapter-ligated nucleic acid fragments.
摘要翻译：制备与油接触的液滴核酸文库的方法，包括：（a）在油中的液滴中的平端核酸片段以产生平端核酸片段; （b）使油中的液滴中的平端核酸片段磷酸化以产生磷酸化的核酸片段; 将A尾连接到油中的液滴中的磷酸化核酸片段以产生A尾核酸片段; 和（d）将核酸衔接子偶联到油中的液滴中的A尾核酸片段，以产生包含衔接子连接的核酸片段的核酸文库。

8. 发明申请

WO2006086008A3 NANOPARTICLES AS COVERT TAGGANTS IN CURRENCY, BANK NOTES, AND RELATED DOCUMENTS 审中-公开
标题翻译：纳税人作为货币，银行票据和相关文件中的标签
公开(公告)号：WO2006086008A3
公开(公告)日：2007-01-04
申请号：PCT/US2005028042
申请日：2005-08-05
申请人： NANOPLEX TECHNOLOGIES INC , NATAN MICHAEL J , NORTON SCOTT , FREEMAN RICHARD GRIFFITH , PENN SHARRON GAYNOR , WALTON IAN D
发明人： NATAN MICHAEL J , NORTON SCOTT , FREEMAN RICHARD GRIFFITH , PENN SHARRON GAYNOR , WALTON IAN D
IPC分类号： G06K9/74 , G01J3/44
CPC分类号： G06K9/00577 , G01J3/44 , G01N21/658 , G01N2201/129 , G07D7/1205
摘要： Methods for applying security tags and/or data to currency and other documents and systems for use are provided.
摘要翻译：提供了将安全标签和/或数据应用于货币和其他文件和系统以供使用的方法。

9. 发明申请

WO0126038A9 METHODS OF IMAGING COLLOIDAL ROD PARTICLES AS NANOBAR CODES 审中-公开
标题翻译：将胶体颗粒作为纳豆代谢物的成像方法
公开(公告)号：WO0126038A9
公开(公告)日：2002-10-03
申请号：PCT/US0027121
申请日：2000-10-02
申请人： PENN STATE RES FOUND , SURROMED INC , NATAN MICHAEL J , WALTON IAN , DIETZ LOUIS J , NORTON SCOTT , KEATING CHRISTINE D
发明人： NATAN MICHAEL J , WALTON IAN , DIETZ LOUIS J , NORTON SCOTT , KEATING CHRISTINE D
IPC分类号： G01N27/62 , B01J13/00 , B01J19/00 , B01L3/00 , B22F1/00 , B82B1/00 , C25D1/04 , C40B40/06 , C40B70/00 , G01N13/10 , G01N21/47 , G01N21/64 , G01N33/543 , G06K7/00 , G06K9/32 , G06K19/06 , G06T1/00 , G06T7/00 , H01F1/00 , G06K9/00
CPC分类号： G06K9/3233 , B01J13/0047 , B01J13/0091 , B01J19/0046 , B01J2219/005 , B01J2219/00502 , B01J2219/00513 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00596 , B01J2219/00657 , B01J2219/0072 , B01J2219/00722 , B01L3/545 , B22F1/004 , B22F2999/00 , B82B1/00 , B82Y25/00 , B82Y30/00 , C25D1/04 , C40B40/06 , C40B70/00 , G01N33/54346 , H01F1/0081 , B22F2207/01
摘要： Methods for imaging colloidal rod particles as nanobar codes is described in which imaging or reading free-standing particles comprising a plurality of segments of length from 10 nm to 50 mu m and width from 5 nm to 50 mu m is performed. The segments of particles may be comprised of any material including metal, allow, a metal allow, a metal nitride, a metal chalcogenide, a metal oxide, a metal sulfide, a metal selenide, a metal telluride, polymeric materials, crystalline or non-crystalline materials.
摘要翻译：描述了将胶体棒粒子作为纳米棒代码成像的方法，其中进行包括长度为10nm至50μm，宽度为5nm至50μm的多个片段的成像或读取独立粒子。颗粒的段可以由包括金属，允许金属允许金属氮化物，金属硫族化物，金属氧化物，金属硫化物，金属硒化物，金属碲化物，聚合物材料，结晶或非金属，结晶材料。

10. 发明申请

WO2011002957A2 DROPLET ACTUATOR DEVICES AND METHODS 审中-公开
标题翻译： DROPLET执行器装置和方法
公开(公告)号：WO2011002957A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040705
申请日：2010-07-01
申请人： ADVANCED LIQUID LOGIC, INC. , POLLACK, Michael G. , SRINIVASAN, Vijay , PAMULA, Vamsee K. , BRACKETT, George , BRAFFORD, Keith R. , CLARK, Darius , HUA, Zhishan , NORTON, Scott , SISTA, Ramakrishna , SMITH, Gregory F. , STURMER, Ryan A. , SUDARSAN, Arjun , THWAR, Prasanna , WANG, Tih-Hong , WINGER, Theodore
发明人： POLLACK, Michael G. , SRINIVASAN, Vijay , PAMULA, Vamsee K. , BRACKETT, George , BRAFFORD, Keith R. , CLARK, Darius , HUA, Zhishan , NORTON, Scott , SISTA, Ramakrishna , SMITH, Gregory F. , STURMER, Ryan A. , SUDARSAN, Arjun , THWAR, Prasanna , WANG, Tih-Hong , WINGER, Theodore
IPC分类号： B41J2/06 , B41J2/175 , B41J29/38
CPC分类号： B01L3/502707 , B01F13/0071 , B01F13/0076 , B01L3/0241 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L3/502792 , B01L2200/0673 , B01L2200/0689 , B01L2300/0819 , B01L2300/0861 , B01L2300/087 , B01L2300/0874 , B01L2300/088 , B01L2300/0883 , B01L2400/0415 , B01L2400/0427 , B01L2400/0442 , B01L2400/0457 , B01L2400/0469 , B01L2400/0622 , B01L2400/0688 , B01L2400/088
摘要： The invention provides droplet actuator devices for facilitating certain droplet actuated molecular techniques. In one embodiment, the invention provides droplet actuators that facilitate droplet operations in three dimensions. In another embodiment, the invention provides for cost-effective production of droplet actuators. In another embodiment, the invention provides for replacing one or more components of a droplet actuator. In another embodiment, the invention provides droplet actuators using printed conductive inks to form electrodes and/or ground planes. In another embodiment, the invention provides a magnetic clamping fixture for assembling droplet actuators. In another embodiment, the invention provides simple, low cost power sources for use in combination with microfluidic systems. In another embodiment, the invention provides an immunoassay multiplexing platform that uses digital microfluidics and real-time imaging of flash-based chemiluminescent signals. In still another embodiment, the invention provides droplet actuator devices that are fabricated using a plasma treatment process to raise substrate surface energy.
摘要翻译：本发明提供了用于促进某些液滴致动分子技术的液滴致动器装置。在一个实施例中，本发明提供了有助于三维液滴操作的液滴致动器。在另一个实施例中，本发明提供了液滴致动器的成本有效的生产。在另一个实施例中，本发明提供了替换液滴致动器的一个或多个部件。在另一个实施例中，本发明提供使用印刷导电油墨形成电极和/或接地平面的液滴致动器。在另一个实施例中，本发明提供一种用于组装液滴致动器的磁性夹紧夹具。在另一个实施例中，本发明提供了用于与微流体系统组合使用的简单的低成本电源。在另一个实施方案中，本发明提供了使用数字微流体和基于闪光的化学发光信号的实时成像的免疫测定多路复用平台。在另一个实施例中，本发明提供使用等离子体处理工艺制造以提高衬底表面能的液滴致动器装置。

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