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1. 发明申请

WO1989002738A1 SUSTAINED-RELEASE NIFEDIPINE FORMULATION 审中-公开
标题翻译：持续释放NIFEDIPINE配方
公开(公告)号：WO1989002738A1
公开(公告)日：1989-04-06
申请号：PCT/GB1988000779
申请日：1988-09-22
申请人： APS RESEARCH LIMITED , BARRY, Brian, William , MULLEY, Bryan, Arthur , YORK, Peter
发明人： APS RESEARCH LIMITED
IPC分类号： A61K31/44
CPC分类号： A61K9/5047 , A61K9/1652 , A61K9/5026 , A61K31/44
摘要： A sustained-release nifedipine (4-(2'-nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine) formulation comprising sufficient granules to provide a predetermined dose or number of doses of nifedipine, each of said granules having a diameter of between 0.5 and 2.5 mm and comprising: (a) a core comprising 100 parts of nifedipine and from 50 to 800 parts of hydroxypropylmethyl cellulose; and (b) a coating covering substantially the whole surface of the core and comprising 100 parts of a water insoluble but water swellable acrylic polymer and from 20 to 70 parts of a water soluble hydroxylated cellulose derivative, the weight of the coating being from 2 to 25 % of the weight of the core. A method for preparing the formulation is also provided.
摘要翻译：持续释放的硝苯地平（4-（2'-硝基苯基）-2,6-二甲基-3,5-二甲氧基-1,4-二氢吡啶）制剂，其包含足够的颗粒以提供硝苯地平的预定剂量或数量的剂量所述颗粒的直径在0.5至2.5mm之间，并且包括：（a）包含100份硝苯地平的核心和50至800份的羟丙基甲基纤维素; 和（b）基本上覆盖芯的整个表面的涂层，并且包含100份水不溶性但可水溶胀的丙烯酸类聚合物和20至70份水溶性羟基化纤维素衍生物，涂层的重量为2至核心重量的25％。还提供了制备该制剂的方法。

2. 发明申请

WO1992001446A1 SUSTAINED-RELEASE FORMULATIONS 审中-公开
标题翻译：持续发行公式
公开(公告)号：WO1992001446A1
公开(公告)日：1992-02-06
申请号：PCT/GB1991001153
申请日：1991-07-12
申请人： APS RESEARCH LIMITED , BARRY, Brian, William , MULLEY, Bryan, Arthur , YORK, Peter
发明人： APS RESEARCH LIMITED
IPC分类号： A61K09/50
CPC分类号： A61K9/5015 , A61K9/5073 , A61K9/5084
摘要： Sustained-release formulations of a water soluble or highly water soluble drug comprising sufficient granules to provide a predetermined dose or number of doses. Each of the granules comprises said water soluble or highly water soluble drug and has a coating of a pharmaceutical wax or wax-like material over substantially its whole surface. The granules are optionally further provided with a coating of a polymer or other non-wax material deposited from an aqueous suspension or solution. A method for preparing the formulations is also provided.
摘要翻译：包含足够的颗粒以提供预定剂量或剂量的水溶性或高度水溶性药物的缓释制剂。每个颗粒包含所述水溶性或高度水溶性的药物，并且在其整个表面上具有药用蜡或蜡状材料的涂层。颗粒任选地进一步提供由水性悬浮液或溶液沉积的聚合物或其它非蜡材料的涂层。还提供了制备制剂的方法。

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