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1. 发明申请

WO2015108585A3 POLYMERIZED MICROARRAYS 审中-公开
标题翻译：聚合微波
公开(公告)号：WO2015108585A3
公开(公告)日：2015-11-05
申请号：PCT/US2014061620
申请日：2014-10-21
申请人： UNIV NEW YORK
发明人： BRAUNSCHWEIG ADAM B , BIAN SHUDAN , ZIEBA SYLWIZ
IPC分类号： B01J19/00 , G01N33/68
CPC分类号： B01J19/0046 , B01J2219/00621 , B01J2219/00637 , B01J2219/00675 , B01J2219/00711 , B01J2219/00731 , G01N33/54353
摘要： Micropatterns of glycan-bearing brush polymers generated by the initiation of oligomerization of acrylate and methacrylate monomers from thiol-terminated surfaces. Chain lengths are controlled in situ by varying exposure time, and these multivalent glycan scaffolds detect glycan binding proteins at sub-micromolar concentrations.
摘要翻译：通过从硫醇封端的表面引发丙烯酸酯和甲基丙烯酸酯单体的低聚而产生的含聚丙烯刷的聚合物的微图案。链长通过不同的暴露时间原位控制，并且这些多价聚糖支架以亚微摩尔浓度检测聚糖结合蛋白。

2. 发明申请

WO2013037836A1 METHOD FOR PREPARING TOPOGRAPHICALLY STRUCTURED MICROARRAYS 审中-公开
标题翻译：制备地层结构微量元素的方法
公开(公告)号：WO2013037836A1
公开(公告)日：2013-03-21
申请号：PCT/EP2012/067856
申请日：2012-09-12
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) , GOBAA, Samy , LUTOLF, Matthias
发明人： GOBAA, Samy , LUTOLF, Matthias
IPC分类号： C12Q1/02 , B41J2/15 , C12N5/00
CPC分类号： G01N33/5041 , B01J19/0046 , B01J2219/00385 , B01J2219/00509 , B01J2219/00596 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C12N5/0068 , C12N2535/10 , C12Q1/02 , G01N33/5026 , G01N33/5032 , G03F7/20 , G03F7/32 , G03F7/36
摘要： A method for preparing a topographically structured hydrogel microarray is described comprising the steps of a) providing one or more types of biomolecule(s) on top of micropillars of an array of micropillars, preferably by means of robotical spotting, b) providing a partially crosslinked hydrogel on a substrate, preferably attached to a substantially rigid and/or planar sub- strate, c) simultaneously soft-embossing a hydrogel microwell array and transferring the biomolecule(s) from the micropillars to the microwells by pressing the micropillars of the array of step a) onto the partially crosslinked layer of hydrogel of step b) until substantial completion of crosslinking and d) demolding the array of micropillars of step a) from the hydrogel microwell array of step c). The method according to the invention has the advantages of resulting in higher biochemical patterning precision, allowing for modulation of biochemical parameters by interfacing microarray manufacture with robotic technology and rendering the microarrays obtained compatible with existing read-out systems such as microscopes. Further, the elasticity of the hydrogel can be varied by tuning its shear modulus.
摘要翻译：描述了一种用于制备地形结构的水凝胶微阵列的方法，其包括以下步骤：a）优选通过机器人点样，在微柱阵列的微柱体的顶部提供一种或多种类型的生物分子，b）提供部分交联的基底上的水凝胶，优选地连接到基本上刚性和/或平面的基底上，c）同时软化压花水凝胶微孔阵列，并将生物分子从微透镜转移到微孔中，方法是通过将微阵列的微阵列步骤a）到步骤b）的部分交联的水凝胶层上，直到基本完成交联，和d）将步骤a）的微柱阵列从步骤c）的水凝胶微孔阵列脱模。根据本发明的方法具有产生更高的生物化学图案化精度的优点，允许通过将微阵列制造与机器人技术相连接并使获得的微阵列与现有的读出系统如显微镜相兼容来调制生物化学参数。此外，水凝胶的弹性可以通过调节其剪切模量来改变。

3. 发明申请

WO2008156732A2 PATTERNING WITH COMPOSITIONS COMPRISING LIPID 审中-公开
标题翻译：包含脂肪组合物的图案
公开(公告)号：WO2008156732A2
公开(公告)日：2008-12-24
申请号：PCT/US2008007498
申请日：2008-06-17
申请人： UNIV NORTHWESTERN , MIRKIN CHAD A , HUANG LING , LENHERT STEVEN , VEGA RAFAEL A
发明人： MIRKIN CHAD A , HUANG LING , LENHERT STEVEN , VEGA RAFAEL A
IPC分类号： B01J19/00 , C40B50/14
CPC分类号： C09D11/03 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B82Y30/00 , C09D11/30 , C40B50/14 , Y10T428/24802 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： Better patterning methods, including for better methods for forming biomolecular arrays, including a method comprising: providing a tip and a substrate surface, disposing a patterning composition at the end of the tip, depositing at least some of the patterning composition from the tip to the substrate surface to form a deposit disposed on the substrate surface, wherein the patterning composition comprises at least one lipid, optionally at least one solvent, and at least one patterning species different from the lipid and the optional solvent. The lipid can be a phospholipid such as DOPC. The patterning species can be an oligonucleotide or a protein. Microarrays and nanoarrays can be prepared including nanoscale resolution of deposits. The lipid can activate patterning or increase the rate of patterning. Simplified tip preparation can be achieved. Nanoscopic, SPM, and AFM tips can be used.
摘要翻译：更好的图案化方法，包括用于形成生物分子阵列的更好的方法，包括一种方法，包括：提供尖端和基底表面，在尖端的末端设置图案化组合物，将至少一些图案化组合物从尖端沉积到衬底表面以形成设置在衬底表面上的沉积物，其中所述图案化组合物包含至少一种脂质，任选的至少一种溶剂和至少一种不同于脂质和任选溶剂的图案化物种。脂质可以是磷脂如DOPC。图案化物质可以是寡核苷酸或蛋白质。可以制备微阵列和纳米阵列，包括沉积物的纳米级分辨率。脂质可以激活图案化或增加图案化速率。可以实现简化的尖端准备。可以使用纳米镜，SPM和AFM提示。

4. 发明申请

WO2006060922A3 MICROFLUIDIC MICROARRAY ASSEMBLIES AND METHODS OF MANUFACTURING AND USING SAME 审中-公开
标题翻译：微流控微型组件及其制造方法和使用方法
公开(公告)号：WO2006060922A3
公开(公告)日：2007-01-11
申请号：PCT/CA2005001884
申请日：2005-12-12
申请人： UNIV FRASER SIMON , LI PAUL CHI HANG , PENG XING YUE , YU HUA ZHONG , PARAMESWAREN MEENAKSHINATHAN , CHEN HONG , CHOU WA LOK
发明人： LI PAUL CHI HANG , PENG XING YUE , YU HUA ZHONG , PARAMESWAREN MEENAKSHINATHAN , CHEN HONG , CHOU WA LOK
IPC分类号： C40B40/00 , C12Q1/68 , C40B50/14 , G01N1/28 , G01N33/543 , G01N33/552
CPC分类号： G01N33/54386 , B01J19/0046 , B01J2219/00421 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00675 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/0074 , B01J2219/00743 , B01L3/0293 , B01L3/502707 , B01L2200/025 , B01L2200/16 , B01L2300/0806 , B01L2300/0819 , B01L2300/0877 , B01L2400/0409 , B82Y30/00 , C40B80/00 , G01N35/00069 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/2575
摘要： The invention encompasses microfluidic microarray assemblies (MMA) and subassemblies and methods for their manufacture and use. In one embodiment, first and second channel plates are provided and are sealingly connected to a test chip in consecutive steps. Each plate includes microfluidic channels configured in a predetermined reagent distribution pattern. The test chip comprises a plurality of discrete test positions, each test position being located at the intersection between a first predetermined reagent pattern and a second predetermined reagent pattern, wherein at least one of said patterns is non-linear. The first channel plate allows the distribution of a first reagent on said test chip, wherein said first reagent is immobilized at said test positions. The second channel plate allows the distribution of a second reagent on said test chip, wherein said second reagent comprises a plurality of different test samples.
摘要翻译：本发明包括微流体微阵列组件（MMA）及其组件及其制造和使用的方法。在一个实施例中，提供第一和第二通道板，并在连续的步骤中密封地连接到测试芯片。每个板包括以预定的试剂分布图案配置的微流体通道。测试芯片包括多个离散测试位置，每个测试位置位于第一预定试剂图案和第二预定试剂图案之间的交点处，其中至少一个所述图案是非线性的。第一通道板允许在所述测试芯片上分配第一试剂，其中所述第一试剂在所述测试位置被固定。第二通道板允许在所述测试芯片上分配第二试剂，其中所述第二试剂包括多个不同的测试样品。

5. 发明申请

WO2006042276A2 ELECTROCHEMICALLY FABRICATED CONDUCTING POLYMER NANOWIRE SENSORS 审中-公开
标题翻译：电化学导电聚合物纳米传感器
公开(公告)号：WO2006042276A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/036671
申请日：2005-10-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , TSENG, Hsian-rong , WANG, Jun , ALAM, Maksudul , GUO, Yaoyao
发明人： TSENG, Hsian-rong , WANG, Jun , ALAM, Maksudul , GUO, Yaoyao
IPC分类号： C12M1/34
CPC分类号： G01N27/127 , B01J2219/00653 , B01J2219/00722 , B01J2219/00731 , B01J2219/00736 , B01L3/5027 , B82Y15/00 , G01N27/126
摘要： Resistive-sensors are provided wherein networks or nanoframeworks of conducting polymer nanowires are electrochemically grown from pre-polymer solutions in the junction gap located between electrode pairs.
摘要翻译：提供电阻传感器，其中导电聚合物纳米线的网络或纳米框架在位于电极对之间的接合间隙中从预聚物溶液电化学生长。

6. 发明申请

WO2005110593A3 PROCESS AND AUTOMATED SYSTEM FOR THE SYNTHESIS OF POLYMERS 审中-公开
标题翻译：用于合成聚合物的工艺和自动化系统
公开(公告)号：WO2005110593A3
公开(公告)日：2006-04-20
申请号：PCT/EP2005005359
申请日：2005-05-17
申请人： APIBIO SAS , LAURENT ALAIN
发明人： LAURENT ALAIN
IPC分类号： B01J19/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00675 , B01J2219/00686 , B01J2219/00713 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B82Y30/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14
摘要： The present invention relates to the process for the stepwise synthesis of polymers, especially biopolymers, on a solid support surface comprising the steps of providing a solid support surface having a binding site, applying a first microdroplet of a solution comprising a first polymer building block on said binding site to attach the first polymer building block to the binding site and applying to the modified binding site of the preceding step a second microdroplet of a solution comprising the same or a different polymer building block, wherein the solution comprises two different solvents wich have a different viscosity and its relative viscosity (? rel =? second solvent<
摘要翻译：本发明涉及在固体支持体表面上逐步合成聚合物，特别是生物聚合物的方法，包括以下步骤：提供具有结合位点的固体支持物表面，将包含第一聚合物结构单元的溶液的第一微滴所述结合位点将第一聚合物结构单元连接到结合位点并向前述步骤的修饰结合位点施加包含相同或不同聚合物结构单元的溶液的第二微滴，其中溶液包含两种不同的溶剂，其具有不同的粘度及其相对粘度（η3）

7. 发明申请

WO2005108625A2 METHOD FOR PREPARING SUBSTRATES HAVING IMMOBILIZED MOLECULES AND SUBSTRATES 审中-公开
标题翻译：用于制备具有固定分子和基底的基底的方法
公开(公告)号：WO2005108625A2
公开(公告)日：2005-11-17
申请号：PCT/US2005/016134
申请日：2005-05-06
申请人： NANOSPHERE, INC. , GARIMELLA, Viswanadham , ZHUKOVYTSKYY, Vadym
发明人： GARIMELLA, Viswanadham , ZHUKOVYTSKYY, Vadym
IPC分类号： C12Q1/68
CPC分类号： C07F7/1836 , B01J19/0046 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B82Y5/00 , C07B2200/11 , C12Q1/6834 , G01N33/54346 , G01N33/54353 , G01N33/552
摘要： A method for the efficient immobilization of molecules onto substrate surfaces that employs an isocyanate compound to form a reactive isocyanate surface, nanoparticles onto surfaces as well as silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface is provided. Also provided are compounds, devices, and kits for modifying surfaces such as glass surfaces.
摘要翻译：提供了一种使用异氰酸酯化合物形成活性异氰酸酯表面，将表面上的纳米颗粒以及甲硅烷基化的分子如甲硅烷基化的寡核苷酸或蛋白质高效地固定在基材表面上的方法，所述方法用于在未修饰的表面如玻璃表面上。还提供了用于改变诸如玻璃表面的表面的化合物，装置和试剂盒。

8. 发明申请

WO2005088310A2 HIGH THROUGHPUT GLYCAN MICROARRAYS 审中-公开
标题翻译：高吞吐量的甘蔗糖微阵列
公开(公告)号：WO2005088310A2
公开(公告)日：2005-09-22
申请号：PCT/US2005007370
申请日：2005-03-07
申请人： SCRIPPS RESEARCH INST , BLIXT OLA , HEAD STEVE
发明人： BLIXT OLA , HEAD STEVE
IPC分类号： G01N33/543
CPC分类号： G01N33/54386 , B01J2219/00387 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00731 , G01N2400/10
摘要： The invention provides arrays of glycans for detecting entities that bind to glycans. In some embodiments, the arrays can be used to detect disease, blood types, antibodies, bacterial or viral infection, cancer, and the like. The invention also provides methods and kits for such detection. In another embodiment, the invention provides methods of preventing or treating disease in a mammal by administering to the mammal a composition that includes at least glycan.
摘要翻译：本发明提供了用于检测与聚糖结合的实体的聚糖阵列。在一些实施方案中，阵列可用于检测疾病，血型，抗体，细菌或病毒感染，癌症等。本发明还提供了用于这种检测的方法和试剂盒。在另一个实施方案中，本发明提供了通过向哺乳动物施用至少包含聚糖的组合物来预防或治疗哺乳动物疾病的方法。

9. 发明申请

WO2005062866A2 OPTICALLY ENCODED PARTICLES, SYSTEM AND HIGH-THROUGHPUT SCREENING 审中-公开
标题翻译：光学编码的颗粒，系统和高通量筛选
公开(公告)号：WO2005062866A2
公开(公告)日：2005-07-14
申请号：PCT/US2004/043001
申请日：2004-12-21
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SAILOR, Michael, J. , MEADE, Shawn, O.
发明人： SAILOR, Michael, J. , MEADE, Shawn, O.
CPC分类号： C40B20/08 , B01J19/0046 , B01J2219/00497 , B01J2219/005 , B01J2219/0054 , B01J2219/00547 , B01J2219/00554 , B01J2219/0056 , B01J2219/00565 , B01J2219/00576 , B01J2219/00596 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B82Y20/00 , C40B20/04 , C40B30/04 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/18 , C40B50/14 , C40B70/00
摘要： The invention concerns a particle (10, 10a) having a code from a library of codes embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum. An assay detection method uses such a particle and detects a spectral shift in the presence of an analyte. Additional embodiments are disclosed including additional features.
摘要翻译：本发明涉及一种具有通过嵌入其物理结构中的代码库的代码的粒子（10,10a），其通过颗粒的不同区域之间的折射率变化。在优选实施例中，薄膜具有以产生在反射率谱中可检测的代码的方式变化的孔隙率。测定检测方法使用这样的颗粒并在存在分析物的情况下检测光谱偏移。公开了另外的实施例，其包括附加特征。

10. 发明申请

WO2005024382A9 NANODEVICES EMPLOYING COMBINATORIAL ARTIFICIAL RECEPTORS 审中-公开
标题翻译：纳米组合使用组合人工受体
公开(公告)号：WO2005024382A9
公开(公告)日：2005-06-09
申请号：PCT/US2004029046
申请日：2004-09-03
申请人： RECEPTORS LLC , CARLSON ROBERT E
发明人： CARLSON ROBERT E
IPC分类号： B01J19/00 , G01N33/543 , G01N33/566 , G01N33/68
CPC分类号： G01N33/588 , B01J19/0046 , B01J2219/00524 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00738 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C07K14/705 , C12N2810/00 , C12N2810/50 , C40B80/00 , G01N33/54326 , G01N33/54346 , G01N33/552
摘要： The present invention includes nanodevices employing combinatorial artificial receptors and methods for making and using the same. In an embodiment the invention includes a method of adhering components together. In an embodiment, the invention includes a device including a first component adhered to a second component via a binding pair of artificial receptors. In an embodiment, the invention includes an agent delivery device having a capsule, and an active agent. In an embodiment, the invention can include a detection device having a magnetic particle and an artificial receptor disposed thereon. In an embodiment, the invention can include a detection device having a quantum dot and an artificial receptor disposed on the quantum dot. In an embodiment, the invention includes a detection device having first particles and second particles that aggregate in the present of a target ligand. In an embodiment, the invention includes a detection device having a cantilever and an artificial receptor disposed thereon. In an embodiment, the invention can include a detection device having a substrate and an artificial receptor disposed thereon. In an embodiment, the invention can include a device for selective removal of a target component including a substrate and an artificial receptor disposed thereon.
摘要翻译：本发明包括采用组合人工受体的纳米器件及其制备和使用方法。在一个实施例中，本发明包括将组件粘合在一起的方法。在一个实施方案中，本发明包括一种装置，该装置包括经由人造受体的结合对粘附到第二组分的第一组分。在一个实施方案中，本发明包括具有胶囊和活性剂的药剂递送装置。在一个实施例中，本发明可以包括具有设置在其上的磁性颗粒和人造受体的检测装置。在一个实施例中，本发明可以包括具有设置在量子点上的量子点和人造受体的检测装置。在一个实施方案中，本发明包括具有第一颗粒和第二颗粒的检测装置，所述第一颗粒和第二颗粒在靶配体存在时聚集。在一个实施例中，本发明包括具有悬臂和位于其上的人造接收器的检测装置。在一个实施例中，本发明可以包括具有衬底和设置在其上的人造受体的检测装置。在一个实施例中，本发明可以包括用于选择性去除包括衬底和位于其上的人造受体的目标组件的装置。

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