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    • 2. 发明申请
    • METHOD FOR PRODUCING[<18>F]FLUORIDE ION
    • 生产[18 F]氟化物离子的方法
    • WO0187235A3
    • 2002-05-30
    • PCT/US0115921
    • 2001-05-16
    • UNIV CALIFORNIA
    • BARRIO JORGE RSATYAMURTHY NAGICHETTIARPHELPS MICHAEL E
    • C01B7/20C07D471/10C07D473/18C07H5/02C07H19/06G21G1/10G21G4/08
    • G21G1/10
    • A method for producing [ F] fluoride ion comprises loading an enclosed chamber (16) of a metal target with [ O]oxygen gas. The [ O] oxygen gas is irradiated in the enclosed chamber (16) to produce [ F] fluoride ion in the chamber (16). The produced[ F]fluoride ion is removed from the chamber (16) without opening the target, preferably by introducing a solubilizing agent into the enclosed chamber (16) to solubilize produced [ F] ion from the enclosed chamber (16) without opening the target. The remaining [ O]oxygen gas is removed from the chamber (16) for reuse prior to removing the [ F]fluoride ion from the chamber (16). The produced [ F]fluoride ion is reactive and can be used to produce radiolabeled compounds such as 2-deoxy-2[ F]fluoro-D-glucose.
    • 用于生产[18 F]氟离子的方法包括用[18 O]氧气装载金属靶的封闭室(16)。 在封闭室(16)中照射[18 O]氧气,以在室(16)中产生[18 F]氟化物离子。 所产生的[18 F]氟化物离子不会打开靶,从腔室(16)中排出,优选通过将增溶剂引入封闭室(16)中以从封闭室中溶解产生的[18 F]离子 (16),而不打开目标。 在从室(16)中除去[18 F]氟化物离子之前,剩余的[18 O]氧气从室(16)中除去以便重新使用。 产生的[18 F]氟离子是反应性的,可用于产生放射性标记的化合物,例如2-脱氧-2 [18 F]氟-D-葡萄糖。