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1. 发明申请

WO2015085002A1 PRODUCTION OF BUTYL ACETATE FROM ETHANOL 审中-公开
标题翻译：从乙醇生产乙酸丁酯
公开(公告)号：WO2015085002A1
公开(公告)日：2015-06-11
申请号：PCT/US2014/068439
申请日：2014-12-03
申请人： GREENYUG, LLC
发明人： GADEWAR, Sagar B. , VICENTE, Brian C. , STOIMENOV, Peter K.
IPC分类号： C07C67/54 , C07C67/08
CPC分类号： C07C67/03 , B01D3/009 , B01J8/0278 , B01J19/0046 , B01J2208/00893 , B01J2208/025 , B01J2219/0059 , B01J2219/0072 , B01J2219/00759 , C07C29/34 , C07C67/40 , C07C67/54 , Y02P20/127 , Y02P20/582 , C07C69/14 , C07C31/12
摘要： A reactive distillation method comprises introducing a feed stream to a reactive distillation column, wherein the feed stream comprises ethanol, contacting the feed stream with one or more catalysts in the reactive distillation column during a distillation, and removing butyl acetate during the distillation from the reactive distillation column as a bottoms stream. The feed stream reacts in the presence of the one or more catalysts to produce a reaction product comprising ethyl acetate, butanol, and water, wherein the butanol and the ethyl acetate react to produce a reaction product comprising the butyl acetate.
摘要翻译：反应蒸馏方法包括将进料流引入反应性蒸馏塔，其中进料流包含乙醇，在蒸馏期间将进料流与反应蒸馏塔中的一种或多种催化剂接触，并在蒸馏期间从反应性物质中除去乙酸丁酯蒸馏塔作为底部流。进料流在一种或多种催化剂的存在下反应以产生包含乙酸乙酯，丁醇和水的反应产物，其中丁醇和乙酸乙酯反应以产生包含乙酸丁酯的反应产物。

2. 发明申请

WO2003059483A2 SEPARATION OF DIENES FROM OLEFINS USING IONIC LIQUIDS 审中-公开
标题翻译：使用离子液体从烯烃中分离二氧化碳
公开(公告)号：WO2003059483A2
公开(公告)日：2003-07-24
申请号：PCT/US2002/041739
申请日：2002-12-31
申请人： CHEVRON U.S.A. INC. , BOUDREAU, Laura, C. , DRIVER, Michael, S. , MUNSON, Curt, L.
发明人： BOUDREAU, Laura, C. , DRIVER, Michael, S. , MUNSON, Curt, L.
IPC分类号： B01D
CPC分类号： C10G29/06 , B01J2219/00308 , B01J2219/00313 , B01J2219/00756 , B01J2219/00759 , C07C7/152 , C07C7/156 , C40B60/14 , C07C11/00
摘要： Methods for separating di-olefins from mono-olefins, and olefins from non-olefins such as paraffins, oxygenates and aromatics, are provided. The methods use metal salts which complex both mono-olefins and di-olefins, but which selectively complex di-olefins in the presence of mono-olefins. The metal salts are dissolved or suspended in ionic liquids, which tend to have virtually no vapor pressure. Preferred salts are Group IB salts, more preferably silver and copper salts. A preferred silver salt is silver tetrafluoroborate. A preferred copper salt is silver CuOTf. Preferred ionic liquids are those which form stable solutions, suspensions or dispersions of the metal salts, which do not dissolve unwanted non-olefins, and which do not isomerize the mono- or di-olefins. The equivalents of the metal salt can be adjusted so that di-olefins are selectively adsorbed from mixtures of mono-and di-olefins. Alternatively, both mono- and di-olefins can be adsorbed, and the mono-olefins selectively desorbed. The latter approach can be preferred when non-olefins are also to be separated. The mono- and di-olefin-containing mixture can be in the gas phase or in the liquid phase. The flow of mono- and di-olefin-containing mixture over/through the ionic liquid can be, for example, co-current, counter-current, or staged in stirred tanks, with countercurrent being preferred.
摘要翻译：提供了从单烯烃分离二烯烃的方法，以及来自非烯烃如链烷烃，含氧化合物和芳烃的烯烃。该方法使用复合单烯烃和二烯烃的金属盐，但是在单烯烃存在下选择性复合的二烯烃。金属盐溶解或悬浮在离子液体中，其倾向于几乎不具有蒸气压。优选的盐是IB族盐，更优选银和铜盐。优选的银盐是四氟硼酸银。优选的铜盐是银CuOTf。优选的离子液体是形成不溶解不需要的非烯烃并且不使单烯烃或二烯烃异构化的金属盐的稳定溶液，悬浮液或分散体的离子液体。可以调节金属盐的当量，使得二烯烃从单烯烃和二烯烃的混合物中选择性吸附。或者，可以吸附单烯烃和二烯烃，并且单烯烃选择性解吸。当非烯烃也被分离时，后一种方法可以是优选的。含单烯烃和二烯烃的混合物可以处于气相或液相中。通过离子液体流过单 - 和二烯烃混合物的流动可以是例如在搅拌釜中的并流，逆流或分级，优选逆流。

3. 发明申请

WO2013012822A1 SYSTEMS, METHODS, AND DEVICES FOR PRODUCING, MANUFACTURING, AND CONTROL OF RADIOPHARMACEUTICALS 审中-公开
标题翻译：用于制造，制造和控制放射线虫的系统，方法和装置
公开(公告)号：WO2013012822A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/046968
申请日：2012-07-16
申请人： CARDINAL HEALTH 414, LLC , ESHIMA, Dennis , HUSNU, Mehmet , STONE, Jim , ALCAIDE, Derrick , PADGETT, Henry , ZAMBANINI, Joseph, E. , KLAUSING, Thomas, A. , BOUTON, Chad, E. , KELLEY, Brian, C. , DANHOF, Scot, N. , HOLLEY, David, A. , STROUP, Jeffery, T. , GLEESON, Jim , HASSENPFLUG, Eric , PRESCOTT, Jim , BENECKE, Herman , GARBARK, Daniel, B.
发明人： ESHIMA, Dennis , HUSNU, Mehmet , STONE, Jim , ALCAIDE, Derrick , PADGETT, Henry , ZAMBANINI, Joseph, E. , KLAUSING, Thomas, A. , BOUTON, Chad, E. , KELLEY, Brian, C. , DANHOF, Scot, N. , HOLLEY, David, A. , STROUP, Jeffery, T. , GLEESON, Jim , HASSENPFLUG, Eric , PRESCOTT, Jim , BENECKE, Herman , GARBARK, Daniel, B.
IPC分类号： G21C1/00
CPC分类号： B01J19/0006 , A61J3/002 , A61K51/0491 , B01J19/004 , B01J19/0046 , B01J2219/00049 , B01J2219/00351 , B01J2219/00355 , B01J2219/00585 , B01J2219/00693 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00759 , B65B1/00 , B65B3/003 , G21G1/10 , G21G2001/0015
摘要： Systems, methods, and devices for generating radionuclides for use in production of radiophamiaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributiveiv delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as pari of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutical output; and providing software and hardware controls for overall and sub-portion operation for optional remote data collection, communication, and/or control.
摘要翻译：用于产生用于放射性药物生产的放射性核素的系统，方法和装置; 合成生成的放射性核素并除去任何不需要的产物; 测量合成放射性核素的数量和活度水平; 将放射性核素分配给模块化盒式系统中的模块化盒式合成单元，用于同时/并行生产放射性药物输出，并允许重新使用和/或快速，安全和一次性更换子系统的一部分; 将非放射性核素组分递送到模块化盒式合成单元作为放射性药物输出的生产; 测量每个放射性药物输出流量的数量和活动水平; 净化放射性药物输出; 在无菌小瓶中分配单个剂量; 自动生成标签和剂量相关信息; 对提取的放射性药物输出样品进行自动化质量控制; 并为可选的远程数据收集，通信和/或控制提供用于整体和子部分操作的软件和硬件控制。

4. 发明申请

WO2003065030A1 FLUID HANDLING METHODS AND SYSTEMS 审中-公开
标题翻译：流体处理方法和系统
公开(公告)号：WO2003065030A1
公开(公告)日：2003-08-07
申请号：PCT/US2003/002379
申请日：2003-01-24
申请人： IRM, LLC , MICKLASH, Kenneth, J., II , ISBELL, John
发明人： MICKLASH, Kenneth, J., II , ISBELL, John
IPC分类号： G01N30/02
CPC分类号： C40B50/14 , B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00313 , B01J2219/00335 , B01J2219/00364 , B01J2219/00376 , B01J2219/00423 , B01J2219/00454 , B01J2219/00459 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/0072 , B01J2219/00759 , B01L3/50255 , B01L3/50853 , B01L2300/042 , B01L2300/0829 , B01L2400/049 , C40B50/08 , G01N30/466 , G01N30/80 , G01N35/1074 , G01N35/1079
摘要： Fluid handling systems and methods include weight scales (204) coupled to a controller (202) for monitoring fluid levels in containers (208) so as to control fluid dispensed by pump (206).
摘要翻译：流体处理系统和方法包括耦合到控制器（202）的重量秤（204），用于监测容器（208）中的液位，以便控制由泵（206）分配的流体。

5. 发明申请

WO2003064585A1 DEVICES, SYSTEMS, AND METHODS OF MANIFOLDING MATERIALS 审中-公开
标题翻译：装置，系统和分配材料的方法
公开(公告)号：WO2003064585A1
公开(公告)日：2003-08-07
申请号：PCT/US2003/002189
申请日：2003-01-24
申请人： IRM, LLC , MICKLASH, Kenneth, J., II , DOWNS, Robert, C. , BUROW, Kristina , BACKES, Brad
发明人： MICKLASH, Kenneth, J., II , DOWNS, Robert, C. , BUROW, Kristina , BACKES, Brad
IPC分类号： C12M1/18
CPC分类号： C40B50/14 , B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00313 , B01J2219/00335 , B01J2219/00364 , B01J2219/00376 , B01J2219/00423 , B01J2219/00454 , B01J2219/00459 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/0072 , B01J2219/00759 , B01L3/50255 , B01L3/50853 , B01L2300/042 , B01L2300/0829 , B01L2400/049 , C40B50/08 , G01N30/466 , G01N30/80 , G01N35/1074 , G01N35/1079
摘要： Devices, systems and methods for manifolding or distributing materials to and/or from reaction wells include fill wells (404) coupled to needles (406) for insertion through cap mats and/or gaskets on the top and/or bottom of the reaction wells.
摘要翻译：用于将材料分配或分配到和/或来自反应井的装置，系统和方法包括连接到针（406）的填充孔（404），用于插入反应井的顶部和/或底部的帽垫和/或垫圈。

6. 发明申请

WO01098239A1 PROCESS FOR THE PURIFICATION OF OLEFINS 审中-公开
标题翻译：烯烃的纯化方法
公开(公告)号：WO01098239A1
公开(公告)日：2001-12-27
申请号：PCT/US2001/017449
申请日：2001-05-29
IPC分类号： C07B61/00 , C07B63/00 , C07C1/04 , C07C2/06 , C07C5/327 , C07C7/04 , C07C7/148 , C07C7/152 , C07C11/02 , C07C11/04 , C07C11/06 , C07C11/08 , C10G2/00 , C10G29/00 , C10G29/06 , C10G55/04 , C10G55/06 , C10G57/02 , C10G67/02 , C10G70/00 , C40B50/08 , C40B60/14 , G01N30/02
CPC分类号： C10G70/002 , B01J2219/00047 , B01J2219/00306 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00759 , C07B63/00 , C07C1/0485 , C07C7/152 , C07C11/02 , C10G29/00 , C40B50/08 , C40B60/14 , G01N30/02 , Y02P30/42
摘要： Methods for separating olefins from non-olefins, such as paraffins, including cycloparaffins, oxygenates and aromatics, are provided. The methods use metal salts to complex olefins, allowing the non-olefins to be separated by a variety of methods, including decantation distillation and gravimetric separation. The metal salts are dissolved or dispersed in ionic liquids, which tend to have virtually no vapor pressure, and which poorly solubilize the non-olefins. Accordingly, the non-olefins phase separate well, and can be distilled without carrying over any of the ionic liquid into the distillate. Preferred salts are Group IB salts, more preferably silver salts. A preferred silver salt is silver tetrafluoroborate. Preferred ionic liquids are those which form stable solutions or dispersions of the metal salts, and which do not dissolve the non-olefins. Further, if the olefins are subject to isomerization, the ionic liquid is preferably relatively non-acidic. The methods involve forming a solution or dispersion of a suitable olefin-complexing salt in an appropriate ionic liquid. An olefin-containing mixture is contacted with the ionic liquid/salt solution, and the olefins are adsorbed. After the paraffins are removed, the olefins can be isolated by desorption. The olefin-containing mixture over/through the ionic liquid phase. The flow of the olefin-containing mixtures over/through the ionic liquid can be, for example, co-current, counter-current, or staged in stirred tanks. Countercurrent is preferred as it is the most efficient. The methods can be optimized using combinatirial chemistry.
摘要翻译：提供了从非烯烃如链烷烃（包括环烷烃，含氧化合物和芳族化合物）中分离烯烃的方法。该方法使用金属盐络合烯烃，允许通过各种方法分离非烯烃，包括倾析蒸馏和重量分离。金属盐溶解或分散在离子液体中，其倾向于几乎不具有蒸气压，并且使非烯烃的溶解性差。因此，非烯烃相分离井，并且可以蒸馏而不将任何离子液体输送到馏出物中。优选的盐是IB族盐，更优选银盐。优选的银盐是四氟硼酸银。优选的离子液体是形成金属盐的稳定溶液或分散体并且不溶解非烯烃的离子液体。此外，如果烯烃经历异构化，离子液体优选是相对非酸性的。所述方法包括在合适的离子液体中形成合适的烯烃络合盐的溶液或分散体。使含烯烃的混合物与离子液体/盐溶液接触，并且吸附烯烃。在除去石蜡之后，可以通过解吸分离烯烃。含烯烃的混合物超过/通过离子液相。通过离子液体的/通过离子液体的含烯烃混合物的流动可以是例如在搅拌釜中的并流，逆流或分级。逆流是首选，因为它是最有效的。该方法可以使用组合化学方法进行优化。

7. 发明申请

WO2016065300A1 MICROFLUIDIC CARTRIDGE 审中-公开
公开(公告)号：WO2016065300A1
公开(公告)日：2016-04-28
申请号：PCT/US2015/057186
申请日：2015-10-23
申请人： ESHOO, Mark W. , HANG, Alice T. , SMITH, Heather L. , MEIJERING, Bernadet , FEITSMA, Harma Martine , VAN ZELST, Martinus Johannes
发明人： ESHOO, Mark W. , HANG, Alice T. , SMITH, Heather L. , MEIJERING, Bernadet , FEITSMA, Harma Martine , VAN ZELST, Martinus Johannes
IPC分类号： C12Q1/68
CPC分类号： B01L3/5027 , B01J2219/00389 , B01J2219/00418 , B01J2219/00486 , B01J2219/00495 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00722 , B01J2219/00759 , B01L2200/0668 , B01L2200/0684 , B01L2200/10 , B01L2300/0627 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/1822 , B01L2400/0487 , C40B60/14
摘要： Provided herein is technology relating to microfluidic cartridges configured to process a biological sample, including but not limited to devices, apparatuses, methods, and systems for generating nucleic acid sequencing libraries that are suitable for use in sequencing methods (e.g., next generation sequencing methods) or other nucleic acid analysis technologies.
摘要翻译：本文提供了涉及用于处理生物样品的微流控盒的技术，包括但不限于用于生成适用于测序方法（例如，下一代测序方法）的核酸测序文库的装置，装置，方法和系统，或其他核酸分析技术。

8. 发明申请

WO2007041486A3 MICROFLUIDIC CHIP FOR SYNTHESIZING RADIOACTIVELY LABELED MOLECULES SUITABLE FOR HUMAN IMAGING WITH POSITRON EMISSION TOMOGRAPHY 审中-公开
标题翻译：用于合成适用于人体成像的放射性标记分子的微流感芯片
公开(公告)号：WO2007041486A3
公开(公告)日：2007-06-07
申请号：PCT/US2006038418
申请日：2006-09-29
申请人： SIEMENS MEDICAL SOLUTIONS , ELIZAROV ARKADIJ M , KOLB HARTMUTH , HEATH JAMES , VAN DAM R MICHAEL
发明人： ELIZAROV ARKADIJ M , KOLB HARTMUTH , HEATH JAMES , VAN DAM R MICHAEL
IPC分类号： B01J19/00
CPC分类号： B01F11/0042 , B01F11/0071 , B01F13/0059 , B01J19/0093 , B01J2219/00286 , B01J2219/00396 , B01J2219/00398 , B01J2219/00414 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00731 , B01J2219/00759 , B01J2219/00783 , B01J2219/00788 , B01J2219/00822 , B01J2219/00824 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00858 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01J2219/00916 , B01J2219/00927 , B01J2219/00986
摘要： The invention concerns automated, inegrated microfluidic devices comprising a chemical reaction chip for performing reactions, such as the preparation of radiopharmaceutical compounds. The chip comprises an integrated microscale column and is configured for liquid flow from the column to at least one flow channel. The fluid flow is controlled by at least two on-chip valves. These double valves are configured consecutively and within proximity of 300 micrometer from each other. The reaction chamber is substantially "coinshaped", e.g. a reaction cylinder, preferably having a height diameter to height ratio greater than 3. Curved inlet and outlet channels ensure en effective elution.
摘要翻译：本发明涉及包括用于进行反应的化学反应芯片例如制备放射性药物化合物的自动化整合的微流体装置。该芯片包括集成的微量柱，并被配置用于从柱流到至少一个流动通道的液体流。流体流动由至少两个片上阀控制。这些双阀门连续配置，并且距离彼此在300微米附近。反应室基本上是“硬币”，例如。反应筒，优选地具有高于3的高度直径与高度之比。弯曲的入口和出口通道确保有效洗脱。

9. 发明申请

WO2005108597A2 PROCESS FOR HIGH THROUGHPUT LIQUID OR GAS CHROMATOGRAPHY/MASS SPECTROMETRY-BASED BIOMOLECULAR SCREENING FOR DRUG DISCOVERY 审中-公开
标题翻译：高通量液相色谱或气相色谱/质谱联用生物分子筛检查药物发现
公开(公告)号：WO2005108597A2
公开(公告)日：2005-11-17
申请号：PCT/US2005/014820
申请日：2005-04-29
申请人： HAYWARD, Mark
发明人： HAYWARD, Mark
IPC分类号： C12Q1/00
CPC分类号： G01N30/466 , B01J2219/00759 , G01N30/72 , G01N30/8658 , G01N2030/628 , G01N2030/324
摘要： Methods of achieving realistic hit rates and reducing or eliminating false positive rates in medicinal compound high throughput screening are provided. The methods of the invention include chromatographic resolution, for example by liquid or gas chromatography of biological substrates and/or substrate products, followed by sensitive with mass spectrometry to measure biological activity screening to generate meaningful drug leads. The methods of the invention save significant method development and thus are directly applicable to the high throughput screening time scale while providing high accuracy and sensitivity.
摘要翻译：提供了在医药化合物高通量筛选中实现实际命中率并减少或消除假阳性率的方法。本发明的方法包括色谱分离，例如通过生物底物和/或底物产物的液体或气相色谱，随后用质谱法敏感以测量生物活性筛选以产生有意义的药物引导。本发明的方法节省了重要的方法开发，并因此直接适用于高通量筛选时间标度，同时提供高准确度和灵敏度。

10. 发明申请

WO0186283A3 APPARATUS AND METHOD FOR MULTIPLE CHANNEL HIGH THROUGHPUT PURIFICATION 审中-公开
标题翻译：用于多通道高通量净化的装置和方法
公开(公告)号：WO0186283A3
公开(公告)日：2002-05-16
申请号：PCT/US0115469
申请日：2001-05-11
申请人： ONTOGEN CORP , MAIEFSKI ROMAINE , WENDELL DON , KRAKOVER JONATHAN D
发明人： MAIEFSKI ROMAINE , WENDELL DON , KRAKOVER JONATHAN D
IPC分类号： G01N37/00 , B01D15/08 , B01J3/00 , B01J3/02 , B01J4/00 , B01J19/00 , C40B20/00 , G01N1/34 , G01N1/40 , G01N30/02 , G01N30/06 , G01N30/08 , G01N30/20 , G01N30/26 , G01N30/30 , G01N30/32 , G01N30/46 , G01N30/60 , G01N30/72 , G01N30/80 , G01N30/82 , G01N30/86 , G01N35/00 , G05D16/20 , G01N30/22 , G05D16/10
CPC分类号： G01N1/405 , B01D15/08 , B01D15/14 , B01D15/1871 , B01D15/1885 , B01D15/40 , B01J2219/00587 , B01J2219/00759 , G01N30/02 , G01N30/60 , G01N35/00 , G05D16/202
摘要： This includes pressure regulator assembly usable in, as an example, a multiple channel high throughput purification system. The pressure regulator assembly is adjustable for pressure control of the fluid flow in the purification system. The apparatus includes a microsampling device useable in a multiple channel high throughput purification system for purifying a plurality of samples, preferably four or more samples from a chemical library. The apparatus also includes a high throughput liquid chromatography column assembly for separating a large sample with a selected mass weight and fluid volume. The apparatus also includes a fraction collection assembly having a frame and a dispensing head movably connected to the frame for movement about three axes. A rinse station is connected to the frame and positioned to removably receive the dispensing tube when the dispensing head is in the rinse position. A pickup station is provided adjacent to an expansion chamber distribution assembly to retain the expansion chambers in a selected position to be picked up by the dispensing head when in the pick up position prior to distribution of the sample into the receiving container.
摘要翻译：这包括可用于例如多通道高通量净化系统的压力调节器组件。压力调节器组件可调整，用于压力控制净化系统中的流体流动。该装置包括可在多通道高通量净化系统中使用的微量取样装置，用于从化学文库纯化多个样品，优选四个或更多个样品。该装置还包括用于分离具有所选质量重量和流体体积的大样品的高通量液相色谱柱组件。该设备还包括具有框架的分数收集组件和可移动地连接到框架上用于围绕三个轴线移动的分配头部。冲洗站连接到框架并定位成当分配头处于冲洗位置时可拆卸地接收分配管。拾取站邻近膨胀室分配组件设置，以将膨胀室保持在选定位置，以便在将样品分配到接收容器之前处于拾取位置时由分配头拾起。

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