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    • 3. 发明申请
    • CORONARY SINUS CANNULA WITH LEFT VENTRICLE LEAD AND PRESSURE TENT
    • 冠状动脉瘤与左侧导管和压力帐篷
    • WO2011005814A1
    • 2011-01-13
    • PCT/US2010/041139
    • 2010-07-07
    • COLUMBIA UNIVERSITYSPOTNITZ, Henry M.WANG, Daniel Y.CABRERIZA, Santos
    • SPOTNITZ, Henry M.WANG, Daniel Y.CABRERIZA, Santos
    • A61N1/00
    • A61N1/056A61N2001/0585
    • Techniques for biventricular pacing include a rigid shaped stylet approximating curves of a coronary sinus and branch vein. Some techniques include a parasternal coronary sinus cannula comprising an outer sheath and an obturator. The obturator is removeably disposed inside the outer sheath from a device end of the hollow shaft. The obturator includes a flexible stem that fits snugly inside the hollow shaft, a malleable core disposed inside the flexible stem, a tapered tip that extends beyond a cardiac end of the shaft when the obturator is disposed inside the outer sheath, and a sensor for determining properties of the subject in a vicinity of the tapered tip. An optional pressure-seal, such as a tent, connected to suction maintains negative intrepleural pressure for insertion under local anesthesia.
    • 用于双心室起搏的技术包括近似冠状窦和分支静脉曲线的刚性形管状针。 一些技术包括胸骨旁冠状窦插管,其包括外护套和闭孔器。 闭孔器可从中空轴的装置端可移除地设置在外护套内。 闭塞器包括柔性杆,其紧密地配合在中空轴内,设置在柔性杆的内部的可延展的芯,当闭塞器设置在外护套内部时延伸超过轴的心脏端的锥形尖端,以及用于确定 受试者在锥形尖端附近的特性。 连接到抽吸器上的可选的压力密封件,例如帐篷,保持阴性胸膜内压力,以便在局部麻醉下插入。
    • 5. 发明申请
    • SOLUTION ADDITIVES FOR THE ATTENUATION OF PROTEIN AGGREGATION
    • 解决蛋白质聚集减弱的添加剂
    • WO2005082109A2
    • 2005-09-09
    • PCT/US2005/006603
    • 2005-02-28
    • MASSACHUSETTS INSTITUTE OF TECHNOLOGYBERNHARDT, Trout, L.WANG, Daniel, I., C.BAYNES, Brian, N.
    • BERNHARDT, Trout, L.WANG, Daniel, I., C.BAYNES, Brian, N.
    • C07C279/14C07C275/16C07D207/16C07D211/60C07D223/06C07D239/04
    • In part, the present invention relates to a compound or polymer comprising a non-protein-binding moiety and at least one protein-binding group. The present invention relates to a method of screening compounds or polymers for the property of inhibiting protein aggregation in solution, a method of preparing a compound or polymer having the property of protein aggregation inhibition in solution, a method of classifying a compound or polymer as either inhibitory of protein aggregation in solution or not inhibitory of protein aggregation in solution, and to a method of determining the preferential binding coefficient, Γ XP , of an additive in a protein solution. The present invention also relates to a method of suppressing or preventing aggregation of a protein in solution, a method of decreasing the toxicological risk associated with administering a protein to a mammal in need thereof, and a method of facilitating native folding of a recombinant protein in solution.
    • 部分地,本发明涉及包含非蛋白结合部分和至少一个蛋白质结合基团的化合物或聚合物。 本发明涉及一种筛选化合物或聚合物以抑制溶液中蛋白质聚集的性质的方法,制备具有溶液中蛋白质聚集抑制性质的化合物或聚合物的方法,将化合物或聚合物分类为 蛋白质聚集在溶液中的抑制或不抑制溶液中的蛋白质聚集,以及确定蛋白质溶液中添加剂的优先结合系数GammaXP的方法。 本发明还涉及抑制或预防溶液中的蛋白质聚集的方法,降低与需要其的哺乳动物相关的蛋白质相关的毒性风险的方法,以及促进重组蛋白质的天然折叠的方法 解。