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1. 发明申请

WO2007047644A3 METHOD FOR MICROCHANNEL SURFACE MODIFICATION 审中-公开
公开(公告)号：WO2007047644A3
公开(公告)日：2007-04-26
申请号：PCT/US2006/040505
申请日：2006-10-13
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , TSENG, Hsian-Rong , SUI, Guodong , WANG, Jinji
发明人： TSENG, Hsian-Rong , SUI, Guodong , WANG, Jinji
IPC分类号： B05D5/00 , B05D3/00
摘要： A method (10) for functionalizing microfluidic channels with specific characteristics by the introduction of hydroxyl groups onto the surface area of the channel using a solution of an acid and a peroxide (30) followed by a reaction of an essentially pure siloxane-based reagent (60) and a funtional group (70). Chemically modified channel surfaces can be designed to prevent non-specific binding or interaction of biological samples with the channel surfaces; surface wetting or dewetting with the control of the hydrophobicity and hydrophilicity of the channel surfaces; confer solvent resistance by attaching inert molecules to the interior channel; and tethering molecules that have available amine, thiol, isocyanato and isothiocyanato or similar groups to permit the attachment of biomolecules to channel surfaces.

2. 发明申请

WO2007047644A2 METHOD FOR MICROCHANNEL SURFACE MODIFICATION 审中-公开
标题翻译：微通道表面改性方法
公开(公告)号：WO2007047644A2
公开(公告)日：2007-04-26
申请号：PCT/US2006040505
申请日：2006-10-13
申请人： UNIV CALIFORNIA , TSENG HSIAN-RONG , SUI GUODONG , WANG JINJI
发明人： TSENG HSIAN-RONG , SUI GUODONG , WANG JINJI
IPC分类号： B05D3/00
CPC分类号： B81C1/00206 , B01L3/5027
摘要： A method for functionalizing microfluidic channels with specific characteristics by the introduction of hydroxyl groups onto the surface area of the channel using a solution of an acid and a peroxide followed by a reaction of an essentially pure siloxane based reagent and a functional group. Chemically modified channel surfaces can be designed to prevent non-specific binding or interaction of biological samples with the channel surfaces; surface wetting or dewetting with the control of the hydrophobicity and hydrophilicity of the channel surfaces; confer solvent resistance by attaching inert molecules to the interior channel; and tethering molecules that have available amine, thiol, isocyanato and isothiocyanato or similar groups to permit the attachment of biomolecules to channel surfaces.
摘要翻译：通过使用酸和过氧化物的溶液，然后基本上纯的基于硅氧烷的试剂和官能团的反应，通过在通道的表面区域上引入羟基来官能化具有特定特性的微流体通道的方法。化学修饰的通道表面可以设计成防止生物样品与通道表面的非特异性结合或相互作用; 表面润湿或去湿，以控制通道表面的疏水性和亲水性; 通过将惰性分子附着到内部通道来赋予耐溶剂性; 和具有可用胺，硫醇，异氰酸酯基和异硫氰酸酯或类似基团的分子，以允许将生物分子附着到通道表面。

3. 发明申请

WO2006071470A3 MICROFLUIDIC DEVICES WITH CHEMICAL REACTION CIRCUITS 审中-公开
公开(公告)号：WO2006071470A3
公开(公告)日：2006-07-06
申请号：PCT/US2005/044072
申请日：2005-12-05
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , FLUIDIGM CORPORATION , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SIEMENS CORPORATION , LEE, Chung-cheng , SUI, Guodong , ELIZAROV, Arkadij , KOLB, Hartmuth, C. , HUANG, Jiang , HEATH, James, R. , PHELPS, Michael, E. , QUAKE, Stephen, R. , TSENG, Hsian-rong , WYATT, Paul , DARIDON, Antoine
发明人： LEE, Chung-cheng , SUI, Guodong , ELIZAROV, Arkadij , KOLB, Hartmuth, C. , HUANG, Jiang , HEATH, James, R. , PHELPS, Michael, E. , QUAKE, Stephen, R. , TSENG, Hsian-rong , WYATT, Paul , DARIDON, Antoine
IPC分类号： B32B37/00 , B44C7/00
摘要： New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.

4. 发明申请

WO2009009021A1 INTEGRATED MICROFLUIDICS FOR HIGHLY PARALLEL SCREENING OF CHEMICAL REACTIONS 审中-公开
标题翻译：综合微流化学高效平行筛选化学反应
公开(公告)号：WO2009009021A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/008318
申请日：2008-07-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , TSENG, Hsian-Rong , WANG, Jinyi , SUI, Guodong , FAULL, Kym, F. , WANG, Yanju , LIN, Wei-Yu
发明人： TSENG, Hsian-Rong , WANG, Jinyi , SUI, Guodong , FAULL, Kym, F. , WANG, Yanju , LIN, Wei-Yu
IPC分类号： G01N1/00
CPC分类号： B01F13/0059 , B01F5/102 , B01J2219/00315 , B01J2219/00317 , B01J2219/00353 , B01J2219/00389 , B01J2219/00479 , B01J2219/00702 , B01J2219/0072 , B01L3/5027 , C07C247/10 , C07C247/12 , C07C247/14 , C07C323/59 , C07C2601/08 , C07C2601/14 , C07D211/68 , C07D213/42 , C07D213/74 , C07D215/42 , C07D235/14 , C07D295/13 , C07D295/32 , C07D307/52 , C07D311/14 , C07D317/28 , C07D333/20 , C40B40/04 , C40B50/08 , C40B60/12 , G01N2035/00544
摘要： A microfluidic system has a microfluidic mixer and a sample storage component that is in fluid connection with the microfluidic mixer. The microfluidic mixer has a mixing section; a target molecule input section that is in fluid connection with the mixing section, the target molecule input section being suitable to provide a fluid into the mixing section that contains molecules to be targeted by chemical reactions; a first reagent input section that is in fluid connection with the mixing section, the first reagent input section being structured to selectively provide a first reagent selected from a plurality of reagents to test a chemical reaction with the target molecules; a second reagent input section that is in fluid connection with the mixing section, the second reagent input section being structured to selectively provide a second reagent selected from a plurality of reagents to test a chemical reaction with the target molecules and said first reagent; and a neutral fluid input section that is in selectable fluid connection with the sample storage component, the neutral fluid input section being structured to selectively provide a neutral fluid into the sample storage component between successive samples provided to the sample storage component to separate successive samples in a stratified arrangement.
摘要翻译：微流体系统具有微流控混合器和与微流体混合器流体连接的样品存储组件。微流体混合器具有混合部分; 与混合部分流体连接的目标分子输入部分，靶分子输入部分适合于通过化学反应将含有分子的流体提供给混合部分; 与所述混合部分流体连接的第一试剂输入部，所述第一试剂输入部构造成选择性地提供选自多种试剂的第一试剂，以测试与所述靶分子的化学反应; 与所述混合部分流体连接的第二试剂输入部，所述第二试剂输入部构造成选择性地提供选自多种试剂的第二试剂，以测试与所述靶分子和所述第一试剂的化学反应; 以及中性流体输入部分，其与所述样品存储部件可选择性地流体连接，所述中性流体输入部分被构造成在提供给所述样品存储部件的连续样品之间选择性地将中性流体提供到所述样品存储部件中，以将分层安排。

5. 发明申请

WO2009067521A1 MICROFLUIDIC CHIPS AND SYSTEMS FOR ANALYZING PROTEIN EXPRESSION, AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于分析蛋白质表达的微流感胶囊和系统及其使用方法
公开(公告)号：WO2009067521A1
公开(公告)日：2009-05-28
申请号：PCT/US2008/084044
申请日：2008-11-19
申请人： FLORIDA ATLANTIC UNIVERSITY , SUI, Guodong
发明人： SUI, Guodong
IPC分类号： B01D57/02 , B01D59/42 , B01D59/50 , B01D61/42
CPC分类号： G01N33/54366 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0421 , B01L2400/0481 , B01L2400/0655 , G01N27/44791
摘要： Microfluidic chips, systems including at least one integrated microfluidic chip operably connected to hardware (e.g., docking device, high voltage electrodes, portable fluorescence microscope, computer, etc.), and methods for analyzing peptides (e.g., toxins), proteins (e.g., cancer biomarkers, recombinant human growth hormone, recombinant human erythropoietin), and protein expression in biological samples (e.g., human serum, urine, or tissue, marine organism, seafood, etc.) have been developed. On a single microfluidic chip as described herein, several sequential processes for analyzing a protein (e.g., cell culturing, cell lysis, protein enrichment, protein labeling, and protein detection) can be performed in an automated fashion. The microfluidic chips, systems, and methods described herein provide real-time, high-throughput, highly-specific detection of proteins such as recombinant erythropoietin, recombinant human growth hormone and marine biotoxins, as well as important biomarkers in the cancer signaling pathway network for early and precise cancer diagnosis.
摘要翻译：微流控芯片，包括可操作地连接到硬件（例如，对接装置，高压电极，便携式荧光显微镜，计算机等）的至少一个集成微流控芯片的系统，以及用于分析肽（例如毒素），蛋白质（例如，已经开发了生物样品（例如，人血清，尿液或组织，海洋生物，海产品等）中的蛋白质表达（例如癌症生物标记物，重组人生长激素，重组人促红细胞生成素）。在如本文所述的单个微流体芯片上，可以以自动方式执行用于分析蛋白质（例如细胞培养，细胞裂解，蛋白质富集，蛋白质标记和蛋白质检测）的若干顺序方法。本文所述的微流控芯片，系统和方法提供蛋白质的实时，高通量，高度特异性检测，例如重组促红细胞生成素，重组人生长激素和海洋生物毒素，以及癌症信号传导途径网络中的重要生物标志物早期和精确的癌症诊断。

6. 发明申请

WO2007103100A2 INTEGRATED MICROFLUIDICS FOR PARALLEL SCREENING OF CHEMICAL REACTIONS 审中-公开
标题翻译：用于化学反应平行筛选的综合微流控
公开(公告)号：WO2007103100A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/005248
申请日：2007-03-02
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , TSENG, Hsian-Rong , KOLB, Hartmuth C. , WANG, Jinyi , SUI, Guodong
发明人： TSENG, Hsian-Rong , KOLB, Hartmuth C. , WANG, Jinyi , SUI, Guodong
IPC分类号： C12M3/00
CPC分类号： B01F13/0059 , B01F5/061 , B01F5/0646 , B01F5/0647 , B01F5/10 , B01F5/108 , B01F2005/0621 , B01F2005/0636 , B01J19/0046 , B01J2219/00286 , B01J2219/00479 , B01J2219/0059 , B01J2219/00599 , B01L3/5027 , Y10T436/2575
摘要： A microfluidic device allows for different reactions to be conducted in parallel with the use of nanoliter quantities of reagents.
摘要翻译：微流体装置允许与使用纳升量的试剂并行进行不同的反应。

7. 发明申请

WO2007044938A2 MICROFLUIDIC SAMPLERS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：微流体抽样器及其制造和使用方法
公开(公告)号：WO2007044938A2
公开(公告)日：2007-04-19
申请号：PCT/US2006040276
申请日：2006-10-13
申请人： UNIV CALIFORNIA , WU CHRISTINE HSIAO-MING , SUI GUODONG , LEE CHENG-CHUNG , HUANG SUNG-CHENG
发明人： WU CHRISTINE HSIAO-MING , SUI GUODONG , LEE CHENG-CHUNG , HUANG SUNG-CHENG
IPC分类号： C12M3/00
CPC分类号： C12M23/16 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/0605 , B01L2200/143 , B01L2300/0816 , B01L2300/0864 , B01L2400/0487 , B01L2400/0622 , G01N35/1097
摘要： This invention provides microfluidic samplers for withdrawing one or more precise micro- or nano-liter volumes of a sample. The invention provides microfabricated automatic systems comprising integrated poly(dimethyl-siloxane) (PDMS) micro fluidics. The sample can be biological samples, including samples from animals or plants. The samples can be fluid or gas. The samples can comprise a biological fluid, such as blood, tears, cerebral spinal fluid (CSF) and the like, from a test subject such as a human or a mouse. The invention also provides methods for making and using the microfluidic samplers of the invention.
摘要翻译：本发明提供微流体取样器，用于取出一个或多个精确的微量或纳升体积的样品。本发明提供包含整合的聚（二甲基硅氧烷）（PDMS）微流体的微制造自动系统。样品可以是生物样品，包括来自动物或植物的样品。样品可以是流体或气体。样品可以包含来自测试对象例如人或小鼠的生物流体，例如血液，眼泪，脑脊髓液（CSF）等。本发明还提供了制造和使用本发明的微流体取样器的方法。

8. 发明申请

WO2007044938A3 MICROFLUIDIC SAMPLERS AND METHODS FOR MAKING AND USING THEM 审中-公开
公开(公告)号：WO2007044938A3
公开(公告)日：2007-04-19
申请号：PCT/US2006/040276
申请日：2006-10-13
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , WU, Christine, Hsiao-Ming , SUI, Guodong , LEE, Cheng-Chung , HUANG, Sung-Cheng
发明人： WU, Christine, Hsiao-Ming , SUI, Guodong , LEE, Cheng-Chung , HUANG, Sung-Cheng
IPC分类号： B01L3/02
摘要： This invention provides microfluidic samplers for withdrawing one or more precise micro- or nano-liter volumes of a sample. The invention provides microfabricated automatic systems comprising integrated poly(dimethyl-siloxane) (PDMS) micro fluidics. The sample can be biological samples, including samples from animals or plants. The samples can be fluid or gas. The samples can comprise a biological fluid, such as blood, tears, cerebral spinal fluid (CSF) and the like, from a test subject such as a human or a mouse. The invention also provides methods for making and using the microfluidic samplers of the invention.

9. 发明申请

WO2007103100A3 INTEGRATED MICROFLUIDICS FOR PARALLEL SCREENING OF CHEMICAL REACTIONS 审中-公开
标题翻译：用于化学反应平行筛选的综合微流化学
公开(公告)号：WO2007103100A3
公开(公告)日：2008-09-18
申请号：PCT/US2007005248
申请日：2007-03-02
申请人： UNIV CALIFORNIA , TSENG HSIAN-RONG , KOLB HARTMUTH C , WANG JINYI , SUI GUODONG
发明人： TSENG HSIAN-RONG , KOLB HARTMUTH C , WANG JINYI , SUI GUODONG
IPC分类号： G01N33/53
CPC分类号： B01F13/0059 , B01F5/061 , B01F5/0646 , B01F5/0647 , B01F5/10 , B01F5/108 , B01F2005/0621 , B01F2005/0636 , B01J19/0046 , B01J2219/00286 , B01J2219/00479 , B01J2219/0059 , B01J2219/00599 , B01L3/5027 , Y10T436/2575
摘要： A microfluidic device allows for different reactions to be conducted in parallel with the use of nanoliter quantities of reagents.
摘要翻译：微流体装置允许使用纳升量的试剂并行进行不同的反应。

10. 发明申请

WO2006071470A2 MICROFLUIDIC DEVICES WITH CHEMICAL REACTION CIRCUITS 审中-公开
标题翻译：具有化学反应电路的微流体装置
公开(公告)号：WO2006071470A2
公开(公告)日：2006-07-06
申请号：PCT/US2005044072
申请日：2005-12-05
申请人： CALIFORNIA INST OF TECHN , FLUIDIGM CORP , UNIV CALIFORNIA , SIEMENS CORP , LEE CHUNG-CHENG , SUI GUODONG , ELIZAROV ARKADIJ , KOLB HARTMUTH C , HUANG JIANG , HEATH JAMES R , PHELPS MICHAEL E , QUAKE STEPHEN R , TSENG HSIAN-RONG , WYATT PAUL , DARIDON ANTOINE
发明人： LEE CHUNG-CHENG , SUI GUODONG , ELIZAROV ARKADIJ , KOLB HARTMUTH C , HUANG JIANG , HEATH JAMES R , PHELPS MICHAEL E , QUAKE STEPHEN R , TSENG HSIAN-RONG , WYATT PAUL , DARIDON ANTOINE
CPC分类号： B01J19/0093 , B01F11/0042 , B01F13/0059 , B01F2215/0404 , B01J2219/00286 , B01J2219/00396 , B01J2219/00398 , B01J2219/00414 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00731 , B01J2219/00759 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01L3/5027 , B33Y80/00 , C07B59/00
摘要： New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.
摘要翻译：提供了用于进行化学反应的新型微流体装置。该器件适用于片上溶剂交换，需要多次化学反应的化学过程和试剂的快速浓缩。

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