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1. 发明申请

WO2010013035A1 METHOD AND PRODUCT 审中-公开
标题翻译：方法和产品
公开(公告)号：WO2010013035A1
公开(公告)日：2010-02-04
申请号：PCT/GB2009/050924
申请日：2009-07-27
申请人： UNIVERSITY OF BRADFORD , PARADKAR, Anant , KELLY, Adrian , COATES, Phil , YORK, Peter
发明人： PARADKAR, Anant , KELLY, Adrian , COATES, Phil , YORK, Peter
IPC分类号： B01D9/00 , A61K9/14 , A61K9/16 , A61K9/20
CPC分类号： B01D9/005 , A61K31/192 , A61K31/445 , A61K31/55 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method of producing a co-crystal, the method comprising the steps of, providing a first substance and a second substance, wherein the first and second substances are compatible to form a co-crystal, mixing said first and second substances together, and exposing the mixture of said first and second substances to prolonged and sustained conditions of pressure and shear, sufficient to form a co-crystal of said first and second substance.The prolonged and sustained conditions of pressure and shear are preferably applied in an extrusion process. Associated compositions and uses thereof are also provided.
摘要翻译：本发明提供一种共晶体的制造方法，该方法包括以下步骤：提供第一物质和第二物质，其中第一和第二物质相容以形成共晶体，将所述第一和第二物质一起并将所述第一和第二物质的混合物暴露于足以形成所述第一和第二物质的共晶体的持续和持续的压力和剪切条件下。压力和剪切的延长和持续条件优选地应用于挤压工艺。还提供了相关组合物及其用途。

2. 发明申请

WO0238127A3 PARTICLE FORMATION METHODS AND THEIR PRODUCTS 审中-公开
标题翻译：颗粒形成方法及其产品
公开(公告)号：WO0238127A3
公开(公告)日：2003-01-09
申请号：PCT/GB0104873
申请日：2001-11-01
申请人： BRADFORD PARTICLE DESIGN LTD , HANNA MAZEN HERMIZ , YORK PETER
发明人： HANNA MAZEN HERMIZ , YORK PETER
IPC分类号： A23L1/00 , A23L1/015 , A61J3/02 , A61K9/16 , A61K9/50 , A61K9/52 , A61K31/49 , A61K47/30 , A61P33/06 , B01J3/00 , B01J19/00
CPC分类号： A23L5/30 , A23L1/0029 , A23P10/30 , A23V2002/00 , A61K9/00 , A61K9/14 , A61K9/1652 , A61K9/167 , A61K9/1694 , B01D9/0054
摘要： Preparation of particles of an active substance having a layer ofan additive at the particle surfaces, by dissolving both the active substance and the additive in a vehicle to form a target solution, and contacting the target solution with an anti-solvent fluid using a SEDS particle formation process, to cause the active substance and additive to coprecipitate. The additive is typically a protective additive, in particular a taste and/or odour masking agent. Also provided is a particulate coformulation made by the method, which has a finite gradient in the relative additive concentration, which concentration increases radially outwards from the active rich core to the additive-rich surface of the particles.
摘要翻译：通过将活性物质和添加剂同时溶解在载体中以形成目标溶液，并且使用SEDS将目标溶液与抗溶剂流体接触来制备在颗粒表面具有添加剂层的活性物质的颗粒， TM>颗粒形成过程，使活性物质和添加剂共沉淀。添加剂通常是保护性添加剂，特别是味道和/或气味掩蔽剂。还提供了通过该方法制备的颗粒共同制剂，其在相对添加剂浓度中具有有限的梯度，该浓度从活性富集芯径向向外增加到颗粒的富含添加剂的表面。

3. 发明申请

WO1996000610A1 METHOD AND APPARATUS FOR THE FORMATION OF PARTICLES 审中-公开
标题翻译：用于形成颗粒的方法和装置
公开(公告)号：WO1996000610A1
公开(公告)日：1996-01-11
申请号：PCT/GB1995001523
申请日：1995-06-30
申请人： UNIVERSITY OF BRADFORD , HANNA, Mazen , YORK, Peter
发明人： UNIVERSITY OF BRADFORD
IPC分类号： B01J02/04
CPC分类号： A61K9/1688 , B01D11/0403 , B01D11/0407 , B01D11/0411 , B01D11/0488 , B01J2/04 , B01J3/008 , B01J3/02 , Y02P20/544
摘要： The invention provides a method for forming particles of a substance, by co-introducing into a particle formation vessel, in which the temperature and pressure are controlled, of a supercritical fluid; a solution or suspension of the substance in a first vehicle; and a second vehicle which is both substantially miscible with the first vehicle and substantially soluble in the supercritical fluid, in such a way that dispersion of the solution or suspension and the second vehicle, and extraction of the vehicles, occur substantially simultaneously and substantially immediately on introduction of the fluids into the vessel, by the action of the supercritical fluid. Preferably the solution/suspension of the substance is introduced separately from the second vehicle, in such a way that contact between the solution/suspension and the second vehicle occurs either substantially simultaneously with, or immediately before, their dispersion by the supercritical fluid and extraction of the vehicles by the supercritical fluid. The method allows a high degree of control over the size, shape, crystalline form and other physico-chemical properties of the particulate product. The invention also provides apparatus for carrying out such a method, using a coaxial nozzle to introduce the fluids into the particle formation vessel, and a particulate product made using the method or the apparatus.
摘要翻译：本发明提供了通过将超临界流体共同引入其中控制温度和压力的颗粒形成容器中来形成物质颗粒的方法; 该物质在第一种载体中的溶液或悬浮液; 以及第二种载体，其基本上与第一种载体混溶并且基本上可溶于超临界流体，使得溶液或悬浮液和第二载体的分散和载体的萃取基本上同时且基本上立即出现在通过超临界流体的作用将流体引入容器中。优选地，物质的溶液/悬浮液与第二载体分开引入，使得溶液/悬浮液和第二载体之间的接触基本上与超临界流体分散或同时或之前由超临界流体分散出来，车辆由超临界流体。该方法允许高度控制颗粒产品的尺寸，形状，结晶形式和其他物理化学性质。本发明还提供了一种使用同轴喷嘴将流体引入颗粒形成容器中的这种方法的装置，以及使用该方法或装置制成的颗粒状产品。

4. 发明申请

WO1992001446A1 SUSTAINED-RELEASE FORMULATIONS 审中-公开
标题翻译：持续发行公式
公开(公告)号：WO1992001446A1
公开(公告)日：1992-02-06
申请号：PCT/GB1991001153
申请日：1991-07-12
申请人： APS RESEARCH LIMITED , BARRY, Brian, William , MULLEY, Bryan, Arthur , YORK, Peter
发明人： APS RESEARCH LIMITED
IPC分类号： A61K09/50
CPC分类号： A61K9/5015 , A61K9/5073 , A61K9/5084
摘要： Sustained-release formulations of a water soluble or highly water soluble drug comprising sufficient granules to provide a predetermined dose or number of doses. Each of the granules comprises said water soluble or highly water soluble drug and has a coating of a pharmaceutical wax or wax-like material over substantially its whole surface. The granules are optionally further provided with a coating of a polymer or other non-wax material deposited from an aqueous suspension or solution. A method for preparing the formulations is also provided.
摘要翻译：包含足够的颗粒以提供预定剂量或剂量的水溶性或高度水溶性药物的缓释制剂。每个颗粒包含所述水溶性或高度水溶性的药物，并且在其整个表面上具有药用蜡或蜡状材料的涂层。颗粒任选地进一步提供由水性悬浮液或溶液沉积的聚合物或其它非蜡材料的涂层。还提供了制备制剂的方法。

5. 发明申请

WO03090715A2 PARTICULATE MATERIALS 审中-公开
标题翻译：颗粒材料
公开(公告)号：WO03090715A2
公开(公告)日：2003-11-06
申请号：PCT/GB0301747
申请日：2003-04-24
申请人： NEKTAR THERAPEUTICS UK LTD , YORK PETER , SHEKUNOV BORIS YU , REHMAN MAHBOOB UR , FEELEY JANE CATHERINE
发明人： YORK PETER , SHEKUNOV BORIS YU , REHMAN MAHBOOB UR , FEELEY JANE CATHERINE
IPC分类号： A61K9/00 , A61K9/16 , A61P11/00 , A61K9/14 , A61K9/72
CPC分类号： A61K9/0075 , A61K9/0043 , A61K9/1688
摘要： The present invention relates to active substances in particulate form, to methods for preparing them and to their uses. The present invention provides particulate powders, such as might be of use for delivery using a dry powder inhaler (DPI) or similar delivery device, having properties which may be beneficial to the DPI delivery process.
摘要翻译：本发明涉及颗粒形式的活性物质，其制备方法和用途。本发明提供了颗粒粉末，例如可能用于使用可能有益于DPI递送过程的性质的干粉吸入器（DPI）或类似递送装置的递送。

6. 发明申请

WO2003088945A1 AEROSOL CONTAINING A PARTICULATE ACTIVE SUBSTANCE 审中-公开
标题翻译：含有颗粒活性物质的气溶胶
公开(公告)号：WO2003088945A1
公开(公告)日：2003-10-30
申请号：PCT/GB2003/001665
申请日：2003-04-15
申请人： NEKTAR THERAPEUTICS UK LTD , KORDIKOWSKI, Andreas , WALKER, Stephen, Ernest , YORK, Peter
发明人： KORDIKOWSKI, Andreas , WALKER, Stephen, Ernest , YORK, Peter
IPC分类号： A61K9/00
CPC分类号： A61K31/4985 , A61K9/008 , A61K9/12 , A61K47/06 , A61K47/08 , B01J2/04 , Y10S514/951 , Y10T428/2982
摘要： The invention relates to active substances in particulate form, and to formulations containing the active substances in suspension in nonsolvent fluid vehicles. The formulations exhibit improved flocculation performance and are of particular use as aerosol formulations for instance for use in metered dose inhalers.
摘要翻译：本发明涉及颗粒形式的活性物质以及含有在非溶剂流体载体中悬浮的活性物质的制剂。制剂表现出改善的絮凝性能，并且特别用作气溶胶制剂，例如用于计量剂量吸入器。

7. 发明申请

WO1995001324A1 SALMETEROL XINAFOATE WITH CONTROLLED PARTICLE SIZE 审中-公开
标题翻译： SALMETEROL XINAFOATE具有受控颗粒尺寸
公开(公告)号：WO1995001324A1
公开(公告)日：1995-01-12
申请号：PCT/GB1994001425
申请日：1994-06-30
申请人： GLAXO GROUP LIMITED , YORK, Peter , HANNA, Mazen
发明人： GLAXO GROUP LIMITED
IPC分类号： C07C215/60
CPC分类号： B01D11/0411 , A61K9/1688 , C07C217/10 , Y02P20/544
摘要： The invention relates to particulate products which may be prepared by methods and apparatus using supercritical fluids. More particularly the invention relates to pharmaceutical products, in particular easily handled and easily fluidised crystalline forms of salmeterol xinafoate, with controlled particle size and shape.
摘要翻译：本发明涉及可通过使用超临界流体的方法和装置制备的颗粒产品。更具体地，本发明涉及具有受控粒度和形状的药物产品，特别是容易处理和容易流化的硫酸沙美特罗结晶形式。

8. 发明申请

WO2013138692A1 DEVICE AND METHOD FOR CONTROLLING TRANSMISSION TORQUE TO PROVIDE HILL ASCENT AND/OR DESCENT ASSISTANCE 审中-公开
标题翻译：用于控制传输扭矩以提供上升和/或下降辅助的装置和方法
公开(公告)号：WO2013138692A1
公开(公告)日：2013-09-19
申请号：PCT/US2013/031926
申请日：2013-03-15
申请人： SHATTUCK, Jared S. , YORK, Peter G. , SCHULTZ, Jeffrey E.
发明人： SHATTUCK, Jared S. , YORK, Peter G. , SCHULTZ, Jeffrey E.
IPC分类号： F16H59/66
CPC分类号： F16D48/06 , B60W10/02 , B60W10/06 , B60W30/18 , F16H61/0009 , F16H61/0059 , F16H61/02 , F16H61/0206 , F16H61/20 , F16H61/66 , F16H2061/205
摘要： A device, system, and method for controlling transmission torque to provide hill ascent and/or descent assistance to a vehicle includes applying a clutch hold pressure to one or more clutches of a transmission to lock an output shaft of the transmission to resist roll-back of the vehicle. The clutch hold pressure is applied based on one or more of a transmission output speed signal, an engine throttle signal, and a vehicle brake signal.
摘要翻译：用于控制传动扭矩以向车辆提供上坡和/或下降辅助的装置，系统和方法包括将离合器保持压力施加到变速器的一个或多个离合器以锁定变速器的输出轴以抵抗回滚的车辆。基于变速器输出速度信号，发动机油门调节信号和车辆制动信号中的一个或多个来施加离合器保持压力。

9. 发明申请

WO1989002738A1 SUSTAINED-RELEASE NIFEDIPINE FORMULATION 审中-公开
标题翻译：持续释放NIFEDIPINE配方
公开(公告)号：WO1989002738A1
公开(公告)日：1989-04-06
申请号：PCT/GB1988000779
申请日：1988-09-22
申请人： APS RESEARCH LIMITED , BARRY, Brian, William , MULLEY, Bryan, Arthur , YORK, Peter
发明人： APS RESEARCH LIMITED
IPC分类号： A61K31/44
CPC分类号： A61K9/5047 , A61K9/1652 , A61K9/5026 , A61K31/44
摘要： A sustained-release nifedipine (4-(2'-nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine) formulation comprising sufficient granules to provide a predetermined dose or number of doses of nifedipine, each of said granules having a diameter of between 0.5 and 2.5 mm and comprising: (a) a core comprising 100 parts of nifedipine and from 50 to 800 parts of hydroxypropylmethyl cellulose; and (b) a coating covering substantially the whole surface of the core and comprising 100 parts of a water insoluble but water swellable acrylic polymer and from 20 to 70 parts of a water soluble hydroxylated cellulose derivative, the weight of the coating being from 2 to 25 % of the weight of the core. A method for preparing the formulation is also provided.
摘要翻译：持续释放的硝苯地平（4-（2'-硝基苯基）-2,6-二甲基-3,5-二甲氧基-1,4-二氢吡啶）制剂，其包含足够的颗粒以提供硝苯地平的预定剂量或数量的剂量所述颗粒的直径在0.5至2.5mm之间，并且包括：（a）包含100份硝苯地平的核心和50至800份的羟丙基甲基纤维素; 和（b）基本上覆盖芯的整个表面的涂层，并且包含100份水不溶性但可水溶胀的丙烯酸类聚合物和20至70份水溶性羟基化纤维素衍生物，涂层的重量为2至核心重量的25％。还提供了制备该制剂的方法。

10. 发明申请

WO2013138693A1 DEVICE AND METHOD FOR CONTROLLING TRANSMISSION TORQUE TO PROVIDE HILL ASCENT AND/OR DESCENT ASSISTANCE USING ROAD GRADE 审中-公开
标题翻译：用于控制传动扭矩以使用道路坡度提供上升和/或下降辅助的装置和方法
公开(公告)号：WO2013138693A1
公开(公告)日：2013-09-19
申请号：PCT/US2013/031929
申请日：2013-03-15
申请人： SHATTUCK, Jared S. , YORK, Peter G. , SCHULTZ, Jeffrey E.
发明人： SHATTUCK, Jared S. , YORK, Peter G. , SCHULTZ, Jeffrey E.
IPC分类号： B60K28/00
CPC分类号： B60W10/02 , B60W10/06 , B60W10/10 , B60W10/11 , B60W30/18009 , B60W30/18118 , B60W2510/104 , B60W2530/10 , B60W2540/10 , B60W2540/103 , B60W2540/12 , B60W2540/165 , B60W2550/142 , B60W2710/1005 , F16H59/52 , F16H61/20 , F16H2059/663 , F16H2061/205
摘要： A device, system, and method for controlling transmission torque to provide hill ascent and/or descent assistance to a vehicle includes applying a clutch hold pressure to one or more clutches of a transmission to lock an output shaft of the transmission to resist roll-back of the vehicle. The clutch hold pressure is determined as a function of the tractive effort of the vehicle and is applied based on one or more of a transmission output speed signal, an engine throttle signal, and a vehicle brake signal.
摘要翻译：一种用于控制传动扭矩以向车辆提供上升和/或下降辅助的装置，系统和方法包括将离合器保持压力施加到变速器的一个或多个离合器以锁定变速器的输出轴以抵抗回退的车辆。离合器保持压力根据车辆的牵引力确定，并且基于变速器输出速度信号，发动机油门调节信号和车辆制动信号中的一个或多个来应用。

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