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1. 发明申请

WO2005082109A3 SOLUTION ADDITIVES FOR THE ATTENUATION OF PROTEIN AGGREGATION 审中-公开
标题翻译：解决蛋白质聚集减弱的添加剂
公开(公告)号：WO2005082109A3
公开(公告)日：2006-05-04
申请号：PCT/US2005006603
申请日：2005-02-28
申请人： MASSACHUSETTS INST TECHNOLOGY , BERNHARDT TROUT L , WANG DANIEL I C , BAYNES BRIAN N
发明人： BERNHARDT TROUT L , WANG DANIEL I C , BAYNES BRIAN N
IPC分类号： C07C233/00 , A61K38/00 , C07C233/01 , C07C237/00
CPC分类号： C07C279/14 , C07C275/16 , C07D207/16 , C07D211/60 , C07D223/06 , C07D239/04
摘要： In part, the present invention relates to a compound or polymer comprising a non-protein-binding moiety and at least one protein-binding group. The present invention relates to a method of screening compounds or polymers for the property of inhibiting protein aggregation in solution, a method of preparing a compound or polymer having the property of protein aggregation inhibition in solution, a method of classifying a compound or polymer as either inhibitory of protein aggregation in solution or not inhibitory of protein aggregation in solution, and to a method of determining the preferential binding coefficient, G XP , of an additive in a protein solution. The present invention also relates to a method of suppressing or preventing aggregation of a protein in solution, a method of decreasing the toxicological risk associated with administering a protein to a mammal in need thereof, and a method of facilitating native folding of a recombinant protein in solution.
摘要翻译：部分地，本发明涉及包含非蛋白结合部分和至少一个蛋白质结合基团的化合物或聚合物。本发明涉及一种筛选化合物或聚合物以抑制溶液中蛋白质聚集的性质的方法，制备具有溶液中蛋白质聚集抑制性质的化合物或聚合物的方法，将化合物或聚合物分类为蛋白质聚集在溶液中的抑制或不抑制溶液中的蛋白质聚集，以及确定蛋白质溶液中添加剂的优先结合系数G XI的方法。本发明还涉及抑制或预防溶液中的蛋白质聚集的方法，降低与需要其的哺乳动物相关的蛋白质相关的毒性风险的方法，以及促进重组蛋白质的天然折叠的方法解。

2. 发明申请

WO2005082109A2 SOLUTION ADDITIVES FOR THE ATTENUATION OF PROTEIN AGGREGATION 审中-公开
标题翻译：解决蛋白质聚集减弱的添加剂
公开(公告)号：WO2005082109A2
公开(公告)日：2005-09-09
申请号：PCT/US2005/006603
申请日：2005-02-28
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BERNHARDT, Trout, L. , WANG, Daniel, I., C. , BAYNES, Brian, N.
发明人： BERNHARDT, Trout, L. , WANG, Daniel, I., C. , BAYNES, Brian, N.
CPC分类号： C07C279/14 , C07C275/16 , C07D207/16 , C07D211/60 , C07D223/06 , C07D239/04
摘要： In part, the present invention relates to a compound or polymer comprising a non-protein-binding moiety and at least one protein-binding group. The present invention relates to a method of screening compounds or polymers for the property of inhibiting protein aggregation in solution, a method of preparing a compound or polymer having the property of protein aggregation inhibition in solution, a method of classifying a compound or polymer as either inhibitory of protein aggregation in solution or not inhibitory of protein aggregation in solution, and to a method of determining the preferential binding coefficient, Γ XP , of an additive in a protein solution. The present invention also relates to a method of suppressing or preventing aggregation of a protein in solution, a method of decreasing the toxicological risk associated with administering a protein to a mammal in need thereof, and a method of facilitating native folding of a recombinant protein in solution.
摘要翻译：部分地，本发明涉及包含非蛋白结合部分和至少一个蛋白质结合基团的化合物或聚合物。本发明涉及一种筛选化合物或聚合物以抑制溶液中蛋白质聚集的性质的方法，制备具有溶液中蛋白质聚集抑制性质的化合物或聚合物的方法，将化合物或聚合物分类为蛋白质聚集在溶液中的抑制或不抑制溶液中的蛋白质聚集，以及确定蛋白质溶液中添加剂的优先结合系数GammaXP的方法。本发明还涉及抑制或预防溶液中的蛋白质聚集的方法，降低与需要其的哺乳动物相关的蛋白质相关的毒性风险的方法，以及促进重组蛋白质的天然折叠的方法解。

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